Q63A07 (AROA_BACCZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	BCE33L2673

Organism

Bacillus cereus (strain ZK / E33L) [Complete proteome] [HAMAP]

Taxonomic identifier

288681 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 429	429	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_0000088221

Sequences

	Sequence		Length	Mass (Da)
	Q63A07 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 673A25B3194479CD	FASTA	429	45,212
	10 20 30 40 50 60 MKERTIQPVN NGLNGNITIP GDKSISHRAV MFGAIAEGKT TIKGFLPGAD CLSTISCFKE 70 80 90 100 110 120 MGVDIVQNGD EVTVVGKGLE GLQEPKAVLD VGNSGTTIRL MSGILANTPF FSCVQGDASI 130 140 150 160 170 180 AKRPMKRVTN PLKQMGANID GREEGTFTPL TIRGGDLKAI EYTSPVASAQ VKSAILLAGL 190 200 210 220 230 240 RAEGVTAVTE PHISRDHTER MLEAFGVKVT REGKTVKLAG GQKLTATDVQ VPGDVSSAAF 250 260 270 280 290 300 FLVAGAIIPN SKLVLENVGM NPTRTGIIDV LEKMGATFTV EPINEGASEP AANITIETSS 310 320 330 340 350 360 LKGIEIGGDI IPRLIDEIPV IALAATQAEG ITVIKDAHEL KVKETNRIDT VVAELTKLGA 370 380 390 400 410 420 RIEATDDGMI IYGKSVLKGN TVNSYGDHRI GMMLAIAGCL AEGKTTIEDA EAVGVSYPTF FEELQKLAK

References

[1]

"Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis." Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Hill K.K., Hitchcock P. , Jackson P.J., Keim P., Kewalramani A.R., Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M., Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B., Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L., Brettin T.S., Gilna P. J. Bacteriol. 188:3382-3390(2006) [PubMed: 16621833] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ZK / E33L.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000001 Genomic DNA. Translation: AAU17588.1.
RefSeq	YP_084260.1. NC_006274.1.
3D structure databases
ProteinModelPortal	Q63A07.
SMR	Q63A07. Positions 7-428.
ModBase	Search...
Protein-protein interaction databases
STRING	Q63A07.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000043333; EBBACP00000042234; EBBACG00000043324.
GeneID	3023950.
GenomeReviews	Gene locus BCE33L2673 in contig CP000001_GR.
KEGG	bcz:BCZK2673.
PATRIC	18888992. VBIBacCer95304_2834.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0128.
GeneTree	EBGT00050000001036.
HOGENOM	HBG646626.
OMA	GEDPRST.
PhylomeDB	Q63A07.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	BCER288681:BCE33L2673-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_BACCZ

Accession

Primary (citable) accession number: Q63A07

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program