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Q63955 (PO4F3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 4, transcription factor 3
Alternative name(s):
Brain-specific homeobox/POU domain protein 3C
Short name=Brain-3C
Short name=Brn-3C
Gene names
Name:Pou4f3
Synonyms:Brn-3c, Brn3c
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in determining or maintaining the identities of a small subset of visual system neurons.

Subcellular location

Nucleus.

Tissue specificity

Brain.

Sequence similarities

Belongs to the POU transcription factor family. Class-4 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Keywords
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processauditory receptor cell differentiation

Inferred from mutant phenotype PubMed 12585968PubMed 8637595. Source: MGI

axon extension

Inferred from genetic interaction PubMed 11807038. Source: MGI

inner ear morphogenesis

Inferred from mutant phenotype PubMed 12585968. Source: MGI

neuromuscular process controlling balance

Inferred from mutant phenotype PubMed 8637595PubMed 9256502. Source: MGI

neuron apoptotic process

Inferred from mutant phenotype PubMed 9735355. Source: MGI

regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 15465029. Source: MGI

retinal ganglion cell axon guidance

Inferred from genetic interaction PubMed 11807038. Source: MGI

sensory perception of sound

Inferred from mutant phenotype PubMed 8637595PubMed 9256502. Source: MGI

vestibulocochlear nerve development

Inferred from mutant phenotype PubMed 12585968. Source: MGI

   Cellular_componentnucleus

Inferred from direct assay PubMed 7623109. Source: UniProtKB

transcription factor complex

Inferred by curator PubMed 15465029. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 15465029. Source: MGI

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 15465029. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338POU domain, class 4, transcription factor 3
PRO_0000100743

Regions

Domain179 – 25678POU-specific
DNA binding274 – 33360Homeobox
Motif56 – 6510POU-IV box

Experimental info

Sequence conflict8 – 92QP → HR in AAB30579. Ref.1
Sequence conflict551A → E no nucleotide entry Ref.2
Sequence conflict1581A → P no nucleotide entry Ref.2
Sequence conflict2101A → S no nucleotide entry Ref.2
Sequence conflict3381H → D in AAB30579. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q63955 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 4B7C78BD788FB944

FASTA33837,016
        10         20         30         40         50         60 
MMAMNAKQPF GMHPVLQEPK FSSLHSGSEA MRRVCLPAPQ LQGNIFGSFD ESLLARAEAL 

        70         80         90        100        110        120 
AAVDIVSHGK NHPFKPDATY HTMSSVPCTS TSPTVPISHP AALTSHPHHA VHQGLEGDLL 

       130        140        150        160        170        180 
EHISPTLSVS GLGAPEHSVM PAQIHPHHLG AMGHLHQAMG MSHPHAVAPH SAMPACLSDV 

       190        200        210        220        230        240 
ESDPRELEAF AERFKQRRIK LGVTQADVGA ALANLKIPGV GSLSQSTICR FESLTLSHNN 

       250        260        270        280        290        300 
MIALKPVLQA WLEEAEAAYR EKNSKPELFN GSERKRKRTS IAAPEKRSLE AYFAIQPRPS 

       310        320        330 
SEKIAAIAEK LDLKKNVVRV WFCNQRQKQK RMKYSAVH 

« Hide

References

« Hide 'large scale' references
[1]"Chromosomal localization and sequences of the murine Brn-3 family of developmental control genes."
Theil T., Zechner U., Klett C., Adolph S., Moeroey T.
Cytogenet. Cell Genet. 66:267-271(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CD.
[2]"Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs."
Gerrero M.R., McEvilly R.J., Turner E., Lin C.R., O'Connell S., Jenne K.J., Hobbs M.V., Rosenfeld M.G.
Proc. Natl. Acad. Sci. U.S.A. 90:10841-10845(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Brain.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S69352 Genomic DNA. Translation: AAB30579.1.
CH466528 Genomic DNA. Translation: EDL10035.1.
BC145941 mRNA. Translation: AAI45942.1.
PIRB49642.
RefSeqNP_620395.2. NM_138945.2.
UniGeneMm.488204.

3D structure databases

ProteinModelPortalQ63955.
SMRQ63955. Positions 183-332.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000025374.

Proteomic databases

PaxDbQ63955.
PRIDEQ63955.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025374; ENSMUSP00000025374; ENSMUSG00000024497.
GeneID18998.
KEGGmmu:18998.
UCSCuc008etv.2. mouse.

Organism-specific databases

CTD5459.
MGIMGI:102523. Pou4f3.

Phylogenomic databases

eggNOGNOG289030.
GeneTreeENSGT00730000110439.
HOGENOMHOG000116305.
HOVERGENHBG031829.
InParanoidA6H6N6.
KOK09366.
OMASHGKSHP.
OrthoDBEOG7RV9G7.
TreeFamTF316413.

Gene expression databases

BgeeQ63955.
CleanExMM_POU4F3.
GenevestigatorQ63955.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio295406.
PROQ63955.
SOURCESearch...

Entry information

Entry namePO4F3_MOUSE
AccessionPrimary (citable) accession number: Q63955
Secondary accession number(s): A6H6N6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: February 19, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot