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Protein

Zinc finger protein with KRAB and SCAN domains 2

Gene

ZKSCAN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri775 – 797C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri803 – 825C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri831 – 853C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri859 – 881C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri887 – 909C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri915 – 937C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 2
Alternative name(s):
Zinc finger protein 694
Gene namesi
Name:ZKSCAN2
Synonyms:ZNF694
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25677. ZKSCAN2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000155592.
PharmGKBiPA162409748.

Polymorphism and mutation databases

BioMutaiZKSCAN2.
DMDMi296453036.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002340161 – 967Zinc finger protein with KRAB and SCAN domains 2Add BLAST967

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei591PhosphoserineCombined sources1
Modified residuei600PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ63HK3.
MaxQBiQ63HK3.
PaxDbiQ63HK3.
PeptideAtlasiQ63HK3.
PRIDEiQ63HK3.

PTM databases

iPTMnetiQ63HK3.
PhosphoSitePlusiQ63HK3.

Expressioni

Gene expression databases

BgeeiENSG00000155592.
CleanExiHS_ZKSCAN2.
ExpressionAtlasiQ63HK3. baseline and differential.
GenevisibleiQ63HK3. HS.

Organism-specific databases

HPAiHPA049141.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331626.

Structurei

3D structure databases

ProteinModelPortaliQ63HK3.
SMRiQ63HK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 127SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini229 – 300KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri775 – 797C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri803 – 825C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri831 – 853C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri859 – 881C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri887 – 909C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri915 – 937C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063287.
HOGENOMiHOG000234618.
HOVERGENiHBG018163.
InParanoidiQ63HK3.
KOiK09229.
OMAiACHRKSK.
OrthoDBiEOG091G02KC.
PhylomeDBiQ63HK3.
TreeFamiTF336839.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 6 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 2 hits.
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q63HK3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVALDSQID APLEVEGCLI MKVEKDPEWA SEPILEGSDS SETFRKCFRQ
60 70 80 90 100
FCYEDVTGPH EAFSKLWELC CRWLKPEMRS KEQILELLVI EQFLTILPEK
110 120 130 140 150
IQAWAQKQCP QSGEEAVALV VHLEKETGRL RQQVSSPVHR EKHSPLGAAW
160 170 180 190 200
EVADFQPEQV ETQPRAVSRE EPGSLHSGHQ EQLNRKRERR PLPKNARPSP
210 220 230 240 250
WVPALADEWN TLDQEVTTTR LPAGSQEPVK DVHVARGFSY RKSVHQIPAQ
260 270 280 290 300
RDLYRDFRKE NVGNVVSLGS AVSTSNKITR LEQRKEPWTL GLHSSNKRSI
310 320 330 340 350
LRSNYVKEKS VHAIQVPARS AGKTWREQQQ WGLEDEKIAG VHWSYEETKT
360 370 380 390 400
FLAILKESRF YETLQACPRN SQVYGAVAEW LRECGFLRTP EQCRTKFKSL
410 420 430 440 450
QKSYRKVRNG HMLEPCAFFE DMDALLNPAA RAPSTDKPKE MIPVPRLKRI
460 470 480 490 500
AISAKEHISL VEEEEAAEDS DDDEIGIEFI RKSEIHGAPV LFQNLSGVHW
510 520 530 540 550
GYEETKTFLD ILRETRFYEA LQACHRKSKL YGAVAEQLRE CGFLRTPEQC
560 570 580 590 600
RTKFKSLQKS YRKVKNGHVL ESCAFYKEMD ALINSRASAP SPSTPEEVPS
610 620 630 640 650
PSRQERGGIE VEPQEPTGWE PEETSQEAVI EDSCSERMSE EEIVQEPEFQ
660 670 680 690 700
GPPGLLQSPN DFEIGSSIKE DPTQIVYKDM EQHRALIEKS KRVVSQSTDP
710 720 730 740 750
SKYRKRECIS GRQWENLQGI RQGKPMSQPR DLGKAVVHQR PFVGKRPYRL
760 770 780 790 800
LKYGESFGRS TRLMCRMTHH KENPYKCGVC GKCFGRSRSL IRHQRIHTGE
810 820 830 840 850
KPFKCLDCGK SFNDSSNFGA HQRIHTGEKP YRCGECGKCF SQSSSLIIHQ
860 870 880 890 900
RTHTGEKPYQ CGECGKSFTN SSHFSAHRRV HTGENPYKCV DCEKSFNNCT
910 920 930 940 950
RFREHRRIHT GEKPYGCAQC GKRFSKSSVL TKHREVHVRE KPLPHPPSLY
960
CPENPHKGKT DEFRKTF
Length:967
Mass (Da):110,941
Last modified:May 18, 2010 - v2
Checksum:i6742FECD4D5D5300
GO
Isoform 2 (identifier: Q63HK3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     498-505: VHWGYEET → KNCALFLW
     506-967: Missing.

