Q63HL4 (Q63HL4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
NADPH--cytochrome P450 reductase PIRNR PIRNR000208
EC=1.6.2.4 PIRNR PIRNR000208

Gene names

Name:

DKFZp686G04235 EMBL CAH56151.1

Organism

Homo sapiens (Human) EMBL CAH56151.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	680 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This enzyme is required for electron transfer from NADP to cytochrome P450 By similarity. PIRNR PIRNR000208
Catalytic activity	NADPH + n oxidized hemoprotein = NADP+ + n reduced hemoprotein. PIRNR PIRNR000208
Subcellular location	Endoplasmic reticulum membrane By similarity PIRNR PIRNR000208.
Sequence similarities	In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. PIRNR PIRNR000208

Ontologies

Keywords
Cellular component	Endoplasmic reticulum PIRNR PIRNR000208 Membrane PIRNR PIRNR000208
Ligand	NADP PIRNR PIRNR000208
Molecular function	Oxidoreductase PIRNR PIRNR000208
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	FMN binding Inferred from electronic annotation. Source: InterPro NADPH-hemoprotein reductase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q63HL4 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: E97717B6B2363D3B	FASTA	680	77,018
	10 20 30 40 50 60 MINMGDSHVD TSSTVSEAVA EEVSLFSMTD MILFSLIVGL LTYWFLFRKK KEEVPEFTKI 70 80 90 100 110 120 QTLASSVRES SFVEKMKKTG RNIIVFYGSQ TGTAEEFANR LSKDAHRYGM RGMSADPEEY 130 140 150 160 170 180 DLADLSSLPE IDNALVVFCM ATYGEGDPTD NAQDFYDWLQ ETDVDLSGVK FAVFGLGNKT 190 200 210 220 230 240 YEHFNAMGKY VDKRLEQLGA QRIFELGLGD DDGNLEEDFI TWREQFWPAV CEHFGVEATG 250 260 270 280 290 300 EESSIRQYEL VVHTDIDAAK VYMGEMGRLK SYENQKPPFD AKNPFLAAVT TNRKLNQGTE 310 320 330 340 350 360 RHLMHLELDI SDSKIRYESG DHVAVYPAND SALVNQLGKI LGADLDVVMS LNNLDEESNK 370 380 390 400 410 420 KHPFPCPTSY RTALTYYLDI TNPPRTNVLY ELAQYASEPS EQELLRKMAS SSGEGKELYL 430 440 450 460 470 480 SWVVEARRHI LAILQDCPSL RPPIDHLCEL LPRLQARYYS IASSSKVHPN SVHICAVVVE 490 500 510 520 530 540 YETKAGRINK GVATNWLRAK EPAGENGGRA LVPMFVRKSQ FRLPFKATTP VIMVGPGTGV 550 560 570 580 590 600 APFIGFIQER AWLRQQGKEV GETLLYYGCR RSDEDYLYRE ELAQFHRDGA LTQLNVAFSR 610 620 630 640 650 660 EQSHKVYVQH LLKQDREHLW KLIEGGAHIY VCGDARNMAR DVQNTFYDIV AELGAMEHAQ 670 680 AVDYIKKLMT KGRYSLDVWS

References

[1]	The German cDNA Consortium Bloecker H., Boecher M., Brandt P., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G., Han M., Wiemann S. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Small intestine EMBL CAH56151.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX648619 mRNA. Translation: CAH56151.1.
IPI	IPI00470467.
UniGene	Hs.354056.
3D structure databases
ProteinModelPortal	Q63HL4.
SMR	Q63HL4. Positions 67-680.
ModBase	Search...
Protein-protein interaction databases
STRING	Q63HL4.
Proteomic databases
PRIDE	Q63HL4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG000432.
Gene expression databases
ArrayExpress	Q63HL4.
Family and domain databases
Gene3D	1.20.990.10. 1 hit.
InterPro	IPR003097. FAD-binding_1. IPR017927. Fd_Rdtase_FAD-bd. IPR001094. Flavdoxin. IPR008254. Flavodoxin/NO_synth. IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase. IPR023173. NADPH_Cyt_P450_Rdtase_dom3. IPR001433. OxRdtase_FAD/NAD-bd. IPR023208. P450R. IPR017938. Riboflavin_synthase-like_b-brl. [Graphical view]
Pfam	PF00667. FAD_binding_1. 1 hit. PF00258. Flavodoxin_1. 1 hit. PF00175. NAD_binding_1. 1 hit. [Graphical view]
PIRSF	PIRSF000208. P450R. 1 hit.
PRINTS	PR00369. FLAVODOXIN. PR00371. FPNCR.
SUPFAM	SSF63380. Riboflavin_synthase_like_b-brl. 1 hit.
PROSITE	PS51384. FAD_FR. 1 hit. PS50902. FLAVODOXIN_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q63HL4_HUMAN

Accession

Primary (citable) accession number: Q63HL4

Entry history

Integrated into UniProtKB/TrEMBL:	October 25, 2004
Last sequence update:	October 25, 2004
Last modified:	March 6, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.