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Q639D2 (ARSC_BACCZ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein ArsC
Alternative name(s):
Arsenate reductase
EC=1.20.4.-
Arsenical pump modifier
Low molecular weight protein-tyrosine-phosphatase
EC=3.1.3.48
Gene names
Name:arsC
Ordered Locus Names:BCE33L2898
OrganismBacillus cereus (strain ZK / E33L) [Complete proteome] [HAMAP]
Taxonomic identifier288681 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length134 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances By similarity. HAMAP-Rule MF_01624

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. HAMAP-Rule MF_01624

Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O. HAMAP-Rule MF_01624

Subunit structure

Monomer By similarity. HAMAP-Rule MF_01624

Sequence similarities

Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.

Ontologies

Keywords
   Biological processArsenical resistance
   DomainRedox-active center
   Molecular functionHydrolase
Oxidoreductase
   PTMDisulfide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processresponse to arsenic-containing substance

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionarsenate reductase (thioredoxin) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

protein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 134134Protein ArsC HAMAP-Rule MF_01624
PRO_0000162515

Sites

Active site111Nucleophile; for reductase activity and phosphatase activity By similarity
Active site831Nucleophile; for reductase activity By similarity
Active site901Nucleophile; for reductase activity By similarity

Amino acid modifications

Disulfide bond11 ↔ 83Redox-active; alternate By similarity
Disulfide bond83 ↔ 90Redox-active; alternate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q639D2 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 715F16EC0EA10F9D

FASTA13415,078
        10         20         30         40         50         60 
MENKKTIYFL CTGNSCRSQM AEAWGKQYLG DKWNVYSAGI EVHGVNPNAI KAMNEVNIDI 

        70         80         90        100        110        120 
TNQTSDIIDA NILNRADLVV TLCSHADSVC PSTPPDVNRV HWGFDDPAGK EWSEFQRVRD 

       130 
EIGERIKRFS ETGE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000001 Genomic DNA. Translation: AAU17365.1.
RefSeqYP_084485.1. NC_006274.1.

3D structure databases

ProteinModelPortalQ639D2.
SMRQ639D2. Positions 1-134.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING288681.BCZK2898.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU17365; AAU17365; BCE33L2898.
GeneID3024191.
KEGGbcz:BCZK2898.
PATRIC18889474. VBIBacCer95304_3075.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0394.
KOK03741.
OMAGHANETC.
OrthoDBEOG6JDWJC.

Enzyme and pathway databases

BioCycBCER288681:GHG7-2966-MONOMER.

Family and domain databases

HAMAPMF_01624. Arsenate_reduct.
InterProIPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERPTHR11717. PTHR11717. 1 hit.
PfamPF01451. LMWPc. 1 hit.
[Graphical view]
SMARTSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMSSF52788. SSF52788. 1 hit.
TIGRFAMsTIGR02691. arsC_pI258_fam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameARSC_BACCZ
AccessionPrimary (citable) accession number: Q639D2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 25, 2004
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families