Q63JB0 (ACDH_BURPS) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 53.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Acetaldehyde dehydrogenase EC=1.2.1.10 Alternative name(s): Acetaldehyde dehydrogenase [acetylating] | ||||
| Gene names |
| ||||
| Organism | Burkholderia pseudomallei (Pseudomonas pseudomallei) | ||||
| Taxonomic identifier | 28450 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group |
Protein attributes
| Sequence length | 297 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01657 |
| Catalytic activity | Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657 |
| Sequence similarities | Belongs to the acetaldehyde dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Aromatic hydrocarbons catabolism |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW cellular amino acid metabolic processInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: InterPro |
| Molecular function | NAD binding Inferred from electronic annotation. Source: InterPro acetaldehyde dehydrogenase (acetylating) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 297 | 297 | Acetaldehyde dehydrogenase HAMAP MF_01657 | PRO_0000387634 | |||||
Regions | |||||||||
| Nucleotide binding | 15 – 18 | 4 | NAD By similarity | ||||||
| Nucleotide binding | 162 – 170 | 9 | NAD By similarity | ||||||
Sites | |||||||||
| Binding site | 272 | 1 | NAD By similarity | ||||||
Sequences
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References
| [1] | "Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei." Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M., Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L., Bentley S.D., Sebaihia M., Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A., Brown N.F., Challis G.L. Parkhill J.Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004) [PubMed: 15377794] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K96243. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX571966 Genomic DNA. Translation: CAH39284.1. |
| RefSeq | YP_111812.1. NC_006351.1. |
3D structure databases | |
| ProteinModelPortal | Q63JB0. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 3095332. |
| GenomeReviews | Gene locus BPSS1808 in contig BX571966_GR. |
| KEGG | bps:BPSS1808. |
| NMPDR | fig|272560.3.peg.1855. |
| PATRIC | 19271922. VBIBurPse99623_6131. |
Phylogenomic databases | |
| HOGENOM | HBG300125. |
| OMA | HVKNDAF. |
| ProtClustDB | PRK08300. |
Enzyme and pathway databases | |
| BioCyc | BPSE272560:BPSS1808-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01657. Ac_ald_DH_ac. [Tree] |
| InterPro | IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| KO | K04073. |
| PANTHER | PTHR21123. Acetylald_dh. 1 hit. |
| Pfam | PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view] |
| PIRSF | PIRSF015689. Actaldh_dh_actl. 1 hit. |
| SMART | SM00859. Semialdhyde_dh. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR03215. Ac_ald_DH_ac. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | ACDH_BURPS | ||||||||
| Accession | Primary (citable) accession number: Q63JB0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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