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Q63S63

- PNCB_BURPS

UniProt

Q63S63 - PNCB_BURPS

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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciBPSE272560:GJNI-2521-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:BPSL2462
OrganismiBurkholderia pseudomallei (strain K96243)
Taxonomic identifieri272560 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000000605: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Nicotinate phosphoribosyltransferasePRO_0000205826Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272560.BPSL2462.

Structurei

3D structure databases

ProteinModelPortaliQ63S63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiSIVCKVI.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63S63-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIITSLLDTD LYKFTMMQVV LHHFPAASVE YRFKCRTPGV DLVPYIDEIR
60 70 80 90 100
AEVRSLCELR FTDSELDYLR RLRFVKSDFV DFLALFHLNE KYISITPSQK
110 120 130 140 150
GGGEIDIEIK GPWLHTILFE IPVLAIVNEV YFRNTQRRPD YREGRGRLRE
160 170 180 190 200
KIKLLGAKPE FADCKIADYG TRRRFSKVWH EEVLRTLQDG LGPQFAGTSN
210 220 230 240 250
VYYAMTHEIT PLGTMAHEYL QACQALGPRL RDSQTYGLEM WAKEYRGDLG
260 270 280 290 300
IALSDVYGMD AFLRDFDMYF CKLFDGARHD SGDPFDWGER LIKHYEENRC
310 320 330 340 350
DPRTKVLVFS DALDIPKVMQ LYARFRGRCK LAFGVGTNLT NDLGYQPLQI
360 370 380 390
VIKMVRCNGQ PVAKLSDSPG KSMCDDKAYL AYLRQVFGIT QPPDDDAGK
Length:399
Mass (Da):45,962
Last modified:October 25, 2004 - v1
Checksum:i64300451032C4FA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571965 Genomic DNA. Translation: CAH36465.1.
RefSeqiYP_109054.1. NC_006350.1.

Genome annotation databases

EnsemblBacteriaiCAH36465; CAH36465; BPSL2462.
GeneIDi3091463.
KEGGibps:BPSL2462.
PATRICi19265199. VBIBurPse99623_2804.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571965 Genomic DNA. Translation: CAH36465.1 .
RefSeqi YP_109054.1. NC_006350.1.

3D structure databases

ProteinModelPortali Q63S63.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272560.BPSL2462.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH36465 ; CAH36465 ; BPSL2462 .
GeneIDi 3091463.
KEGGi bps:BPSL2462.
PATRICi 19265199. VBIBurPse99623_2804.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
KOi K00763.
OMAi SIVCKVI.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci BPSE272560:GJNI-2521-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K96243.

Entry informationi

Entry nameiPNCB_BURPS
AccessioniPrimary (citable) accession number: Q63S63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 25, 2004
Last modified: October 1, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3