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Protein

Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase

Gene

BPSL2194

Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).By similarity

Catalytic activityi

4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate.
Oxaloacetate = pyruvate + CO2.

Cofactori

a divalent metal cationBy similarityNote: Divalent metal cation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102SubstrateBy similarity1
Metal bindingi103Divalent metal cationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandMetal-binding

Enzyme and pathway databases

BioCyciBPSE272560:G1G3Q-2284-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase (EC:4.1.3.17)
Short name:
HMG aldolase
Alternative name(s):
Oxaloacetate decarboxylase (EC:4.1.1.3)
Short name:
OAA decarboxylase
Regulator of ribonuclease activity homolog
RraA-like protein
Gene namesi
Ordered Locus Names:BPSL2194
OrganismiBurkholderia pseudomallei (strain K96243)
Taxonomic identifieri272560 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000000605 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002096061 – 165Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolaseAdd BLAST165

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi272560.BPSL2194

Structurei

3D structure databases

ProteinModelPortaliQ63SX7
SMRiQ63SX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni80 – 83Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the class II aldolase/RraA-like family.Curated

Phylogenomic databases

eggNOGiCOG0684 LUCA
HOGENOMiHOG000252803
KOiK02553
OMAiYADWNGV

Family and domain databases

CDDicd16841 RraA_family, 1 hit
InterProiView protein in InterPro
IPR010203 RraA
IPR005493 RraA/RraA-like
IPR036704 RraA/RraA-like_sf
PfamiView protein in Pfam
PF03737 RraA-like, 1 hit
SUPFAMiSSF89562 SSF89562, 1 hit
TIGRFAMsiTIGR01935 NOT-MenG, 1 hit

Sequencei

Sequence statusi: Complete.

Q63SX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFATTDLCD AHEDRLAAGT LRVLEPVFRP FGGVRRFAGP AATLKLFEDN
60 70 80 90 100
SLVRTALEQD GAGRVLVVDG GGSLRCALVG GNLGKLAEKN GWAGIVVNGC
110 120 130 140 150
VRDSDELAEC RVGVLALAAH PRKSDKRGAG VSDAPVDVRG TRIVPGDWIY
160
ADADGVLVSD DALLE
Length:165
Mass (Da):17,301
Last modified:October 25, 2004 - v1
Checksum:iACCDBB82E0923ACA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571965 Genomic DNA Translation: CAH36196.1
RefSeqiWP_004191744.1, NZ_CP009538.1
YP_108789.1, NC_006350.1

Genome annotation databases

EnsemblBacteriaiCAH36196; CAH36196; BPSL2194
GeneIDi3093172
KEGGibps:BPSL2194
PATRICifig|272560.51.peg.3254

Similar proteinsi

Entry informationi

Entry nameiRRAAH_BURPS
AccessioniPrimary (citable) accession number: Q63SX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 25, 2004
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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