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Q63Q86 (HISX_BURPS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:BPSL3139
OrganismBurkholderia pseudomallei (strain K96243) [Reference proteome] [HAMAP]
Taxonomic identifier272560 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135750

Sites

Active site3351Proton acceptor By similarity
Active site3361Proton acceptor By similarity
Metal binding2671Zinc By similarity
Metal binding2701Zinc By similarity
Metal binding3691Zinc By similarity
Metal binding4281Zinc By similarity
Binding site1381NAD By similarity
Binding site1991NAD By similarity
Binding site2221NAD By similarity
Binding site2451Substrate By similarity
Binding site2671Substrate By similarity
Binding site2701Substrate By similarity
Binding site3361Substrate By similarity
Binding site3691Substrate By similarity
Binding site4231Substrate By similarity
Binding site4281Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q63Q86 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 3E9BD760F554A7E8

FASTA44547,363
        10         20         30         40         50         60 
MAIKIRKLDS TSEGFAAELR AVLAFEASED DAIERAVAQI LADVKARGDA AVLDYTNRFD 

        70         80         90        100        110        120 
RLNAASVAAL ELPQSELEAA LEGLEPKRRA ALEAAAARVR GYHEKQKIEC GSHSWQYTEA 

       130        140        150        160        170        180 
DGTVLGQKVT PLDRVGLYVP GGKAAYPSSV LMNAIPARVA GVGEIVMVVP TPDGLKNDLV 

       190        200        210        220        230        240 
LAAALLGGVD RVFTIGGAQA VAALAYGTQT VPAVDKICGP GNAYVASAKR RVFGTVGIDM 

       250        260        270        280        290        300 
IAGPSEILVL CDGTTDPSWV AMDLFSQAEH DELAQSILLC PDEAFIERVE KAIGELLPTM 

       310        320        330        340        350        360 
PRQDVIRASL EGRGALVKVR DMAEACRIAN DIAPEHLEIS ALEPHQWGKQ IRHAGAIFLG 

       370        380        390        400        410        420 
RYTSESLGDY CAGPNHVLPT SRTARFSSPL GVYDFFKRSS LIEVSAEGAH TLGEIASELA 

       430        440 
YGEGLQAHAK SAEYRMKGAG DRQKG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571965 Genomic DNA. Translation: CAH37149.1.
RefSeqYP_109732.1. NC_006350.1.

3D structure databases

ProteinModelPortalQ63Q86.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272560.BPSL3139.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH37149; CAH37149; BPSL3139.
GeneID3091925.
KEGGbps:BPSL3139.
PATRIC19266799. VBIBurPse99623_3588.

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMAPSEILII.
OrthoDBEOG6CVVCR.
ProtClustDBPRK00877.

Enzyme and pathway databases

BioCycBPSE272560:GJNI-3223-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_BURPS
AccessionPrimary (citable) accession number: Q63Q86
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: October 25, 2004
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways