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Protein

PI-PLC X domain-containing protein 3

Gene

PLCXD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37PROSITE-ProRule annotation1
Active sitei114PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Transducer
Biological processLipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
PI-PLC X domain-containing protein 3
Gene namesi
Name:PLCXD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000182836.9
HGNCiHGNC:31822 PLCXD3
MIMi617016 gene
neXtProtiNX_Q63HM9

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi345557
OpenTargetsiENSG00000182836
PharmGKBiPA134886053

Polymorphism and mutation databases

BioMutaiPLCXD3
DMDMi229462782

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003056931 – 321PI-PLC X domain-containing protein 3Add BLAST321

Proteomic databases

MaxQBiQ63HM9
PaxDbiQ63HM9
PeptideAtlasiQ63HM9
PRIDEiQ63HM9
ProteomicsDBi65882

PTM databases

iPTMnetiQ63HM9
PhosphoSitePlusiQ63HM9

Expressioni

Tissue specificityi

Expressed at highest levels in heart. Also detected in kidney, lung, small intestine and colon. Expressed at very low levels, if any, in leukocytes, thymus and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000182836
CleanExiHS_PLCXD3
GenevisibleiQ63HM9 HS

Organism-specific databases

HPAiHPA046849

Interactioni

Protein-protein interaction databases

IntActiQ63HM9, 1 interactor
STRINGi9606.ENSP00000333751

Structurei

3D structure databases

ProteinModelPortaliQ63HM9
SMRiQ63HM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 197PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST176

Phylogenomic databases

eggNOGiKOG4306 Eukaryota
ENOG410Z30Q LUCA
GeneTreeiENSGT00530000063361
HOVERGENiHBG069284
InParanoidiQ63HM9
OMAiIYRRCPI
OrthoDBiEOG091G0B2T
PhylomeDBiQ63HM9
TreeFamiTF314457

Family and domain databases

Gene3Di3.20.20.190, 1 hit
InterProiView protein in InterPro
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR000909 PLipase_C_PInositol-sp_X_dom
SMARTiView protein in SMART
SM00148 PLCXc, 1 hit
SUPFAMiSSF51695 SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50007 PIPLC_X_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q63HM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSQGKNEL KLADWMATLP ESMHSIPLTN LAIPGSHDSF SFYIDEASPV
60 70 80 90 100
GPEQPETVQN FVSVFGTVAK KLMRKWLATQ TMNFTGQLGA GIRYFDLRIS
110 120 130 140 150
TKPRDPDNEL YFAHGLFSAK VNEGLEEINA FLTDHHKEVV FLDFNHFYGM
160 170 180 190 200
QKYHHEKLVQ MLKDIYGNKM CPAIFAQEVS LKYLWEKDYQ VLVFYHSPVA
210 220 230 240 250
LEVPFLWPGQ MMPAPWANTT DPEKLIQFLQ ASITERRKKG SFFISQVVLT
260 270 280 290 300
PKASTVVKGV ASGLRETITE RALPAMMQWV RTQKPGESGI NIVTADFVEL
310 320
GDFISTVIKL NYVFDEGEAN T
Length:321
Mass (Da):36,313
Last modified:May 5, 2009 - v2
Checksum:i8CAE049F287BD1B6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti174I → T in CAH56150 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX648329 mRNA Translation: CAH56150.1
AC008830 Genomic DNA No translation available.
CCDSiCCDS34150.1
RefSeqiNP_001005473.1, NM_001005473.2
UniGeneiHs.145404

Genome annotation databases

EnsembliENST00000328457; ENSP00000333751; ENSG00000182836
ENST00000377801; ENSP00000367032; ENSG00000182836
GeneIDi345557
KEGGihsa:345557
UCSCiuc003jmm.2 human

Similar proteinsi

Entry informationi

Entry nameiPLCX3_HUMAN
AccessioniPrimary (citable) accession number: Q63HM9
Secondary accession number(s): A6NL04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 5, 2009
Last modified: June 20, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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