Q63RM9 (UPPP2_BURPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase 2
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2

Gene names

Name:	uppP2
Ordered Locus Names:	BPSL2643

Organism

Burkholderia pseudomallei (Pseudomonas pseudomallei)

Taxonomic identifier

28450 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Undecaprenyl-diphosphatase 2 HAMAP MF_01006		PRO_0000151127
Regions
	Transmembrane	85 – 105	21	Helical; Potential
	Transmembrane	108 – 128	21	Helical; Potential
	Transmembrane	187 – 207	21	Helical; Potential
	Transmembrane	217 – 237	21	Helical; Potential
	Transmembrane	253 – 273	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q63RM9 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 608BFAFD49296177	FASTA	276	30,284
	10 20 30 40 50 60 MDWILICKAL ALGIVEGLTE FLPVSSTGHL IVAGSFLRFH PEQAKTFDVV IQFGAILAVC 70 80 90 100 110 120 WEYRRRIIDV VTGLPAQREA RRFTMNVVIA TVPAVALALL FEKTIKSVLF APVPVAVALV 130 140 150 160 170 180 VGGAAILWVE GRQRERSEPA RVQSIDALTP FDALKVGLAQ CCALIPGMSR SGSTIIGGML 190 200 210 220 230 240 FGLERRVATE FSFFLAIPVI FGATLYETAK DWRAFNVDSV GLFAIGLVAA FVSAFACVRW 250 260 270 LLRYVASHDF TAFAWYRIAF GLFVLLVGYS GWIEWT

References

[1]

"Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei." Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M., Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L., Bentley S.D., Sebaihia M., Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A., Brown N.F., Challis G.L. , Cherevach I., Chillingworth T., Cronin A., Crossett B., Davis P., DeShazer D., Feltwell T., Fraser A., Hance Z., Hauser H., Holroyd S., Jagels K., Keith K.E., Maddison M., Moule S., Price C., Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M., Simmonds M., Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M., Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J. Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004) [PubMed: 15377794] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K96243.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571965 Genomic DNA. Translation: CAH36651.1.
RefSeq	YP_109239.1. NC_006350.1.
3D structure databases
ProteinModelPortal	Q63RM9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3093292.
GenomeReviews	Gene locus BPSL2643 in contig BX571965_GR.
KEGG	bps:BPSL2643.
PATRIC	19265633. VBIBurPse99623_3013.
Phylogenomic databases
HOGENOM	HBG391969.
OMA	IAFMPAV.
PhylomeDB	Q63RM9.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	BPSE272560:BPSL2643-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
KO	K06153.
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. Undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP2_BURPS

Accession

Primary (citable) accession number: Q63RM9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program