Q63JB0 (ACDH_BURPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase
EC=1.2.1.10

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]

Gene names

Name:	mhpF
Ordered Locus Names:	BPSS1808

Organism

Burkholderia pseudomallei (strain K96243) [Reference proteome] [HAMAP]

Taxonomic identifier

272560 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group › Burkholderia pseudomallei

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aromatic compound catabolic process Inferred from electronic annotation. Source: HAMAP cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	NAD binding Inferred from electronic annotation. Source: HAMAP acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	Acetaldehyde dehydrogenase HAMAP-Rule MF_01657		PRO_0000387634
Regions
	Nucleotide binding	15 – 18	4	NAD By similarity
	Nucleotide binding	162 – 170	9	NAD By similarity
Sites
	Active site	130	1	Acyl-thioester intermediate By similarity
	Binding site	272	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q63JB0 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 03A1F8782B7CA1CB	FASTA	297	32,346
	10 20 30 40 50 60 MKSKSSRTRV AILGSGSIGL DLMFKVKASE QFDLKFVVGR NANSDGLRLA RSCNVETSSD 70 80 90 100 110 120 GLDFLKAHED AYDLVFDATS AAAHKVNNRF FSDAGKFVID LTPAKVGRLC VPCINLDDMG 130 140 150 160 170 180 AEQNVNLITC GGQASLPLAY ALKQAVDEID YLEVVSAIAS RSAGIATREN IDEYMTTTEY 190 200 210 220 230 240 ALAKFSDAKK TKAILNINPA EPGVRMQTTL YAYARYRDFD RVRASVADMV EKVREYVPGY 250 260 270 280 290 RLVVEPLESQ GRITIGLTVR GRGDYLPEYA GNLDIINCAA LAVASHRHAT ARLGATQ

References

[1]

"Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei." Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M., Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L., Bentley S.D., Sebaihia M., Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A., Brown N.F., Challis G.L. , Cherevach I., Chillingworth T., Cronin A., Crossett B., Davis P., DeShazer D., Feltwell T., Fraser A., Hance Z., Hauser H., Holroyd S., Jagels K., Keith K.E., Maddison M., Moule S., Price C., Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M., Simmonds M., Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M., Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J. Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K96243.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571966 Genomic DNA. Translation: CAH39284.1.
RefSeq	YP_111812.1. NC_006351.1.
3D structure databases
ProteinModelPortal	Q63JB0.
ModBase	Search...
Protein-protein interaction databases
STRING	272560.BPSS1808.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3095332.
KEGG	bps:BPSS1808.
PATRIC	19271922. VBIBurPse99623_6131.
Phylogenomic databases
eggNOG	COG4569.
HOGENOM	HOG000052149.
KO	K04073.
OMA	LKQQVQF.
ProtClustDB	PRK08300.
Enzyme and pathway databases
BioCyc	BPSE272560:GJNI-5382-MONOMER.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
HAMAP	MF_01657. Ac_ald_DH_ac.
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
PANTHER	PTHR21123. PTHR21123. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH_BURPS

Accession

Primary (citable) accession number: Q63JB0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	October 25, 2004
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program