PLCXD3

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	37	PROSITE-ProRule annotation		1
Active siteⁱ	114	PROSITE-ProRule annotation		1

GO - Molecular functionⁱ

phosphoric diester hydrolase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

lipid catabolic process Source: UniProtKB-KW
signal transduction Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Transducer
Biological process	Lipid degradation, Lipid metabolism

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: PI-PLC X domain-containing protein 3
Gene namesⁱ	Name:PLCXD3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000182836.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31822 PLCXD3
MIMⁱ	617016 gene
neXtProtⁱ	NX_Q63HM9

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	345557
Open Targets More...OpenTargetsⁱ	ENSG00000182836
PharmGKBⁱ	PA134886053

Polymorphism and mutation databases

BioMutaⁱ	PLCXD3
DMDMⁱ	229462782

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000305693	1 – 321	PI-PLC X domain-containing protein 3Add BLAST		321

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q63HM9
PaxDbⁱ	Q63HM9
PeptideAtlas More...PeptideAtlasⁱ	Q63HM9
PRIDEⁱ	Q63HM9
ProteomicsDBⁱ	65882

PTM databases

iPTMnetⁱ	Q63HM9
PhosphoSitePlusⁱ	Q63HM9

Expressionⁱ

Tissue specificityⁱ

Expressed at highest levels in heart. Also detected in kidney, lung, small intestine and colon. Expressed at very low levels, if any, in leukocytes, thymus and skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000182836
CleanExⁱ	HS_PLCXD3
Genevisibleⁱ	Q63HM9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA046849

HPAⁱ

HPA046849

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q63HM9, 1 interactor
STRINGⁱ	9606.ENSP00000333751

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q63HM9
SMRⁱ	Q63HM9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	22 – 197	PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST		176

Phylogenomic databases

eggNOGⁱ	KOG4306 Eukaryota ENOG410Z30Q LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063361
HOVERGENⁱ	HBG069284
InParanoidⁱ	Q63HM9
OMAⁱ	IYRRCPI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B2T
PhylomeDBⁱ	Q63HM9
TreeFamⁱ	TF314457

Family and domain databases

Gene3Dⁱ	3.20.20.190, 1 hit
InterProⁱ	View protein in InterPro IPR017946 PLC-like_Pdiesterase_TIM-brl IPR000909 PLipase_C_PInositol-sp_X_dom
SMARTⁱ	View protein in SMART SM00148 PLCXc, 1 hit
SUPFAMⁱ	SSF51695 SSF51695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50007 PIPLC_X_DOMAIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q63HM9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASSQGKNEL KLADWMATLP ESMHSIPLTN LAIPGSHDSF SFYIDEASPV 
        60         70         80         90        100
GPEQPETVQN FVSVFGTVAK KLMRKWLATQ TMNFTGQLGA GIRYFDLRIS 
       110        120        130        140        150
TKPRDPDNEL YFAHGLFSAK VNEGLEEINA FLTDHHKEVV FLDFNHFYGM 
       160        170        180        190        200
QKYHHEKLVQ MLKDIYGNKM CPAIFAQEVS LKYLWEKDYQ VLVFYHSPVA 
       210        220        230        240        250
LEVPFLWPGQ MMPAPWANTT DPEKLIQFLQ ASITERRKKG SFFISQVVLT 
       260        270        280        290        300
PKASTVVKGV ASGLRETITE RALPAMMQWV RTQKPGESGI NIVTADFVEL 
       310        320 
GDFISTVIKL NYVFDEGEAN T

Length:321

Mass (Da):36,313

Last modified:May 5, 2009 - v2

Checksum:ⁱ8CAE049F287BD1B6

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	174	I → T in CAH56150 (PubMed:17974005).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX648329 mRNA Translation: CAH56150.1 AC008830 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34150.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001005473.1, NM_001005473.2
UniGeneⁱ	Hs.145404

