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Q63HL4 (Q63HL4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADPH--cytochrome P450 reductase PIRNR PIRNR000208

EC=1.6.2.4 PIRNR PIRNR000208
Gene names
Name:DKFZp686G04235 EMBL CAH56151.1
OrganismHomo sapiens (Human) EMBL CAH56151.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length680 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This enzyme is required for electron transfer from NADP to cytochrome P450 By similarity. PIRNR PIRNR000208

Catalytic activity

NADPH + n oxidized hemoprotein = NADP+ + n reduced hemoprotein. PIRNR PIRNR000208

Subcellular location

Endoplasmic reticulum membrane By similarity PIRNR PIRNR000208.

Sequence similarities

In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. PIRNR PIRNR000208

Sequences

Sequence LengthMass (Da)Tools
Q63HL4 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: E97717B6B2363D3B

FASTA68077,018
        10         20         30         40         50         60 
MINMGDSHVD TSSTVSEAVA EEVSLFSMTD MILFSLIVGL LTYWFLFRKK KEEVPEFTKI 

        70         80         90        100        110        120 
QTLASSVRES SFVEKMKKTG RNIIVFYGSQ TGTAEEFANR LSKDAHRYGM RGMSADPEEY 

       130        140        150        160        170        180 
DLADLSSLPE IDNALVVFCM ATYGEGDPTD NAQDFYDWLQ ETDVDLSGVK FAVFGLGNKT 

       190        200        210        220        230        240 
YEHFNAMGKY VDKRLEQLGA QRIFELGLGD DDGNLEEDFI TWREQFWPAV CEHFGVEATG 

       250        260        270        280        290        300 
EESSIRQYEL VVHTDIDAAK VYMGEMGRLK SYENQKPPFD AKNPFLAAVT TNRKLNQGTE 

       310        320        330        340        350        360 
RHLMHLELDI SDSKIRYESG DHVAVYPAND SALVNQLGKI LGADLDVVMS LNNLDEESNK 

       370        380        390        400        410        420 
KHPFPCPTSY RTALTYYLDI TNPPRTNVLY ELAQYASEPS EQELLRKMAS SSGEGKELYL 

       430        440        450        460        470        480 
SWVVEARRHI LAILQDCPSL RPPIDHLCEL LPRLQARYYS IASSSKVHPN SVHICAVVVE 

       490        500        510        520        530        540 
YETKAGRINK GVATNWLRAK EPAGENGGRA LVPMFVRKSQ FRLPFKATTP VIMVGPGTGV 

       550        560        570        580        590        600 
APFIGFIQER AWLRQQGKEV GETLLYYGCR RSDEDYLYRE ELAQFHRDGA LTQLNVAFSR 

       610        620        630        640        650        660 
EQSHKVYVQH LLKQDREHLW KLIEGGAHIY VCGDARNMAR DVQNTFYDIV AELGAMEHAQ 

       670        680 
AVDYIKKLMT KGRYSLDVWS 

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References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX648619 mRNA. Translation: CAH56151.1.
UniGeneHs.354056.

3D structure databases

ProteinModelPortalQ63HL4.
SMRQ63HL4. Positions 67-680.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ63HL4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG000432.

Family and domain databases

Gene3D1.20.990.10. 1 hit.
3.40.50.360. 1 hit.
InterProIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR023208. P450R.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PIRSFPIRSF000208. P450R. 1 hit.
PRINTSPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMSSF52218. SSF52218. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ63HL4_HUMAN
AccessionPrimary (citable) accession number: Q63HL4
Entry history
Integrated into UniProtKB/TrEMBL: October 25, 2004
Last sequence update: October 25, 2004
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.