Reviewed, UniProtKB/Swiss-Prot Q63ES4 (HEMH1_BACCZ)

Names and origin

Protein names

Recommended name:
    Ferrochelatase 1
    EC=4.99.1.1
Alternative name(s):
    Protoheme ferro-lyase 1
    Heme synthetase 1

Gene names

Name:	hemH1
Ordered Locus Names:	BCE33L0987

Organism

Bacillus cereus (strain ZK / E33L) [Complete proteome] [HAMAP]

Taxonomic identifier

288681 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ferrochelatase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Ferrochelatase 1 HAMAP MF_00323		PRO_0000175108
Sites
	Metal binding	182	1	Iron By similarity
	Metal binding	263	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q63ES4-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 2EEB6E7E33769B11	FASTA	311	35,330
	10 20 30 40 50 60 MKKKIGLLVM AYGTPYKEED IERYYTHIRR GRKPSPEMLE DLTERYRAIG GISPLATITL 70 80 90 100 110 120 EQAKKLEKRL NEVQDEVEYH MYLGLKHIEP FIEDAVKEMH NDGIQDAIAL VLAPHYSTFS 130 140 150 160 170 180 VKSYVGRAQE EAEKLGNLTI HGIDSWYKEP KFIQYWVDAV KGIYNGMSDA EREKAVLIVS 190 200 210 220 230 240 AHSLPEKIIA MGDPYPDQLN ETADYIARGA EVANYAVGWQ SAGNTPDPWI GPDVQDLTRE 250 260 270 280 290 300 LNEKYGYTSF VYAPVGFVAE HLEVLYDNDF ECKVVTDEIG AKYYRPEMPN ASDAFIDSLT 310 DVVVKKKESV M

References

[1]

"Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis." Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Hill K.K., Hitchcock P. , Jackson P.J., Keim P., Kewalramani A.R., Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M., Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B., Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L., Brettin T.S., Gilna P. J. Bacteriol. 188:3382-3390(2006) [PubMed: 16621833] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000001 Genomic DNA. Translation: AAU19259.1.
RefSeq	YP_082588.1.
3D structure databases
SMR	Q63ES4. Positions 1-311.
ModBase	Search...
Protein-protein interaction databases
STRING	Q63ES4.
Genome annotation databases
GeneID	3025192.
GenomeReviews	Gene locus BCE33L0987 in contig CP000001_GR.
KEGG	bcz:BCZK0987.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q63ES4.
OMA	NEMIVSH.
Enzyme and pathway databases
BioCyc	BCER288681:BCE33L0987-MON.
Family and domain databases
HAMAP	MF_00323. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
ProDom	PD002792. Ferrochelatase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00109. hemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH1_BACCZ

Accession

Primary (citable) accession number: Q63ES4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	October 25, 2004
Last modified:	November 3, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)