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Q63RN0

- TRMB_BURPS

UniProt

Q63RN0 - TRMB_BURPS

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, BPSL2642
Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951S-adenosyl-L-methionine By similarity
Binding sitei120 – 1201S-adenosyl-L-methionine By similarity
Binding sitei147 – 1471S-adenosyl-L-methionine By similarity
Active sitei170 – 1701 By similarity
Binding sitei170 – 1701S-adenosyl-L-methionine By similarity
Binding sitei174 – 1741Substrate By similarity
Binding sitei206 – 2061Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBPSE272560:GJNI-2715-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:BPSL2642
OrganismiBurkholderia pseudomallei (strain K96243)
Taxonomic identifieri272560 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000000605: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000171311Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272560.BPSL2642.

Structurei

3D structure databases

ProteinModelPortaliQ63RN0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni241 – 2444Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiVETIRIR.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63RN0-1 [UniParc]FASTAAdd to Basket

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MIHDDDPNAP GAPHDDDATA APASATRAAP AAGDDDDANP LHLRRIRSFV    50
TRAGRVSTGQ RRAIDELGPR FVIPYGSAQP DWDAIFGRRA PRVLEIGFGM 100
GASTAEIAAL RPGDDFIGVE VHEPGVGALL KLIGEQQLSN IRIIQHDAVE 150
VLAQMIAPDS LDGVHIFFPD PWHKARHHKR RLIQPPFVAQ LAAHLKPGAY 200
LHCATDWQNY AEQMLEVLSA DPSLENTAQD YAPRPGYRPV TKFERRGLRL 250
GHGVWDLVFR KKHAG 265
Length:265
Mass (Da):29,102
Last modified:October 25, 2004 - v1
Checksum:iD19E15399EE03B40
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571965 Genomic DNA. Translation: CAH36650.1.
RefSeqiYP_109238.1. NC_006350.1.

Genome annotation databases

EnsemblBacteriaiCAH36650; CAH36650; BPSL2642.
GeneIDi3093291.
KEGGibps:BPSL2642.
PATRICi19265631. VBIBurPse99623_3012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571965 Genomic DNA. Translation: CAH36650.1 .
RefSeqi YP_109238.1. NC_006350.1.

3D structure databases

ProteinModelPortali Q63RN0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272560.BPSL2642.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH36650 ; CAH36650 ; BPSL2642 .
GeneIDi 3093291.
KEGGi bps:BPSL2642.
PATRICi 19265631. VBIBurPse99623_3012.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi VETIRIR.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci BPSE272560:GJNI-2715-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K96243.

Entry informationi

Entry nameiTRMB_BURPS
AccessioniPrimary (citable) accession number: Q63RN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: October 25, 2004
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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