PLCXD3

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	37	PROSITE-ProRule annotation		1
Active siteⁱ	114	PROSITE-ProRule annotation		1

GO - Molecular functionⁱ

phosphoric diester hydrolase activity Source: InterPro
signal transducer activity Source: UniProtKB-KW

Complete GO annotation...

GO - Biological processⁱ

lipid catabolic process Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Molecular function	Hydrolase, Transducer
Biological process	Lipid degradation, Lipid metabolism

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: PI-PLC X domain-containing protein 3
Gene namesⁱ	Name:PLCXD3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31822. PLCXD3.

HGNCⁱ

HGNC:31822. PLCXD3.

Subcellular locationⁱ

Cytoplasm
1 Publication
Manual assertion based on experiment inⁱ
- Ref.3
  "Cloning, tissue distribution and sub-cellular localisation of phospholipase C X-domain containing protein (PLCXD) isoforms."
  Gellatly S.A., Kalujnaia S., Cramb G.
  Biochem. Biophys. Res. Commun. 424:651-656(2012) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	345557.
Open Targets More...OpenTargetsⁱ	ENSG00000182836.
PharmGKBⁱ	PA134886053.

Polymorphism and mutation databases

BioMutaⁱ	PLCXD3.
DMDMⁱ	229462782.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000305693	1 – 321	PI-PLC X domain-containing protein 3Add BLAST		321

Proteomic databases

EPDⁱ	Q63HM9.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q63HM9.
PaxDbⁱ	Q63HM9.
PeptideAtlas More...PeptideAtlasⁱ	Q63HM9.
PRIDEⁱ	Q63HM9.

PTM databases

iPTMnetⁱ	Q63HM9.
PhosphoSitePlusⁱ	Q63HM9.

Expressionⁱ

Tissue specificityⁱ

Expressed at highest levels in heart. Also detected in kidney, lung, small intestine and colon. Expressed at very low levels, if any, in leukocytes, thymus and skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000182836.
CleanExⁱ	HS_PLCXD3.
Genevisibleⁱ	Q63HM9. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA046849.

HPAⁱ

HPA046849.

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q63HM9. 1 interactor.
STRINGⁱ	9606.ENSP00000333751.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q63HM9.
SMRⁱ	Q63HM9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	22 – 197	PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST		176

Phylogenomic databases

eggNOGⁱ	KOG4306. Eukaryota. ENOG410Z30Q. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063361.
HOVERGENⁱ	HBG069284.
InParanoidⁱ	Q63HM9.
OMAⁱ	IYRRCPI.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B2T.
PhylomeDBⁱ	Q63HM9.
TreeFamⁱ	TF314457.

Family and domain databases

Gene3Dⁱ	3.20.20.190. 1 hit.
InterProⁱ	View protein in InterPro IPR017946. PLC-like_Pdiesterase_TIM-brl. IPR000909. PLipase_C_PInositol-sp_X_dom.
SMARTⁱ	View protein in SMART SM00148. PLCXc. 1 hit.
SUPFAMⁱ	SSF51695. SSF51695. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50007. PIPLC_X_DOMAIN. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q63HM9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASSQGKNEL KLADWMATLP ESMHSIPLTN LAIPGSHDSF SFYIDEASPV 
        60         70         80         90        100
GPEQPETVQN FVSVFGTVAK KLMRKWLATQ TMNFTGQLGA GIRYFDLRIS 
       110        120        130        140        150
TKPRDPDNEL YFAHGLFSAK VNEGLEEINA FLTDHHKEVV FLDFNHFYGM 
       160        170        180        190        200
QKYHHEKLVQ MLKDIYGNKM CPAIFAQEVS LKYLWEKDYQ VLVFYHSPVA 
       210        220        230        240        250
LEVPFLWPGQ MMPAPWANTT DPEKLIQFLQ ASITERRKKG SFFISQVVLT 
       260        270        280        290        300
PKASTVVKGV ASGLRETITE RALPAMMQWV RTQKPGESGI NIVTADFVEL 
       310        320 
GDFISTVIKL NYVFDEGEAN T

Length:321

Mass (Da):36,313

Last modified:May 5, 2009 - v2

Checksum:ⁱ8CAE049F287BD1B6

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	174	I → T in CAH56150 (PubMed:17974005).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX648329 mRNA. Translation: CAH56150.1. AC008830 Genomic DNA. No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34150.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001005473.1. NM_001005473.2.
UniGeneⁱ	Hs.145404.

