GTP-binding protein Rab-3D - Rattus norvegicus (Rat)

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Q63942 (RAB3D_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 107. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
GTP-binding protein Rab-3D

Gene names

Name:	Rab3d
Synonyms:	Rab16

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Protein transport. Probably involved in regulated exocytosis By similarity.
Subunit structure	Interacts with RIMS1, RIMS2, RPH3A and RPH3AL By similarity. Interacts with RAB3IP. Ref.5
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Tissue specificity	Highest levels found in lung. Ref.4
Post-translational modification	In fetal glands the majority of the proteins are methylated, whereas in neonatal and adult glands, only 50% are methylated. Ref.6
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	Exocytosis Protein transport Transport
Cellular component	Cell membrane Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	exocytosis Inferred from electronic annotation. Source: UniProtKB-KW peptidyl-cysteine methylation Inferred from electronic annotation. Source: Compara protein transport Inferred from electronic annotation. Source: UniProtKB-KW regulation of exocytosis Inferred from electronic annotation. Source: Compara small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrion Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell transport vesicle Inferred from direct assay PubMed 14578858. Source: RGD zymogen granule Inferred from electronic annotation. Source: Compara
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 219

219

GTP-binding protein Rab-3D

PRO_0000121090

Regions

Nucleotide binding

29 – 37

GTP By similarity

Nucleotide binding

77 – 81

GTP By similarity

Nucleotide binding

135 – 138

GTP By similarity

Nucleotide binding

165 – 167

GTP By similarity

Motif

51 – 59

Effector region By similarity

Amino acid modifications

Modified residue

219

Cysteine methyl ester; partial Ref.6

Lipidation

217

S-geranylgeranyl cysteine By similarity

Lipidation

219

S-geranylgeranyl cysteine By similarity

Experimental info

Sequence conflict

205

A → S in AAA41996. Ref.4

Sequences

Sequence

Length

Mass (Da)

Tools

Q63942 [UniParc].

Last modified November 1, 1998. Version 2.
Checksum: ED82C97D66BF194A
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FASTA

219

24,290

        10         20         30         40         50         60 
MASASEPPAS PRDAADQNFD YMFKLLLIGN SSVGKTSFLF RYADDSFTPA FVSTVGIDFK 

        70         80         90        100        110        120 
VKTVYRHDKR IKLQIWDTAG QERYRTITTA YYRGAMGFLL MYDIANQESF TAVQDWATQI 

       130        140        150        160        170        180 
KTYSWDNAQV ILVGNKCDLE DERVVSAEDG QRLAGDLGFE FFEASAKENI NVKQVFERLV 

       190        200        210 
DIICDKMNES LEPSSSPGSN GKGPALGDTP PPQPSSCGC

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Involvement of the ras-like GTPase rab3d in RBL-2H3 mast cell exocytosis following stimulation via high affinity IgE receptors (Fc epsilonRI)." Roa M., Paumet F., le Mao J., David B., Blank U. J. Immunol. 159:2815-2823(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[3]	"RT-PCR cloning of Rab3 isoforms expressed in peritoneal mast cells." Oberhauser A.F., Balan V., Fernandez-Badilla C.L., Fernandez J.M. FEBS Lett. 339:171-174(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-82. Tissue: Mast cell.
[4]	"Rab15, a novel low molecular weight GTP-binding protein specifically expressed in rat brain." Elferink L.A., Anzai K., Scheller R.H. J. Biol. Chem. 267:5768-5775(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-219, TISSUE SPECIFICITY. Strain: Sprague-Dawley. Tissue: Brain.
[5]	"Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A." Brondyk W.H., McKiernan C.J., Fortner K.A., Stabila P., Holz R.W., Macara I.G. Mol. Cell. Biol. 15:1137-1143(1995) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RAB3IP.
[6]	"Carboxyl methylation of rab3D is developmentally regulated in the rat pancreas: correlation with exocrine function." Valentijn J.A., Jamieson J.D. Eur. J. Cell Biol. 76:204-211(1998) [PubMed] [Europe PMC] [Abstract] Cited for: METHYLATION AT CYS-219. Tissue: Pancreas.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U90206 mRNA. Translation: AAB81202.1. BC081741 mRNA. Translation: AAH81741.1. S68808 mRNA. Translation: AAB29895.1. M83681 mRNA. Translation: AAA41996.1.
IPI	IPI00213685.
PIR	I67631.
RefSeq	NP_542147.1. NM_080580.2.
UniGene	Rn.9822.
3D structure databases
ProteinModelPortal	Q63942.
SMR	Q63942. Positions 20-189.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q63942. 1 interaction.
PTM databases
PhosphoSite	Q63942.
Proteomic databases
PaxDb	Q63942.
PRIDE	Q63942.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000015609; ENSRNOP00000015609; ENSRNOG00000011582.
GeneID	140665.
KEGG	rno:140665.
UCSC	RGD:620924. rat.
Organism-specific databases
CTD	9545.
RGD	620924. Rab3d.
Phylogenomic databases
eggNOG	COG1100.
GeneTree	ENSGT00690000101942.
HOGENOM	HOG000233968.
HOVERGEN	HBG009351.
InParanoid	Q63942.
KO	K07884.
OMA	GKGPTLG.
OrthoDB	EOG4TB4C6.
Gene expression databases
Genevestigator	Q63942.
GermOnline	ENSRNOG00000011582. Rattus norvegicus.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	620635.

Entry information

Entry name

RAB3D_RAT

Accession

Primary (citable) accession number: Q63942
Secondary accession number(s): P35291

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1998
Last modified:	April 3, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents