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Protein

Teashirt homolog 3

Gene

TSHZ3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 238C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri275 – 299C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri386 – 404C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST19
DNA bindingi891 – 961Homeobox; atypicalPROSITE-ProRule annotationAdd BLAST71
Zinc fingeri976 – 998C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1041 – 1064C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Teashirt homolog 3
Alternative name(s):
Zinc finger protein 537
Gene namesi
Name:TSHZ3
Synonyms:KIAA1474, TSH3, ZNF537
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30700. TSHZ3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication
  • Cell projectiongrowth cone By similarity

  • Note: Colocalizes with APBB1 in axonal growth cone (By similarity). Colocalizes with APBB1 in the nucleus.By similarity

GO - Cellular componenti

  • growth cone Source: UniProtKB-SubCell
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi953 – 955VKY → ATA: Does not inhibit interaction with APBB1. 1 Publication3

Organism-specific databases

DisGeNETi57616.
OpenTargetsiENSG00000121297.
PharmGKBiPA134887020.

Polymorphism and mutation databases

BioMutaiTSHZ3.
DMDMi85541971.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470661 – 1081Teashirt homolog 3Add BLAST1081

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei682PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ63HK5.
MaxQBiQ63HK5.
PaxDbiQ63HK5.
PeptideAtlasiQ63HK5.
PRIDEiQ63HK5.

PTM databases

iPTMnetiQ63HK5.
PhosphoSitePlusiQ63HK5.

Expressioni

Tissue specificityi

Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.2 Publications

Developmental stagei

Expressed in peri-urothelial cells of the proximal ureter and renal pelvis at 9 weeks of gestation.1 Publication

Gene expression databases

BgeeiENSG00000121297.
CleanExiHS_TSHZ3.
ExpressionAtlasiQ63HK5. baseline and differential.
GenevisibleiQ63HK5. HS.

Organism-specific databases

HPAiHPA008834.

Interactioni

Subunit structurei

Interacts (via homeobox domain) with APBB1 (via PID domain 1). Interacts (via N-terminus) with HDAC1 and HDAC2; the interaction is direct. Found in a trimeric complex with APBB1 and HDAC1; the interaction between HDAC1 and APBB1 is mediated by TSHZ3.1 Publication

Protein-protein interaction databases

BioGridi121663. 21 interactors.
IntActiQ63HK5. 15 interactors.
MINTiMINT-4725267.
STRINGi9606.ENSP00000240587.

Structurei

Secondary structure

11081
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi213 – 220Combined sources8
Beta strandi222 – 225Combined sources4
Helixi226 – 235Combined sources10
Beta strandi278 – 280Combined sources3
Helixi287 – 296Combined sources10
Turni297 – 301Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DMINMR-A202-303[»]
ProteinModelPortaliQ63HK5.
SMRiQ63HK5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ63HK5.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili606 – 630Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi142 – 164Ser-richAdd BLAST23
Compositional biasi493 – 496Poly-Glu4

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri214 – 238C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri275 – 299C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri386 – 404C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST19
Zinc fingeri976 – 998C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1041 – 1064C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Coiled coil, Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IFDT. Eukaryota.
ENOG410XQQR. LUCA.
GeneTreeiENSGT00390000014977.
HOGENOMiHOG000231480.
HOVERGENiHBG079626.
InParanoidiQ63HK5.
KOiK09236.
OMAiYIMSDLS.
OrthoDBiEOG091G01GX.
PhylomeDBiQ63HK5.
TreeFamiTF328447.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR027008. Teashirt_fam.
IPR026810. Tshz3.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR12487. PTHR12487. 1 hit.
PTHR12487:SF5. PTHR12487:SF5. 1 hit.
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63HK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRRKQQAPR RAAAYVSEEL KAAALVDEGL DPEEHTADGE PSAKYMCPEK
60 70 80 90 100
ELARACPSYQ NSPAAEFSCH EMDSESHISE TSDRMADFES GSIKNEEETK
110 120 130 140 150
EVTVPLEDTT VSDSLEQMKA VYNNFLSNSY WSNLNLNLHQ PSSEKNNGSS
160 170 180 190 200
SSSSSSSSSC GSGSFDWHQS AMAKTLQQVS QSRMLPEPSL FSTVQLYRQS
210 220 230 240 250
SKLYGSIFTG ASKFRCKDCS AAYDTLVELT VHMNETGHYR DDNHETDNNN
260 270 280 290 300
PKRWSKPRKR SLLEMEGKED AQKVLKCMYC GHSFESLQDL SVHMIKTKHY
310 320 330 340 350
QKVPLKEPVT PVAAKIIPAT RKKASLELEL PSSPDSTGGT PKATISDTND
360 370 380 390 400
ALQKNSNPYI TPNNRYGHQN GASYAWHFEA RKSQILKCME CGSSHDTLQE
410 420 430 440 450
LTAHMMVTGH FIKVTNSAMK KGKPIVETPV TPTITTLLDE KVQSVPLAAT
460 470 480 490 500
TFTSPSNTPA SISPKLNVEV KKEVDKEKAV TDEKPKQKDK PGEEEEKCDI
510 520 530 540 550
SSKYHYLTEN DLEESPKGGL DILKSLENTV TSAINKAQNG TPSWGGYPSI
560 570 580 590 600
HAAYQLPNMM KLSLGSSGKS TPLKPMFGNS EIVSPTKNQT LVSPPSSQTS
610 620 630 640 650
PMPKTNFHAM EELVKKVTEK VAKVEEKMKE PDGKLSPPKR ATPSPCSSEV
660 670 680 690 700
GEPIKMEASS DGGFRSQENS PSPPRDGCKD GSPLAEPVEN GKELVKPLAS
710 720 730 740 750
SLSGSTAIIT DHPPEQPFVN PLSALQSVMN IHLGKAAKPS LPALDPMSML
760 770 780 790 800
FKMSNSLAEK AAVATPPPLQ SKKADHLDRY FYHVNNDQPI DLTKGKSDKG
810 820 830 840 850
CSLGSVLLSP TSTAPATSSS TVTTAKTSAV VSFMSNSPLR ENALSDISDM
860 870 880 890 900
LKNLTESHTS KSSTPSSISE KSDIDGATLE EAEESTPAQK RKGRQSNWNP
910 920 930 940 950
QHLLILQAQF AASLRQTSEG KYIMSDLSPQ ERMHISRFTG LSMTTISHWL
960 970 980 990 1000
ANVKYQLRRT GGTKFLKNLD TGHPVFFCND CASQIRTPST YISHLESHLG
1010 1020 1030 1040 1050
FRLRDLSKLS TEQINSQIAQ TKSPSEKMVT SSPEEDLGTS YQCKLCNRTF
1060 1070 1080
ASKHAVKLHL SKTHGKSPED HLLYVSELEK Q
Length:1,081
Mass (Da):118,566
Last modified:January 10, 2006 - v2
Checksum:iB4E0A4347B04E74A
GO

