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Q63CV4 (ILVC2_BACCZ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase 2

EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase 2
Alpha-keto-beta-hydroxylacil reductoisomerase 2
Gene names
Name:ilvC2
Ordered Locus Names:BCE33L1668
OrganismBacillus cereus (strain ZK / E33L) [Complete proteome] [HAMAP]
Taxonomic identifier288681 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Ketol-acid reductoisomerase 2 HAMAP MF_00435
PRO_0000226156

Sites

Active site1061 Potential

Sequences

Sequence LengthMass (Da)Tools
Q63CV4 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 8441FB8359CB9B39

FASTA33536,765
        10         20         30         40         50         60 
MKTYYEKDAN VDLLQGKTVA VVGYGSQGHA QAQNLRDSGV EVVVGVRPGK SYEVAKADGF 

        70         80         90        100        110        120 
EVMSVSEAVR TAQVVQMLLP DEQQAHVYKA EIEENLREGQ MLLFSHGFNI HFGQINPPSY 

       130        140        150        160        170        180 
VDVAMVAPKS PGHLVRRVFQ EGNGVPALVA VHQDATGTAL HVALAYAKGV GCTRAGVIET 

       190        200        210        220        230        240 
TFQEETETDL FGEQAVLCGG VTALVKAGFE TLTEGGYRPE IAYFECLHEL KLIVDLMYEG 

       250        260        270        280        290        300 
GLTNMRHSIS DTAEFGDYVT GSRIVTDGTK KEMKRVLTEI QQGEFAKKWI LENQAGRPTH 

       310        320        330 
NAMKKAEQNH GLEKVGAELR EMMSWIHAPK ELVKK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000001 Genomic DNA. Translation: AAU18586.1.
RefSeqYP_083263.1. NC_006274.1.

3D structure databases

ProteinModelPortalQ63CV4.
SMRQ63CV4. Positions 1-326.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ63CV4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000043897; EBBACP00000042798; EBBACG00000043888.
GeneID3024009.
GenomeReviewsGene locus BCE33L1668 in contig CP000001_GR.
KEGGbcz:BCZK1668.
PATRIC18886828. VBIBacCer95304_1753.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0059.
GeneTreeEBGT00050000000943.
HOGENOMHBG286525.
OMARPGKSYE.
PhylomeDBQ63CV4.
ProtClustDBPRK13403.

Enzyme and pathway databases

BioCycBCER288681:BCE33L1668-MONOMER.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
Gene3DG3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00053.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC2_BACCZ
AccessionPrimary (citable) accession number: Q63CV4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 25, 2004
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families