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Protein

Undecaprenyl-diphosphatase 3

Gene

uppP3

Organism
Bacillus cereus (strain ZK / E33L)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBCER288681:GHG7-1351-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 3UniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance protein 3UniRule annotation
Undecaprenyl pyrophosphate phosphatase 3UniRule annotation
Gene namesi
Name:uppP3UniRule annotation
Synonyms:bacA3
Ordered Locus Names:BCE33L1270
OrganismiBacillus cereus (strain ZK / E33L)
Taxonomic identifieri288681 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002612 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalUniRule annotationAdd
BLAST
Transmembranei33 – 5321HelicalUniRule annotationAdd
BLAST
Transmembranei74 – 9421HelicalUniRule annotationAdd
BLAST
Transmembranei97 – 11721HelicalUniRule annotationAdd
BLAST
Transmembranei133 – 15321HelicalUniRule annotationAdd
BLAST
Transmembranei174 – 19421HelicalUniRule annotationAdd
BLAST
Transmembranei207 – 22721HelicalUniRule annotationAdd
BLAST
Transmembranei233 – 25321HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Undecaprenyl-diphosphatase 3PRO_0000151096Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
KOiK06153.
OMAiDWLIGLI.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63DZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAVEGLTEF LPVSSTGHMI LTGHLIGFDD DRAKVFEVVI QLGSILAVVV
60 70 80 90 100
IFWKRLWSLV GIGKVTDGPS LNLLHIIIGM IPAGVLGVLF HSAIKEVLFG
110 120 130 140 150
PGPVVISLVA GGILMIVAEK FSKPSTARTL DEITYKQAFT IGMFQCLALW
160 170 180 190 200
PGFSRSGSTI SGGLLARVSH TAAAEYTFIL AVPMMVAASG LDLIKSWDIL
210 220 230 240 250
STADIPLFAT GFITAFVVAM LAIVSFLKLL SRVKLTPFAY YRFILAAVFY

FFIM
Length:254
Mass (Da):27,350
Last modified:October 25, 2004 - v1
Checksum:i9C71CC091AF28D5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000001 Genomic DNA. Translation: AAU18978.1.

Genome annotation databases

EnsemblBacteriaiAAU18978; AAU18978; BCE33L1270.
KEGGibcz:BCZK1270.
PATRICi18886000. VBIBacCer95304_1339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000001 Genomic DNA. Translation: AAU18978.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU18978; AAU18978; BCE33L1270.
KEGGibcz:BCZK1270.
PATRICi18886000. VBIBacCer95304_1339.

Phylogenomic databases

eggNOGiCOG1968.
KOiK06153.
OMAiDWLIGLI.
OrthoDBiEOG6QP13M.

Enzyme and pathway databases

BioCyciBCER288681:GHG7-1351-MONOMER.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ZK / E33L.

Entry informationi

Entry nameiUPPP3_BACCZ
AccessioniPrimary (citable) accession number: Q63DZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 25, 2004
Last modified: June 24, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.