Q63HR2 (TENC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tensin-like C1 domain-containing phosphatase
EC=3.1.3.-

Alternative name(s):
C1 domain-containing phosphatase and tensin homolog
Short name=C1-TEN
Tensin-2

Gene names

Name:	TENC1
Synonyms:	KIAA1075, TNS2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1409 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling. Ref.7
Subunit structure	Interacts with AXL. Ref.1
Subcellular location	Cell junction › focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note: Detected at the end of actin stress fibers. Ref.2
Tissue specificity	Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine. Ref.1 Ref.2
Sequence similarities	Contains 1 C2 tensin-type domain. Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 phosphatase tensin-type domain. Contains 1 SH2 domain.
Sequence caution	The sequence AAI29829.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAI29830.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAI31504.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAA83027.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAH56176.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	SH2 domain Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Protein phosphatase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular homeostasis Inferred from electronic annotation. Source: Compara collagen metabolic process Inferred from electronic annotation. Source: Compara intracellular signal transduction Inferred from electronic annotation. Source: InterPro kidney development Inferred from electronic annotation. Source: Compara multicellular organism growth Inferred from electronic annotation. Source: Compara multicellular organismal homeostasis Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from mutant phenotype PubMed 16951145. Source: UniProtKB response to muscle activity Inferred from electronic annotation. Source: Compara
Cellular_component	focal adhesion Inferred from direct assay PubMed 16951145. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q63HR2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q63HR2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     776-872: Missing.

Isoform 4 (identifier: Q63HR2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MKSSGPVERLLRALGRRDSSRAASR → MDGGGVCVGRGDLLSSPQALGQLLRKESRPRRAMK

Isoform 5 (identifier: Q63HR2-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-124: Missing.

Isoform 6 (identifier: Q63HR2-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1273-1274: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1409

1409

Tensin-like C1 domain-containing phosphatase

PRO_0000292987

Regions

Domain

122 – 294

173

Phosphatase tensin-type

Domain

299 – 425

127

C2 tensin-type

Domain

1140 – 1247

108

SH2

Zinc finger

31 – 79

49

Phorbol-ester/DAG-type

Compositional bias

489 – 533

45

Pro-rich

Compositional bias

724 – 1122

399

Pro-rich

Sites

Active site

231

1

Phosphocysteine intermediate Probable

Amino acid modifications

Modified residue

455

1

Phosphoserine By similarity

Modified residue

466

1

Phosphoserine By similarity

Modified residue

481

1

Phosphoserine By similarity

Modified residue

483

1

Phosphotyrosine By similarity

Modified residue

832

1

Phosphoserine By similarity

Modified residue

835

1

Phosphoserine By similarity

Modified residue

914

1

Phosphothreonine By similarity

Natural variations

Alternative sequence

1 – 124

124

Missing in isoform 5.

VSP_026457

Alternative sequence

1 – 25

25

MKSSG…RAASR → MDGGGVCVGRGDLLSSPQAL GQLLRKESRPRRAMK in isoform 4.

VSP_026458

Alternative sequence

776 – 872

97

Missing in isoform 2.

VSP_026460

Alternative sequence

1273 – 1274

2

Missing in isoform 6.

VSP_026461

Natural variant

353

1

S → T in dnSNP:rs11170389.
Corresponds to variant rs11170389 [ dbSNP | Ensembl ].

VAR_033043

Natural variant

670

1

A → T.
Corresponds to variant rs11558984 [ dbSNP | Ensembl ].

VAR_052547

Experimental info

Mutagenesis

231

1

C → S: Abolishes inhibition of AKT1 kinase activity. Ref.7

Sequence conflict

702

1

A → V in AAH54099. Ref.6

Sequence conflict

898

1

P → Q in AAH54099. Ref.6

Sequence conflict

1036

1

P → L in CAB70815. Ref.5

Sequence conflict

1083

1

G → E in AAI29830. Ref.6

Sequence conflict

1119

1

P → S in AAH54099. Ref.6

Sequence conflict

1148

1

D → G in AAH54099. Ref.6

Sequence conflict

1236

1

P → L in CAH56176. Ref.5

Sequence conflict

1246

1

P → L in AAM74225. Ref.1

Sequence conflict

1246

1

P → L in AAN03866. Ref.1

Sequence conflict

1246

1

P → L in AAL14641. Ref.2

Sequence conflict

1246

1

P → L in BAA83027. Ref.3

Secondary structure

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1409

Helix Strand Turn

Details...