Genome annotation databases

Ensemblⁱ	ENST00000328457; ENSP00000333751; ENSG00000182836. ENST00000377801; ENSP00000367032; ENSG00000182836.
GeneIDⁱ	345557.
KEGGⁱ	hsa:345557.
UCSC genome browser More...UCSCⁱ	uc003jmm.2. human.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX648329 mRNA. Translation: CAH56150.1. AC008830 Genomic DNA. No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34150.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001005473.1. NM_001005473.2.
UniGeneⁱ	Hs.145404.

3D structure databases

ProteinModelPortalⁱ	Q63HM9.
SMRⁱ	Q63HM9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q63HM9. 1 interactor.
STRINGⁱ	9606.ENSP00000333751.

PTM databases

iPTMnetⁱ	Q63HM9.
PhosphoSitePlusⁱ	Q63HM9.

Polymorphism and mutation databases

BioMutaⁱ	PLCXD3.
DMDMⁱ	229462782.

Proteomic databases

EPDⁱ	Q63HM9.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q63HM9.
PaxDbⁱ	Q63HM9.
PeptideAtlas More...PeptideAtlasⁱ	Q63HM9.
PRIDEⁱ	Q63HM9.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	345557.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000328457; ENSP00000333751; ENSG00000182836. ENST00000377801; ENSP00000367032; ENSG00000182836.
GeneIDⁱ	345557.
KEGGⁱ	hsa:345557.
UCSC genome browser More...UCSCⁱ	uc003jmm.2. human.

Organism-specific databases

CTDⁱ	345557.
DisGeNET More...DisGeNETⁱ	345557.
GeneCardsⁱ	PLCXD3.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31822. PLCXD3.
Human Protein Atlas More...HPAⁱ	HPA046849.
MIMⁱ	617016. gene.
neXtProtⁱ	NX_Q63HM9.
Open Targets More...OpenTargetsⁱ	ENSG00000182836.
PharmGKBⁱ	PA134886053.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4306. Eukaryota. ENOG410Z30Q. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063361.
HOVERGENⁱ	HBG069284.
InParanoidⁱ	Q63HM9.
OMAⁱ	IYRRCPI.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B2T.
PhylomeDBⁱ	Q63HM9.
TreeFamⁱ	TF314457.

Miscellaneous databases

GenomeRNAiⁱ	345557.
Protein Ontology More...PROⁱ	PR:Q63HM9.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000182836.
CleanExⁱ	HS_PLCXD3.
Genevisibleⁱ	Q63HM9. HS.

Family and domain databases

Gene3Dⁱ	3.20.20.190. 1 hit.
InterProⁱ	View protein in InterPro IPR017946. PLC-like_Pdiesterase_TIM-brl. IPR000909. PLipase_C_PInositol-sp_X_dom.
SMARTⁱ	View protein in SMART SM00148. PLCXc. 1 hit.
SUPFAMⁱ	SSF51695. SSF51695. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50007. PIPLC_X_DOMAIN. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLCX3_HUMAN
Accessionⁱ	Q63HM9Primary (citable) accession number: Q63HM9 Secondary accession number(s): A6NL04
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
	Last sequence update:	May 5, 2009
	Last modified:	June 7, 2017
	This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q63HM9 (PLCX3_HUMAN)

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PI-PLC X domain-containing protein 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