Reviewed, UniProtKB/Swiss-Prot Q63DL6 (AROC1_BACCZ)

Names and origin

Protein names

Recommended name:
    Chorismate synthase 1
    EC=4.2.3.5
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate phospholyase 1

Gene names

Name:	aroC1
Ordered Locus Names:	BCE33L1398

Organism

Bacillus cereus (strain ZK / E33L) [Complete proteome] [HAMAP]

Taxonomic identifier

288681 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Chorismate synthase 1 HAMAP MF_00300		PRO_0000140545

Sequences

	Sequence		Length	Mass (Da)
	Q63DL6-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: ED88C88BC12B2F5F	FASTA	390	42,408
	10 20 30 40 50 60 MRYITAGESH GPQLTTIIEG VPAGLPLVAD DINEELARRQ KGYGRGRRMQ IETDQVQIVS 70 80 90 100 110 120 GVRHGETLGS PIALVVENRD FAHWTKIMGA EPLTEQEEKE MKRKVTKPRP GHADLNGAIK 130 140 150 160 170 180 YGHRDMRNVL ERSSARETTV RVAAGAVAKK VLAELGIAVA GHVIEIGGVQ AKETTYRSIE 190 200 210 220 230 240 ELKSITEASP VRCLDEEAGN QMIKAIDDAK SNGDSIGGIV EVIVEGMPIG VGSYVHYDRK 250 260 270 280 290 300 LDAKLAAAIM SINAFKGVEI GIGFEAAHRP GSEVHDEILW DEEHGYTRRT NNAGGLEGGM 310 320 330 340 350 360 TTGMPIVVRG VMKPIPTLYK PLQSVDIDTK EPFTASIERS DSCAVPAASV VAEAVVAWEL 370 380 390 ATALIEQFGL DRMDLIRENI EKHNEYARGF

References

[1]

"Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis." Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Hill K.K., Hitchcock P. , Jackson P.J., Keim P., Kewalramani A.R., Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M., Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B., Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L., Brettin T.S., Gilna P. J. Bacteriol. 188:3382-3390(2006) [PubMed: 16621833] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000001 Genomic DNA. Translation: AAU18851.1.
RefSeq	YP_082996.1.
3D structure databases
SMR	Q63DL6. Positions 1-390.
ModBase	Search...
Protein-protein interaction databases
STRING	Q63DL6.
Genome annotation databases
GeneID	3025480.
GenomeReviews	Gene locus BCE33L1398 in contig CP000001_GR.
KEGG	bcz:BCZK1398.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0082.
HOGENOM	HBG292336.
OMA	MLRWLTA.
Enzyme and pathway databases
BioCyc	BCER288681:BCE33L1398-MONOMER.
Family and domain databases
HAMAP	MF_00300_B. Chorismate_synth_B. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. aroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC1_BACCZ

Accession

Primary (citable) accession number: Q63DL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	October 25, 2004
Last modified:	February 9, 2010
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)