Reviewed, UniProtKB/Swiss-Prot Q63955 (PO4F3_MOUSE)

Names and origin

Protein names

Recommended name:
    POU domain, class 4, transcription factor 3
Alternative name(s):
    Brain-specific homeobox/POU domain protein 3C
      Short name=Brn-3C

Gene names

Name:	Pou4f3
Synonyms:	Brn-3c, Brn3c

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May play a role in determining or maintaining the identities of a small subset of visual system neurons.
Subcellular location	Nucleus.
Tissue specificity	Brain.
Sequence similarities	Belongs to the POU transcription factor family. Class-4 subfamily. Contains 1 homeobox DNA-binding domain. Contains 1 POU-specific domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Gene Ontology (GO)
Biological process	auditory receptor cell differentiation Inferred from mutant phenotype. Source: MGI axon extension involved in development Inferred from genetic interaction. Source: MGI inner ear morphogenesis Inferred from mutant phenotype. Source: MGI neuromuscular process controlling balance Inferred from mutant phenotype. Source: MGI neuron apoptosis Inferred from mutant phenotype. Source: MGI regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: MGI retinal ganglion cell axon guidance Inferred from genetic interaction. Source: MGI sensory perception of sound Inferred from mutant phenotype. Source: MGI vestibulocochlear nerve development Inferred from mutant phenotype. Source: MGI
Cellular component	transcription factor complex Inferred by curator. Source: MGI
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	POU domain, class 4, transcription factor 3		PRO_0000100743
Regions
	Domain	179 – 256	78	POU-specific
	DNA binding	274 – 333	60	Homeobox
	Motif	56 – 65	10	POU-IV box
Experimental info
	Sequence conflict	8 – 9	2	HR → QP Ref.2
	Sequence conflict	55	1	A → E Ref.2
	Sequence conflict	158	1	A → P Ref.2
	Sequence conflict	210	1	A → S Ref.2
	Sequence conflict	338	1	D → H Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q63955-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 58E8AD0306AAAA18	FASTA	338	37,063
	10 20 30 40 50 60 MMAMNAKHRF GMHPVLQEPK FSSLHSGSEA MRRVCLPAPQ LQGNIFGSFD ESLLARAEAL 70 80 90 100 110 120 AAVDIVSHGK NHPFKPDATY HTMSSVPCTS TSPTVPISHP AALTSHPHHA VHQGLEGDLL 130 140 150 160 170 180 EHISPTLSVS GLGAPEHSVM PAQIHPHHLG AMGHLHQAMG MSHPHAVAPH SAMPACLSDV 190 200 210 220 230 240 ESDPRELEAF AERFKQRRIK LGVTQADVGA ALANLKIPGV GSLSQSTICR FESLTLSHNN 250 260 270 280 290 300 MIALKPVLQA WLEEAEAAYR EKNSKPELFN GSERKRKRTS IAAPEKRSLE AYFAIQPRPS 310 320 330 SEKIAAIAEK LDLKKNVVRV WFCNQRQKQK RMKYSAVD

References

[1]	"Chromosomal localization and sequences of the murine Brn-3 family of developmental control genes." Theil T., Zechner U., Klett C., Adolph S., Moeroey T. Cytogenet. Cell Genet. 66:267-271(1994) [PubMed: 8162704] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CD.
[2]	"Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs." Gerrero M.R., McEvilly R.J., Turner E., Lin C.R., O'Connell S., Jenne K.J., Hobbs M.V., Rosenfeld M.G. Proc. Natl. Acad. Sci. U.S.A. 90:10841-10845(1993) [PubMed: 8248179] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	S69352 Genomic DNA. Translation: AAB30579.1.
IPI	IPI00135756.
PIR	B49642.
RefSeq	NP_620395.1.
UniGene	Mm.221181
3D structure databases
HSSP	HSSP built from PDB template 1CQT based on UniProtKB P14859.
ModBase	Search...
Proteomic databases
PRIDE	Q63955.
Genome annotation databases
Ensembl	ENSMUSG00000024497. Mus musculus. [Contig view]
GeneID	18998.
KEGG	mmu:18998.
Organism-specific databases
MGI	MGI:102523. Pou4f3.
Phylogenomic databases
HOGENOM	Q63955.
HOVERGEN	Q63955.
Gene expression databases
ArrayExpress	Q63955.
Bgee	Q63955.
CleanEx	MM_POU4F3.
GermOnline	ENSMUSG00000024497. Mus musculus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. IPR013847. POU. IPR015584. POU_4_related. IPR000327. POU_specific. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
PANTHER	PTHR11636:SF10. POU_4_related. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. PF00157. Pou. 1 hit. [Graphical view]
PRINTS	PR00028. POUDOMAIN.
ProDom	PD000010. Homeobox. 1 hit. PD000583. POU. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. SM00352. POU. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00035. POU_1. 1 hit. PS00465. POU_2. 1 hit. PS51179. POU_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	295406.
SOURCE	Search...

Entry information

Entry name

PO4F3_MOUSE

Accession

Primary (citable) accession number: Q63955

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 5, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)