Sequence cautioni

The sequence CAB66739 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063635469E → G.2 PublicationsCorresponds to variant rs143453460dbSNPEnsembl.1
Natural variantiVAR_052708687P → L.Corresponds to variant rs4805664dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX648745 mRNA. Translation: CAH56184.1.
AB040907 mRNA. Translation: BAA95998.1.
AL136805 mRNA. Translation: CAB66739.1. Different initiation.
CCDSiCCDS12421.2.
RefSeqiNP_065907.2. NM_020856.3.
UniGeneiHs.278436.

Genome annotation databases

EnsembliENST00000240587; ENSP00000240587; ENSG00000121297.
GeneIDi57616.
KEGGihsa:57616.
UCSCiuc002nsy.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

Life's first breath - Issue 122 of October 2010

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX648745 mRNA. Translation: CAH56184.1.
AB040907 mRNA. Translation: BAA95998.1.
AL136805 mRNA. Translation: CAB66739.1. Different initiation.
CCDSiCCDS12421.2.
RefSeqiNP_065907.2. NM_020856.3.
UniGeneiHs.278436.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DMINMR-A202-303[»]
ProteinModelPortaliQ63HK5.
SMRiQ63HK5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121663. 21 interactors.
IntActiQ63HK5. 15 interactors.
MINTiMINT-4725267.
STRINGi9606.ENSP00000240587.

PTM databases

iPTMnetiQ63HK5.
PhosphoSitePlusiQ63HK5.

Polymorphism and mutation databases

BioMutaiTSHZ3.
DMDMi85541971.

Proteomic databases

EPDiQ63HK5.
MaxQBiQ63HK5.
PaxDbiQ63HK5.
PeptideAtlasiQ63HK5.
PRIDEiQ63HK5.

Protocols and materials databases

DNASUi57616.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240587; ENSP00000240587; ENSG00000121297.
GeneIDi57616.
KEGGihsa:57616.
UCSCiuc002nsy.5. human.

Organism-specific databases

CTDi57616.
DisGeNETi57616.
GeneCardsiTSHZ3.
HGNCiHGNC:30700. TSHZ3.
HPAiHPA008834.
MIMi614119. gene.
neXtProtiNX_Q63HK5.
OpenTargetsiENSG00000121297.
PharmGKBiPA134887020.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFDT. Eukaryota.
ENOG410XQQR. LUCA.
GeneTreeiENSGT00390000014977.
HOGENOMiHOG000231480.
HOVERGENiHBG079626.
InParanoidiQ63HK5.
KOiK09236.
OMAiYIMSDLS.
OrthoDBiEOG091G01GX.
PhylomeDBiQ63HK5.
TreeFamiTF328447.

Miscellaneous databases

ChiTaRSiTSHZ3. human.
EvolutionaryTraceiQ63HK5.
GeneWikiiTSHZ3.
GenomeRNAii57616.
PROiQ63HK5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121297.
CleanExiHS_TSHZ3.
ExpressionAtlasiQ63HK5. baseline and differential.
GenevisibleiQ63HK5. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR027008. Teashirt_fam.
IPR026810. Tshz3.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR12487. PTHR12487. 1 hit.
PTHR12487:SF5. PTHR12487:SF5. 1 hit.
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSH3_HUMAN
AccessioniPrimary (citable) accession number: Q63HK5
Secondary accession number(s): Q9H0G6, Q9P254
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.