Genome annotation databases

Ensemblⁱ	ENST00000328457; ENSP00000333751; ENSG00000182836 ENST00000377801; ENSP00000367032; ENSG00000182836
GeneIDⁱ	345557
KEGGⁱ	hsa:345557
UCSC genome browser More...UCSCⁱ	uc003jmm.2 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q63HM9	PLCXD3 isoform 1		PANTR		321
PLCXD3 isoform 1		PONAB		321
Phosphatidylinositol specific phospholipase C X domain containing 3		PANPA		321
Phosphatidylinositol specific phospholipase C X domain containing 3		GORGO		321
cDNA FLJ45199 fis, clone BRCAN2003814, highly similar to Homo sapiens phosphatidylinositol-specific phospholipase C, X domain containing 3 (PLCXD3), mRNA		HUMAN		322
+108

Protein	Similar proteins		Species	Score	Length
Q63HM9	PLCXD3 isoform 1		PANTR		321
PLCXD3 isoform 1		PONAB		321
Phosphatidylinositol specific phospholipase C X domain containing 3		PANPA		321
Phosphatidylinositol specific phospholipase C X domain containing 3		GORGO		321
cDNA FLJ45199 fis, clone BRCAN2003814, highly similar to Homo sapiens phosphatidylinositol-specific phospholipase C, X domain containing 3 (PLCXD3), mRNA		HUMAN		322
+230

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX648329 mRNA Translation: CAH56150.1 AC008830 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34150.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001005473.1, NM_001005473.2
UniGeneⁱ	Hs.145404

3D structure databases

ProteinModelPortalⁱ	Q63HM9
SMRⁱ	Q63HM9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q63HM9, 1 interactor
STRINGⁱ	9606.ENSP00000333751

PTM databases

iPTMnetⁱ	Q63HM9
PhosphoSitePlusⁱ	Q63HM9

Polymorphism and mutation databases

BioMutaⁱ	PLCXD3
DMDMⁱ	229462782

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q63HM9
PaxDbⁱ	Q63HM9
PeptideAtlas More...PeptideAtlasⁱ	Q63HM9
PRIDEⁱ	Q63HM9
ProteomicsDBⁱ	65882

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	345557
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000328457; ENSP00000333751; ENSG00000182836 ENST00000377801; ENSP00000367032; ENSG00000182836
GeneIDⁱ	345557
KEGGⁱ	hsa:345557
UCSC genome browser More...UCSCⁱ	uc003jmm.2 human

Organism-specific databases

CTDⁱ	345557
DisGeNET More...DisGeNETⁱ	345557
EuPathDBⁱ	HostDB:ENSG00000182836.9
GeneCardsⁱ	PLCXD3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31822 PLCXD3
Human Protein Atlas More...HPAⁱ	HPA046849
MIMⁱ	617016 gene
neXtProtⁱ	NX_Q63HM9
Open Targets More...OpenTargetsⁱ	ENSG00000182836
PharmGKBⁱ	PA134886053
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4306 Eukaryota ENOG410Z30Q LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063361
HOVERGENⁱ	HBG069284
InParanoidⁱ	Q63HM9
OMAⁱ	IYRRCPI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B2T
PhylomeDBⁱ	Q63HM9
TreeFamⁱ	TF314457

Miscellaneous databases

ChiTaRSⁱ	PLCXD3 human
GenomeRNAiⁱ	345557
Protein Ontology More...PROⁱ	PR:Q63HM9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000182836
CleanExⁱ	HS_PLCXD3
Genevisibleⁱ	Q63HM9 HS

Family and domain databases

Gene3Dⁱ	3.20.20.190, 1 hit
InterProⁱ	View protein in InterPro IPR017946 PLC-like_Pdiesterase_TIM-brl IPR000909 PLipase_C_PInositol-sp_X_dom
SMARTⁱ	View protein in SMART SM00148 PLCXc, 1 hit
SUPFAMⁱ	SSF51695 SSF51695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50007 PIPLC_X_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLCX3_HUMAN
Accessionⁱ	Q63HM9Primary (citable) accession number: Q63HM9 Secondary accession number(s): A6NL04
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
	Last sequence update:	May 5, 2009
	Last modified:	June 20, 2018
	This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q63HM9 (PLCX3_HUMAN)

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PI-PLC X domain-containing protein 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