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Protein

Pecanex-like protein 4

Gene

PCNX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pecanex-like protein 4
Alternative name(s):
Hepatitis C virus F protein-binding protein 2
Short name:
HCV F protein-binding protein 2
Pecanex homolog protein 4Imported
Gene namesi
Name:PCNX4Imported
Synonyms:C14orf135, FBP2, PCNXL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20349. PCNX4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Transmembranei307 – 327HelicalSequence analysisAdd BLAST21
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Transmembranei388 – 405HelicalSequence analysisAdd BLAST18
Transmembranei448 – 468HelicalSequence analysisAdd BLAST21
Transmembranei494 – 514HelicalSequence analysisAdd BLAST21
Transmembranei534 – 552HelicalSequence analysisAdd BLAST19
Transmembranei565 – 585HelicalSequence analysisAdd BLAST21
Transmembranei607 – 629HelicalSequence analysisAdd BLAST23
Transmembranei634 – 654HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64430.
OpenTargetsiENSG00000126773.
PharmGKBiPA134919147.

Polymorphism and mutation databases

BioMutaiPCNXL4.
DMDMi206729932.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002538921 – 1172Pecanex-like protein 4Add BLAST1172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi1120N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1147N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ63HM2.
PeptideAtlasiQ63HM2.
PRIDEiQ63HM2.

PTM databases

iPTMnetiQ63HM2.
PhosphoSitePlusiQ63HM2.

Expressioni

Gene expression databases

BgeeiENSG00000126773.
CleanExiHS_C14orf135.
HS_FBP2.
ExpressionAtlasiQ63HM2. baseline and differential.
GenevisibleiQ63HM2. HS.

Organism-specific databases

HPAiHPA002076.
HPA003390.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
P0C0453EBI-1104540,EBI-9351969From a different organism.

Protein-protein interaction databases

BioGridi122178. 3 interactors.
IntActiQ63HM2. 6 interactors.
MINTiMINT-1482013.
STRINGi9606.ENSP00000384801.

Structurei

3D structure databases

ProteinModelPortaliQ63HM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pecanex family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INC2. Eukaryota.
ENOG410XRMG. LUCA.
GeneTreeiENSGT00390000013164.
HOGENOMiHOG000067757.
HOVERGENiHBG056012.
InParanoidiQ63HM2.
OMAiLHHFAGF.
OrthoDBiEOG091G03MB.
PhylomeDBiQ63HM2.

Family and domain databases

InterProiIPR007735. Pecanex.
[Graphical view]
PfamiPF05041. Pecanex_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63HM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPDVPLLND YKQDFFLKRF PQTVLGGPRF KLGYCAPPYI YVNQIILFLM
60 70 80 90 100
PWVWGGVGTL LYQLGILKDY YTAALSGGLM LFTAFVIQFT SLYAKNKSTT
110 120 130 140 150
VERILTTDIL AEEDEHEFTS CTGAETVKFL IPGKKYVANT VFHSILAGLA
160 170 180 190 200
CGLGTWYLLP NRITLLYGST GGTALLFFFG WMTLCIAEYS LIVNTATETA
210 220 230 240 250
TFQTQDTYEI IPLMRPLYIF FFVSVDLAHR FVVNMPALEH MNQILHILFV
260 270 280 290 300
FLPFLWALGT LPPPDALLLW AMEQVLEFGL GGSSMSTHLR LLVMFIMSAG
310 320 330 340 350
TAIASYFIPS TVGVVLFMTG FGFLLSLNLS DMGHKIGTKS KDLPSGPEKH
360 370 380 390 400
FSWKECLFYI IILVLALLET SLLHHFAGFS QISKSNSQAI VGYGLMILLI
410 420 430 440 450
ILWILREIQS VYIIGIFRNP FYPKDVQTVT VFFEKQTRLM KIGIVRRILL
460 470 480 490 500
TLVSPFAMIA FLSLDSSLQG LHSVSVCIGF TRAFRMVWQN TENALLETVI
510 520 530 540 550
VSTVHLISST DIWWNRSLDT GLRLLLVGII RDRLIQFISK LQFAVTVLLT
560 570 580 590 600
SWTEKKQRRK TTATLCILNI VFSPFVLVII VFSTLLSSPL LPLFTLPVFL
610 620 630 640 650
VGFPRPIQSW PGAAGTTACV CADTVYYYQM VPRLTAVLQT AMAAGSLGLL
660 670 680 690 700
LPGSHYLGRF QDRLMWIMIL ECGYTYCSIN IKGLELQETS CHTAEARRVD
710 720 730 740 750
EVFEDAFEQE YTRVCSLNEH FGNVLTPCTV LPVKLYSDAR NVLSGIIDSH
760 770 780 790 800
ENLKEFKGDL IKVLVWILVQ YCSKRPGMKE NVHNTENKGK APLMLPALNT
810 820 830 840 850
LPPPKSPEDI DSLNSETFND WSDDNIFDDE PTIKKVIEEK HQLKDLPGTN
860 870 880 890 900
LFIPGSVESQ RVGDHSTGTV PENDLYKAVL LGYPAVDKGK QEDMPYIPLM
910 920 930 940 950
EFSCSHSHLV CLPAEWRTSC MPSSKMKEMS SLFPEDWYQF VLRQLECYHS
960 970 980 990 1000
EEKASNVLEE IAKDKVLKDF YVHTVMTCYF SLFGIDNMAP SPGHILRVYG
1010 1020 1030 1040 1050
GVLPWSVALD WLTEKPELFQ LALKAFRYTL KLMIDKASLG PIEDFRELIK
1060 1070 1080 1090 1100
YLEEYERDWY IGLVSDEKWK EAILQEKPYL FSLGYDSNMG IYTGRVLSLQ
1110 1120 1130 1140 1150
ELLIQVGKLN PEAVRGQWAN LSWELLYATN DDEERYSIQA HPLLLRNLTV
1160 1170
QAAEPPLGYP IYSSKPLHIH LY
Length:1,172
Mass (Da):132,702
Last modified:September 23, 2008 - v4
Checksum:i4F55E9D8A776D618
GO

