UniProtKB - Q63HM9 (PLCX3_HUMAN)
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Protein
PI-PLC X domain-containing protein 3
Gene
PLCXD3
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 37 | PROSITE-ProRule annotation | 1 | |
Active sitei | 114 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- phosphoric diester hydrolase activity Source: InterPro
- signal transducer activity Source: UniProtKB-KW
GO - Biological processi
- lipid catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Transducer |
Biological process | Lipid degradation, Lipid metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: PI-PLC X domain-containing protein 3 |
Gene namesi | Name:PLCXD3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000182836.9. |
HGNCi | HGNC:31822. PLCXD3. |
MIMi | 617016. gene. |
neXtProti | NX_Q63HM9. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 345557. |
OpenTargetsi | ENSG00000182836. |
PharmGKBi | PA134886053. |
Polymorphism and mutation databases
BioMutai | PLCXD3. |
DMDMi | 229462782. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305693 | 1 – 321 | PI-PLC X domain-containing protein 3Add BLAST | 321 |
Proteomic databases
MaxQBi | Q63HM9. |
PaxDbi | Q63HM9. |
PeptideAtlasi | Q63HM9. |
PRIDEi | Q63HM9. |
PTM databases
iPTMneti | Q63HM9. |
PhosphoSitePlusi | Q63HM9. |
Expressioni
Tissue specificityi
Expressed at highest levels in heart. Also detected in kidney, lung, small intestine and colon. Expressed at very low levels, if any, in leukocytes, thymus and skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSG00000182836. |
CleanExi | HS_PLCXD3. |
Genevisiblei | Q63HM9. HS. |
Organism-specific databases
HPAi | HPA046849. |
Interactioni
Protein-protein interaction databases
IntActi | Q63HM9. 1 interactor. |
STRINGi | 9606.ENSP00000333751. |
Structurei
3D structure databases
ProteinModelPortali | Q63HM9. |
SMRi | Q63HM9. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 197 | PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST | 176 |
Phylogenomic databases
eggNOGi | KOG4306. Eukaryota. ENOG410Z30Q. LUCA. |
GeneTreei | ENSGT00530000063361. |
HOVERGENi | HBG069284. |
InParanoidi | Q63HM9. |
OMAi | IYRRCPI. |
OrthoDBi | EOG091G0B2T. |
PhylomeDBi | Q63HM9. |
TreeFami | TF314457. |
Family and domain databases
Gene3Di | 3.20.20.190. 1 hit. |
InterProi | View protein in InterPro IPR017946. PLC-like_Pdiesterase_TIM-brl. IPR000909. PLipase_C_PInositol-sp_X_dom. |
SMARTi | View protein in SMART SM00148. PLCXc. 1 hit. |
SUPFAMi | SSF51695. SSF51695. 1 hit. |
PROSITEi | View protein in PROSITE PS50007. PIPLC_X_DOMAIN. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q63HM9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASSQGKNEL KLADWMATLP ESMHSIPLTN LAIPGSHDSF SFYIDEASPV
60 70 80 90 100
GPEQPETVQN FVSVFGTVAK KLMRKWLATQ TMNFTGQLGA GIRYFDLRIS
110 120 130 140 150
TKPRDPDNEL YFAHGLFSAK VNEGLEEINA FLTDHHKEVV FLDFNHFYGM
160 170 180 190 200
QKYHHEKLVQ MLKDIYGNKM CPAIFAQEVS LKYLWEKDYQ VLVFYHSPVA
210 220 230 240 250
LEVPFLWPGQ MMPAPWANTT DPEKLIQFLQ ASITERRKKG SFFISQVVLT
260 270 280 290 300
PKASTVVKGV ASGLRETITE RALPAMMQWV RTQKPGESGI NIVTADFVEL
310 320
GDFISTVIKL NYVFDEGEAN T
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 174 | I → T in CAH56150 (PubMed:17974005).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX648329 mRNA. Translation: CAH56150.1. AC008830 Genomic DNA. No translation available. |
CCDSi | CCDS34150.1. |
RefSeqi | NP_001005473.1. NM_001005473.2. |
UniGenei | Hs.145404. |
Genome annotation databases
Ensembli | ENST00000328457; ENSP00000333751; ENSG00000182836. ENST00000377801; ENSP00000367032; ENSG00000182836. |
GeneIDi | 345557. |
KEGGi | hsa:345557. |
UCSCi | uc003jmm.2. human. |
Similar proteinsi
Entry informationi
Entry namei | PLCX3_HUMAN | |
Accessioni | Q63HM9Primary (citable) accession number: Q63HM9 Secondary accession number(s): A6NL04 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | May 5, 2009 | |
Last modified: | February 28, 2018 | |
This is version 94 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |