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Q63DX8

- LEU1_BACCZ

UniProt

Q63DX8 - LEU1_BACCZ

Protein

2-isopropylmalate synthase

Gene

leuA

Organism
Bacillus cereus (strain ZK / E33L)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).UniRule annotation

    Catalytic activityi

    Acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 2-isopropylmalate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. leucine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesis

    Enzyme and pathway databases

    BioCyciBCER288681:GHG7-1366-MONOMER.
    UniPathwayiUPA00048; UER00070.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-isopropylmalate synthaseUniRule annotation (EC:2.3.3.13UniRule annotation)
    Alternative name(s):
    Alpha-IPM synthaseUniRule annotation
    Alpha-isopropylmalate synthaseUniRule annotation
    Gene namesi
    Name:leuAUniRule annotation
    Ordered Locus Names:BCE33L1285
    OrganismiBacillus cereus (strain ZK / E33L)
    Taxonomic identifieri288681 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000002612: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5065062-isopropylmalate synthasePRO_1000149134Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi288681.BCZK1285.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63DX8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0119.
    KOiK01649.
    OMAiRKINIFD.
    OrthoDBiEOG6CGCF3.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01025. LeuA_type1.
    InterProiIPR013709. 2-isopropylmalate_synth_dimer.
    IPR002034. AIPM/Hcit_synth_CS.
    IPR013785. Aldolase_TIM.
    IPR005671. LeuA_bact_synth.
    IPR000891. PYR_CT.
    [Graphical view]
    PfamiPF00682. HMGL-like. 1 hit.
    PF08502. LeuA_dimer. 1 hit.
    [Graphical view]
    SMARTiSM00917. LeuA_dimer. 1 hit.
    [Graphical view]
    SUPFAMiSSF110921. SSF110921. 1 hit.
    TIGRFAMsiTIGR00973. leuA_bact. 1 hit.
    PROSITEiPS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
    PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
    PS50991. PYR_CT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q63DX8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKILFMDTT LRDGEQSPGV NLNEQEKLQI ARQLERLGIH VMEAGFAAAS    50
    EGDFQSVKRI ANTIQNATVM SLARAKESDI RRAYEAVKGA VSPRLHVFLA 100
    TSDIHMKYKL CMSKEDVLDS IYRSVTLGKS LFPTVQFSAE DATRTARDFL 150
    AEAVEVAIRA GANVINIPDT VGYTNPEEYY SLFKYLQESV PSYEKAIFSC 200
    HCHDDLGMAV ANSLAAVEGG ALQVEGTING IGERAGNAAL EEVAVALHIR 250
    KDFYKAEPSM TLKEIKATST LVSRLTGMVV PKNKAIVGAN AFAHESGIHQ 300
    DGVLKEVTTY EIIEPALVGE SQNLFVLGKH SGRHAFTEKM KELGYEFTND 350
    ERDAVFEAFK KLADRKKEIT EEDLRALMLG EAAFAAQQYN ITQLQVHFVS 400
    NSTQCATVVL KDEEGNVFED AATGSGSIEA IYNAIQRILG LECELADYRI 450
    QSITQGQDAL AHVHVELKEG AHQVSGFGVA QDVLEASARA YVHAAGKLKS 500
    FIQLVK 506
    Length:506
    Mass (Da):55,401
    Last modified:October 25, 2004 - v1
    Checksum:i4AB125DDC8596189
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000001 Genomic DNA. Translation: AAU18963.1.
    RefSeqiYP_082884.1. NC_006274.1.

    Genome annotation databases

    EnsemblBacteriaiAAU18963; AAU18963; BCE33L1285.
    GeneIDi3023896.
    KEGGibcz:BCZK1285.
    PATRICi18886034. VBIBacCer95304_1356.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000001 Genomic DNA. Translation: AAU18963.1 .
    RefSeqi YP_082884.1. NC_006274.1.

    3D structure databases

    ProteinModelPortali Q63DX8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 288681.BCZK1285.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU18963 ; AAU18963 ; BCE33L1285 .
    GeneIDi 3023896.
    KEGGi bcz:BCZK1285.
    PATRICi 18886034. VBIBacCer95304_1356.

    Phylogenomic databases

    eggNOGi COG0119.
    KOi K01649.
    OMAi RKINIFD.
    OrthoDBi EOG6CGCF3.

    Enzyme and pathway databases

    UniPathwayi UPA00048 ; UER00070 .
    BioCyci BCER288681:GHG7-1366-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01025. LeuA_type1.
    InterProi IPR013709. 2-isopropylmalate_synth_dimer.
    IPR002034. AIPM/Hcit_synth_CS.
    IPR013785. Aldolase_TIM.
    IPR005671. LeuA_bact_synth.
    IPR000891. PYR_CT.
    [Graphical view ]
    Pfami PF00682. HMGL-like. 1 hit.
    PF08502. LeuA_dimer. 1 hit.
    [Graphical view ]
    SMARTi SM00917. LeuA_dimer. 1 hit.
    [Graphical view ]
    SUPFAMi SSF110921. SSF110921. 1 hit.
    TIGRFAMsi TIGR00973. leuA_bact. 1 hit.
    PROSITEi PS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
    PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
    PS50991. PYR_CT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ZK / E33L.

    Entry informationi

    Entry nameiLEU1_BACCZ
    AccessioniPrimary (citable) accession number: Q63DX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3