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Q63994

- CD33_MOUSE

UniProt

Q63994 - CD33_MOUSE

Protein

Myeloid cell surface antigen CD33

Gene

Cd33

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid By similarity. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei118 – 1181Sialic acidBy similarity

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myeloid cell surface antigen CD33
    Alternative name(s):
    Sialic acid-binding Ig-like lectin 3
    Short name:
    Siglec-3
    CD_antigen: CD33
    Gene namesi
    Name:Cd33
    Synonyms:Siglec3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:99440. Cd33.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 403387Myeloid cell surface antigen CD33PRO_0000014879Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi36 ↔ 169PROSITE-ProRule annotation
    Disulfide bondi41 ↔ 100PROSITE-ProRule annotation
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi163 ↔ 212PROSITE-ProRule annotation
    Glycosylationi230 – 2301N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ63994.

    PTM databases

    PhosphoSiteiQ63994.

    Expressioni

    Gene expression databases

    BgeeiQ63994.
    CleanExiMM_CD33.
    GenevestigatoriQ63994.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63994.
    SMRiQ63994. Positions 21-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 240223ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini268 – 403136CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei241 – 26727HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 120104Ig-like V-typeAdd
    BLAST
    Domaini145 – 22884Ig-like C2-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320441.
    GeneTreeiENSGT00560000076846.
    HOGENOMiHOG000236324.
    InParanoidiQ63994.
    KOiK06473.
    OMAiHEDSPVA.
    OrthoDBiEOG73JKV5.
    PhylomeDBiQ63994.
    TreeFamiTF332441.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 33-B (identifier: Q63994-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLWPLPLFLL CAGSLAQDLE FQLVAPESVT VEEGLCVHVP CSVFYPSIKL    50
    TLGPVTGSWL RKGVSLHEDS PVATSDPRQL VQKATQGRFQ LLGDPQKHDC 100
    SLFIRDAQKN DTGMYFFRVV REPFVRYSYK KSQLSLHVTS LSRTPDIIIP 150
    GTLEAGYPSN LTCSVPWACE QGTPPTFSWM STALTSLSSR TTDSSVLTFT 200
    PQPQDHGTKL TCLVTFSGAG VTVERTIQLN VTRKSGQMRE LVLVAVGEAT 250
    VKLLILGLCL VFLIVMFCRR KTTKLSVHMG CENPIKRQEA ITSYNHCLSP 300
    TASDAVTPGC SIHRLISRTP RCTAILRIQD PYRRTHLRNR AVSTLRFPWI 350
    SWEGSLRSTQ RSKCTKLCSP VKNLCPLWLP VDNSCIPLIP EWVMLLCVSL 400
    TLS 403
    Length:403
    Mass (Da):44,824
    Last modified:November 1, 1996 - v1
    Checksum:iF1FE6D5C393F0FF1
    GO
    Isoform 33-A (identifier: Q63994-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         287-403: RQEAITSYNH...MLLCVSLTLS → AHQQDSKVHS...GGKPQEYSEI

    Show »
    Length:334
    Mass (Da):36,951
    Checksum:iA3EC9608B5AFE617
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei287 – 403117RQEAI…SLTLS → AHQQDSKVHSNPENPRPLQK DSPQEQSSVHTKISLDFMGG KPQEYSEI in isoform 33-A. 2 PublicationsVSP_002534Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S71345 mRNA. Translation: AAB30842.1.
    S71403 mRNA. Translation: AAB30843.2.
    BC132379 mRNA. Translation: AAI32380.1.
    CCDSiCCDS21173.1. [Q63994-2]
    CCDS52224.1. [Q63994-1]
    RefSeqiNP_001104528.1. NM_001111058.1. [Q63994-1]
    NP_067268.1. NM_021293.3. [Q63994-2]
    UniGeneiMm.140157.

    Genome annotation databases

    EnsembliENSMUST00000004728; ENSMUSP00000004728; ENSMUSG00000004609. [Q63994-1]
    ENSMUST00000039861; ENSMUSP00000045458; ENSMUSG00000004609. [Q63994-2]
    GeneIDi12489.
    KEGGimmu:12489.
    UCSCiuc009gmy.2. mouse. [Q63994-2]
    uc009gna.1. mouse. [Q63994-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Siglec-3

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S71345 mRNA. Translation: AAB30842.1 .
    S71403 mRNA. Translation: AAB30843.2 .
    BC132379 mRNA. Translation: AAI32380.1 .
    CCDSi CCDS21173.1. [Q63994-2 ]
    CCDS52224.1. [Q63994-1 ]
    RefSeqi NP_001104528.1. NM_001111058.1. [Q63994-1 ]
    NP_067268.1. NM_021293.3. [Q63994-2 ]
    UniGenei Mm.140157.

    3D structure databases

    ProteinModelPortali Q63994.
    SMRi Q63994. Positions 21-232.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q63994.

    Proteomic databases

    PRIDEi Q63994.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004728 ; ENSMUSP00000004728 ; ENSMUSG00000004609 . [Q63994-1 ]
    ENSMUST00000039861 ; ENSMUSP00000045458 ; ENSMUSG00000004609 . [Q63994-2 ]
    GeneIDi 12489.
    KEGGi mmu:12489.
    UCSCi uc009gmy.2. mouse. [Q63994-2 ]
    uc009gna.1. mouse. [Q63994-1 ]

    Organism-specific databases

    CTDi 945.
    MGIi MGI:99440. Cd33.

    Phylogenomic databases

    eggNOGi NOG320441.
    GeneTreei ENSGT00560000076846.
    HOGENOMi HOG000236324.
    InParanoidi Q63994.
    KOi K06473.
    OMAi HEDSPVA.
    OrthoDBi EOG73JKV5.
    PhylomeDBi Q63994.
    TreeFami TF332441.

    Miscellaneous databases

    NextBioi 281404.
    PROi Q63994.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q63994.
    CleanExi MM_CD33.
    Genevestigatori Q63994.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of two isoforms of the murine homolog of the myeloid CD33 antigen."
      Tchilian E.Z., Beverley P.C., Young B.D., Watt S.M.
      Blood 83:3188-3198(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 33-A AND 33-B).
      Strain: BALB/c.
      Tissue: Bone marrow.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 33-A).
      Tissue: Brain.

    Entry informationi

    Entry nameiCD33_MOUSE
    AccessioniPrimary (citable) accession number: Q63994
    Secondary accession number(s): A2RT59, Q63997
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3