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Q63RQ7 (GLK_BURPS) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional protein glk

Including the following 2 domains:

  1. Glucokinase
    EC=2.7.1.2
    Alternative name(s):
    Glucose kinase
  2. Putative HTH-type transcriptional regulator
Gene names
Name:glk
Ordered Locus Names:BPSL2614
OrganismBurkholderia pseudomallei (strain K96243) [Reference proteome] [HAMAP]
Taxonomic identifier272560 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

Protein attributes

Sequence length641 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-glucose = ADP + D-glucose 6-phosphate. HAMAP-Rule MF_00524

Subcellular location

Membrane; Single-pass membrane protein Potential HAMAP-Rule MF_00524.

Sequence similarities

In the N-terminal section; belongs to the bacterial glucokinase family.

Contains 1 HTH rpiR-type DNA-binding domain.

Contains 1 SIS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 641641Bifunctional protein glk HAMAP-Rule MF_00524
PRO_0000268799

Regions

Transmembrane576 – 59621Helical; Potential
Domain341 – 41777HTH rpiR-type
Domain461 – 600140SIS
Nucleotide binding23 – 286ATP Potential
DNA binding377 – 39620H-T-H motif By similarity
Region1 – 340340Glucokinase HAMAP-Rule MF_00524
Region341 – 641301Putative HTH-type transcriptional regulator HAMAP-Rule MF_00524
Compositional bias591 – 63949Ala-rich HAMAP-Rule MF_00524

Sequences

Sequence LengthMass (Da)Tools
Q63RQ7 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: DF273867FE0AD163

FASTA64168,347
        10         20         30         40         50         60 
MSTGAQTKAA AASQHADGPR LLADVGGTNA RFALETGPGE ITQIRVYPGA EYPTLTDAIR 

        70         80         90        100        110        120 
KYLKDAKIGR VNHAAIAIAN PVDGDQVRMT NHNWSFSIEA TRRALGFDTL LVVNDFTALA 

       130        140        150        160        170        180 
MALPGLTDAQ RVQIGGGARR QNSVIGLMGP GTGLGVSGLI PADDRWIALG SEGGHATFAP 

       190        200        210        220        230        240 
MDEREDLVLQ YARRKYPHVS FERVCAGPGM EIIYRALAAR DKKRIAANVD TADIVERAHA 

       250        260        270        280        290        300 
GDALALEAVE CFCAILGTFA GNLAVTLGAL GGIYIGGGVV PKLGELFMRS PFRARFEAKG 

       310        320        330        340        350        360 
RFEAYLANIP TYLITAEYPA FLGVSAILAE QLSNRTGGAS SAVFERIRQM RDALTPAERR 

       370        380        390        400        410        420 
VADLALNHPR SIINDPIVDI ARKADVSQPT VIRFCRSLGC QGLSDFKLKL ATGLTGTIPM 

       430        440        450        460        470        480 
SHSQVHLGDT ATDFGAKVLD NTVSAILQLR EHLNFEHVEQ AIDILNNARR IEFYGLGNSN 

       490        500        510        520        530        540 
IVAQDAHYKF FRFGIPTIAY GDLYMQAASA ALLGKGDVIV AVSKSGRAPE LLRVLDVAMQ 

       550        560        570        580        590        600 
AGAKVIAITS SNTPLAKRAT VALETDHIEM RESQLSMISR ILHLVMIDIL AVGVAIRRAA 

       610        620        630        640 
PNAELAEAMA RAKARAGASA GDEAADVLDW LSHGAAPAAK D 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571965 Genomic DNA. Translation: CAH36622.1.
RefSeqYP_109210.1. NC_006350.1.

3D structure databases

ProteinModelPortalQ63RQ7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272560.BPSL2614.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH36622; CAH36622; BPSL2614.
GeneID3091975.
KEGGbps:BPSL2614.
PATRIC19265563. VBIBurPse99623_2979.

Phylogenomic databases

eggNOGCOG1737.
HOGENOMHOG000257466.
KOK00845.
OMAQYARKKW.
OrthoDBEOG64BQ47.

Enzyme and pathway databases

BioCycBPSE272560:GJNI-2686-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
HAMAPMF_00524. Glucokinase.
InterProIPR003836. Glucokinase.
IPR009057. Homeodomain-like.
IPR000281. HTH_RpiR.
IPR001347. SIS.
IPR000843. Tscrpt_reg_HTH_LacI.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF02685. Glucokinase. 1 hit.
PF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
TIGRFAMsTIGR00749. glk. 1 hit.
PROSITEPS00356. HTH_LACI_1. 1 hit.
PS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLK_BURPS
AccessionPrimary (citable) accession number: Q63RQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 25, 2004
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families