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Q63GB4

- GSA1_BACCZ

UniProt

Q63GB4 - GSA1_BACCZ

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase 1

Gene
hemL1, BCE33L0438
Organism
Bacillus cereus (strain ZK / E33L)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBCER288681:GHG7-486-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase 1 (EC:5.4.3.8)
Short name:
GSA 1
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase 1
Short name:
GSA-AT 1
Gene namesi
Name:hemL1
Ordered Locus Names:BCE33L0438
OrganismiBacillus cereus (strain ZK / E33L)
Taxonomic identifieri288681 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002612: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Glutamate-1-semialdehyde 2,1-aminomutase 1UniRule annotationPRO_0000243542Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei268 – 2681N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi288681.BCZK0438.

Structurei

3D structure databases

ProteinModelPortaliQ63GB4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
KOiK01845.
OMAiPVVMERA.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63GB4-1 [UniParc]FASTAAdd to Basket

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MKFTKSEALH KEALEHIVGG VNSPSRSFKA VGGGAPVAME RGKGAYFWDV    50
DGNKYIDYLA AYGPIITGHA HPHITKAITT AAENGVLYGT PTALEVKFAK 100
MLKEAMPALD KVRFVNSGTE AVMTTIRVAR AYTGRTKIMK FAGCYHGHSD 150
LVLVAAGSGP STLGTPDSAG VPQSIAQEVI TVPFNNIETL KEALDKWGHE 200
VAAILVEPIV GNFGIVEPKP GFLEKVNELV HEAGALVIYD EVITAFRFMY 250
GGAQDLLGVT PDLTALGKVI GGGLPIGAYG GKKEIMEQVA PLGPAYQAGT 300
MAGNPASMAS GIACLEVLQQ EGLYEKLDEL GAMLEKGILE QAAKHNIDIT 350
LNRLKGALTV YFTTNTIEDY DAAQDTDGEM FGKFFKLMLQ EGVNLAPSKY 400
EAWFLTTEHT KEDIEYTIEA VGRAFAALAD NK 432
Length:432
Mass (Da):46,234
Last modified:October 25, 2004 - v1
Checksum:iDAD7F86B6E2DAE18
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000001 Genomic DNA. Translation: AAU19801.1.
RefSeqiYP_082047.1. NC_006274.1.

Genome annotation databases

EnsemblBacteriaiAAU19801; AAU19801; BCE33L0438.
GeneIDi3024136.
KEGGibcz:BCZK0438.
PATRICi18884172. VBIBacCer95304_0468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000001 Genomic DNA. Translation: AAU19801.1 .
RefSeqi YP_082047.1. NC_006274.1.

3D structure databases

ProteinModelPortali Q63GB4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 288681.BCZK0438.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU19801 ; AAU19801 ; BCE33L0438 .
GeneIDi 3024136.
KEGGi bcz:BCZK0438.
PATRICi 18884172. VBIBacCer95304_0468.

Phylogenomic databases

eggNOGi COG0001.
KOi K01845.
OMAi PVVMERA.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci BCER288681:GHG7-486-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ZK / E33L.

Entry informationi

Entry nameiGSA1_BACCZ
AccessioniPrimary (citable) accession number: Q63GB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 25, 2004
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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