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Q63L73

- THIM_BURPS

UniProt

Q63L73 - THIM_BURPS

Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei126 – 1261ATPUniRule annotation
    Binding sitei172 – 1721ATPUniRule annotation
    Binding sitei199 – 1991Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBPSE272560:GJNI-4698-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
    Short name:
    TH kinaseUniRule annotation
    Short name:
    Thz kinaseUniRule annotation
    Gene namesi
    Name:thiMUniRule annotation
    Ordered Locus Names:BPSS1135
    OrganismiBurkholderia pseudomallei (strain K96243)
    Taxonomic identifieri272560 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000000605: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Hydroxyethylthiazole kinasePRO_0000383826Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272560.BPSS1135.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63L73.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiMANEAPE.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q63L73-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESISWNTPS VRDALAAVKR DAPFVYGLTN YVAANLSANV LLAVGAAPAI    50
    GAAADWPARF GAGANALWIN TAALMSSGAD TLLTAARAAS KAGTRWVLDP 100
    VALGAGAPEY DAIVRDLLAL RPTVIRGNAS ELIALAGGTA AGKGVDTTAS 150
    PESALAFIGD LARRSGAVVA VSGPTDYVTD GVATLAVAGG DARLTRVTGA 200
    GCALGALIAA LLAQRGAALA AASAAHAIYA TAAERAADAR GTASFAVRFV 250
    DELSLLDPAE SSRDRSAGQI GAKRRE 276
    Length:276
    Mass (Da):27,510
    Last modified:October 25, 2004 - v1
    Checksum:i1F7B2E4B381E6D6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571966 Genomic DNA. Translation: CAH38603.1.
    RefSeqiYP_111148.1. NC_006351.1.

    Genome annotation databases

    EnsemblBacteriaiCAH38603; CAH38603; BPSS1135.
    GeneIDi3095703.
    KEGGibps:BPSS1135.
    PATRICi19270242. VBIBurPse99623_5291.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571966 Genomic DNA. Translation: CAH38603.1 .
    RefSeqi YP_111148.1. NC_006351.1.

    3D structure databases

    ProteinModelPortali Q63L73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272560.BPSS1135.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH38603 ; CAH38603 ; BPSS1135 .
    GeneIDi 3095703.
    KEGGi bps:BPSS1135.
    PATRICi 19270242. VBIBurPse99623_5291.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi MANEAPE.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci BPSE272560:GJNI-4698-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K96243.

    Entry informationi

    Entry nameiTHIM_BURPS
    AccessioniPrimary (citable) accession number: Q63L73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3