Note: No experimental confirmation available.
Show »
Length:505
Mass (Da):57,823
Checksum:i85BF8E901A2F1776
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti667S → G in CAH56131 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033597253L → F.Corresponds to variant rs2112811dbSNPEnsembl.1
Natural variantiVAR_033598615E → D.1 PublicationCorresponds to variant rs8059494dbSNPEnsembl.1
Natural variantiVAR_057460947P → S.Corresponds to variant rs7197424dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018189498 – 505VHWGYEET → KNCALFLW in isoform 2. 1 Publication8
Alternative sequenceiVSP_018190506 – 967Missing in isoform 2. 1 PublicationAdd BLAST462

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131342 mRNA. Translation: BAD18498.1.
BX648785 mRNA. Translation: CAH56131.1.
AC008741 Genomic DNA. No translation available.
BC130007 mRNA. Translation: AAI30008.1.
BC151139 mRNA. Translation: AAI51140.1.
CCDSiCCDS32410.1. [Q63HK3-1]
RefSeqiNP_001012999.3. NM_001012981.4. [Q63HK3-1]
UniGeneiHs.513451.

Genome annotation databases

EnsembliENST00000328086; ENSP00000331626; ENSG00000155592. [Q63HK3-1]
GeneIDi342357.
KEGGihsa:342357.
UCSCiuc002dod.5. human. [Q63HK3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131342 mRNA. Translation: BAD18498.1.
BX648785 mRNA. Translation: CAH56131.1.
AC008741 Genomic DNA. No translation available.
BC130007 mRNA. Translation: AAI30008.1.
BC151139 mRNA. Translation: AAI51140.1.
CCDSiCCDS32410.1. [Q63HK3-1]
RefSeqiNP_001012999.3. NM_001012981.4. [Q63HK3-1]
UniGeneiHs.513451.

3D structure databases

ProteinModelPortaliQ63HK3.
SMRiQ63HK3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000331626.

PTM databases

iPTMnetiQ63HK3.
PhosphoSitePlusiQ63HK3.

Polymorphism and mutation databases

BioMutaiZKSCAN2.
DMDMi296453036.

Proteomic databases

EPDiQ63HK3.
MaxQBiQ63HK3.
PaxDbiQ63HK3.
PeptideAtlasiQ63HK3.
PRIDEiQ63HK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328086; ENSP00000331626; ENSG00000155592. [Q63HK3-1]
GeneIDi342357.
KEGGihsa:342357.
UCSCiuc002dod.5. human. [Q63HK3-1]

Organism-specific databases

CTDi342357.
GeneCardsiZKSCAN2.
HGNCiHGNC:25677. ZKSCAN2.
HPAiHPA049141.
neXtProtiNX_Q63HK3.
OpenTargetsiENSG00000155592.
PharmGKBiPA162409748.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063287.
HOGENOMiHOG000234618.
HOVERGENiHBG018163.
InParanoidiQ63HK3.
KOiK09229.
OMAiACHRKSK.
OrthoDBiEOG091G02KC.
PhylomeDBiQ63HK3.
TreeFamiTF336839.

Miscellaneous databases

GenomeRNAii342357.
PROiQ63HK3.

Gene expression databases

BgeeiENSG00000155592.
CleanExiHS_ZKSCAN2.
ExpressionAtlasiQ63HK3. baseline and differential.
GenevisibleiQ63HK3. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 6 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 2 hits.
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZKSC2_HUMAN
AccessioniPrimary (citable) accession number: Q63HK3
Secondary accession number(s): A1L3B4, Q6ZN77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.