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Q63AN4

- UPPP4_BACCZ

UniProt

Q63AN4 - UPPP4_BACCZ

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Protein
Undecaprenyl-diphosphatase 4
Gene
uppP4, bacA4, BCE33L2444
Organism
Bacillus cereus (strain ZK / E33L)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBCER288681:GHG7-2514-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 4 (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein 4
Undecaprenyl pyrophosphate phosphatase 4
Gene namesi
Name:uppP4
Synonyms:bacA4
Ordered Locus Names:BCE33L2444
OrganismiBacillus cereus (strain ZK / E33L)
Taxonomic identifieri288681 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002612: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Reviewed prediction
Add
BLAST
Transmembranei39 – 5921Helical; Reviewed prediction
Add
BLAST
Transmembranei71 – 9121Helical; Reviewed prediction
Add
BLAST
Transmembranei99 – 11921Helical; Reviewed prediction
Add
BLAST
Transmembranei133 – 15321Helical; Reviewed prediction
Add
BLAST
Transmembranei174 – 19421Helical; Reviewed prediction
Add
BLAST
Transmembranei208 – 22821Helical; Reviewed prediction
Add
BLAST
Transmembranei239 – 25921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Undecaprenyl-diphosphatase 4UniRule annotation
PRO_0000151097Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi288681.BCZK2444.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
KOiK06153.
OMAiTITHATI.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63AN4-1 [UniParc]FASTAAdd to Basket

« Hide

MNWLEAFILG IIQGLTEFLP ISSTGHLYLG RHLFQLDEAG LFLDTMLHIG    50
TLLAVFIYYK KEFIYLIKNP FSKLMLLLIV GTIPAVVIGL LFKDFFEDIS 100
KTGITIGWEF LVTGFFLYMA DKQKNGRKKM DDITYKDAFI IGSFQAAAIF 150
PAISRSGMTI VAALWRKLDR ETAAYFSFLL STPAIVGAII LQFVDVFQGK 200
AESISSTSLI VGTLSAAFFG YIAVSWMIQY LKRHSLKVFA YYVWGLGILI 250
LTLQFTDVF 259
Length:259
Mass (Da):29,177
Last modified:October 25, 2004 - v1
Checksum:i371001B71F60F5E9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000001 Genomic DNA. Translation: AAU17815.1.
RefSeqiYP_084033.1. NC_006274.1.

Genome annotation databases

EnsemblBacteriaiAAU17815; AAU17815; BCE33L2444.
GeneIDi3025477.
KEGGibcz:BCZK2444.
PATRICi18888502. VBIBacCer95304_2589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000001 Genomic DNA. Translation: AAU17815.1 .
RefSeqi YP_084033.1. NC_006274.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 288681.BCZK2444.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU17815 ; AAU17815 ; BCE33L2444 .
GeneIDi 3025477.
KEGGi bcz:BCZK2444.
PATRICi 18888502. VBIBacCer95304_2589.

Phylogenomic databases

eggNOGi COG1968.
KOi K06153.
OMAi TITHATI.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci BCER288681:GHG7-2514-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ZK / E33L.

Entry informationi

Entry nameiUPPP4_BACCZ
AccessioniPrimary (citable) accession number: Q63AN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 25, 2004
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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