Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Endoglin

Gene

Eng

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells.1 Publication

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: MGI
  • artery morphogenesis Source: BHF-UCL
  • atrial cardiac muscle tissue morphogenesis Source: BHF-UCL
  • atrioventricular canal morphogenesis Source: BHF-UCL
  • bone development Source: Ensembl
  • cardiac atrium morphogenesis Source: BHF-UCL
  • cardiac ventricle morphogenesis Source: BHF-UCL
  • cell adhesion Source: UniProtKB-KW
  • cell migration involved in endocardial cushion formation Source: MGI
  • cellular response to mechanical stimulus Source: Ensembl
  • central nervous system vasculogenesis Source: MGI
  • chronological cell aging Source: BHF-UCL
  • dorsal aorta morphogenesis Source: BHF-UCL
  • endocardial cushion morphogenesis Source: BHF-UCL
  • epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
  • extracellular matrix constituent secretion Source: Ensembl
  • heart development Source: MGI
  • heart looping Source: BHF-UCL
  • negative regulation of cell migration Source: MGI
  • negative regulation of gene expression Source: BHF-UCL
  • negative regulation of protein autophosphorylation Source: MGI
  • outflow tract septum morphogenesis Source: BHF-UCL
  • patterning of blood vessels Source: BHF-UCL
  • positive regulation of angiogenesis Source: DFLAT
  • positive regulation of BMP signaling pathway Source: MGI
  • positive regulation of collagen biosynthetic process Source: Ensembl
  • positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
  • positive regulation of protein phosphorylation Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of vascular smooth muscle cell differentiation Source: BHF-UCL
  • regulation of transcription, DNA-templated Source: MGI
  • regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  • response to corticosteroid Source: Ensembl
  • smooth muscle tissue development Source: BHF-UCL
  • transforming growth factor beta receptor signaling pathway Source: BHF-UCL
  • vascular smooth muscle cell development Source: BHF-UCL
  • vasculogenesis Source: BHF-UCL
  • venous blood vessel morphogenesis Source: BHF-UCL
  • ventricular trabecula myocardium morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Angiogenesis, Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglin
Alternative name(s):
Cell surface MJ7/18 antigen
CD_antigen: CD105
Gene namesi
Name:Eng
Synonyms:Edg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:95392. Eng.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 581ExtracellularSequence analysisAdd BLAST555
Transmembranei582 – 606HelicalSequence analysisAdd BLAST25
Topological domaini607 – 653CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002115727 – 653EndoglinAdd BLAST627

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi89N-linked (GlcNAc...)Sequence analysis1
Glycosylationi135N-linked (GlcNAc...)Sequence analysis1
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1
Glycosylationi307N-linked (GlcNAc...)Sequence analysis1
Glycosylationi322N-linked (GlcNAc...)Sequence analysis1
Modified residuei641Phosphoserine; by TGFBR11 Publication1
Modified residuei644Phosphoserine; by TGFBR11 Publication1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ63961.
MaxQBiQ63961.
PaxDbiQ63961.
PRIDEiQ63961.

PTM databases

iPTMnetiQ63961.
PhosphoSitePlusiQ63961.

Expressioni

Tissue specificityi

Endoglin is restricted to endothelial cells in all tissues except bone marrow and is also found in stromal cells within the connective tissue of intestine, stomach, heart, skeletal muscle, uterus, ovary, oviduct, testis and thymus.

Gene expression databases

BgeeiENSMUSG00000026814.
CleanExiMM_ENG.
ExpressionAtlasiQ63961. baseline and differential.
GenevisibleiQ63961. MM.

Interactioni

Subunit structurei

Homodimer that forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2. Interacts with GDF2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-47636N.
IntActiQ63961. 6 interactors.
MINTiMINT-4116867.
STRINGi10090.ENSMUSP00000009705.

Structurei

3D structure databases

ProteinModelPortaliQ63961.
SMRiQ63961.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi336 – 574Ser/Thr-richAdd BLAST239

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQ57. Eukaryota.
ENOG410YK9H. LUCA.
GeneTreeiENSGT00530000063861.
HOGENOMiHOG000112346.
HOVERGENiHBG005573.
InParanoidiQ63961.
KOiK06526.
OMAiMGHTLEW.
OrthoDBiEOG091G030O.
TreeFamiTF337375.

