Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

POU domain, class 4, transcription factor 3

Gene

Pou4f3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor (PubMed:8290353). Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (PubMed:8637595).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi274 – 333HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • auditory receptor cell differentiation Source: MGI
  • axon extension Source: MGI
  • inner ear development Source: MGI
  • inner ear morphogenesis Source: MGI
  • inner ear receptor cell differentiation Source: MGI
  • neuromuscular process controlling balance Source: MGI
  • neuron apoptotic process Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • retinal ganglion cell axon guidance Source: MGI
  • sensory perception of sound Source: MGI
  • vestibulocochlear nerve development Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 4, transcription factor 3Imported
Alternative name(s):
Brain-specific homeobox/POU domain protein 3C
Short name:
Brain-3C
Short name:
Brn-3C
Brn-3.11 Publication
Gene namesi
Name:Pou4f3Imported
Synonyms:Brn-3.11 Publication, Brn-3cImported, Brn3cImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:102523. Pou4f3.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: MGI
  • nucleus Source: UniProtKB
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mutants are deaf and show deficits in balance and coordination that become severe at about P14 and exhibit hyperactivity by 5-6 weeks.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007431 – 338POU domain, class 4, transcription factor 3Add BLAST338

Proteomic databases

PaxDbiQ63955.
PRIDEiQ63955.

PTM databases

PhosphoSitePlusiQ63955.

Expressioni

Tissue specificityi

Brain.

Developmental stagei

Expressed in developing spinal cord from E13 to postanal day 1, not expressed in adults (PubMed:8290353). Expressed by few neurons of dorsal root ganglion from, at least, E10.5 to E15.5 (PubMed:22326227).2 Publications

Gene expression databases

BgeeiENSMUSG00000024497.
CleanExiMM_POU4F3.
GenevisibleiQ63955. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025374.

Structurei

3D structure databases

ProteinModelPortaliQ63955.
SMRiQ63955.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 256POU-specificPROSITE-ProRule annotationAdd BLAST78

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi56 – 65POU-IV box10

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG1168. Eukaryota.
ENOG410XPNX. LUCA.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000116305.
HOVERGENiHBG031829.
InParanoidiQ63955.
KOiK09366.
OMAiDVTYHTM.
OrthoDBiEOG091G0WBK.
TreeFamiTF316413.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR032961. POU4F3.
IPR000327. POU_dom.
[Graphical view]
PANTHERiPTHR11636:SF43. PTHR11636:SF43. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63955-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAMNAKQPF GMHPVLQEPK FSSLHSGSEA MRRVCLPAPQ LQGNIFGSFD
60 70 80 90 100
ESLLARAEAL AAVDIVSHGK NHPFKPDATY HTMSSVPCTS TSPTVPISHP
110 120 130 140 150
AALTSHPHHA VHQGLEGDLL EHISPTLSVS GLGAPEHSVM PAQIHPHHLG
160 170 180 190 200
AMGHLHQAMG MSHPHAVAPH SAMPACLSDV ESDPRELEAF AERFKQRRIK
210 220 230 240 250
LGVTQADVGA ALANLKIPGV GSLSQSTICR FESLTLSHNN MIALKPVLQA
260 270 280 290 300
WLEEAEAAYR EKNSKPELFN GSERKRKRTS IAAPEKRSLE AYFAIQPRPS
310 320 330
SEKIAAIAEK LDLKKNVVRV WFCNQRQKQK RMKYSAVH
Length:338
Mass (Da):37,016
Last modified:July 27, 2011 - v2
Checksum:i4B7C78BD788FB944
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8 – 9QP → HR in AAB30579 (PubMed:8162704).Curated2
Sequence conflicti55A → E no nucleotide entry (PubMed:8248179).Curated1
Sequence conflicti158A → P no nucleotide entry (PubMed:8248179).Curated1
Sequence conflicti210A → S no nucleotide entry (PubMed:8248179).Curated1
Sequence conflicti338H → D in AAB30579 (PubMed:8162704).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69352 Genomic DNA. Translation: AAB30579.1.
CH466528 Genomic DNA. Translation: EDL10035.1.
BC145941 mRNA. Translation: AAI45942.1.
CCDSiCCDS29212.1.
PIRiB49642.
RefSeqiNP_620395.2. NM_138945.2.
UniGeneiMm.488204.

Genome annotation databases

EnsembliENSMUST00000025374; ENSMUSP00000025374; ENSMUSG00000024497.
GeneIDi18998.
KEGGimmu:18998.
UCSCiuc008etv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69352 Genomic DNA. Translation: AAB30579.1.
CH466528 Genomic DNA. Translation: EDL10035.1.
BC145941 mRNA. Translation: AAI45942.1.
CCDSiCCDS29212.1.
PIRiB49642.
RefSeqiNP_620395.2. NM_138945.2.
UniGeneiMm.488204.

3D structure databases

ProteinModelPortaliQ63955.
SMRiQ63955.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025374.

PTM databases

PhosphoSitePlusiQ63955.

Proteomic databases

PaxDbiQ63955.
PRIDEiQ63955.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025374; ENSMUSP00000025374; ENSMUSG00000024497.
GeneIDi18998.
KEGGimmu:18998.
UCSCiuc008etv.2. mouse.

Organism-specific databases

CTDi5459.
MGIiMGI:102523. Pou4f3.

Phylogenomic databases

eggNOGiKOG1168. Eukaryota.
ENOG410XPNX. LUCA.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000116305.
HOVERGENiHBG031829.
InParanoidiQ63955.
KOiK09366.
OMAiDVTYHTM.
OrthoDBiEOG091G0WBK.
TreeFamiTF316413.

Miscellaneous databases

PROiQ63955.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024497.
CleanExiMM_POU4F3.
GenevisibleiQ63955. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR032961. POU4F3.
IPR000327. POU_dom.
[Graphical view]
PANTHERiPTHR11636:SF43. PTHR11636:SF43. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPO4F3_MOUSE
AccessioniPrimary (citable) accession number: Q63955
Secondary accession number(s): A6H6N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.