Sequence cautioni

The sequence AAH33843 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB14277 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB66516 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAH56141 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti535I → F in CAH56141 (PubMed:17974005).Curated1
Sequence conflicti554 – 555EK → QE in CAH56141 (PubMed:17974005).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028745770Q → H.Corresponds to variant rs3742642dbSNPEnsembl.1
Natural variantiVAR_028746811D → Y.Corresponds to variant rs12895606dbSNPEnsembl.1
Natural variantiVAR_0287471000G → S.1 PublicationCorresponds to variant rs167437dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157911 Genomic DNA. No translation available.
AL163853 Genomic DNA. No translation available.
BX648440 mRNA. Translation: CAH56141.1. Different initiation.
BC033843 mRNA. Translation: AAH33843.2. Different initiation.
AL136581 mRNA. Translation: CAB66516.1. Different initiation.
AY553876 mRNA. Translation: AAS64574.1.
AK022861 mRNA. Translation: BAB14277.1. Different initiation.
CCDSiCCDS81809.1.
RefSeqiNP_001317106.1. NM_001330177.1.
NP_071940.4. NM_022495.5.
UniGeneiHs.509499.

Genome annotation databases

EnsembliENST00000406854; ENSP00000384801; ENSG00000126773.
GeneIDi64430.
KEGGihsa:64430.
UCSCiuc059ccm.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157911 Genomic DNA. No translation available.
AL163853 Genomic DNA. No translation available.
BX648440 mRNA. Translation: CAH56141.1. Different initiation.
BC033843 mRNA. Translation: AAH33843.2. Different initiation.
AL136581 mRNA. Translation: CAB66516.1. Different initiation.
AY553876 mRNA. Translation: AAS64574.1.
AK022861 mRNA. Translation: BAB14277.1. Different initiation.
CCDSiCCDS81809.1.
RefSeqiNP_001317106.1. NM_001330177.1.
NP_071940.4. NM_022495.5.
UniGeneiHs.509499.

3D structure databases

ProteinModelPortaliQ63HM2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122178. 3 interactors.
IntActiQ63HM2. 6 interactors.
MINTiMINT-1482013.
STRINGi9606.ENSP00000384801.

PTM databases

iPTMnetiQ63HM2.
PhosphoSitePlusiQ63HM2.

Polymorphism and mutation databases

BioMutaiPCNXL4.
DMDMi206729932.

Proteomic databases

PaxDbiQ63HM2.
PeptideAtlasiQ63HM2.
PRIDEiQ63HM2.

Protocols and materials databases

DNASUi64430.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000406854; ENSP00000384801; ENSG00000126773.
GeneIDi64430.
KEGGihsa:64430.
UCSCiuc059ccm.1. human.

Organism-specific databases

CTDi64430.
DisGeNETi64430.
GeneCardsiPCNXL4.
H-InvDBHIX0011707.
HGNCiHGNC:20349. PCNX4.
HPAiHPA002076.
HPA003390.
neXtProtiNX_Q63HM2.
OpenTargetsiENSG00000126773.
PharmGKBiPA134919147.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INC2. Eukaryota.
ENOG410XRMG. LUCA.
GeneTreeiENSGT00390000013164.
HOGENOMiHOG000067757.
HOVERGENiHBG056012.
InParanoidiQ63HM2.
OMAiLHHFAGF.
OrthoDBiEOG091G03MB.
PhylomeDBiQ63HM2.

Miscellaneous databases

GenomeRNAii64430.
PROiQ63HM2.

Gene expression databases

BgeeiENSG00000126773.
CleanExiHS_C14orf135.
HS_FBP2.
ExpressionAtlasiQ63HM2. baseline and differential.
GenevisibleiQ63HM2. HS.

Family and domain databases

InterProiIPR007735. Pecanex.
[Graphical view]
PfamiPF05041. Pecanex_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCX4_HUMAN
AccessioniPrimary (citable) accession number: Q63HM2
Secondary accession number(s): A8MXM2, Q9BQG8, Q9H9F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 99 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.