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Q63J95

- Q63J95_BURPS

UniProt

Q63J95 - Q63J95_BURPS

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Protein

Peptidyl-prolyl cis-trans isomerase

Gene

fbp

Organism
Burkholderia pseudomallei (strain K96243)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111ChlorideImported
Binding sitei50 – 501Sulfate 2Imported

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

GO - Biological processi

  1. protein folding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, RotamaseUniRule annotation

Enzyme and pathway databases

BioCyciBPSE272560:GJNI-5397-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)
Gene namesi
Name:fbpImported
Ordered Locus Names:BPSS1823Imported
OrganismiBurkholderia pseudomallei (strain K96243)Imported
Taxonomic identifieri272560 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000000605: Chromosome 2

Interactioni

Protein-protein interaction databases

STRINGi272560.BPSS1823.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KE0NMR-A1-113[»]
2KO7NMR-A1-113[»]
2Y78X-ray0.91A1-113[»]
3UQAX-ray1.55A2-113[»]
ProteinModelPortaliQ63J95.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ63J95.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 243Sulfate 1 bindingImported

Sequence similaritiesi

Contains 1 PPIase FKBP-type domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000154887.
KOiK01802.
OMAiQKGKKFD.
OrthoDBiEOG6DRPKW.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63J95-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVVTTESGL KYEDLTEGSG AEARAGQTVS VHYTGWLTDG QKFDSSKDRN
60 70 80 90 100
DPFAFVLGGG MVIKGWDEGV QGMKVGGVRR LTIPPQLGYG ARGAGGVIPP
110
NATLVFEVEL LDV
Length:113
Mass (Da):11,930
Last modified:October 25, 2004 - v1
Checksum:i10AB26FB56F3F284
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571966 Genomic DNA. Translation: CAH39299.1.
RefSeqiYP_111827.1. NC_006351.1.

Genome annotation databases

EnsemblBacteriaiCAH39299; CAH39299; BPSS1823.
GeneIDi3094935.
KEGGibps:BPSS1823.
PATRICi19271960. VBIBurPse99623_6150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571966 Genomic DNA. Translation: CAH39299.1 .
RefSeqi YP_111827.1. NC_006351.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2KE0 NMR - A 1-113 [» ]
2KO7 NMR - A 1-113 [» ]
2Y78 X-ray 0.91 A 1-113 [» ]
3UQA X-ray 1.55 A 2-113 [» ]
ProteinModelPortali Q63J95.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272560.BPSS1823.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH39299 ; CAH39299 ; BPSS1823 .
GeneIDi 3094935.
KEGGi bps:BPSS1823.
PATRICi 19271960. VBIBurPse99623_6150.

Phylogenomic databases

HOGENOMi HOG000154887.
KOi K01802.
OMAi QKGKKFD.
OrthoDBi EOG6DRPKW.

Enzyme and pathway databases

BioCyci BPSE272560:GJNI-5397-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q63J95.

Family and domain databases

InterProi IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00254. FKBP_C. 1 hit.
[Graphical view ]
PROSITEi PS50059. FKBP_PPIASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K96243Imported.
  2. "The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development."
    Norville I.H., O'Shea K., Sarkar-Tyson M., Zheng S., Titball R.W., Varani G., Harmer N.J.
    Biochem. J. 437:413-422(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  3. "A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins."
    Begley D.W., Fox D., Jenner D., Juli C., Pierce P.G., Abendroth J., Muruthi M., Safford K., Anderson V., Atkins K., Barnes S.R., Moen S.O., Raymond A.C., Stacy R., Myler P.J., Staker B.L., Harmer N.J., Norville I.H.
    , Holzgrabe U., Sarkar-Tyson M., Edwards T.E., Lorimer D.D.
    Antimicrob. Agents Chemother. 58:1458-1467(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 2-113.

Entry informationi

Entry nameiQ63J95_BURPS
AccessioniPrimary (citable) accession number: Q63J95
Entry historyi
Integrated into UniProtKB/TrEMBL: October 25, 2004
Last sequence update: October 25, 2004
Last modified: November 26, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3