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Q63KK7

- BETA_BURPS

UniProt

Q63KK7 - BETA_BURPS

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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei474 – 4741UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 3630FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciBPSE272560:GJNI-4921-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:BPSS1355
OrganismiBurkholderia pseudomallei (strain K96243)
Taxonomic identifieri272560 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000000605: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565Oxygen-dependent choline dehydrogenasePRO_0000258919Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272560.BPSS1355.

Structurei

3D structure databases

ProteinModelPortaliQ63KK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiLTDDYNG.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63KK7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTREFDYII CGAGSAGNVL ATRLTEDPGV TVLLLEAGGP DYRFDFRTQM
60 70 80 90 100
PAALAYPLQG RRYNWAYETD PEPHMNHRRM ECGRGKGLGG SSLINGMCYI
110 120 130 140 150
RGNALDYDNW ATHKALEDWA YLDCLPYFRK AETRDVGPND YHGGDGPVSV
160 170 180 190 200
TTSKPGVNPL FEAMVEAGVQ AGYPRTDDLN GYQQEGFGPM DRTVTPRGRR
210 220 230 240 250
ASTARGYLDQ ARARPNLEIV THALADRILF SGKRATGVTF LHGSARVTAH
260 270 280 290 300
ARREVLVCSG AIASPQLLQR SGVGPGEWLR ELDIPVVLDL PGVGRNLQDH
310 320 330 340 350
LEMYIQFECK EPVSLYPALK WWNQPKIGLE WMLNGTGLGA SNHFEAGGFI
360 370 380 390 400
RTRDDDPWPN IQYHFLPVAI NYNGSNAIEM HGFQAHVGSM RSPSRGRVKL
410 420 430 440 450
KSRDPHAHPS ILFNYMAEAL DWREFRDAIR ATREIMRQPA LDRFRGRELN
460 470 480 490 500
PGADLKSDNE LDTFVRARAE TAFHPSCSCK MGYDDMAVVD NEGRVHGIDG
510 520 530 540 550
LRVVDASIMP IITTGNLNAP TIMIAEKIAD RIRQHKPLER SNAQYYVANG
560
APARGGKPAR APAVV
Length:565
Mass (Da):62,703
Last modified:October 25, 2004 - v1
Checksum:i6990A10A40FD48C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571966 Genomic DNA. Translation: CAH38826.1.
RefSeqiWP_009940671.1. NC_006351.1.
YP_111365.1. NC_006351.1.

Genome annotation databases

EnsemblBacteriaiCAH38826; CAH38826; BPSS1355.
GeneIDi3096018.
KEGGibps:BPSS1355.
PATRICi19270810. VBIBurPse99623_5575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571966 Genomic DNA. Translation: CAH38826.1 .
RefSeqi WP_009940671.1. NC_006351.1.
YP_111365.1. NC_006351.1.

3D structure databases

ProteinModelPortali Q63KK7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272560.BPSS1355.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH38826 ; CAH38826 ; BPSS1355 .
GeneIDi 3096018.
KEGGi bps:BPSS1355.
PATRICi 19270810. VBIBurPse99623_5575.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi LTDDYNG.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci BPSE272560:GJNI-4921-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K96243.

Entry informationi

Entry nameiBETA_BURPS
AccessioniPrimary (citable) accession number: Q63KK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 25, 2004
Last modified: November 26, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3