Q63HM9 (PLCX3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
PI-PLC X domain-containing protein 3

Gene names

Name:

PLCXD3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 PI-PLC X-box domain.

Ontologies

Keywords
Biological process	Lipid degradation
Molecular function	Hydrolase Transducer
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phospholipase C activity Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	PI-PLC X domain-containing protein 3		PRO_0000305693
Regions
	Domain	22 – 197	176	PI-PLC X-box
Sites
	Active site	37	1	By similarity
	Active site	114	1	By similarity
Experimental info
	Sequence conflict	174	1	I → T in CAH56150. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q63HM9 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: 8CAE049F287BD1B6	FASTA	321	36,313
	10 20 30 40 50 60 MASSQGKNEL KLADWMATLP ESMHSIPLTN LAIPGSHDSF SFYIDEASPV GPEQPETVQN 70 80 90 100 110 120 FVSVFGTVAK KLMRKWLATQ TMNFTGQLGA GIRYFDLRIS TKPRDPDNEL YFAHGLFSAK 130 140 150 160 170 180 VNEGLEEINA FLTDHHKEVV FLDFNHFYGM QKYHHEKLVQ MLKDIYGNKM CPAIFAQEVS 190 200 210 220 230 240 LKYLWEKDYQ VLVFYHSPVA LEVPFLWPGQ MMPAPWANTT DPEKLIQFLQ ASITERRKKG 250 260 270 280 290 300 SFFISQVVLT PKASTVVKGV ASGLRETITE RALPAMMQWV RTQKPGESGI NIVTADFVEL 310 320 GDFISTVIKL NYVFDEGEAN T

References

[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterine endothelium.
[2]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed: 15372022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX648329 mRNA. Translation: CAH56150.1. AC008830 Genomic DNA. No translation available.
IPI	IPI00470475.
RefSeq	NP_001005473.1. NM_001005473.2.
UniGene	Hs.145404.
3D structure databases
ProteinModelPortal	Q63HM9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q63HM9.
Polymorphism databases
DMDM	229462782.
Proteomic databases
PRIDE	Q63HM9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328457; ENSP00000333751; ENSG00000182836. ENST00000377801; ENSP00000367032; ENSG00000182836.
GeneID	345557.
KEGG	hsa:345557.
Organism-specific databases
CTD	345557.
GeneCards	GC05M041342.
H-InvDB	HIX0024816.
HGNC	HGNC:31822. PLCXD3.
neXtProt	NX_Q63HM9.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14463.
GeneTree	ENSGT00530000063361.
HOVERGEN	HBG069284.
InParanoid	Q63HM9.
OMA	KFADWMA.
OrthoDB	EOG42FSHW.
PhylomeDB	Q63HM9.
Gene expression databases
ArrayExpress	Q63HM9.
Bgee	Q63HM9.
CleanEx	HS_PLCXD3.
Genevestigator	Q63HM9.
Family and domain databases
InterPro	IPR017946. PLC-like_Pdiesterase_TIM-brl. IPR000909. PLipase_C_PInositol-sp_X_dom. [Graphical view]
Gene3D	G3DSA:3.20.20.190. PLC-like_Pdiesterase_TIM-brl. 1 hit.
Pfam	PF00388. PI-PLC-X. 1 hit. [Graphical view]
SUPFAM	SSF51695. PLC-like_Pdiesterase_TIM-brl. 1 hit.
PROSITE	PS50007. PIPLC_X_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	98869.

Entry information

Entry name

PLCX3_HUMAN

Accession

Primary (citable) accession number: Q63HM9
Secondary accession number(s): A6NL04

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	May 5, 2009
Last modified:	December 14, 2011
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.