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Q63JF5

- GCH4_BURPS

UniProt

Q63JF5 - GCH4_BURPS

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Burkholderia pseudomallei (strain K96243)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei154 – 1541May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBPSE272560:GJNI-5334-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:BPSS1761
OrganismiBurkholderia pseudomallei (strain K96243)
Taxonomic identifieri272560 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000000605: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269GTP cyclohydrolase FolE2PRO_0000147707Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272560.BPSS1761.

Structurei

3D structure databases

ProteinModelPortaliQ63JF5.
SMRiQ63JF5. Positions 21-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63JF5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLMNPEFAM PDVQSTVDTR QMPIQRVGVR AVRHPLTVRT AEGETQATVG
60 70 80 90 100
TWNLDVHLPA DQKGTHMSRF VALLEERGGP LTADAFRTML ATMLEKLEAR
110 120 130 140 150
AGRIEVSFPY FVNKTAPVSG VRSLLDYEVT LTGDVRDGLT RVFAKVLVPV
160 170 180 190 200
TSLCPCSKKI SQYGAHNQRS HVTIDAELAA DVPVEDLIRI AEEEASCELW
210 220 230 240 250
GLLKRPDEKF VTERAYENPK FVEDLVRDVA RRLDADERIV AYVLEAENFE
260
SIHNHSAYAL IERDKRRGA
Length:269
Mass (Da):30,188
Last modified:October 25, 2004 - v1
Checksum:i832F04704D584F29
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571966 Genomic DNA. Translation: CAH39236.1.
RefSeqiYP_111767.1. NC_006351.1.

Genome annotation databases

EnsemblBacteriaiCAH39236; CAH39236; BPSS1761.
GeneIDi3095897.
KEGGibps:BPSS1761.
PATRICi19271810. VBIBurPse99623_6075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571966 Genomic DNA. Translation: CAH39236.1 .
RefSeqi YP_111767.1. NC_006351.1.

3D structure databases

ProteinModelPortali Q63JF5.
SMRi Q63JF5. Positions 21-265.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272560.BPSS1761.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH39236 ; CAH39236 ; BPSS1761 .
GeneIDi 3095897.
KEGGi bps:BPSS1761.
PATRICi 19271810. VBIBurPse99623_6075.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci BPSE272560:GJNI-5334-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K96243.

Entry informationi

Entry nameiGCH4_BURPS
AccessioniPrimary (citable) accession number: Q63JF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 25, 2004
Last modified: October 1, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3