Reviewed, UniProtKB/Swiss-Prot Q63DZ3 (UPPP3_BACCZ)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 3
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 3
    Bacitracin resistance protein 3

Gene names

Name:	uppP3
Synonyms:	bacA3
Ordered Locus Names:	BCE33L1270

Organism

Bacillus cereus (strain ZK / E33L) [Complete proteome] [HAMAP]

Taxonomic identifier

288681 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Undecaprenyl-diphosphatase 3 HAMAP MF_01006		PRO_0000151096
Regions
	Transmembrane	8 – 28	21	Potential
	Transmembrane	33 – 53	21	Potential
	Transmembrane	74 – 94	21	Potential
	Transmembrane	97 – 117	21	Potential
	Transmembrane	133 – 153	21	Potential
	Transmembrane	174 – 194	21	Potential
	Transmembrane	207 – 227	21	Potential
	Transmembrane	233 – 253	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q63DZ3-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 9C71CC091AF28D5A	FASTA	254	27,350
	10 20 30 40 50 60 MGAVEGLTEF LPVSSTGHMI LTGHLIGFDD DRAKVFEVVI QLGSILAVVV IFWKRLWSLV 70 80 90 100 110 120 GIGKVTDGPS LNLLHIIIGM IPAGVLGVLF HSAIKEVLFG PGPVVISLVA GGILMIVAEK 130 140 150 160 170 180 FSKPSTARTL DEITYKQAFT IGMFQCLALW PGFSRSGSTI SGGLLARVSH TAAAEYTFIL 190 200 210 220 230 240 AVPMMVAASG LDLIKSWDIL STADIPLFAT GFITAFVVAM LAIVSFLKLL SRVKLTPFAY 250 YRFILAAVFY FFIM

References

[1]

"Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis." Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Hill K.K., Hitchcock P. , Jackson P.J., Keim P., Kewalramani A.R., Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M., Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B., Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L., Brettin T.S., Gilna P. J. Bacteriol. 188:3382-3390(2006) [PubMed: 16621833] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000001 Genomic DNA. Translation: AAU18978.1.
RefSeq	YP_082869.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q63DZ3.
Genome annotation databases
GeneID	3024012.
GenomeReviews	Gene locus BCE33L1270 in contig CP000001_GR.
KEGG	bcz:BCZK1270.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q63DZ3.
OMA	MRVFAVY.
Enzyme and pathway databases
BioCyc	BCER288681:BCE33L1270-MON.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP3_BACCZ

Accession

Primary (citable) accession number: Q63DZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	October 25, 2004
Last modified:	November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)