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Q63DW7

- HIS3_BACCZ

UniProt

Q63DW7 - HIS3_BACCZ

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Protein

Phosphoribosyl-AMP cyclohydrolase

Gene

hisI

Organism
Bacillus cereus (strain ZK / E33L)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.UniRule annotation

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotationNote: Binds 1 Mg(2+) ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi71 – 711MagnesiumUniRule annotation
Metal bindingi72 – 721Zinc; shared with dimeric partnerUniRule annotation
Metal bindingi73 – 731MagnesiumUniRule annotation
Metal bindingi75 – 751MagnesiumUniRule annotation
Metal bindingi88 – 881Zinc; shared with dimeric partnerUniRule annotation
Metal bindingi95 – 951Zinc; shared with dimeric partnerUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoribosyl-AMP cyclohydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBCER288681:GHG7-1377-MONOMER.
UniPathwayiUPA00031; UER00008.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosyl-AMP cyclohydrolaseUniRule annotation (EC:3.5.4.19UniRule annotation)
Short name:
PRA-CHUniRule annotation
Gene namesi
Name:hisIUniRule annotation
Ordered Locus Names:BCE33L1296
OrganismiBacillus cereus (strain ZK / E33L)
Taxonomic identifieri288681 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002612: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 101101Phosphoribosyl-AMP cyclohydrolasePRO_0000229809Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi288681.BCZK1296.

Structurei

3D structure databases

ProteinModelPortaliQ63DW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PRA-CH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0139.
KOiK01496.
OMAiGQVCYWS.
OrthoDBiEOG6PGKB6.

Family and domain databases

HAMAPiMF_01021. HisI.
InterProiIPR026660. PRA-CH.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view]
PfamiPF01502. PRA-CH. 1 hit.
[Graphical view]
ProDomiPD002610. PRA_CycHdrlase. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q63DW7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPNFSKGLL PAVVIEEGTK EVLMLAYMNE EAYEKTLKTK RTWFYSRSRR
60 70 80 90 100
SLWNKGETSG HVQHVQSLYL DCDQDAIVVV VKQVGPACHT GEKTCFHYKI

I
Length:101
Mass (Da):11,607
Last modified:October 25, 2004 - v1
Checksum:iFDA6E19DE50A01F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000001 Genomic DNA. Translation: AAU18951.1.
RefSeqiYP_082895.1. NC_006274.1.

Genome annotation databases

EnsemblBacteriaiAAU18951; AAU18951; BCE33L1296.
GeneIDi3025043.
KEGGibcz:BCZK1296.
PATRICi18886056. VBIBacCer95304_1367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000001 Genomic DNA. Translation: AAU18951.1 .
RefSeqi YP_082895.1. NC_006274.1.

3D structure databases

ProteinModelPortali Q63DW7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 288681.BCZK1296.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU18951 ; AAU18951 ; BCE33L1296 .
GeneIDi 3025043.
KEGGi bcz:BCZK1296.
PATRICi 18886056. VBIBacCer95304_1367.

Phylogenomic databases

eggNOGi COG0139.
KOi K01496.
OMAi GQVCYWS.
OrthoDBi EOG6PGKB6.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00008 .
BioCyci BCER288681:GHG7-1377-MONOMER.

Family and domain databases

HAMAPi MF_01021. HisI.
InterProi IPR026660. PRA-CH.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view ]
Pfami PF01502. PRA-CH. 1 hit.
[Graphical view ]
ProDomi PD002610. PRA_CycHdrlase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ZK / E33L.

Entry informationi

Entry nameiHIS3_BACCZ
AccessioniPrimary (citable) accession number: Q63DW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 25, 2004
Last modified: November 26, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3