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Protein

Shikimate kinase

Gene

aroK

Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.UniRule annotation

Catalytic activityi

ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (aroG), Phospho-2-dehydro-3-deoxyheptonate aldolase (aroG)
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ), 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA), 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi21MagnesiumUniRule annotation1
Binding sitei39SubstrateUniRule annotation1
Binding sitei63SubstrateUniRule annotation1
Binding sitei85Substrate; via amide nitrogenUniRule annotation1
Binding sitei123ATPUniRule annotation1
Binding sitei142SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 22ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPSE272560:G1G3Q-3320-MONOMER
UniPathwayiUPA00053; UER00088

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate kinaseUniRule annotation (EC:2.7.1.71UniRule annotation)
Short name:
SKUniRule annotation
Gene namesi
Name:aroKUniRule annotation
Ordered Locus Names:BPSL3169
OrganismiBurkholderia pseudomallei (strain K96243)
Taxonomic identifieri272560 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000000605 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002378581 – 184Shikimate kinaseAdd BLAST184

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi272560.BPSL3169

Structurei

3D structure databases

ProteinModelPortaliQ63Q56
SMRiQ63Q56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the shikimate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KHV Bacteria
COG0703 LUCA
HOGENOMiHOG000032568
KOiK00891
OMAiHGEPHFR

Family and domain databases

CDDicd00464 SK, 1 hit
HAMAPiMF_00109 Shikimate_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR031322 Shikimate/glucono_kinase
IPR000623 Shikimate_kinase/TSH1
IPR023000 Shikimate_kinase_CS
PfamiView protein in Pfam
PF01202 SKI, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS01128 SHIKIMATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q63Q56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQARDPHVNV IFVGLMGAGK TTVGRAVARR LDRPFFDSDH EIEARTGARI
60 70 80 90 100
PVIFELEGEA GFRDREAQMI AELTQRENIV LATGGGAILR PENRKLLHER
110 120 130 140 150
GLVVYLRANP HDLWLRTRKD KNRPLLQTDD PKAKLEALYE ARDPLYRECA
160 170 180
HFVIETGRPS VNGLVNMVLM QLEMAGIVAK PLQA
Length:184
Mass (Da):20,715
Last modified:October 25, 2004 - v1
Checksum:iBC2A5A026049D9B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571965 Genomic DNA Translation: CAH37179.1
RefSeqiWP_004535019.1, NZ_CP009538.1
YP_109762.1, NC_006350.1

Genome annotation databases

EnsemblBacteriaiCAH37179; CAH37179; BPSL3169
GeneIDi3092396
KEGGibps:BPSL3169
PATRICifig|272560.51.peg.2070

Similar proteinsi

Entry informationi

Entry nameiAROK_BURPS
AccessioniPrimary (citable) accession number: Q63Q56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 25, 2004
Last modified: February 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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