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Q63HK5

- TSH3_HUMAN

UniProt

Q63HK5 - TSH3_HUMAN

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Protein

Teashirt homolog 3

Gene

TSHZ3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri214 – 23825C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri275 – 29925C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40419C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
DNA bindingi891 – 96171Homeobox; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri976 – 99823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1041 – 106424C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. DNA binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. in utero embryonic development Source: Ensembl
  2. kidney morphogenesis Source: Ensembl
  3. kidney smooth muscle cell differentiation Source: Ensembl
  4. lung development Source: Ensembl
  5. metanephros development Source: Ensembl
  6. musculoskeletal movement Source: Ensembl
  7. negative regulation of transcription, DNA-templated Source: UniProtKB
  8. positive regulation of smooth muscle cell differentiation Source: Ensembl
  9. regulation of respiratory gaseous exchange by neurological system process Source: UniProtKB
  10. sensory perception of touch Source: Ensembl
  11. transcription, DNA-templated Source: UniProtKB-KW
  12. ureteric bud development Source: Ensembl
  13. ureteric peristalsis Source: Ensembl
  14. ureter smooth muscle cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Teashirt homolog 3
Alternative name(s):
Zinc finger protein 537
Gene namesi
Name:TSHZ3
Synonyms:KIAA1474, TSH3, ZNF537
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:30700. TSHZ3.

Subcellular locationi

Nucleus 1 PublicationPROSITE-ProRule annotation. Cell projectiongrowth cone By similarity
Note: Colocalizes with APBB1 in axonal growth cone (By similarity). Colocalizes with APBB1 in the nucleus.By similarity

GO - Cellular componenti

  1. growth cone Source: Ensembl
  2. mitochondrion Source: Ensembl
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi953 – 9553VKY → ATA: Does not inhibit interaction with APBB1. 1 Publication

Organism-specific databases

PharmGKBiPA134887020.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10811081Teashirt homolog 3PRO_0000047066Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei682 – 6821Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ63HK5.
PaxDbiQ63HK5.
PRIDEiQ63HK5.

PTM databases

PhosphoSiteiQ63HK5.

Expressioni

Tissue specificityi

Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.2 Publications

Developmental stagei

Expressed in peri-urothelial cells of the proximal ureter and renal pelvis at 9 weeks of gestation.1 Publication

Gene expression databases

BgeeiQ63HK5.
CleanExiHS_TSHZ3.
ExpressionAtlasiQ63HK5. baseline and differential.
GenevestigatoriQ63HK5.

Organism-specific databases

HPAiHPA008834.

Interactioni

Subunit structurei

Interacts (via homeobox domain) with APBB1 (via PID domain 1). Interacts (via N-terminus) with HDAC1 and HDAC2; the interaction is direct. Found in a trimeric complex with APBB1 and HDAC1; the interaction between HDAC1 and APBB1 is mediated by TSHZ3.1 Publication

Protein-protein interaction databases

BioGridi121663. 6 interactions.
IntActiQ63HK5. 1 interaction.
MINTiMINT-4725267.
STRINGi9606.ENSP00000240587.

Structurei

Secondary structure

1
1081
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi213 – 2208
Beta strandi222 – 2254
Helixi226 – 23510
Beta strandi278 – 2803
Helixi287 – 29610
Turni297 – 3015

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DMINMR-A202-303[»]
ProteinModelPortaliQ63HK5.
SMRiQ63HK5. Positions 200-303.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ63HK5.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili606 – 63025Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi142 – 16423Ser-richAdd
BLAST
Compositional biasi493 – 4964Poly-Glu

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri214 – 23825C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri275 – 29925C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40419C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri976 – 99823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1041 – 106424C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG83709.
GeneTreeiENSGT00390000014977.
HOGENOMiHOG000231480.
HOVERGENiHBG079626.
InParanoidiQ63HK5.
KOiK09236.
OMAiDPMSMLF.
OrthoDBiEOG7NPFSF.
PhylomeDBiQ63HK5.
TreeFamiTF328447.

Family and domain databases

InterProiIPR001356. Homeobox_dom.
IPR027008. Teashirt_fam.
IPR026810. Tshz3.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR12487. PTHR12487. 1 hit.
PTHR12487:SF5. PTHR12487:SF5. 1 hit.
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63HK5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRRKQQAPR RAAAYVSEEL KAAALVDEGL DPEEHTADGE PSAKYMCPEK
60 70 80 90 100
ELARACPSYQ NSPAAEFSCH EMDSESHISE TSDRMADFES GSIKNEEETK
110 120 130 140 150
EVTVPLEDTT VSDSLEQMKA VYNNFLSNSY WSNLNLNLHQ PSSEKNNGSS
160 170 180 190 200
SSSSSSSSSC GSGSFDWHQS AMAKTLQQVS QSRMLPEPSL FSTVQLYRQS
210 220 230 240 250
SKLYGSIFTG ASKFRCKDCS AAYDTLVELT VHMNETGHYR DDNHETDNNN
260 270 280 290 300
PKRWSKPRKR SLLEMEGKED AQKVLKCMYC GHSFESLQDL SVHMIKTKHY
310 320 330 340 350
QKVPLKEPVT PVAAKIIPAT RKKASLELEL PSSPDSTGGT PKATISDTND
360 370 380 390 400
ALQKNSNPYI TPNNRYGHQN GASYAWHFEA RKSQILKCME CGSSHDTLQE
410 420 430 440 450
LTAHMMVTGH FIKVTNSAMK KGKPIVETPV TPTITTLLDE KVQSVPLAAT
460 470 480 490 500
TFTSPSNTPA SISPKLNVEV KKEVDKEKAV TDEKPKQKDK PGEEEEKCDI
510 520 530 540 550
SSKYHYLTEN DLEESPKGGL DILKSLENTV TSAINKAQNG TPSWGGYPSI
560 570 580 590 600
HAAYQLPNMM KLSLGSSGKS TPLKPMFGNS EIVSPTKNQT LVSPPSSQTS
610 620 630 640 650
PMPKTNFHAM EELVKKVTEK VAKVEEKMKE PDGKLSPPKR ATPSPCSSEV
660 670 680 690 700
GEPIKMEASS DGGFRSQENS PSPPRDGCKD GSPLAEPVEN GKELVKPLAS
710 720 730 740 750
SLSGSTAIIT DHPPEQPFVN PLSALQSVMN IHLGKAAKPS LPALDPMSML
760 770 780 790 800
FKMSNSLAEK AAVATPPPLQ SKKADHLDRY FYHVNNDQPI DLTKGKSDKG
810 820 830 840 850
CSLGSVLLSP TSTAPATSSS TVTTAKTSAV VSFMSNSPLR ENALSDISDM
860 870 880 890 900
LKNLTESHTS KSSTPSSISE KSDIDGATLE EAEESTPAQK RKGRQSNWNP
910 920 930 940 950
QHLLILQAQF AASLRQTSEG KYIMSDLSPQ ERMHISRFTG LSMTTISHWL
960 970 980 990 1000
ANVKYQLRRT GGTKFLKNLD TGHPVFFCND CASQIRTPST YISHLESHLG
1010 1020 1030 1040 1050
FRLRDLSKLS TEQINSQIAQ TKSPSEKMVT SSPEEDLGTS YQCKLCNRTF
1060 1070 1080
ASKHAVKLHL SKTHGKSPED HLLYVSELEK Q
Length:1,081
Mass (Da):118,566
Last modified:January 10, 2006 - v2
Checksum:iB4E0A4347B04E74A
GO

Sequence cautioni

The sequence CAB66739.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti469 – 4691E → G.2 Publications
Corresponds to variant rs143453460 [ dbSNP | Ensembl ].
VAR_063635
Natural varianti687 – 6871P → L.
Corresponds to variant rs4805664 [ dbSNP | Ensembl ].
VAR_052708

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX648745 mRNA. Translation: CAH56184.1.
AB040907 mRNA. Translation: BAA95998.1.
AL136805 mRNA. Translation: CAB66739.1. Different initiation.
CCDSiCCDS12421.2.
RefSeqiNP_065907.2. NM_020856.2.
UniGeneiHs.278436.

