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Q63994

- CD33_MOUSE

UniProt

Q63994 - CD33_MOUSE

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Protein

Myeloid cell surface antigen CD33

Gene

Cd33

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Sialic acidBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid cell surface antigen CD33
Alternative name(s):
Sialic acid-binding Ig-like lectin 3
Short name:
Siglec-3
CD_antigen: CD33
Gene namesi
Name:Cd33
Synonyms:Siglec3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:99440. Cd33.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 403387Myeloid cell surface antigen CD33PRO_0000014879Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 169PROSITE-ProRule annotation
Disulfide bondi41 ↔ 100PROSITE-ProRule annotation
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi163 ↔ 212PROSITE-ProRule annotation
Glycosylationi230 – 2301N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ63994.

PTM databases

PhosphoSiteiQ63994.

Expressioni

Gene expression databases

BgeeiQ63994.
CleanExiMM_CD33.
GenevestigatoriQ63994.

Structurei

3D structure databases

ProteinModelPortaliQ63994.
SMRiQ63994. Positions 21-232.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 240223ExtracellularSequence AnalysisAdd
BLAST
Topological domaini268 – 403136CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei241 – 26727HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 120104Ig-like V-typeAdd
BLAST
Domaini145 – 22884Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320441.
GeneTreeiENSGT00760000119139.
HOGENOMiHOG000236324.
InParanoidiQ63994.
KOiK06473.
OMAiHEDSPVA.
OrthoDBiEOG73JKV5.
PhylomeDBiQ63994.
TreeFamiTF332441.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 33-B (identifier: Q63994-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLWPLPLFLL CAGSLAQDLE FQLVAPESVT VEEGLCVHVP CSVFYPSIKL
60 70 80 90 100
TLGPVTGSWL RKGVSLHEDS PVATSDPRQL VQKATQGRFQ LLGDPQKHDC
110 120 130 140 150
SLFIRDAQKN DTGMYFFRVV REPFVRYSYK KSQLSLHVTS LSRTPDIIIP
160 170 180 190 200
GTLEAGYPSN LTCSVPWACE QGTPPTFSWM STALTSLSSR TTDSSVLTFT
210 220 230 240 250
PQPQDHGTKL TCLVTFSGAG VTVERTIQLN VTRKSGQMRE LVLVAVGEAT
260 270 280 290 300
VKLLILGLCL VFLIVMFCRR KTTKLSVHMG CENPIKRQEA ITSYNHCLSP
310 320 330 340 350
TASDAVTPGC SIHRLISRTP RCTAILRIQD PYRRTHLRNR AVSTLRFPWI
360 370 380 390 400
SWEGSLRSTQ RSKCTKLCSP VKNLCPLWLP VDNSCIPLIP EWVMLLCVSL

TLS
Length:403
Mass (Da):44,824
Last modified:November 1, 1996 - v1
Checksum:iF1FE6D5C393F0FF1
GO
Isoform 33-A (identifier: Q63994-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-403: RQEAITSYNH...MLLCVSLTLS → AHQQDSKVHS...GGKPQEYSEI

Show »
Length:334
Mass (Da):36,951
Checksum:iA3EC9608B5AFE617
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei287 – 403117RQEAI…SLTLS → AHQQDSKVHSNPENPRPLQK DSPQEQSSVHTKISLDFMGG KPQEYSEI in isoform 33-A. 2 PublicationsVSP_002534Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S71345 mRNA. Translation: AAB30842.1.
S71403 mRNA. Translation: AAB30843.2.
BC132379 mRNA. Translation: AAI32380.1.
CCDSiCCDS21173.1. [Q63994-2]
CCDS52224.1. [Q63994-1]
RefSeqiNP_001104528.1. NM_001111058.1. [Q63994-1]
NP_067268.1. NM_021293.3. [Q63994-2]
UniGeneiMm.140157.

Genome annotation databases

EnsembliENSMUST00000004728; ENSMUSP00000004728; ENSMUSG00000004609. [Q63994-1]
ENSMUST00000039861; ENSMUSP00000045458; ENSMUSG00000004609. [Q63994-2]
GeneIDi12489.
KEGGimmu:12489.
UCSCiuc009gmy.2. mouse. [Q63994-2]
uc009gna.1. mouse. [Q63994-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Siglec-3

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S71345 mRNA. Translation: AAB30842.1 .
S71403 mRNA. Translation: AAB30843.2 .
BC132379 mRNA. Translation: AAI32380.1 .
CCDSi CCDS21173.1. [Q63994-2 ]
CCDS52224.1. [Q63994-1 ]
RefSeqi NP_001104528.1. NM_001111058.1. [Q63994-1 ]
NP_067268.1. NM_021293.3. [Q63994-2 ]
UniGenei Mm.140157.

3D structure databases

ProteinModelPortali Q63994.
SMRi Q63994. Positions 21-232.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q63994.

Proteomic databases

PRIDEi Q63994.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004728 ; ENSMUSP00000004728 ; ENSMUSG00000004609 . [Q63994-1 ]
ENSMUST00000039861 ; ENSMUSP00000045458 ; ENSMUSG00000004609 . [Q63994-2 ]
GeneIDi 12489.
KEGGi mmu:12489.
UCSCi uc009gmy.2. mouse. [Q63994-2 ]
uc009gna.1. mouse. [Q63994-1 ]

Organism-specific databases

CTDi 945.
MGIi MGI:99440. Cd33.

Phylogenomic databases

eggNOGi NOG320441.
GeneTreei ENSGT00760000119139.
HOGENOMi HOG000236324.
InParanoidi Q63994.
KOi K06473.
OMAi HEDSPVA.
OrthoDBi EOG73JKV5.
PhylomeDBi Q63994.
TreeFami TF332441.

Miscellaneous databases

NextBioi 281404.
PROi Q63994.
SOURCEi Search...

Gene expression databases

Bgeei Q63994.
CleanExi MM_CD33.
Genevestigatori Q63994.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of two isoforms of the murine homolog of the myeloid CD33 antigen."
    Tchilian E.Z., Beverley P.C., Young B.D., Watt S.M.
    Blood 83:3188-3198(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 33-A AND 33-B).
    Strain: BALB/c.
    Tissue: Bone marrow.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 33-A).
    Tissue: Brain.

Entry informationi

Entry nameiCD33_MOUSE
AccessioniPrimary (citable) accession number: Q63994
Secondary accession number(s): A2RT59, Q63997
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3