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Q63DX2

- HISX_BACCZ

UniProt

Q63DX2 - HISX_BACCZ

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Protein

Histidinol dehydrogenase

Gene
hisD, BCE33L1291
Organism
Bacillus cereus (strain ZK / E33L)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NAD By similarity
Binding sitei188 – 1881NAD By similarity
Binding sitei211 – 2111NAD By similarity
Binding sitei234 – 2341Substrate By similarity
Metal bindingi256 – 2561Zinc By similarity
Binding sitei256 – 2561Substrate By similarity
Metal bindingi259 – 2591Zinc By similarity
Binding sitei259 – 2591Substrate By similarity
Active sitei324 – 3241Proton acceptor By similarity
Active sitei325 – 3251Proton acceptor By similarity
Binding sitei325 – 3251Substrate By similarity
Metal bindingi358 – 3581Zinc By similarity
Binding sitei358 – 3581Substrate By similarity
Binding sitei412 – 4121Substrate By similarity
Metal bindingi417 – 4171Zinc By similarity
Binding sitei417 – 4171Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciBCER288681:GHG7-1372-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:BCE33L1291
OrganismiBacillus cereus (strain ZK / E33L)
Taxonomic identifieri288681 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002612: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Histidinol dehydrogenaseUniRule annotationPRO_0000135723Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi288681.BCZK1291.

Structurei

3D structure databases

ProteinModelPortaliQ63DX2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63DX2-1 [UniParc]FASTAAdd to Basket

« Hide

MEIVCEDFQK ALTKIKLLRE NANIIEETVQ RSVREIVQNV RESRDEALSF    50
YTKKFDGVEI KDVRVSEEEI KQASMFVESS FLEALQEAKK NIISYHEKQK 100
RQSMFDCTSK GIIRGQIIRP LENIGVYVPG GTASYPSSVL MNVLPAKLAG 150
VKKIVMVTPP RAGGIDPHIL VAASLAGVDE IYMIGGAQAI AALAYGTESI 200
PKVDKIVGPG NLYVALAKRE VYGIVNIDMI AGPSEIVVIA DETGNAKYIA 250
ADLLSQAEHD ERATAICITT NIELAKEVEK EIERQLETLP RSEIARESIN 300
RNGAIFIVPS IDEALQLSNE IAPEHLELHI KEPMNALAYV KHAGSIFLGP 350
YAPEPLGDYL AGPNHVLPTS GTARFFSPLS VDDFVKKSSF LSYTEEALRD 400
VKHHIVELAN KEGLHAHARS IQIRFGEEE 429
Length:429
Mass (Da):47,271
Last modified:October 25, 2004 - v1
Checksum:iEBF5F9843321CD2C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000001 Genomic DNA. Translation: AAU18958.1.
RefSeqiWP_000406993.1. NC_006274.1.
YP_082890.1. NC_006274.1.

Genome annotation databases

EnsemblBacteriaiAAU18958; AAU18958; BCE33L1291.
GeneIDi3023156.
KEGGibcz:BCZK1291.
PATRICi18886046. VBIBacCer95304_1362.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000001 Genomic DNA. Translation: AAU18958.1 .
RefSeqi WP_000406993.1. NC_006274.1.
YP_082890.1. NC_006274.1.

3D structure databases

ProteinModelPortali Q63DX2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 288681.BCZK1291.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU18958 ; AAU18958 ; BCE33L1291 .
GeneIDi 3023156.
KEGGi bcz:BCZK1291.
PATRICi 18886046. VBIBacCer95304_1362.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci BCER288681:GHG7-1372-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ZK / E33L.

Entry informationi

Entry nameiHISX_BACCZ
AccessioniPrimary (citable) accession number: Q63DX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 25, 2004
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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