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Q63955

- PO4F3_MOUSE

UniProt

Q63955 - PO4F3_MOUSE

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Protein

POU domain, class 4, transcription factor 3

Gene

Pou4f3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in determining or maintaining the identities of a small subset of visual system neurons.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi274 – 33360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  4. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. auditory receptor cell differentiation Source: MGI
  2. axon extension Source: MGI
  3. inner ear development Source: MGI
  4. inner ear morphogenesis Source: MGI
  5. inner ear receptor cell differentiation Source: MGI
  6. neuromuscular process controlling balance Source: MGI
  7. neuron apoptotic process Source: MGI
  8. regulation of transcription from RNA polymerase II promoter Source: MGI
  9. retinal ganglion cell axon guidance Source: MGI
  10. sensory perception of sound Source: MGI
  11. vestibulocochlear nerve development Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 4, transcription factor 3
Alternative name(s):
Brain-specific homeobox/POU domain protein 3C
Short name:
Brain-3C
Short name:
Brn-3C
Gene namesi
Name:Pou4f3
Synonyms:Brn-3c, Brn3c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:102523. Pou4f3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338POU domain, class 4, transcription factor 3PRO_0000100743Add
BLAST

Proteomic databases

PaxDbiQ63955.
PRIDEiQ63955.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiQ63955.
CleanExiMM_POU4F3.
GenevestigatoriQ63955.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025374.

Structurei

3D structure databases

ProteinModelPortaliQ63955.
SMRiQ63955. Positions 183-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini179 – 25678POU-specificPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi56 – 6510POU-IV box

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG289030.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000116305.
HOVERGENiHBG031829.
InParanoidiQ63955.
KOiK09366.
OMAiSHGKSHP.
OrthoDBiEOG7RV9G7.
TreeFamiTF316413.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63955-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMAMNAKQPF GMHPVLQEPK FSSLHSGSEA MRRVCLPAPQ LQGNIFGSFD
60 70 80 90 100
ESLLARAEAL AAVDIVSHGK NHPFKPDATY HTMSSVPCTS TSPTVPISHP
110 120 130 140 150
AALTSHPHHA VHQGLEGDLL EHISPTLSVS GLGAPEHSVM PAQIHPHHLG
160 170 180 190 200
AMGHLHQAMG MSHPHAVAPH SAMPACLSDV ESDPRELEAF AERFKQRRIK
210 220 230 240 250
LGVTQADVGA ALANLKIPGV GSLSQSTICR FESLTLSHNN MIALKPVLQA
260 270 280 290 300
WLEEAEAAYR EKNSKPELFN GSERKRKRTS IAAPEKRSLE AYFAIQPRPS
310 320 330
SEKIAAIAEK LDLKKNVVRV WFCNQRQKQK RMKYSAVH
Length:338
Mass (Da):37,016
Last modified:July 27, 2011 - v2
Checksum:i4B7C78BD788FB944
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 92QP → HR in AAB30579. (PubMed:8162704)Curated
Sequence conflicti55 – 551A → E no nucleotide entry (PubMed:8248179)Curated
Sequence conflicti158 – 1581A → P no nucleotide entry (PubMed:8248179)Curated
Sequence conflicti210 – 2101A → S no nucleotide entry (PubMed:8248179)Curated
Sequence conflicti338 – 3381H → D in AAB30579. (PubMed:8162704)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69352 Genomic DNA. Translation: AAB30579.1.
CH466528 Genomic DNA. Translation: EDL10035.1.
BC145941 mRNA. Translation: AAI45942.1.
CCDSiCCDS29212.1.
PIRiB49642.
RefSeqiNP_620395.2. NM_138945.2.
UniGeneiMm.488204.

Genome annotation databases

EnsembliENSMUST00000025374; ENSMUSP00000025374; ENSMUSG00000024497.
GeneIDi18998.
KEGGimmu:18998.
UCSCiuc008etv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69352 Genomic DNA. Translation: AAB30579.1 .
CH466528 Genomic DNA. Translation: EDL10035.1 .
BC145941 mRNA. Translation: AAI45942.1 .
CCDSi CCDS29212.1.
PIRi B49642.
RefSeqi NP_620395.2. NM_138945.2.
UniGenei Mm.488204.

3D structure databases

ProteinModelPortali Q63955.
SMRi Q63955. Positions 183-332.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000025374.

Proteomic databases

PaxDbi Q63955.
PRIDEi Q63955.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025374 ; ENSMUSP00000025374 ; ENSMUSG00000024497 .
GeneIDi 18998.
KEGGi mmu:18998.
UCSCi uc008etv.2. mouse.

Organism-specific databases

CTDi 5459.
MGIi MGI:102523. Pou4f3.

Phylogenomic databases

eggNOGi NOG289030.
GeneTreei ENSGT00760000118935.
HOGENOMi HOG000116305.
HOVERGENi HBG031829.
InParanoidi Q63955.
KOi K09366.
OMAi SHGKSHP.
OrthoDBi EOG7RV9G7.
TreeFami TF316413.

Miscellaneous databases

NextBioi 295406.
PROi Q63955.
SOURCEi Search...

Gene expression databases

Bgeei Q63955.
CleanExi MM_POU4F3.
Genevestigatori Q63955.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Chromosomal localization and sequences of the murine Brn-3 family of developmental control genes."
    Theil T., Zechner U., Klett C., Adolph S., Moeroey T.
    Cytogenet. Cell Genet. 66:267-271(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CD.
  2. "Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs."
    Gerrero M.R., McEvilly R.J., Turner E., Lin C.R., O'Connell S., Jenne K.J., Hobbs M.V., Rosenfeld M.G.
    Proc. Natl. Acad. Sci. U.S.A. 90:10841-10845(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPO4F3_MOUSE
AccessioniPrimary (citable) accession number: Q63955
Secondary accession number(s): A6H6N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3