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Protein

Translocator protein BipD

Gene

bipD

Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Required for invasion of epithelial cells, as well as for survival within host cells, escape from endocytic vesicles and subsequent actin-tail formation. Probably regulates the secretion of effectors BipB and BipC and their final integration into the target cell membrane.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Translocator protein BipD
Gene namesi
Name:bipD
Ordered Locus Names:BPSS1529
OrganismiBurkholderia pseudomallei (strain K96243)
Taxonomic identifieri272560 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000000605 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003440091 – 310Translocator protein BipDAdd BLAST310

Proteomic databases

PRIDEiQ63K37.

Interactioni

Protein-protein interaction databases

STRINGi272560.BPSS1529.

Structurei

Secondary structure

1310
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi37 – 42Combined sources6
Helixi48 – 63Combined sources16
Beta strandi68 – 70Combined sources3
Beta strandi73 – 75Combined sources3
Helixi83 – 110Combined sources28
Beta strandi122 – 125Combined sources4
Helixi128 – 167Combined sources40
Helixi168 – 171Combined sources4
Beta strandi172 – 175Combined sources4
Turni176 – 178Combined sources3
Beta strandi179 – 182Combined sources4
Helixi184 – 196Combined sources13
Beta strandi200 – 202Combined sources3
Helixi209 – 216Combined sources8
Beta strandi220 – 222Combined sources3
Beta strandi227 – 230Combined sources4
Helixi233 – 240Combined sources8
Beta strandi247 – 250Combined sources4
Helixi251 – 302Combined sources52

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IXRX-ray2.60A10-310[»]
2IZPX-ray2.10A/B8-310[»]
2J9TX-ray2.70A/B10-310[»]
3NFTX-ray1.51A10-310[»]
ProteinModelPortaliQ63K37.
SMRiQ63K37.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ63K37.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili127 – 171Sequence analysisAdd BLAST45
Coiled coili250 – 299Sequence analysisAdd BLAST50

Domaini

The N-terminal domain is an intra-molecular chaperone that prevents premature oligomerization of the residues on the coiled-coil region that are involved in interactions with the needle and/or itself. The residues in the C-terminal domain probably form oligomeric structures at the tip of the needle that are responsible for the regulation of secretion of other effectors.

Sequence similaritiesi

Belongs to the invasin protein D family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000280678.
KOiK13287.
OMAiERWETEH.

Family and domain databases

InterProiIPR009483. Plasmid_invsIpaD.
IPR013386. T3SS_IpaD/SipD/SspD.
[Graphical view]
PfamiPF06511. IpaD. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02553. SipD_IpaD_SspD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63K37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMHVDMGRA LTVRDWPALE ALAKTMPADA GARAMTDDDL RAAGVDRRVP
60 70 80 90 100
EQKLGAAIDE FASLRLPDRI DGRFVDGRRA NLTVFDDARV AVRGHARAQR
110 120 130 140 150
NLLERLETEL LGGTLDTAGD EGGIQPDPIL QGLVDVIGQG KSDIDAYATI
160 170 180 190 200
VEGLTKYFQS VADVMSKLQD YISAKDDKNM KIDGGKIKAL IQQVIDHLPT
210 220 230 240 250
MQLPKGADIA RWRKELGDAV SISDSGVVTI NPDKLIKMRD SLPPDGTVWD
260 270 280 290 300
TARYQAWNTA FSGQKDNIQN DVQTLVEKYS HQNSNFDNLV KVLSGAISTL
310
TDTAKSYLQI
Length:310
Mass (Da):33,975
Last modified:October 25, 2004 - v1
Checksum:iD6C446F4D919069D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34A → E in ABL67521 (Ref. 1) Curated1
Sequence conflicti292V → M in ABL67521 (Ref. 1) Curated1
Sequence conflicti303T → A in ABL67521 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF120623 Genomic DNA. Translation: ABL67521.1.
BX571966 Genomic DNA. Translation: CAH39002.1.
RefSeqiWP_004188590.1. NZ_CP009537.1.
YP_111535.1. NC_006351.1.

Genome annotation databases

EnsemblBacteriaiCAH39002; CAH39002; BPSS1529.
GeneIDi3096115.
KEGGibps:BPSS1529.
PATRICi19271232. VBIBurPse99623_5786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF120623 Genomic DNA. Translation: ABL67521.1.
BX571966 Genomic DNA. Translation: CAH39002.1.
RefSeqiWP_004188590.1. NZ_CP009537.1.
YP_111535.1. NC_006351.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IXRX-ray2.60A10-310[»]
2IZPX-ray2.10A/B8-310[»]
2J9TX-ray2.70A/B10-310[»]
3NFTX-ray1.51A10-310[»]
ProteinModelPortaliQ63K37.
SMRiQ63K37.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272560.BPSS1529.

Proteomic databases

PRIDEiQ63K37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH39002; CAH39002; BPSS1529.
GeneIDi3096115.
KEGGibps:BPSS1529.
PATRICi19271232. VBIBurPse99623_5786.

Phylogenomic databases

HOGENOMiHOG000280678.
KOiK13287.
OMAiERWETEH.

Miscellaneous databases

EvolutionaryTraceiQ63K37.

Family and domain databases

InterProiIPR009483. Plasmid_invsIpaD.
IPR013386. T3SS_IpaD/SipD/SspD.
[Graphical view]
PfamiPF06511. IpaD. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02553. SipD_IpaD_SspD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBIPD_BURPS
AccessioniPrimary (citable) accession number: Q63K37
Secondary accession number(s): A1EC20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: October 25, 2004
Last modified: November 2, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Human meliodoisis patients have detectable antibody response to BipD. However, BipD does not act as a protective antigen.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.