POU domain, class 4, transcription factor 3

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Q63955 (PO4F3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 97. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
POU domain, class 4, transcription factor 3

Alternative name(s):
Brain-specific homeobox/POU domain protein 3C
Short name=Brain-3C
Short name=Brn-3C

Gene names

Name:	Pou4f3
Synonyms:	Brn-3c, Brn3c

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in determining or maintaining the identities of a small subset of visual system neurons.
Subcellular location	Nucleus.
Tissue specificity	Brain.
Sequence similarities	Belongs to the POU transcription factor family. Class-4 subfamily. Contains 1 homeobox DNA-binding domain. Contains 1 POU-specific domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	auditory receptor cell differentiation Inferred from mutant phenotype. Source: MGI axon extension involved in development Inferred from genetic interaction. Source: MGI inner ear morphogenesis Inferred from mutant phenotype. Source: MGI neuromuscular process controlling balance Inferred from mutant phenotype. Source: MGI neuron apoptosis Inferred from mutant phenotype. Source: MGI regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: MGI retinal ganglion cell axon guidance Inferred from genetic interaction. Source: MGI sensory perception of sound Inferred from mutant phenotype. Source: MGI vestibulocochlear nerve development Inferred from mutant phenotype. Source: MGI
Cellular component	transcription factor complex Inferred by curator. Source: MGI
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 338

338

POU domain, class 4, transcription factor 3

PRO_0000100743

Regions

Domain

179 – 256

POU-specific

DNA binding

274 – 333

Homeobox

Motif

56 – 65

POU-IV box

Experimental info

Sequence conflict

8 – 9

QP → HR in AAB30579. Ref.1

Sequence conflict

A → E no nucleotide entry Ref.2

Sequence conflict

158

A → P no nucleotide entry Ref.2

Sequence conflict

210

A → S no nucleotide entry Ref.2

Sequence conflict

338

H → D in AAB30579. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q63955 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 4B7C78BD788FB944
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FASTA

338

37,016

        10         20         30         40         50         60 
MMAMNAKQPF GMHPVLQEPK FSSLHSGSEA MRRVCLPAPQ LQGNIFGSFD ESLLARAEAL 

        70         80         90        100        110        120 
AAVDIVSHGK NHPFKPDATY HTMSSVPCTS TSPTVPISHP AALTSHPHHA VHQGLEGDLL 

       130        140        150        160        170        180 
EHISPTLSVS GLGAPEHSVM PAQIHPHHLG AMGHLHQAMG MSHPHAVAPH SAMPACLSDV 

       190        200        210        220        230        240 
ESDPRELEAF AERFKQRRIK LGVTQADVGA ALANLKIPGV GSLSQSTICR FESLTLSHNN 

       250        260        270        280        290        300 
MIALKPVLQA WLEEAEAAYR EKNSKPELFN GSERKRKRTS IAAPEKRSLE AYFAIQPRPS 

       310        320        330 
SEKIAAIAEK LDLKKNVVRV WFCNQRQKQK RMKYSAVH

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Chromosomal localization and sequences of the murine Brn-3 family of developmental control genes." Theil T., Zechner U., Klett C., Adolph S., Moeroey T. Cytogenet. Cell Genet. 66:267-271(1994) [PubMed: 8162704] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CD.
[2]	"Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs." Gerrero M.R., McEvilly R.J., Turner E., Lin C.R., O'Connell S., Jenne K.J., Hobbs M.V., Rosenfeld M.G. Proc. Natl. Acad. Sci. U.S.A. 90:10841-10845(1993) [PubMed: 8248179] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Brain.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S69352 Genomic DNA. Translation: AAB30579.1. CH466528 Genomic DNA. Translation: EDL10035.1. BC145941 mRNA. Translation: AAI45942.1.
IPI	IPI00135756.
PIR	B49642.
RefSeq	NP_620395.2. NM_138945.2.
UniGene	Mm.221181.
3D structure databases
ProteinModelPortal	Q63955.
SMR	Q63955. Positions 181-331.
ModBase	Search...
Protein-protein interaction databases
STRING	Q63955.
Proteomic databases
PRIDE	Q63955.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000025374; ENSMUSP00000025374; ENSMUSG00000024497.
GeneID	18998.
KEGG	mmu:18998.
Organism-specific databases
CTD	5459.
MGI	MGI:102523. Pou4f3.
Phylogenomic databases
eggNOG	maNOG16644.
GeneTree	ENSGT00580000081294.
HOGENOM	HBG714425.
HOVERGEN	HBG031829.
InParanoid	Q63955.
OrthoDB	EOG4NP745.
Gene expression databases
ArrayExpress	Q63955.
Bgee	Q63955.
CleanEx	MM_POU4F3.
Genevestigator	Q63955.
GermOnline	ENSMUSG00000024497. Mus musculus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. IPR010982. Lambda_DNA-bd. IPR013847. POU. IPR015584. POU4-related. IPR000327. POU_specific. [Graphical view]
Gene3D	G3DSA:1.10.260.40. G3DSA:1.10.260.40. 1 hit. G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KO	K09366.
PANTHER	PTHR11636:SF10. POU_4_related. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. PF00157. Pou. 1 hit. [Graphical view]
PRINTS	PR00028. POUDOMAIN.
SMART	SM00389. HOX. 1 hit. SM00352. POU. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit. SSF47413. Lambda_like_DNA. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00035. POU_1. 1 hit. PS00465. POU_2. 1 hit. PS51179. POU_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	295406.
SOURCE	Search...

Entry information

Entry name

PO4F3_MOUSE

Accession

Primary (citable) accession number: Q63955
Secondary accession number(s): A6H6N6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 27, 2011
Last modified:	December 14, 2011
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents