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Q63G24 (Q63G24_BACCZ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase 1 HAMAP MF_01208
Short name=OPRT 1 HAMAP MF_01208
Short name=OPRTase 1 HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE EMBL AAU19709.1
Synonyms:pyrE1 HAMAP MF_01208
Ordered Locus Names:BCE33L0532
OrganismBacillus cereus (strain ZK / E33L) [Complete proteome] [HAMAP] EMBL AAU19709.1
Taxonomic identifier288681 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 SAAS SAAS004467

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 SAAS SAAS023031

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 SAAS SAAS023031

Subunit structure

Homodimer By similarity. HAMAP MF_01208 SAAS SAAS004467

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region114 – 12295-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site2315-phosphoribose 1-diphosphate By similarity HAMAP MF_01208
Binding site8815-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site8915-phosphoribose 1-diphosphate By similarity HAMAP MF_01208
Binding site9215-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1181Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
Q63G24 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: EB1890E5075E8F71

FASTA18019,974
        10         20         30         40         50         60 
MEKWELAKEI YNTSRLTGTF KLRSGQVSNQ YFDKYLFESN PALLVEIAKQ LKELIPPETE 

        70         80         90        100        110        120 
VLAGLEMGGI PVATALSLQT GIPVVFVRKE AKKYGTCKLA EGVDITEKNV CVVEDVITTG 

       130        140        150        160        170        180 
GQILLSTKDL RELGAKVDHV LGVIERTKEG RENLLEDGLQ LHSLFTMDEL IEGEKQHAKS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000001 Genomic DNA. Translation: AAU19709.1.
RefSeqYP_082138.1. NC_006274.1.

3D structure databases

ProteinModelPortalQ63G24.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ63G24.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000042946; EBBACP00000041847; EBBACG00000042937.
GeneID3022622.
GenomeReviewsGene locus BCE33L0532 in contig CP000001_GR.
KEGGbcz:BCZK0532.
PATRIC18884402. VBIBacCer95304_0564.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0461.
GeneTreeEBGT00050000002725.
HOGENOMHBG404341.
OMAQTCLVIN.
PhylomeDBQ63G24.
ProtClustDBCLSK925627.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ63G24_BACCZ
AccessionPrimary (citable) accession number: Q63G24
Entry history
Integrated into UniProtKB/TrEMBL: October 25, 2004
Last sequence update: October 25, 2004
Last modified: December 14, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info