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Protein

Aquaporin Z

Gene

aqpZ

Organism
Burkholderia pseudomallei (strain K96243)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei22 – 221Involved in tetramerization or stability of the tetramerUniRule annotation
Sitei45 – 451Selectivity filterUniRule annotation
Sitei176 – 1761Selectivity filterUniRule annotation
Sitei185 – 1851Selectivity filterUniRule annotation
Sitei191 – 1911Selectivity filterUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

TransportUniRule annotation

Enzyme and pathway databases

BioCyciBPSE272560:GJNI-3412-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin ZUniRule annotation
Gene namesi
Name:aqpZUniRule annotationImported
Ordered Locus Names:BPSL3314Imported
OrganismiBurkholderia pseudomallei (strain K96243)Imported
Taxonomic identifieri272560 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000000605 Componenti: Chromosome 1

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalUniRule annotationAdd
BLAST
Transmembranei36 – 5621HelicalUniRule annotationAdd
BLAST
Transmembranei84 – 10421HelicalUniRule annotationAdd
BLAST
Transmembranei133 – 15321HelicalUniRule annotationAdd
BLAST
Transmembranei162 – 18221HelicalUniRule annotationAdd
BLAST
Transmembranei208 – 22821HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi272560.BPSL3314.

Structurei

3D structure databases

ProteinModelPortaliQ63PQ9.
SMRiQ63PQ9. Positions 5-211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi65 – 673NPA 1UniRule annotation
Motifi188 – 1903NPA 2UniRule annotation

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).UniRule annotation

Sequence similaritiesi

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]UniRule annotation

Keywords - Domaini

RepeatUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105D8C. Bacteria.
COG0580. LUCA.
HOGENOMiHOG000288286.
KOiK06188.
OMAiNISGCHV.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
HAMAPiMF_01146. Aquaporin_Z. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023743. Aquaporin_Z.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63PQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLPQRLAAE VFGTFWLVLG GCGSAVLAAA FPGLGIGFAG VALAFGLTVL
60 70 80 90 100
TMAFAIGHVS GCHLNPAVSV GLTVAGRFPA RDLVPYVIAQ VIGATLGAFV
110 120 130 140 150
LYLIATGKPG FDVAGSGFAT NGYDARSPGH YSLAAAFICE VVLTGFFLFV
160 170 180 190 200
ILGSTDKRAP AGFAPIAIGL CLTLIHLISI PVTNTSVNPA RSTGPALFVG
210 220 230
SEAIGQLWLF WVAPIIGAAI AGVVYPLVAG RDES
Length:234
Mass (Da):23,820
Last modified:October 25, 2004 - v1
Checksum:i0880426F9EA3689B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571965 Genomic DNA. Translation: CAH37327.1.
RefSeqiWP_004535818.1. NZ_CP009538.1.
YP_109910.1. NC_006350.1.

Genome annotation databases

EnsemblBacteriaiCAH37327; CAH37327; BPSL3314.
GeneIDi3093879.
KEGGibps:BPSL3314.
PATRICi19267179. VBIBurPse99623_3768.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571965 Genomic DNA. Translation: CAH37327.1.
RefSeqiWP_004535818.1. NZ_CP009538.1.
YP_109910.1. NC_006350.1.

3D structure databases

ProteinModelPortaliQ63PQ9.
SMRiQ63PQ9. Positions 5-211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272560.BPSL3314.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH37327; CAH37327; BPSL3314.
GeneIDi3093879.
KEGGibps:BPSL3314.
PATRICi19267179. VBIBurPse99623_3768.

Phylogenomic databases

eggNOGiENOG4105D8C. Bacteria.
COG0580. LUCA.
HOGENOMiHOG000288286.
KOiK06188.
OMAiNISGCHV.

Enzyme and pathway databases

BioCyciBPSE272560:GJNI-3412-MONOMER.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
HAMAPiMF_01146. Aquaporin_Z. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023743. Aquaporin_Z.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ63PQ9_BURPS
AccessioniPrimary (citable) accession number: Q63PQ9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 25, 2004
Last sequence update: October 25, 2004
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.