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Q63S63

- PNCB_BURPS

UniProt

Q63S63 - PNCB_BURPS

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciBPSE272560:GJNI-2521-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:BPSL2462
    OrganismiBurkholderia pseudomallei (strain K96243)
    Taxonomic identifieri272560 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000000605: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 399399Nicotinate phosphoribosyltransferasePRO_0000205826Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272560.BPSL2462.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63S63.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284928.
    KOiK00763.
    OMAiSIVCKVI.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q63S63-1 [UniParc]FASTAAdd to Basket

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    MIITSLLDTD LYKFTMMQVV LHHFPAASVE YRFKCRTPGV DLVPYIDEIR    50
    AEVRSLCELR FTDSELDYLR RLRFVKSDFV DFLALFHLNE KYISITPSQK 100
    GGGEIDIEIK GPWLHTILFE IPVLAIVNEV YFRNTQRRPD YREGRGRLRE 150
    KIKLLGAKPE FADCKIADYG TRRRFSKVWH EEVLRTLQDG LGPQFAGTSN 200
    VYYAMTHEIT PLGTMAHEYL QACQALGPRL RDSQTYGLEM WAKEYRGDLG 250
    IALSDVYGMD AFLRDFDMYF CKLFDGARHD SGDPFDWGER LIKHYEENRC 300
    DPRTKVLVFS DALDIPKVMQ LYARFRGRCK LAFGVGTNLT NDLGYQPLQI 350
    VIKMVRCNGQ PVAKLSDSPG KSMCDDKAYL AYLRQVFGIT QPPDDDAGK 399
    Length:399
    Mass (Da):45,962
    Last modified:October 25, 2004 - v1
    Checksum:i64300451032C4FA1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571965 Genomic DNA. Translation: CAH36465.1.
    RefSeqiYP_109054.1. NC_006350.1.

    Genome annotation databases

    EnsemblBacteriaiCAH36465; CAH36465; BPSL2462.
    GeneIDi3091463.
    KEGGibps:BPSL2462.
    PATRICi19265199. VBIBurPse99623_2804.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571965 Genomic DNA. Translation: CAH36465.1 .
    RefSeqi YP_109054.1. NC_006350.1.

    3D structure databases

    ProteinModelPortali Q63S63.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272560.BPSL2462.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH36465 ; CAH36465 ; BPSL2462 .
    GeneIDi 3091463.
    KEGGi bps:BPSL2462.
    PATRICi 19265199. VBIBurPse99623_2804.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284928.
    KOi K00763.
    OMAi SIVCKVI.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci BPSE272560:GJNI-2521-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K96243.

    Entry informationi

    Entry nameiPNCB_BURPS
    AccessioniPrimary (citable) accession number: Q63S63
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3