Reviewed, UniProtKB/Swiss-Prot Q63HM9 (PLCX3_HUMAN)

Names and origin

Protein names

Recommended name:
    PI-PLC X domain-containing protein 3

Gene names

Name:

PLCXD3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 1 PI-PLC X-box domain.

Ontologies

Keywords
Biological process	Lipid degradation
Molecular function	Hydrolase Transducer
Gene Ontology (GO)
Biological process	intracellular signaling cascade Inferred from electronic annotation. Source: InterPro lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phospholipase C activity Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	PI-PLC X domain-containing protein 3		PRO_0000305693
Regions
	Domain	22 – 197	176	PI-PLC X-box
Sites
	Active site	37	1	By similarity
	Active site	114	1	By similarity
Experimental info
	Sequence conflict	174	1	I → T in CAH56150. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q63HM9-1 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: 8CAE049F287BD1B6	FASTA	321	36,313
	10 20 30 40 50 60 MASSQGKNEL KLADWMATLP ESMHSIPLTN LAIPGSHDSF SFYIDEASPV GPEQPETVQN 70 80 90 100 110 120 FVSVFGTVAK KLMRKWLATQ TMNFTGQLGA GIRYFDLRIS TKPRDPDNEL YFAHGLFSAK 130 140 150 160 170 180 VNEGLEEINA FLTDHHKEVV FLDFNHFYGM QKYHHEKLVQ MLKDIYGNKM CPAIFAQEVS 190 200 210 220 230 240 LKYLWEKDYQ VLVFYHSPVA LEVPFLWPGQ MMPAPWANTT DPEKLIQFLQ ASITERRKKG 250 260 270 280 290 300 SFFISQVVLT PKASTVVKGV ASGLRETITE RALPAMMQWV RTQKPGESGI NIVTADFVEL 310 320 GDFISTVIKL NYVFDEGEAN T

References

[1]

"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterine endothelium.

[2]

"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed: 15372022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX648329 mRNA. Translation: CAH56150.1. AC008830 Genomic DNA. No translation available.
IPI	IPI00470475.
RefSeq	NP_001005473.1.
UniGene	Hs.145404
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q63HM9.
Genome annotation databases
Ensembl	ENSG00000182836. Homo sapiens. [Contig view]
GeneID	345557.
KEGG	hsa:345557.
Organism-specific databases
GeneCards	GC05M041342.
HGNC	HGNC:31822. PLCXD3.
PharmGKB	PA134886053.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q63HM9.
HOVERGEN	Q63HM9.
Gene expression databases
ArrayExpress	Q63HM9.
Bgee	Q63HM9.
CleanEx	HS_PLCXD3.
Family and domain databases
InterPro	IPR000909. Phospholipase_C_Pinositol-sp_X. IPR017946. PLC-like_Pdiesterase_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.190. PLC-like_Pdiesterase_TIM-brl. 1 hit.
PROSITE	PS50007. PIPLC_X_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	98869.

Entry information

Entry name

PLCX3_HUMAN

Accession

Primary (citable) accession number: Q63HM9
Secondary accession number(s): A6NL04

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	May 5, 2009
Last modified:	June 16, 2009
This is version 29 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)