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Q63942 (RAB3D_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP-binding protein Rab-3D
Gene names
Name:Rab3d
Synonyms:Rab16
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Protein transport. Probably involved in regulated exocytosis By similarity.

Subunit structure

Interacts with RIMS1, RIMS2, RPH3A and RPH3AL By similarity. Interacts with RAB3IP. Ref.5

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Tissue specificity

Highest levels found in lung. Ref.4

Post-translational modification

In fetal glands the majority of the proteins are methylated, whereas in neonatal and adult glands, only 50% are methylated. Ref.6

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 219218GTP-binding protein Rab-3D
PRO_0000121090

Regions

Nucleotide binding29 – 379GTP By similarity
Nucleotide binding77 – 815GTP By similarity
Nucleotide binding135 – 1384GTP By similarity
Nucleotide binding165 – 1673GTP By similarity
Motif51 – 599Effector region By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue2191Cysteine methyl ester; partial Ref.6
Lipidation2171S-geranylgeranyl cysteine By similarity
Lipidation2191S-geranylgeranyl cysteine By similarity

Experimental info

Sequence conflict2051A → S in AAA41996. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q63942 [UniParc].

Last modified November 1, 1998. Version 2.
Checksum: ED82C97D66BF194A

FASTA21924,290
        10         20         30         40         50         60 
MASASEPPAS PRDAADQNFD YMFKLLLIGN SSVGKTSFLF RYADDSFTPA FVSTVGIDFK 

        70         80         90        100        110        120 
VKTVYRHDKR IKLQIWDTAG QERYRTITTA YYRGAMGFLL MYDIANQESF TAVQDWATQI 

       130        140        150        160        170        180 
KTYSWDNAQV ILVGNKCDLE DERVVSAEDG QRLAGDLGFE FFEASAKENI NVKQVFERLV 

       190        200        210 
DIICDKMNES LEPSSSPGSN GKGPALGDTP PPQPSSCGC 

« Hide

References

« Hide 'large scale' references
[1]"Involvement of the ras-like GTPase rab3d in RBL-2H3 mast cell exocytosis following stimulation via high affinity IgE receptors (Fc epsilonRI)."
Roa M., Paumet F., le Mao J., David B., Blank U.
J. Immunol. 159:2815-2823(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[3]"RT-PCR cloning of Rab3 isoforms expressed in peritoneal mast cells."
Oberhauser A.F., Balan V., Fernandez-Badilla C.L., Fernandez J.M.
FEBS Lett. 339:171-174(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-82.
Tissue: Mast cell.
[4]"Rab15, a novel low molecular weight GTP-binding protein specifically expressed in rat brain."
Elferink L.A., Anzai K., Scheller R.H.
J. Biol. Chem. 267:5768-5775(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-219, TISSUE SPECIFICITY.
Strain: Sprague-Dawley.
Tissue: Brain.
[5]"Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A."
Brondyk W.H., McKiernan C.J., Fortner K.A., Stabila P., Holz R.W., Macara I.G.
Mol. Cell. Biol. 15:1137-1143(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RAB3IP.
[6]"Carboxyl methylation of rab3D is developmentally regulated in the rat pancreas: correlation with exocrine function."
Valentijn J.A., Jamieson J.D.
Eur. J. Cell Biol. 76:204-211(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: METHYLATION AT CYS-219.
Tissue: Pancreas.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U90206 mRNA. Translation: AAB81202.1.
BC081741 mRNA. Translation: AAH81741.1.
S68808 mRNA. Translation: AAB29895.1.
M83681 mRNA. Translation: AAA41996.1.
PIRI67631.
RefSeqNP_542147.1. NM_080580.2.
XP_006242656.1. XM_006242594.1.
XP_006242657.1. XM_006242595.1.
UniGeneRn.9822.

3D structure databases

ProteinModelPortalQ63942.
SMRQ63942. Positions 20-189.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ63942. 1 interaction.
MINTMINT-1506189.

PTM databases

PhosphoSiteQ63942.

Proteomic databases

PaxDbQ63942.
PRIDEQ63942.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000015609; ENSRNOP00000015609; ENSRNOG00000011582.
GeneID140665.
KEGGrno:140665.
UCSCRGD:620924. rat.

Organism-specific databases

CTD9545.
RGD620924. Rab3d.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00740000115041.
HOGENOMHOG000233968.
HOVERGENHBG009351.
InParanoidQ63942.
KOK07884.
OMAEPSSCSC.
OrthoDBEOG7JQBPC.
PhylomeDBQ63942.
TreeFamTF313199.

Gene expression databases

GenevestigatorQ63942.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio620635.
PROQ63942.

Entry information

Entry nameRAB3D_RAT
AccessionPrimary (citable) accession number: Q63942
Secondary accession number(s): P35291
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: June 11, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families