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Q63RN0

- TRMB_BURPS

UniProt

Q63RN0 - TRMB_BURPS

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, BPSL2642
Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951S-adenosyl-L-methionine By similarity
Binding sitei120 – 1201S-adenosyl-L-methionine By similarity
Binding sitei147 – 1471S-adenosyl-L-methionine By similarity
Active sitei170 – 1701 By similarity
Binding sitei170 – 1701S-adenosyl-L-methionine By similarity
Binding sitei174 – 1741Substrate By similarity
Binding sitei206 – 2061Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciBPSE272560:GJNI-2715-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:BPSL2642
    OrganismiBurkholderia pseudomallei (strain K96243)
    Taxonomic identifieri272560 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000000605: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 265265tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000171311Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272560.BPSL2642.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63RN0.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni241 – 2444Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiVETIRIR.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q63RN0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIHDDDPNAP GAPHDDDATA APASATRAAP AAGDDDDANP LHLRRIRSFV    50
    TRAGRVSTGQ RRAIDELGPR FVIPYGSAQP DWDAIFGRRA PRVLEIGFGM 100
    GASTAEIAAL RPGDDFIGVE VHEPGVGALL KLIGEQQLSN IRIIQHDAVE 150
    VLAQMIAPDS LDGVHIFFPD PWHKARHHKR RLIQPPFVAQ LAAHLKPGAY 200
    LHCATDWQNY AEQMLEVLSA DPSLENTAQD YAPRPGYRPV TKFERRGLRL 250
    GHGVWDLVFR KKHAG 265
    Length:265
    Mass (Da):29,102
    Last modified:October 25, 2004 - v1
    Checksum:iD19E15399EE03B40
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571965 Genomic DNA. Translation: CAH36650.1.
    RefSeqiYP_109238.1. NC_006350.1.

    Genome annotation databases

    EnsemblBacteriaiCAH36650; CAH36650; BPSL2642.
    GeneIDi3093291.
    KEGGibps:BPSL2642.
    PATRICi19265631. VBIBurPse99623_3012.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571965 Genomic DNA. Translation: CAH36650.1 .
    RefSeqi YP_109238.1. NC_006350.1.

    3D structure databases

    ProteinModelPortali Q63RN0.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 272560.BPSL2642.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH36650 ; CAH36650 ; BPSL2642 .
    GeneIDi 3093291.
    KEGGi bps:BPSL2642.
    PATRICi 19265631. VBIBurPse99623_3012.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi VETIRIR.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci BPSE272560:GJNI-2715-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K96243.

    Entry informationi

    Entry nameiTRMB_BURPS
    AccessioniPrimary (citable) accession number: Q63RN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: October 25, 2004
    Last modified: June 11, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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