Helix

1137 – 1140

4

Beta strand

1141 – 1144

4

Helix

1147 – 1154

8

Beta strand

1161 – 1166

6

Beta strand

1168 – 1170

3

Beta strand

1173 – 1179

7

Beta strand

1184 – 1189

6

Beta strand

1190 – 1192

3

Helix

1194 – 1198

5

Beta strand

1199 – 1205

7

Beta strand

1210 – 1213

4

Beta strand

1222 – 1224

3

Helix

1225 – 1230

6

Turn

1231 – 1234

4

Beta strand

1237 – 1241

5

Helix

1266 – 1272

7

Beta strand

1274 – 1285

12

Helix

1291 – 1304

14

Beta strand

1305 – 1307

3

Beta strand

1312 – 1319

8

Beta strand

1322 – 1329

8

Beta strand

1332 – 1339

8

Helix

1340 – 1342

3

Beta strand

1343 – 1348

6

Beta strand

1350 – 1352

3

Beta strand

1354 – 1356

3

Turn

1358 – 1360

3

Beta strand

1362 – 1372

11

Beta strand

1375 – 1385

11

Beta strand

1389 – 1391

3

Helix

1393 – 1405

13

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 26, 2007. Version 2. Checksum: 67824299A1382140	FASTA	1,409	152,580
	10 20 30 40 50 60 MKSSGPVERL LRALGRRDSS RAASRPRKAE PHSFREKVFR KKPPVCAVCK VTIDGTGVSC 70 80 90 100 110 120 RVCKVATHRK CEAKVTSACQ ALPPVELRRN TAPVRRIEHL GSTKSLNHSK QRSTLPRSFS 130 140 150 160 170 180 LDPLMERRWD LDLTYVTERI LAAAFPARPD EQRHRGHLRE LAHVLQSKHR DKYLLFNLSE 190 200 210 220 230 240 KRHDLTRLNP KVQDFGWPEL HAPPLDKLCS ICKAMETWLS ADPQHVVVLY CKGNKGKLGV 250 260 270 280 290 300 IVSAYMHYSK ISAGADQALA TLTMRKFCED KVATELQPSQ RRYISYFSGL LSGSIRMNSS 310 320 330 340 350 360 PLFLHYVLIP MLPAFEPGTG FQPFLKIYQS MQLVYTSGVY HIAGPGPQQL CISLEPALLL 370 380 390 400 410 420 KGDVMVTCYH KGGRGTDRTL VFRVQFHTCT IHGPQLTFPK DQLDEAWTDE RFPFQASVEF 430 440 450 460 470 480 VFSSSPEKIK GSTPRNDPSV SVDYNTTEPA VRWDSYENFN QHHEDSVDGS LTHTRGPLDG 490 500 510 520 530 540 SPYAQVQRPP RQTPPAPSPE PPPPPMLSVS SDSGHSSTLT TEPAAESPGR PPPTAAERQE 550 560 570 580 590 600 LDRLLGGCGV ASGGRGAGRE TAILDDEEQP TVGGGPHLGV YPGHRPGLSR HCSCRQGYRE 610 620 630 640 650 660 PCGVPNGGYY RPEGTLERRR LAYGGYEGSP QGYAEASMEK RRLCRSLSEG LYPYPPEMGK 670 680 690 700 710 720 PATGDFGYRA PGYREVVILE DPGLPALYPC PACEEKLALP TAALYGLRLE REAGEGWASE 730 740 750 760 770 780 AGKPLLHPVR PGHPLPLLLP ACGHHHAPMP DYSCLKPPKA GEEGHEGCSY TMCPEGRYGH 790 800 810 820 830 840 PGYPALVTYS YGGAVPSYCP AYGRVPHSCG SPGEGRGYPS PGAHSPRAGS ISPGSPPYPQ 850 860 870 880 890 900 SRKLSYEIPT EEGGDRYPLP GHLASAGPLA SAESLEPVSW REGPSGHSTL PRSPRDAPCS 910 920 930 940 950 