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Protein

Peptidyl-prolyl cis-trans isomerase

Gene

fbp

Organism
Burkholderia pseudomallei (strain K96243)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, RotamaseUniRule annotation

Enzyme and pathway databases

BioCyciBPSE272560:GJNI-5397-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)
Gene namesi
Name:fbpImported
Ordered Locus Names:BPSS1823Imported
OrganismiBurkholderia pseudomallei (strain K96243)Imported
Taxonomic identifieri272560 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000000605 Componenti: Chromosome 2

Interactioni

Protein-protein interaction databases

STRINGi272560.BPSS1823.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KE0NMR-A1-113[»]
2KO7NMR-A1-113[»]
2Y78X-ray0.91A1-113[»]
3UQAX-ray1.55A4-113[»]
ProteinModelPortaliQ63J95.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ63J95.

Family & Domainsi

Sequence similaritiesi

Contains 1 PPIase FKBP-type domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000154887.
KOiK03772.
OMAiPFEFPIG.
OrthoDBiEOG6DRPKW.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63J95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVVTTESGL KYEDLTEGSG AEARAGQTVS VHYTGWLTDG QKFDSSKDRN
60 70 80 90 100
DPFAFVLGGG MVIKGWDEGV QGMKVGGVRR LTIPPQLGYG ARGAGGVIPP
110
NATLVFEVEL LDV
Length:113
Mass (Da):11,930
Last modified:October 25, 2004 - v1
Checksum:i10AB26FB56F3F284
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571966 Genomic DNA. Translation: CAH39299.1.
RefSeqiWP_004525093.1. NZ_CP009537.1.
YP_111827.1. NC_006351.1.

Genome annotation databases

EnsemblBacteriaiCAH39299; CAH39299; BPSS1823.
GeneIDi3094935.
KEGGibps:BPSS1823.
PATRICi19271960. VBIBurPse99623_6150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571966 Genomic DNA. Translation: CAH39299.1.
RefSeqiWP_004525093.1. NZ_CP009537.1.
YP_111827.1. NC_006351.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KE0NMR-A1-113[»]
2KO7NMR-A1-113[»]
2Y78X-ray0.91A1-113[»]
3UQAX-ray1.55A4-113[»]
ProteinModelPortaliQ63J95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272560.BPSS1823.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH39299; CAH39299; BPSS1823.
GeneIDi3094935.
KEGGibps:BPSS1823.
PATRICi19271960. VBIBurPse99623_6150.

Phylogenomic databases

HOGENOMiHOG000154887.
KOiK03772.
OMAiPFEFPIG.
OrthoDBiEOG6DRPKW.

Enzyme and pathway databases

BioCyciBPSE272560:GJNI-5397-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ63J95.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K96243Imported.
  2. "The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development."
    Norville I.H., O'Shea K., Sarkar-Tyson M., Zheng S., Titball R.W., Varani G., Harmer N.J.
    Biochem. J. 437:413-422(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  3. "A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins."
    Begley D.W., Fox D., Jenner D., Juli C., Pierce P.G., Abendroth J., Muruthi M., Safford K., Anderson V., Atkins K., Barnes S.R., Moen S.O., Raymond A.C., Stacy R., Myler P.J., Staker B.L., Harmer N.J., Norville I.H.
    , Holzgrabe U., Sarkar-Tyson M., Edwards T.E., Lorimer D.D.
    Antimicrob. Agents Chemother. 58:1458-1467(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 4-113.

Entry informationi

Entry nameiQ63J95_BURPS
AccessioniPrimary (citable) accession number: Q63J95
Entry historyi
Integrated into UniProtKB/TrEMBL: October 25, 2004
Last sequence update: October 25, 2004
Last modified: July 22, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.