Genome annotation databases

EnsembliENST00000240587; ENSP00000240587; ENSG00000121297.
GeneIDi57616.
KEGGihsa:57616.
UCSCiuc002nsy.4. human.

Polymorphism databases

DMDMi85541971.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

Life's first breath - Issue 122 of October 2010

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX648745 mRNA. Translation: CAH56184.1 .
AB040907 mRNA. Translation: BAA95998.1 .
AL136805 mRNA. Translation: CAB66739.1 . Different initiation.
CCDSi CCDS12421.2.
RefSeqi NP_065907.2. NM_020856.2.
UniGenei Hs.278436.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DMI NMR - A 202-303 [» ]
ProteinModelPortali Q63HK5.
SMRi Q63HK5. Positions 200-303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121663. 6 interactions.
IntActi Q63HK5. 1 interaction.
MINTi MINT-4725267.
STRINGi 9606.ENSP00000240587.

PTM databases

PhosphoSitei Q63HK5.

Polymorphism databases

DMDMi 85541971.

Proteomic databases

MaxQBi Q63HK5.
PaxDbi Q63HK5.
PRIDEi Q63HK5.

Protocols and materials databases

DNASUi 57616.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000240587 ; ENSP00000240587 ; ENSG00000121297 .
GeneIDi 57616.
KEGGi hsa:57616.
UCSCi uc002nsy.4. human.

Organism-specific databases

CTDi 57616.
GeneCardsi GC19M031765.
HGNCi HGNC:30700. TSHZ3.
HPAi HPA008834.
MIMi 614119. gene.
neXtProti NX_Q63HK5.
PharmGKBi PA134887020.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG83709.
GeneTreei ENSGT00390000014977.
HOGENOMi HOG000231480.
HOVERGENi HBG079626.
InParanoidi Q63HK5.
KOi K09236.
OMAi DPMSMLF.
OrthoDBi EOG7NPFSF.
PhylomeDBi Q63HK5.
TreeFami TF328447.

Miscellaneous databases

ChiTaRSi TSHZ3. human.
EvolutionaryTracei Q63HK5.
GeneWikii TSHZ3.
GenomeRNAii 57616.
NextBioi 64282.
PROi Q63HK5.
SOURCEi Search...

Gene expression databases

Bgeei Q63HK5.
CleanExi HS_TSHZ3.
ExpressionAtlasi Q63HK5. baseline and differential.
Genevestigatori Q63HK5.

Family and domain databases

InterProi IPR001356. Homeobox_dom.
IPR027008. Teashirt_fam.
IPR026810. Tshz3.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
PANTHERi PTHR12487. PTHR12487. 1 hit.
PTHR12487:SF5. PTHR12487:SF5. 1 hit.
SMARTi SM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS50071. HOMEOBOX_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-469.
    Tissue: Endometrial tumor.
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-1081.
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 176-1081.
    Tissue: Testis.
  4. "Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4."
    Caubit X., Lye C.M., Martin E., Core N., Long D.A., Vola C., Jenkins D., Garratt A.N., Skaer H., Woolf A.S., Fasano L.
    Development 135:3301-3310(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: FUNCTION, INTERACTION WITH APBB1; HDAC1 AND HDAC2, IDENTIFICATION IN A TRIMERIC COMPLEX WITH APBB1 AND HDAC1, CHROMATIN-BINDING, MUTAGENESIS OF 953-VAL--TYR-955, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-682, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction."
    Jenkins D., Caubit X., Dimovski A., Matevska N., Lye C.M., Cabuk F., Gucev Z., Tasic V., Fasano L., Woolf A.S.
    Nephrol. Dial. Transplant. 25:54-60(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLY-469, DEVELOPMENTAL STAGE.
  10. "Solution structure of the first and the second ZF-C2H2-like domains of human teashirt homolog 3."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 200-303.

Entry informationi

Entry nameiTSH3_HUMAN
AccessioniPrimary (citable) accession number: Q63HK5
Secondary accession number(s): Q9H0G6, Q9P254
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: October 29, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3