960 ASSELSGPST PLHTSSPVQG KESTRRQDTR SPTSAPTQRL SPGEALPPVS QAGTGKAPEL 970 980 990 1000 1010 1020 PSGSGPEPLA PSPVSPTFPP SSPSDWPQER SPGGHSDGAS PRSPVPTTLP GLRHAPWQGP 1030 1040 1050 1060 1070 1080 RGPPDSPDGS PLTPVPSQMP WLVASPEPPQ SSPTPAFPLA ASYDTNGLSQ PPLPEKRHLP 1090 1100 1110 1120 1130 1140 GPGQQPGPWG PEQASSPARG ISHHVTFAPL LSDNVPQTPE PPTQESQSNV KFVQDTSKFW 1150 1160 1170 1180 1190 1200 YKPHLSRDQA IALLKDKDPG AFLIRDSHSF QGAYGLALKV ATPPPSAQPW KGDPVEQLVR 1210 1220 1230 1240 1250 1260 HFLIETGPKG VKIKGCPSEP YFGSLSALVS QHSISPISLP CCLRIPSKDP LEETPEAPVP 1270 1280 1290 1300 1310 1320 TNMSTAADLL RQGAACSVLY LTSVETESLT GPQAVARASS AALSCSPRPT PAVVHFKVSA 1330 1340 1350 1360 1370 1380 QGITLTDNQR KLFFRRHYPV NSITFSSTDP QDRRWTNPDG TTSKIFGFVA KKPGSPWENV 1390 1400 CHLFAELDPD QPAGAIVTFI TKVLLGQRK
	Isoform 2 [UniParc]. Checksum: BD63FB8C01E97D9A	FASTA	1,312	142,685
	10 20 30 40 50 60 MKSSGPVERL LRALGRRDSS RAASRPRKAE PHSFREKVFR KKPPVCAVCK VTIDGTGVSC 70 80 90 100 110 120 RVCKVATHRK CEAKVTSACQ ALPPVELRRN TAPVRRIEHL GSTKSLNHSK QRSTLPRSFS 130 140 150 160 170 180 LDPLMERRWD LDLTYVTERI LAAAFPARPD EQRHRGHLRE LAHVLQSKHR DKYLLFNLSE 190 200 210 220 230 240 KRHDLTRLNP KVQDFGWPEL HAPPLDKLCS ICKAMETWLS ADPQHVVVLY CKGNKGKLGV 250 260 270 280 290 300 IVSAYMHYSK ISAGADQALA TLTMRKFCED KVATELQPSQ RRYISYFSGL LSGSIRMNSS 310 320 330 340 350 360 PLFLHYVLIP MLPAFEPGTG FQPFLKIYQS MQLVYTSGVY HIAGPGPQQL CISLEPALLL 370 380 390 400 410 420 KGDVMVTCYH KGGRGTDRTL VFRVQFHTCT IHGPQLTFPK DQLDEAWTDE RFPFQASVEF 430 440 450 460 470 480 VFSSSPEKIK GSTPRNDPSV SVDYNTTEPA VRWDSYENFN QHHEDSVDGS LTHTRGPLDG 490 500 510 520 530 540 SPYAQVQRPP RQTPPAPSPE PPPPPMLSVS SDSGHSSTLT TEPAAESPGR PPPTAAERQE 550 560 570 580 590 600 LDRLLGGCGV ASGGRGAGRE TAILDDEEQP TVGGGPHLGV YPGHRPGLSR HCSCRQGYRE 610 620 630 640 650 660 PCGVPNGGYY RPEGTLERRR LAYGGYEGSP QGYAEASMEK RRLCRSLSEG LYPYPPEMGK 670 680 690 700 710 720 PATGDFGYRA PGYREVVILE DPGLPALYPC PACEEKLALP TAALYGLRLE REAGEGWASE 730 740 750 760 770 780 AGKPLLHPVR PGHPLPLLLP ACGHHHAPMP DYSCLKPPKA GEEGHEGCSY TMCPEESLEP 790 800 810 820 830 840 VSWREGPSGH STLPRSPRDA PCSASSELSG PSTPLHTSSP VQGKESTRRQ DTRSPTSAPT 850 860 870 880 890 900 QRLSPGEALP PVSQAGTGKA PELPSGSGPE PLAPSPVSPT FPPSSPSDWP QERSPGGHSD 910 920 930 940 950 960 GASPRSPVPT TLPGLRHAPW QGPRGPPDSP DGSPLTPVPS QMPWLVASPE PPQSSPTPAF 970 980 990 1000 1010 1020 PLAASYDTNG