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Q63955

- PO4F3_MOUSE

UniProt

Q63955 - PO4F3_MOUSE

Protein

POU domain, class 4, transcription factor 3

Gene

Pou4f3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May play a role in determining or maintaining the identities of a small subset of visual system neurons.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi274 – 33360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. auditory receptor cell differentiation Source: MGI
    2. axon extension Source: MGI
    3. inner ear development Source: MGI
    4. inner ear morphogenesis Source: MGI
    5. inner ear receptor cell differentiation Source: MGI
    6. neuromuscular process controlling balance Source: MGI
    7. neuron apoptotic process Source: MGI
    8. regulation of transcription from RNA polymerase II promoter Source: MGI
    9. retinal ganglion cell axon guidance Source: MGI
    10. sensory perception of sound Source: MGI
    11. vestibulocochlear nerve development Source: MGI

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 4, transcription factor 3
    Alternative name(s):
    Brain-specific homeobox/POU domain protein 3C
    Short name:
    Brain-3C
    Short name:
    Brn-3C
    Gene namesi
    Name:Pou4f3
    Synonyms:Brn-3c, Brn3c
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:102523. Pou4f3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 338338POU domain, class 4, transcription factor 3PRO_0000100743Add
    BLAST

    Proteomic databases

    PaxDbiQ63955.
    PRIDEiQ63955.

    Expressioni

    Tissue specificityi

    Brain.

    Gene expression databases

    BgeeiQ63955.
    CleanExiMM_POU4F3.
    GenevestigatoriQ63955.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000025374.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63955.
    SMRiQ63955. Positions 183-332.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini179 – 25678POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi56 – 6510POU-IV box

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG289030.
    GeneTreeiENSGT00750000117482.
    HOGENOMiHOG000116305.
    HOVERGENiHBG031829.
    InParanoidiA6H6N6.
    KOiK09366.
    OMAiSHGKSHP.
    OrthoDBiEOG7RV9G7.
    TreeFamiTF316413.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q63955-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMAMNAKQPF GMHPVLQEPK FSSLHSGSEA MRRVCLPAPQ LQGNIFGSFD    50
    ESLLARAEAL AAVDIVSHGK NHPFKPDATY HTMSSVPCTS TSPTVPISHP 100
    AALTSHPHHA VHQGLEGDLL EHISPTLSVS GLGAPEHSVM PAQIHPHHLG 150
    AMGHLHQAMG MSHPHAVAPH SAMPACLSDV ESDPRELEAF AERFKQRRIK 200
    LGVTQADVGA ALANLKIPGV GSLSQSTICR FESLTLSHNN MIALKPVLQA 250
    WLEEAEAAYR EKNSKPELFN GSERKRKRTS IAAPEKRSLE AYFAIQPRPS 300
    SEKIAAIAEK LDLKKNVVRV WFCNQRQKQK RMKYSAVH 338
    Length:338
    Mass (Da):37,016
    Last modified:July 27, 2011 - v2
    Checksum:i4B7C78BD788FB944
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 92QP → HR in AAB30579. (PubMed:8162704)Curated
    Sequence conflicti55 – 551A → E no nucleotide entry (PubMed:8248179)Curated
    Sequence conflicti158 – 1581A → P no nucleotide entry (PubMed:8248179)Curated
    Sequence conflicti210 – 2101A → S no nucleotide entry (PubMed:8248179)Curated
    Sequence conflicti338 – 3381H → D in AAB30579. (PubMed:8162704)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S69352 Genomic DNA. Translation: AAB30579.1.
    CH466528 Genomic DNA. Translation: EDL10035.1.
    BC145941 mRNA. Translation: AAI45942.1.
    CCDSiCCDS29212.1.
    PIRiB49642.
    RefSeqiNP_620395.2. NM_138945.2.
    UniGeneiMm.488204.

    Genome annotation databases

    EnsembliENSMUST00000025374; ENSMUSP00000025374; ENSMUSG00000024497.
    GeneIDi18998.
    KEGGimmu:18998.
    UCSCiuc008etv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S69352 Genomic DNA. Translation: AAB30579.1 .
    CH466528 Genomic DNA. Translation: EDL10035.1 .
    BC145941 mRNA. Translation: AAI45942.1 .
    CCDSi CCDS29212.1.
    PIRi B49642.
    RefSeqi NP_620395.2. NM_138945.2.
    UniGenei Mm.488204.

    3D structure databases

    ProteinModelPortali Q63955.
    SMRi Q63955. Positions 183-332.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000025374.

    Proteomic databases

    PaxDbi Q63955.
    PRIDEi Q63955.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025374 ; ENSMUSP00000025374 ; ENSMUSG00000024497 .
    GeneIDi 18998.
    KEGGi mmu:18998.
    UCSCi uc008etv.2. mouse.

    Organism-specific databases

    CTDi 5459.
    MGIi MGI:102523. Pou4f3.

    Phylogenomic databases

    eggNOGi NOG289030.
    GeneTreei ENSGT00750000117482.
    HOGENOMi HOG000116305.
    HOVERGENi HBG031829.
    InParanoidi A6H6N6.
    KOi K09366.
    OMAi SHGKSHP.
    OrthoDBi EOG7RV9G7.
    TreeFami TF316413.

    Miscellaneous databases

    NextBioi 295406.
    PROi Q63955.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q63955.
    CleanExi MM_POU4F3.
    Genevestigatori Q63955.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chromosomal localization and sequences of the murine Brn-3 family of developmental control genes."
      Theil T., Zechner U., Klett C., Adolph S., Moeroey T.
      Cytogenet. Cell Genet. 66:267-271(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: CD.
    2. "Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs."
      Gerrero M.R., McEvilly R.J., Turner E., Lin C.R., O'Connell S., Jenne K.J., Hobbs M.V., Rosenfeld M.G.
      Proc. Natl. Acad. Sci. U.S.A. 90:10841-10845(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Brain.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiPO4F3_MOUSE
    AccessioniPrimary (citable) accession number: Q63955
    Secondary accession number(s): A6H6N6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3