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Q63942

- RAB3D_RAT

UniProt

Q63942 - RAB3D_RAT

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Protein

GTP-binding protein Rab-3D

Gene
Rab3d, Rab16
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in regulated exocytosis By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 379GTP By similarity
Nucleotide bindingi77 – 815GTP By similarity
Nucleotide bindingi135 – 1384GTP By similarity
Nucleotide bindingi165 – 1673GTP By similarity

GO - Molecular functioni

  1. GTPase binding Source: RGD
  2. GTP binding Source: UniProtKB-KW
  3. protein binding Source: UniProtKB

GO - Biological processi

  1. exocytosis Source: UniProtKB-KW
  2. peptidyl-cysteine methylation Source: Ensembl
  3. protein transport Source: UniProtKB-KW
  4. regulation of exocytosis Source: Ensembl
  5. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein Rab-3D
Gene namesi
Name:Rab3d
Synonyms:Rab16
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi620924. Rab3d.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
  2. plasma membrane Source: UniProtKB-SubCell
  3. transport vesicle Source: RGD
  4. zymogen granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 219218GTP-binding protein Rab-3DPRO_0000121090Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Lipidationi217 – 2171S-geranylgeranyl cysteine By similarity
Modified residuei219 – 2191Cysteine methyl ester; partial1 Publication
Lipidationi219 – 2191S-geranylgeranyl cysteine By similarity

Post-translational modificationi

In fetal glands the majority of the proteins are methylated, whereas in neonatal and adult glands, only 50% are methylated.1 Publication

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ63942.
PRIDEiQ63942.

PTM databases

PhosphoSiteiQ63942.

Expressioni

Tissue specificityi

Highest levels found in lung.1 Publication

Gene expression databases

GenevestigatoriQ63942.

Interactioni

Subunit structurei

Interacts with RIMS1, RIMS2, RPH3A and RPH3AL By similarity. Interacts with RAB3IP.1 Publication

Protein-protein interaction databases

IntActiQ63942. 1 interaction.
MINTiMINT-1506189.

Structurei

3D structure databases

ProteinModelPortaliQ63942.
SMRiQ63942. Positions 20-189.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi51 – 599Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00740000115041.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ63942.
KOiK07884.
OMAiEPSSCSC.
OrthoDBiEOG7JQBPC.
PhylomeDBiQ63942.
TreeFamiTF313199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63942-1 [UniParc]FASTAAdd to Basket

« Hide

MASASEPPAS PRDAADQNFD YMFKLLLIGN SSVGKTSFLF RYADDSFTPA    50
FVSTVGIDFK VKTVYRHDKR IKLQIWDTAG QERYRTITTA YYRGAMGFLL 100
MYDIANQESF TAVQDWATQI KTYSWDNAQV ILVGNKCDLE DERVVSAEDG 150
QRLAGDLGFE FFEASAKENI NVKQVFERLV DIICDKMNES LEPSSSPGSN 200
GKGPALGDTP PPQPSSCGC 219
Length:219
Mass (Da):24,290
Last modified:November 1, 1998 - v2
Checksum:iED82C97D66BF194A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti205 – 2051A → S in AAA41996. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U90206 mRNA. Translation: AAB81202.1.
BC081741 mRNA. Translation: AAH81741.1.
S68808 mRNA. Translation: AAB29895.1.
M83681 mRNA. Translation: AAA41996.1.
PIRiI67631.
RefSeqiNP_542147.1. NM_080580.2.
XP_006242656.1. XM_006242594.1.
XP_006242657.1. XM_006242595.1.
UniGeneiRn.9822.

Genome annotation databases

EnsembliENSRNOT00000015609; ENSRNOP00000015609; ENSRNOG00000011582.
GeneIDi140665.
KEGGirno:140665.
UCSCiRGD:620924. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U90206 mRNA. Translation: AAB81202.1 .
BC081741 mRNA. Translation: AAH81741.1 .
S68808 mRNA. Translation: AAB29895.1 .
M83681 mRNA. Translation: AAA41996.1 .
PIRi I67631.
RefSeqi NP_542147.1. NM_080580.2.
XP_006242656.1. XM_006242594.1.
XP_006242657.1. XM_006242595.1.
UniGenei Rn.9822.

3D structure databases

ProteinModelPortali Q63942.
SMRi Q63942. Positions 20-189.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q63942. 1 interaction.
MINTi MINT-1506189.

PTM databases

PhosphoSitei Q63942.

Proteomic databases

PaxDbi Q63942.
PRIDEi Q63942.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000015609 ; ENSRNOP00000015609 ; ENSRNOG00000011582 .
GeneIDi 140665.
KEGGi rno:140665.
UCSCi RGD:620924. rat.

Organism-specific databases

CTDi 9545.
RGDi 620924. Rab3d.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00740000115041.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi Q63942.
KOi K07884.
OMAi EPSSCSC.
OrthoDBi EOG7JQBPC.
PhylomeDBi Q63942.
TreeFami TF313199.

Miscellaneous databases

NextBioi 620635.
PROi Q63942.

Gene expression databases

Genevestigatori Q63942.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Involvement of the ras-like GTPase rab3d in RBL-2H3 mast cell exocytosis following stimulation via high affinity IgE receptors (Fc epsilonRI)."
    Roa M., Paumet F., le Mao J., David B., Blank U.
    J. Immunol. 159:2815-2823(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "RT-PCR cloning of Rab3 isoforms expressed in peritoneal mast cells."
    Oberhauser A.F., Balan V., Fernandez-Badilla C.L., Fernandez J.M.
    FEBS Lett. 339:171-174(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-82.
    Tissue: Mast cell.
  4. "Rab15, a novel low molecular weight GTP-binding protein specifically expressed in rat brain."
    Elferink L.A., Anzai K., Scheller R.H.
    J. Biol. Chem. 267:5768-5775(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-219, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  5. "Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A."
    Brondyk W.H., McKiernan C.J., Fortner K.A., Stabila P., Holz R.W., Macara I.G.
    Mol. Cell. Biol. 15:1137-1143(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAB3IP.
  6. "Carboxyl methylation of rab3D is developmentally regulated in the rat pancreas: correlation with exocrine function."
    Valentijn J.A., Jamieson J.D.
    Eur. J. Cell Biol. 76:204-211(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: METHYLATION AT CYS-219.
    Tissue: Pancreas.

Entry informationi

Entry nameiRAB3D_RAT
AccessioniPrimary (citable) accession number: Q63942
Secondary accession number(s): P35291
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: June 11, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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