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Q639M5 (PCP_BACCZ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyrrolidone-carboxylate peptidase

EC=3.4.19.3
Alternative name(s):
5-oxoprolyl-peptidase
Pyroglutamyl-peptidase I
Short name=PGP-I
Short name=Pyrase
Gene names
Name:pcp
Ordered Locus Names:BCE33L2805
OrganismBacillus cereus (strain ZK / E33L) [Complete proteome] [HAMAP]
Taxonomic identifier288681 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length215 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Removes 5-oxoproline from various penultimate amino acid residues except L-proline By similarity. HAMAP-Rule MF_00417

Catalytic activity

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro. HAMAP-Rule MF_00417

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00417

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00417.

Sequence similarities

Belongs to the peptidase C15 family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

pyroglutamyl-peptidase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 215215Pyrrolidone-carboxylate peptidase HAMAP-Rule MF_00417
PRO_0000184710

Sites

Active site801 By similarity
Active site1431 By similarity
Active site1671 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q639M5 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 5770466D2DFFA352

FASTA21523,598
        10         20         30         40         50         60 
MKTVLLTGFD PFGGESINPA WEVAKSLHEK TIREYKIISK QVPTVFHKSI QVLKEYIDEL 

        70         80         90        100        110        120 
NPEIIICIGQ AGGRPDITIE RVAINIDDAR IADNEGNQPV DVPVVEEGSA AYWSTLPMKA 

       130        140        150        160        170        180 
IVKRLQAEGI PASVSQTAGT FVCNHLFYGL MHELEKQDQK IKGGFVHIPF LPEQASKYPG 

       190        200        210 
QSSMSLSTIR KGIELAVEVT TTVEVDIVEV GGTTH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000001 Genomic DNA. Translation: AAU17456.1.
RefSeqYP_084392.1. NC_006274.1.

3D structure databases

ProteinModelPortalQ639M5.
SMRQ639M5. Positions 1-207.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING288681.BCZK2805.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU17456; AAU17456; BCE33L2805.
GeneID3025704.
KEGGbcz:BCZK2805.
PATRIC18889268. VBIBacCer95304_2972.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2039.
KOK01304.
OMAAKQLPCV.
OrthoDBEOG6X1124.

Enzyme and pathway databases

BioCycBCER288681:GHG7-2873-MONOMER.

Family and domain databases

Gene3D3.40.630.20. 1 hit.
HAMAPMF_00417. Pyrrolid_peptidase.
InterProIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
[Graphical view]
PANTHERPTHR23402. PTHR23402. 1 hit.
PfamPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSPR00706. PYROGLUPTASE.
SUPFAMSSF53182. SSF53182. 1 hit.
TIGRFAMsTIGR00504. pyro_pdase. 1 hit.
PROSITEPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePCP_BACCZ
AccessionPrimary (citable) accession number: Q639M5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 25, 2004
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries