SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q639D2

- ARSC_BACCZ

UniProt

Q639D2 - ARSC_BACCZ

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Protein ArsC
Gene
arsC, BCE33L2898
Organism
Bacillus cereus (strain ZK / E33L)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances By similarity.UniRule annotation

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation
Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei11 – 111Nucleophile; for reductase activity and phosphatase activity By similarity
Active sitei83 – 831Nucleophile; for reductase activity By similarity
Active sitei90 – 901Nucleophile; for reductase activity By similarity

GO - Molecular functioni

  1. arsenate reductase (thioredoxin) activity Source: UniProtKB-HAMAP
  2. protein tyrosine phosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. response to arsenic-containing substance Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Oxidoreductase

Keywords - Biological processi

Arsenical resistance

Enzyme and pathway databases

BioCyciBCER288681:GHG7-2966-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ArsC
Alternative name(s):
Arsenate reductase (EC:1.20.4.-)
Arsenical pump modifier
Low molecular weight protein-tyrosine-phosphatase (EC:3.1.3.48)
Gene namesi
Name:arsC
Ordered Locus Names:BCE33L2898
OrganismiBacillus cereus (strain ZK / E33L)
Taxonomic identifieri288681 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002612: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 134134Protein ArsCUniRule annotation
PRO_0000162515Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi11 ↔ 83Redox-active; alternate By similarity
Disulfide bondi83 ↔ 90Redox-active; alternate By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi288681.BCZK2898.

Structurei

3D structure databases

ProteinModelPortaliQ639D2.
SMRiQ639D2. Positions 1-134.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG0394.
KOiK03741.
OMAiGHANETC.
OrthoDBiEOG6JDWJC.

Family and domain databases

HAMAPiMF_01624. Arsenate_reduct.
InterProiIPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717. PTHR11717. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q639D2-1 [UniParc]FASTAAdd to Basket

« Hide

MENKKTIYFL CTGNSCRSQM AEAWGKQYLG DKWNVYSAGI EVHGVNPNAI    50
KAMNEVNIDI TNQTSDIIDA NILNRADLVV TLCSHADSVC PSTPPDVNRV 100
HWGFDDPAGK EWSEFQRVRD EIGERIKRFS ETGE 134
Length:134
Mass (Da):15,078
Last modified:October 25, 2004 - v1
Checksum:i715F16EC0EA10F9D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000001 Genomic DNA. Translation: AAU17365.1.
RefSeqiYP_084485.1. NC_006274.1.

Genome annotation databases

EnsemblBacteriaiAAU17365; AAU17365; BCE33L2898.
GeneIDi3024191.
KEGGibcz:BCZK2898.
PATRICi18889474. VBIBacCer95304_3075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000001 Genomic DNA. Translation: AAU17365.1 .
RefSeqi YP_084485.1. NC_006274.1.

3D structure databases

ProteinModelPortali Q639D2.
SMRi Q639D2. Positions 1-134.
ModBasei Search...

Protein-protein interaction databases

STRINGi 288681.BCZK2898.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU17365 ; AAU17365 ; BCE33L2898 .
GeneIDi 3024191.
KEGGi bcz:BCZK2898.
PATRICi 18889474. VBIBacCer95304_3075.

Phylogenomic databases

eggNOGi COG0394.
KOi K03741.
OMAi GHANETC.
OrthoDBi EOG6JDWJC.

Enzyme and pathway databases

BioCyci BCER288681:GHG7-2966-MONOMER.

Family and domain databases

HAMAPi MF_01624. Arsenate_reduct.
InterProi IPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view ]
PANTHERi PTHR11717. PTHR11717. 1 hit.
Pfami PF01451. LMWPc. 1 hit.
[Graphical view ]
SMARTi SM00226. LMWPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52788. SSF52788. 1 hit.
TIGRFAMsi TIGR02691. arsC_pI258_fam. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ZK / E33L.

Entry informationi

Entry nameiARSC_BACCZ
AccessioniPrimary (citable) accession number: Q639D2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 25, 2004
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi