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Q63J95

- Q63J95_BURPS

UniProt

Q63J95 - Q63J95_BURPS

Protein

Peptidyl-prolyl cis-trans isomerase

Gene

fbp

Organism
Burkholderia pseudomallei (strain K96243)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111ChlorideImported
    Binding sitei50 – 501Sulfate 2Imported

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. protein folding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, RotamaseUniRule annotation

    Enzyme and pathway databases

    BioCyciBPSE272560:GJNI-5397-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)
    Gene namesi
    Name:fbpImported
    Ordered Locus Names:BPSS1823Imported
    OrganismiBurkholderia pseudomallei (strain K96243)Imported
    Taxonomic identifieri272560 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000000605: Chromosome 2

    Interactioni

    Protein-protein interaction databases

    STRINGi272560.BPSS1823.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2KE0NMR-A1-113[»]
    2KO7NMR-A1-113[»]
    2Y78X-ray0.91A1-113[»]
    3UQAX-ray1.55A2-113[»]
    ProteinModelPortaliQ63J95.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ63J95.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni22 – 243Sulfate 1 bindingImported

    Sequence similaritiesi

    Contains 1 PPIase FKBP-type domain.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000154887.
    KOiK01802.
    OMAiQKGKKFD.
    OrthoDBiEOG6DRPKW.

    Family and domain databases

    InterProiIPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00254. FKBP_C. 1 hit.
    [Graphical view]
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q63J95-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVVTTESGL KYEDLTEGSG AEARAGQTVS VHYTGWLTDG QKFDSSKDRN    50
    DPFAFVLGGG MVIKGWDEGV QGMKVGGVRR LTIPPQLGYG ARGAGGVIPP 100
    NATLVFEVEL LDV 113
    Length:113
    Mass (Da):11,930
    Last modified:October 25, 2004 - v1
    Checksum:i10AB26FB56F3F284
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571966 Genomic DNA. Translation: CAH39299.1.
    RefSeqiYP_111827.1. NC_006351.1.

    Genome annotation databases

    EnsemblBacteriaiCAH39299; CAH39299; BPSS1823.
    GeneIDi3094935.
    KEGGibps:BPSS1823.
    PATRICi19271960. VBIBurPse99623_6150.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571966 Genomic DNA. Translation: CAH39299.1 .
    RefSeqi YP_111827.1. NC_006351.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2KE0 NMR - A 1-113 [» ]
    2KO7 NMR - A 1-113 [» ]
    2Y78 X-ray 0.91 A 1-113 [» ]
    3UQA X-ray 1.55 A 2-113 [» ]
    ProteinModelPortali Q63J95.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272560.BPSS1823.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH39299 ; CAH39299 ; BPSS1823 .
    GeneIDi 3094935.
    KEGGi bps:BPSS1823.
    PATRICi 19271960. VBIBurPse99623_6150.

    Phylogenomic databases

    HOGENOMi HOG000154887.
    KOi K01802.
    OMAi QKGKKFD.
    OrthoDBi EOG6DRPKW.

    Enzyme and pathway databases

    BioCyci BPSE272560:GJNI-5397-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q63J95.

    Family and domain databases

    InterProi IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00254. FKBP_C. 1 hit.
    [Graphical view ]
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K96243Imported.
    2. "The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development."
      Norville I.H., O'Shea K., Sarkar-Tyson M., Zheng S., Titball R.W., Varani G., Harmer N.J.
      Biochem. J. 437:413-422(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.
    3. "A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins."
      Begley D.W., Fox D., Jenner D., Juli C., Pierce P.G., Abendroth J., Muruthi M., Safford K., Anderson V., Atkins K., Barnes S.R., Moen S.O., Raymond A.C., Stacy R., Myler P.J., Staker B.L., Harmer N.J., Norville I.H.
      , Holzgrabe U., Sarkar-Tyson M., Edwards T.E., Lorimer D.D.
      Antimicrob. Agents Chemother. 58:1458-1467(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 2-113.

    Entry informationi

    Entry nameiQ63J95_BURPS
    AccessioniPrimary (citable) accession number: Q63J95
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 25, 2004
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3