Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Translocator protein BipD

Gene

bipD

Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for invasion of epithelial cells, as well as for survival within host cells, escape from endocytic vesicles and subsequent actin-tail formation. Probably regulates the secretion of effectors BipB and BipC and their final integration into the target cell membrane.2 Publications

Miscellaneous

Human meliodoisis patients have detectable antibody response to BipD. However, BipD does not act as a protective antigen.

GO - Biological processi

Keywordsi

Biological processVirulence

Enzyme and pathway databases

BioCyciBPSE272560:G1G3Q-5221-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Translocator protein BipD
Gene namesi
Name:bipD
Ordered Locus Names:BPSS1529
OrganismiBurkholderia pseudomallei (strain K96243)
Taxonomic identifieri272560 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000000605 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003440091 – 310Translocator protein BipDAdd BLAST310

Proteomic databases

PRIDEiQ63K37

Interactioni

Protein-protein interaction databases

STRINGi272560.BPSS1529

Structurei

Secondary structure

1310
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi37 – 42Combined sources6
Helixi48 – 63Combined sources16
Beta strandi68 – 70Combined sources3
Beta strandi73 – 75Combined sources3
Helixi83 – 110Combined sources28
Beta strandi122 – 125Combined sources4
Helixi128 – 167Combined sources40
Helixi168 – 171Combined sources4
Beta strandi172 – 175Combined sources4
Turni176 – 178Combined sources3
Beta strandi179 – 182Combined sources4
Helixi184 – 196Combined sources13
Beta strandi200 – 202Combined sources3
Helixi209 – 216Combined sources8
Beta strandi220 – 222Combined sources3
Beta strandi227 – 230Combined sources4
Helixi233 – 240Combined sources8
Beta strandi247 – 250Combined sources4
Helixi251 – 302Combined sources52

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IXRX-ray2.60A10-310[»]
2IZPX-ray2.10A/B8-310[»]
2J9TX-ray2.70A/B10-310[»]
3NFTX-ray1.51A10-310[»]
ProteinModelPortaliQ63K37
SMRiQ63K37
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ63K37

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili127 – 171Sequence analysisAdd BLAST45
Coiled coili250 – 299Sequence analysisAdd BLAST50

Domaini

The N-terminal domain is an intra-molecular chaperone that prevents premature oligomerization of the residues on the coiled-coil region that are involved in interactions with the needle and/or itself. The residues in the C-terminal domain probably form oligomeric structures at the tip of the needle that are responsible for the regulation of secretion of other effectors.

Sequence similaritiesi

Belongs to the invasin protein D family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000280678
KOiK13287
OMAiERWETEH

Family and domain databases

Gene3Di1.20.1710.10, 1 hit
InterProiView protein in InterPro
IPR036708 BipD-like_sf
IPR009483 Plasmid_invsIpaD
PfamiView protein in Pfam
PF06511 IpaD, 1 hit
SUPFAMiSSF140693 SSF140693, 1 hit
TIGRFAMsiTIGR02553 SipD_IpaD_SspD, 1 hit

Sequencei

Sequence statusi: Complete.

Q63K37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMHVDMGRA LTVRDWPALE ALAKTMPADA GARAMTDDDL RAAGVDRRVP
60 70 80 90 100
EQKLGAAIDE FASLRLPDRI DGRFVDGRRA NLTVFDDARV AVRGHARAQR
110 120 130 140 150
NLLERLETEL LGGTLDTAGD EGGIQPDPIL QGLVDVIGQG KSDIDAYATI
160 170 180 190 200
VEGLTKYFQS VADVMSKLQD YISAKDDKNM KIDGGKIKAL IQQVIDHLPT
210 220 230 240 250
MQLPKGADIA RWRKELGDAV SISDSGVVTI NPDKLIKMRD SLPPDGTVWD
260 270 280 290 300
TARYQAWNTA FSGQKDNIQN DVQTLVEKYS HQNSNFDNLV KVLSGAISTL
310
TDTAKSYLQI
Length:310
Mass (Da):33,975
Last modified:October 25, 2004 - v1
Checksum:iD6C446F4D919069D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34A → E in ABL67521 (Ref. 1) Curated1
Sequence conflicti292V → M in ABL67521 (Ref. 1) Curated1
Sequence conflicti303T → A in ABL67521 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF120623 Genomic DNA Translation: ABL67521.1
BX571966 Genomic DNA Translation: CAH39002.1
RefSeqiWP_004188590.1, NZ_CP009537.1
YP_111535.1, NC_006351.1

Genome annotation databases

EnsemblBacteriaiCAH39002; CAH39002; BPSS1529
GeneIDi3096115
KEGGibps:BPSS1529
PATRICifig|272560.51.peg.4884

Similar proteinsi

Entry informationi

Entry nameiBIPD_BURPS
AccessioniPrimary (citable) accession number: Q63K37
Secondary accession number(s): A1EC20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: October 25, 2004
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health