Family and domain databases

InterProiIPR001507. ZP_dom.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63961-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRGVLPLPI TLLFVIYSFV PTTGLAERVG CDLQPVDPTR GEVTFTTSQV
60 70 80 90 100
SEGCVAQAAN AVREVHVLFL DFPGMLSHLE LTLQASKQNG TETQEVFLVL
110 120 130 140 150
VSNKNVFVKF QAPEIPLHLA YDSSLVIFQG QPRVNITVLP SLTSRKQILD
160 170 180 190 200
WAATKGAITS IAALDDPQSI VLQLGQDPKA PFLCLPEAHK DMGATLEWQP
210 220 230 240 250
RAQTPVQSCR LEGVSGHKEA YILRILPGSE AGPRTVTVMM ELSCTSGDAI
260 270 280 290 300
LILHGPPYVS WFIDINHSMQ ILTTGEYSVK IFPGSKVKGV ELPDTPQGLI
310 320 330 340 350
AEARKLNASI VTSFVELPLV SNVSLRASSC GGVFQTTPAP VVTTPPKDTC
360 370 380 390 400
SPVLLMSLIQ PKCGNQVMTL ALNKKHVQTL QCTITGLTFW DSSCQAEDTD
410 420 430 440 450
DHLVLSSAYS SCGMKVTAHV VSNEVIISFP SGSPPLRKKV QCIDMDSLSF
460 470 480 490 500
QLGLYLSPHF LQASNTIELG QQAFVQVSVS PLTSEVTVQL DSCHLDLGPE
510 520 530 540 550
GDMVELIQSR TAKGSCVTLL SPSPEGDPRF SFLLRVYMVP TPTAGTLSCN
560 570 580 590 600
LALRPSTLSQ EVYKTVSMRL NIVSPDLSGK GLVLPSVLGI TFGAFLIGAL
610 620 630 640 650
LTAALWYIYS HTRGPSKREP VVAVAAPASS ESSSTNHSIG STQSTPCSTS

SMA
Length:653
Mass (Da):70,021
Last modified:July 27, 2011 - v2
Checksum:iAD9DD2F823FB06A1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94Q → R in CAA54917 (PubMed:8194490).Curated1
Sequence conflicti287V → D in AAB30196 (PubMed:8125301).Curated1
Sequence conflicti572I → V in CAA54917 (PubMed:8194490).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69407 mRNA. Translation: AAB30196.1.
X77952 mRNA. Translation: CAA54917.1.
AL772271 Genomic DNA. Translation: CAM16615.1.
CH466542 Genomic DNA. Translation: EDL08562.1.
BC029080 mRNA. Translation: AAH29080.1.
CCDSiCCDS15925.1.
PIRiI48341.
RefSeqiNP_031958.2. NM_007932.2.
UniGeneiMm.225297.

Genome annotation databases

EnsembliENSMUST00000009705; ENSMUSP00000009705; ENSMUSG00000026814.
GeneIDi13805.
KEGGimmu:13805.
UCSCiuc008jgk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69407 mRNA. Translation: AAB30196.1.
X77952 mRNA. Translation: CAA54917.1.
AL772271 Genomic DNA. Translation: CAM16615.1.
CH466542 Genomic DNA. Translation: EDL08562.1.
BC029080 mRNA. Translation: AAH29080.1.
CCDSiCCDS15925.1.
PIRiI48341.
RefSeqiNP_031958.2. NM_007932.2.
UniGeneiMm.225297.

3D structure databases

ProteinModelPortaliQ63961.
SMRiQ63961.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-47636N.
IntActiQ63961. 6 interactors.
MINTiMINT-4116867.
STRINGi10090.ENSMUSP00000009705.

PTM databases

iPTMnetiQ63961.
PhosphoSitePlusiQ63961.

Proteomic databases

EPDiQ63961.
MaxQBiQ63961.
PaxDbiQ63961.
PRIDEiQ63961.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009705; ENSMUSP00000009705; ENSMUSG00000026814.
GeneIDi13805.
KEGGimmu:13805.
UCSCiuc008jgk.2. mouse.

Organism-specific databases

CTDi2022.
MGIiMGI:95392. Eng.

Phylogenomic databases

eggNOGiENOG410IQ57. Eukaryota.
ENOG410YK9H. LUCA.
GeneTreeiENSGT00530000063861.
HOGENOMiHOG000112346.
HOVERGENiHBG005573.
InParanoidiQ63961.
KOiK06526.
OMAiMGHTLEW.
OrthoDBiEOG091G030O.
TreeFamiTF337375.

Miscellaneous databases

PROiQ63961.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026814.
CleanExiMM_ENG.
ExpressionAtlasiQ63961. baseline and differential.
GenevisibleiQ63961. MM.

Family and domain databases

InterProiIPR001507. ZP_dom.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEGLN_MOUSE
AccessioniPrimary (citable) accession number: Q63961
Secondary accession number(s): Q61520, Q8K100
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.