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Protein

PI-PLC X domain-containing protein 3

Gene

PLCXD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371PROSITE-ProRule annotation
Active sitei114 – 1141PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transducer

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
PI-PLC X domain-containing protein 3
Gene namesi
Name:PLCXD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:31822. PLCXD3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134886053.

Polymorphism and mutation databases

BioMutaiPLCXD3.
DMDMi229462782.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321PI-PLC X domain-containing protein 3PRO_0000305693Add
BLAST

Proteomic databases

MaxQBiQ63HM9.
PaxDbiQ63HM9.
PRIDEiQ63HM9.

PTM databases

iPTMnetiQ63HM9.
PhosphoSiteiQ63HM9.

Expressioni

Gene expression databases

BgeeiQ63HM9.
CleanExiHS_PLCXD3.
GenevisibleiQ63HM9. HS.

Organism-specific databases

HPAiHPA046849.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333751.

Structurei

3D structure databases

ProteinModelPortaliQ63HM9.
SMRiQ63HM9. Positions 8-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 197176PI-PLC X-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4306. Eukaryota.
ENOG410Z30Q. LUCA.
GeneTreeiENSGT00530000063361.
HOVERGENiHBG069284.
InParanoidiQ63HM9.
OMAiSLQYLWE.
OrthoDBiEOG776SQ6.
PhylomeDBiQ63HM9.
TreeFamiTF314457.

Family and domain databases

Gene3Di3.20.20.190. 1 hit.
InterProiIPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
[Graphical view]
SMARTiSM00148. PLCXc. 1 hit.
[Graphical view]
SUPFAMiSSF51695. SSF51695. 1 hit.
PROSITEiPS50007. PIPLC_X_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63HM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSQGKNEL KLADWMATLP ESMHSIPLTN LAIPGSHDSF SFYIDEASPV
60 70 80 90 100
GPEQPETVQN FVSVFGTVAK KLMRKWLATQ TMNFTGQLGA GIRYFDLRIS
110 120 130 140 150
TKPRDPDNEL YFAHGLFSAK VNEGLEEINA FLTDHHKEVV FLDFNHFYGM
160 170 180 190 200
QKYHHEKLVQ MLKDIYGNKM CPAIFAQEVS LKYLWEKDYQ VLVFYHSPVA
210 220 230 240 250
LEVPFLWPGQ MMPAPWANTT DPEKLIQFLQ ASITERRKKG SFFISQVVLT
260 270 280 290 300
PKASTVVKGV ASGLRETITE RALPAMMQWV RTQKPGESGI NIVTADFVEL
310 320
GDFISTVIKL NYVFDEGEAN T
Length:321
Mass (Da):36,313
Last modified:May 5, 2009 - v2
Checksum:i8CAE049F287BD1B6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti174 – 1741I → T in CAH56150 (PubMed:17974005).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX648329 mRNA. Translation: CAH56150.1.
AC008830 Genomic DNA. No translation available.
CCDSiCCDS34150.1.
RefSeqiNP_001005473.1. NM_001005473.2.
UniGeneiHs.145404.

Genome annotation databases

EnsembliENST00000328457; ENSP00000333751; ENSG00000182836.
ENST00000377801; ENSP00000367032; ENSG00000182836.
GeneIDi345557.
KEGGihsa:345557.
UCSCiuc003jmm.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX648329 mRNA. Translation: CAH56150.1.
AC008830 Genomic DNA. No translation available.
CCDSiCCDS34150.1.
RefSeqiNP_001005473.1. NM_001005473.2.
UniGeneiHs.145404.

3D structure databases

ProteinModelPortaliQ63HM9.
SMRiQ63HM9. Positions 8-197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333751.

PTM databases

iPTMnetiQ63HM9.
PhosphoSiteiQ63HM9.

Polymorphism and mutation databases

BioMutaiPLCXD3.
DMDMi229462782.

Proteomic databases

MaxQBiQ63HM9.
PaxDbiQ63HM9.
PRIDEiQ63HM9.

Protocols and materials databases

DNASUi345557.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328457; ENSP00000333751; ENSG00000182836.
ENST00000377801; ENSP00000367032; ENSG00000182836.
GeneIDi345557.
KEGGihsa:345557.
UCSCiuc003jmm.2. human.

Organism-specific databases

CTDi345557.
GeneCardsiPLCXD3.
HGNCiHGNC:31822. PLCXD3.
HPAiHPA046849.
neXtProtiNX_Q63HM9.
PharmGKBiPA134886053.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4306. Eukaryota.
ENOG410Z30Q. LUCA.
GeneTreeiENSGT00530000063361.
HOVERGENiHBG069284.
InParanoidiQ63HM9.
OMAiSLQYLWE.
OrthoDBiEOG776SQ6.
PhylomeDBiQ63HM9.
TreeFamiTF314457.

Miscellaneous databases

GenomeRNAii345557.
PROiQ63HM9.

Gene expression databases

BgeeiQ63HM9.
CleanExiHS_PLCXD3.
GenevisibleiQ63HM9. HS.

Family and domain databases

Gene3Di3.20.20.190. 1 hit.
InterProiIPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
[Graphical view]
SMARTiSM00148. PLCXc. 1 hit.
[Graphical view]
SUPFAMiSSF51695. SSF51695. 1 hit.
PROSITEiPS50007. PIPLC_X_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterine endothelium.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPLCX3_HUMAN
AccessioniPrimary (citable) accession number: Q63HM9
Secondary accession number(s): A6NL04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 5, 2009
Last modified: June 8, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.