LSQPPLPEKR HLPGPGQQPG PWGPEQASSP ARGISHHVTF APLLSDNVPQ 1030 1040 1050 1060 1070 1080 TPEPPTQESQ SNVKFVQDTS KFWYKPHLSR DQAIALLKDK DPGAFLIRDS HSFQGAYGLA 1090 1100 1110 1120 1130 1140 LKVATPPPSA QPWKGDPVEQ LVRHFLIETG PKGVKIKGCP SEPYFGSLSA LVSQHSISPI 1150 1160 1170 1180 1190 1200 SLPCCLRIPS KDPLEETPEA PVPTNMSTAA DLLRQGAACS VLYLTSVETE SLTGPQAVAR 1210 1220 1230 1240 1250 1260 ASSAALSCSP RPTPAVVHFK VSAQGITLTD NQRKLFFRRH YPVNSITFSS TDPQDRRWTN 1270 1280 1290 1300 1310 PDGTTSKIFG FVAKKPGSPW ENVCHLFAEL DPDQPAGAIV TFITKVLLGQ RK
	Isoform 4 [UniParc]. Checksum: 7F26C74F3E88A801	FASTA	1,419	153,564
	10 20 30 40 50 60 MDGGGVCVGR GDLLSSPQAL GQLLRKESRP RRAMKPRKAE PHSFREKVFR KKPPVCAVCK 70 80 90 100 110 120 VTIDGTGVSC RVCKVATHRK CEAKVTSACQ ALPPVELRRN TAPVRRIEHL GSTKSLNHSK 130 140 150 160 170 180 QRSTLPRSFS LDPLMERRWD LDLTYVTERI LAAAFPARPD EQRHRGHLRE LAHVLQSKHR 190 200 210 220 230 240 DKYLLFNLSE KRHDLTRLNP KVQDFGWPEL HAPPLDKLCS ICKAMETWLS ADPQHVVVLY 250 260 270 280 290 300 CKGNKGKLGV IVSAYMHYSK ISAGADQALA TLTMRKFCED KVATELQPSQ RRYISYFSGL 310 320 330 340 350 360 LSGSIRMNSS PLFLHYVLIP MLPAFEPGTG FQPFLKIYQS MQLVYTSGVY HIAGPGPQQL 370 380 390 400 410 420 CISLEPALLL KGDVMVTCYH KGGRGTDRTL VFRVQFHTCT IHGPQLTFPK DQLDEAWTDE 430 440 450 460 470 480 RFPFQASVEF VFSSSPEKIK GSTPRNDPSV SVDYNTTEPA VRWDSYENFN QHHEDSVDGS 490 500 510 520 530 540 LTHTRGPLDG SPYAQVQRPP RQTPPAPSPE PPPPPMLSVS SDSGHSSTLT TEPAAESPGR 550 560 570 580 590 600 PPPTAAERQE LDRLLGGCGV ASGGRGAGRE TAILDDEEQP TVGGGPHLGV YPGHRPGLSR 610 620 630 640 650 660 HCSCRQGYRE PCGVPNGGYY RPEGTLERRR LAYGGYEGSP QGYAEASMEK RRLCRSLSEG 670 680 690 700 710 720 LYPYPPEMGK PATGDFGYRA PGYREVVILE DPGLPALYPC PACEEKLALP TAALYGLRLE 730 740 750 760 770 780 REAGEGWASE AGKPLLHPVR PGHPLPLLLP ACGHHHAPMP DYSCLKPPKA GEEGHEGCSY 790 800 810 820 830 840 TMCPEGRYGH PGYPALVTYS YGGAVPSYCP AYGRVPHSCG SPGEGRGYPS PGAHSPRAGS 850 860 870 880 890 900 ISPGSPPYPQ SRKLSYEIPT EEGGDRYPLP GHLASAGPLA SAESLEPVSW REGPSGHSTL 910 920 930 940 950 960 PRSPRDAPCS ASSELSGPST PLHTSSPVQG KESTRRQDTR SPTSAPTQRL SPGEALPPVS 970 980 990 1000 1010 1020 QAGTGKAPEL PSGSGPEPLA PSPVSPTFPP SSPSDWPQER SPGGHSDGAS PRSPVPTTLP 1030 1040 1050 1060 1070 1080 GLRHAPWQGP RGPPDSPDGS PLTPVPSQMP WLVASPEPPQ SSPTPAFPLA ASYDTNGLSQ 1090 1100 1110 1120 1130 1140 PPLPEKRHLP GPGQQPGPWG PEQASSPARG ISHHVTFAPL LSDNVPQTPE PPTQESQSNV 1150 1160 1170 1180 1190 1200 KFVQDTSKFW YKPHLSRDQA IALLKDKDPG AFLIRDSHSF QGAYGLALKV ATPPPSAQPW 1210 1220 1230 1240 1250 1260 KGDPVEQLVR HFLIETGPKG VKIKGCPSEP YFGSLSALVS QHSISPISLP CCLRIPSKDP 1270 1280 1290 1300 1310 1320 LEETPEAPVP TNMSTAADLL RQGAACSVLY LTSVETESLT GPQAVARASS AALSCSPRPT 1330 1340 1350 1360 1370 1380 PAVVHFKVSA QGITLTDNQR KLFFRRHYPV NSITFSSTDP QDRRWTNPDG TTSKIFGFVA 1390 1400 1410 KKPGSPWENV CHLFAELDPD QPAGAIVTFI TKVLLGQRK
	Isoform 5 [UniParc]. Checksum: F52B6ED198BEE396	FASTA	1,285	138,828
	10 20 30 40 50 60 MERRWDLDLT YVTERILAAA FPARPDEQRH RGHLRELAHV LQSKHRDKYL LFNLSEKRHD 70 80 90 100 110 120 LTRLNPKVQD FGWPELHAPP LDKLCSICKA METWLSADPQ HVVVLYCKGN KGKLGVIVSA 130 140 150 160 170 180 YMHYSKISAG ADQALATLTM RKFCEDKVAT ELQPSQRRYI SYFSGLLSGS IRMNSSPLFL 190 200 210 220 230 240 HYVLIPMLPA FEPGTGFQPF LKIYQSMQLV YTSGVYHIAG PGPQQLCISL EPALLLKGDV 250 260 270 280 290 300 MVTCYHKGGR GTDRTLVFRV QFHTCTIHGP QLTFPKDQLD EAWTDERFPF QASVEFVFSS 310 320 330 340 350 360 SPEKIKGSTP RNDPSVSVDY NTTEPAVRWD SYENFNQHHE DSVDGSLTHT RGPLDGSPYA 370 380 390 400 410 420 QVQRPPRQTP PAPSPEPPPP PMLSVSSDSG HSSTLTTEPA AESPGRPPPT AAERQELDRL 430 440 450 460 470 480 LGGCGVASGG RGAGRETAIL DDEEQPTVGG GPHLGVYPGH RPGLSRHCSC RQGYREPCGV 490 500 510 520 530 540 PNGGYYRPEG TLERRRLAYG GYEGSPQGYA EASMEKRRLC RSLSEGLYPY PPEMGKPATG 550 560 570 580 590 600 DFGYRAPGYR EVVILEDPGL PALYPCPACE EKLALPTAAL YGLRLEREAG EGWASEAGKP 610 620 630 640 650 660 LLHPVRPGHP LPLLLPACGH HHAPMPDYSC LKPPKAGEEG HEGCSYTMCP EGRYGHPGYP 670 680 690 700 710 720 ALVTYSYGGA VPSYCPAYGR VPHSCGSPGE GRGYPSPGAH SPRAGSISPG SPPYPQSRKL 730 740 750 760 770 780 SYEIPTEEGG DRYPLPGHLA SAGPLASAES LEPVSWREGP SGHSTLPRSP RDAPCSASSE 790 800 810 820 830 840 LSGPSTPLHT SSPVQGKEST RRQDTRSPTS APTQRLSPGE ALPPVSQAGT GKAPELPSGS 850 860 870 880 890 900 GPEPLAPSPV SPTFPPSSPS DWPQERSPGG HSDGASPRSP VPTTLPGLRH APWQGPRGPP 910 920 930 940 950 960 DSPDGSPLTP VPSQMPWLVA SPEPPQSSPT PAFPLAASYD TNGLSQPPLP EKRHLPGPGQ 970 980 990 1000 1010 1020 QPGPWGPEQA SSPARGISHH VTFAPLLSDN VPQTPEPPTQ ESQSNVKFVQ DTSKFWYKPH 1030 1040 1050 1060 1070 1080 LSRDQAIALL KDKDPGAFLI RDSHSFQGAY GLALKVATPP PSAQPWKGDP VEQLVRHFLI 1090 1100 1110 1120 1130 1140 ETGPKGVKIK GCPSEPYFGS LSALVSQHSI SPISLPCCLR IPSKDPLEET PEAPVPTNMS 1150 1160 1170 1180 1190 1200 TAADLLRQGA ACSVLYLTSV ETESLTGPQA VARASSAALS CSPRPTPAVV HFKVSAQGIT 1210 1220 1230 1240 1250 1260 LTDNQRKLFF RRHYPVNSIT FSSTDPQDRR WTNPDGTTSK IFGFVAKKPG SPWENVCHLF 1270 1280 AELDPDQPAG AIVTFITKVL LGQRK
	Isoform 6 [UniParc]. Checksum: C19BCA8F1535E663	FASTA	1,407	152,452
	10 20 30 40 50 60 MKSSGPVERL LRALGRRDSS RAASRPRKAE PHSFREKVFR KKPPVCAVCK VTIDGTGVSC 70 80 90 100 110 120 RVCKVATHRK CEAKVTSACQ ALPPVELRRN TAPVRRIEHL GSTKSLNHSK QRSTLPRSFS 130 140 150 160 170 180 LDPLMERRWD LDLTYVTERI LAAAFPARPD EQRHRGHLRE LAHVLQSKHR DKYLLFNLSE 190 200 210 220 230 240 KRHDLTRLNP KVQDFGWPEL HAPPLDKLCS ICKAMETWLS ADPQHVVVLY CKGNKGKLGV 250 260 270 280 290 300 IVSAYMHYSK ISAGADQALA TLTMRKFCED KVATELQPSQ RRYISYFSGL LSGSIRMNSS 310 320 330 340 350 360 PLFLHYVLIP MLPAFEPGTG FQPFLKIYQS MQLVYTSGVY HIAGPGPQQL CISLEPALLL 370 380 390 400 410 420 KGDVMVTCYH KGGRGTDRTL VFRVQFHTCT IHGPQLTFPK DQLDEAWTDE RFPFQASVEF 430 440 450 460 470 480 VFSSSPEKIK GSTPRNDPSV SVDYNTTEPA VRWDSYENFN QHHEDSVDGS LTHTRGPLDG 490 500 510 520 530 540 SPYAQVQRPP RQTPPAPSPE PPPPPMLSVS SDSGHSSTLT TEPAAESPGR PPPTAAERQE 550 560 570 580 590 600 LDRLLGGCGV ASGGRGAGRE TAILDDEEQP TVGGGPHLGV YPGHRPGLSR HCSCRQGYRE 610 620 630 640 650 660 PCGVPNGGYY RPEGTLERRR LAYGGYEGSP QGYAEASMEK RRLCRSLSEG LYPYPPEMGK 670 680 690 700 710 720 PATGDFGYRA PGYREVVILE DPGLPALYPC PACEEKLALP TAALYGLRLE REAGEGWASE 730 740 750 760 770 780 AGKPLLHPVR PGHPLPLLLP ACGHHHAPMP DYSCLKPPKA GEEGHEGCSY TMCPEGRYGH 790 800 810 820 830 840 PGYPALVTYS YGGAVPSYCP AYGRVPHSCG SPGEGRGYPS PGAHSPRAGS ISPGSPPYPQ 850 860 870 880 890 900 SRKLSYEIPT EEGGDRYPLP GHLASAGPLA SAESLEPVSW REGPSGHSTL PRSPRDAPCS 910 920 930 940 950 960 ASSELSGPST PLHTSSPVQG KESTRRQDTR SPTSAPTQRL SPGEALPPVS QAGTGKAPEL 970 980 990 1000 1010 1020 PSGSGPEPLA PSPVSPTFPP SSPSDWPQER SPGGHSDGAS PRSPVPTTLP GLRHAPWQGP 1030 1040 1050 1060 1070 1080 RGPPDSPDGS PLTPVPSQMP WLVASPEPPQ SSPTPAFPLA ASYDTNGLSQ PPLPEKRHLP 1090 1100 1110 1120 1130 1140 GPGQQPGPWG PEQASSPARG ISHHVTFAPL LSDNVPQTPE PPTQESQSNV KFVQDTSKFW 1150 1160 1170 1180 1190 1200 YKPHLSRDQA IALLKDKDPG AFLIRDSHSF QGAYGLALKV ATPPPSAQPW KGDPVEQLVR 1210 1220 1230 1240 1250 1260 HFLIETGPKG VKIKGCPSEP YFGSLSALVS QHSISPISLP CCLRIPSKDP LEETPEAPVP 1270 1280 1290 1300 1310 1320 TNMSTAADLL RQACSVLYLT SVETESLTGP QAVARASSAA LSCSPRPTPA VVHFKVSAQG 1330 1340 1350 1360 1370 1380 ITLTDNQRKL FFRRHYPVNS ITFSSTDPQD RRWTNPDGTT SKIFGFVAKK PGSPWENVCH 1390 1400 LFAELDPDQP AGAIVTFITK VLLGQRK

References

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[1]	"Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin." Hafizi S., Alindri F., Karlsson R., Dahlbaeck B. Biochem. Biophys. Res. Commun. 299:793-800(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4), INTERACTION WITH AXL, TISSUE SPECIFICITY. Tissue: Kidney.
[2]	"Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration." Chen H., Duncan I.C., Bozorgchami H., Lo S.H. Proc. Natl. Acad. Sci. U.S.A. 99:733-738(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[3]	"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 759-1409 (ISOFORM 6). Tissue: Colon endothelium and Testis.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 364-1398 (ISOFORM 2). Tissue: Brain and Uterus.
[7]	"C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration." Hafizi S., Ibraimi F., Dahlbaeck B. FASEB J. 19:971-973(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, MUTAGENESIS OF CYS-231.
[8]	"Solution structure of the PTB domain of KIAA1075 protein from human." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 1263-1409.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF518729 mRNA. Translation: AAM74225.1.
AF518728 mRNA. Translation: AAN03866.1.
AF417490 mRNA. Translation: AAL14641.1.
AB028998 mRNA. Translation: BAA83027.2. Different initiation.
AL137564 mRNA. Translation: CAB70815.1.
BX647126 mRNA. Translation: CAH56176.1. Sequence problems.
BC054099 mRNA. Translation: AAH54099.1.
BC110854 mRNA. Translation: AAI10855.1.
BC129828 mRNA. Translation: AAI29829.1. Different initiation.
BC129829 mRNA. Translation: AAI29830.1. Different initiation.
BC131503 mRNA. Translation: AAI31504.1. Different initiation.
BC142668 mRNA. Translation: AAI42669.1.
BC142712 mRNA. Translation: AAI42713.1.

IPI

IPI00385317.
IPI00396051.
IPI00465295.
IPI00550368.
IPI00848267.

PIR

T46500.

RefSeq

NP_056134.2. NM_015319.2.
NP_736610.2. NM_170754.2.
NP_938072.1. NM_198316.1.

UniGene

Hs.343334.
Hs.6147.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DKQ	NMR	-	A	1263-1409	[»]
2KNO	NMR	-	A	1135-1249	[»]
2L6K	NMR	-	A	1135-1248	[»]
2LOZ	NMR	-	A	1263-1409	[»]
3HQC	X-ray	1.80	A	1264-1409	[»]

ProteinModelPortal

Q63HR2.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q63HR2. 6 interactions.

MINT

MINT-2870924.

PTM databases

PhosphoSite

Q63HR2.

Polymorphism databases

DMDM

150416153.

Proteomic databases

PaxDb

Q63HR2.

PRIDE

Q63HR2.

Protocols and materials databases

DNASU

23371.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000314250; ENSP00000319684; ENSG00000111077.
ENST00000314276; ENSP00000319756; ENSG00000111077.
ENST00000379902; ENSP00000369232; ENSG00000111077.
ENST00000546602; ENSP00000449363; ENSG00000111077.
ENST00000552570; ENSP00000447021; ENSG00000111077.

GeneID

23371.

KEGG

hsa:23371.

UCSC

uc001sbl.3. human.
uc001sbn.3. human.
uc001sbq.3. human.
uc009zmr.3. human.

Organism-specific databases

CTD

23371.

GeneCards

GC12P053440.

HGNC

HGNC:19737. TENC1.

HPA

HPA034659.

MIM

607717. gene.

neXtProt

NX_Q63HR2.

PharmGKB

PA134976096.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG2453.

HOVERGEN

HBG108559.

OMA

HAPWQGP.

Enzyme and pathway databases

SignaLink

Q63HR2.

Gene expression databases

ArrayExpress

Q63HR2.

Bgee

Q63HR2.

Genevestigator

Q63HR2.

Family and domain databases

Gene3D

2.30.29.30. 1 hit.
3.30.505.10. 1 hit.

InterPro

IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR011993. PH_like_dom.
IPR014019. Phosphatase_tensin-typ.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR013625. PTB.
IPR006020. PTyr_interaction_dom.
IPR000980. SH2.
IPR014020. Tensin_phosphatase_C2-dom.
[Graphical view]

Pfam

PF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]

SMART

SM00109. C1. 1 hit.
SM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]

SUPFAM

SSF49562. C2_CaLB. 1 hit.

PROSITE

PS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

TENC1. human.

EvolutionaryTrace

Q63HR2.

GenomeRNAi

23371.

NextBio

45448.

SOURCE

Search...

Entry information

Entry name

TENC1_HUMAN

Accession

Primary (citable) accession number: Q63HR2
Secondary accession number(s): A2VDF2 , A2VDF3, A2VDI8, A5PKY4, Q2NL80, Q76MW6, Q7Z5T9, Q8NFF9, Q8NFG0, Q96P25, Q9NT29, Q9UPS7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	June 26, 2007
Last modified:	May 29, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.