Q63AN4 (UPPP4_BACCZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase 4
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein 4
Undecaprenyl pyrophosphate phosphatase 4

Gene names

Name:	uppP4
Synonyms:	bacA4
Ordered Locus Names:	BCE33L2444

Organism

Bacillus cereus (strain ZK / E33L) [Complete proteome] [HAMAP]

Taxonomic identifier

288681 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 259	259	Undecaprenyl-diphosphatase 4 HAMAP MF_01006		PRO_0000151097
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	71 – 91	21	Helical; Potential
	Transmembrane	99 – 119	21	Helical; Potential
	Transmembrane	133 – 153	21	Helical; Potential
	Transmembrane	174 – 194	21	Helical; Potential
	Transmembrane	208 – 228	21	Helical; Potential
	Transmembrane	239 – 259	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q63AN4 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 371001B71F60F5E9	FASTA	259	29,177
	10 20 30 40 50 60 MNWLEAFILG IIQGLTEFLP ISSTGHLYLG RHLFQLDEAG LFLDTMLHIG TLLAVFIYYK 70 80 90 100 110 120 KEFIYLIKNP FSKLMLLLIV GTIPAVVIGL LFKDFFEDIS KTGITIGWEF LVTGFFLYMA 130 140 150 160 170 180 DKQKNGRKKM DDITYKDAFI IGSFQAAAIF PAISRSGMTI VAALWRKLDR ETAAYFSFLL 190 200 210 220 230 240 STPAIVGAII LQFVDVFQGK AESISSTSLI VGTLSAAFFG YIAVSWMIQY LKRHSLKVFA 250 YYVWGLGILI LTLQFTDVF

References

[1]

"Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis." Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Hill K.K., Hitchcock P. , Jackson P.J., Keim P., Kewalramani A.R., Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M., Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B., Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L., Brettin T.S., Gilna P. J. Bacteriol. 188:3382-3390(2006) [PubMed: 16621833] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ZK / E33L.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000001 Genomic DNA. Translation: AAU17815.1.
RefSeq	YP_084033.1. NC_006274.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q63AN4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000042095; EBBACP00000040996; EBBACG00000042086.
GeneID	3025477.
GenomeReviews	Gene locus BCE33L2444 in contig CP000001_GR.
KEGG	bcz:BCZK2444.
PATRIC	18888502. VBIBacCer95304_2589.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
GeneTree	EBGT00050000002490.
HOGENOM	HBG391969.
OMA	FKAWIAS.
PhylomeDB	Q63AN4.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	BCER288681:BCE33L2444-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
KO	K06153.
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP4_BACCZ

Accession

Primary (citable) accession number: Q63AN4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program