Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q63JF5 (GCH4_BURPS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:BPSS1761
OrganismBurkholderia pseudomallei (strain K96243) [Reference proteome] [HAMAP]
Taxonomic identifier272560 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000147707

Sites

Site1541May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q63JF5 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 832F04704D584F29

FASTA26930,188
        10         20         30         40         50         60 
MNLMNPEFAM PDVQSTVDTR QMPIQRVGVR AVRHPLTVRT AEGETQATVG TWNLDVHLPA 

        70         80         90        100        110        120 
DQKGTHMSRF VALLEERGGP LTADAFRTML ATMLEKLEAR AGRIEVSFPY FVNKTAPVSG 

       130        140        150        160        170        180 
VRSLLDYEVT LTGDVRDGLT RVFAKVLVPV TSLCPCSKKI SQYGAHNQRS HVTIDAELAA 

       190        200        210        220        230        240 
DVPVEDLIRI AEEEASCELW GLLKRPDEKF VTERAYENPK FVEDLVRDVA RRLDADERIV 

       250        260 
AYVLEAENFE SIHNHSAYAL IERDKRRGA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571966 Genomic DNA. Translation: CAH39236.1.
RefSeqYP_111767.1. NC_006351.1.

3D structure databases

ProteinModelPortalQ63JF5.
SMRQ63JF5. Positions 21-265.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272560.BPSS1761.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH39236; CAH39236; BPSS1761.
GeneID3095897.
KEGGbps:BPSS1761.
PATRIC19271810. VBIBurPse99623_6075.

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OMAINMYVDL.
OrthoDBEOG6X6RBH.
ProtClustDBPRK13674.

Enzyme and pathway databases

BioCycBPSE272560:GJNI-5334-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_BURPS
AccessionPrimary (citable) accession number: Q63JF5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 25, 2004
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways