Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q63942

- RAB3D_RAT

UniProt

Q63942 - RAB3D_RAT

Protein

GTP-binding protein Rab-3D

Gene

Rab3d

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (01 Nov 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Protein transport. Probably involved in regulated exocytosis By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi29 – 379GTPBy similarity
    Nucleotide bindingi77 – 815GTPBy similarity
    Nucleotide bindingi135 – 1384GTPBy similarity
    Nucleotide bindingi165 – 1673GTPBy similarity

    GO - Molecular functioni

    1. GTPase binding Source: RGD
    2. GTP binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. exocytosis Source: UniProtKB-KW
    2. peptidyl-cysteine methylation Source: Ensembl
    3. protein transport Source: UniProtKB-KW
    4. regulation of exocytosis Source: Ensembl
    5. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Exocytosis, Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP-binding protein Rab-3D
    Gene namesi
    Name:Rab3d
    Synonyms:Rab16
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi620924. Rab3d.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl
    2. plasma membrane Source: UniProtKB-SubCell
    3. transport vesicle Source: RGD
    4. zymogen granule Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 219218GTP-binding protein Rab-3DPRO_0000121090Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Lipidationi217 – 2171S-geranylgeranyl cysteineBy similarity
    Modified residuei219 – 2191Cysteine methyl ester; partial1 Publication
    Lipidationi219 – 2191S-geranylgeranyl cysteineBy similarity

    Post-translational modificationi

    In fetal glands the majority of the proteins are methylated, whereas in neonatal and adult glands, only 50% are methylated.1 Publication

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiQ63942.
    PRIDEiQ63942.

    PTM databases

    PhosphoSiteiQ63942.

    Expressioni

    Tissue specificityi

    Highest levels found in lung.1 Publication

    Gene expression databases

    GenevestigatoriQ63942.

    Interactioni

    Subunit structurei

    Interacts with RIMS1, RIMS2, RPH3A and RPH3AL By similarity. Interacts with RAB3IP.By similarity1 Publication

    Protein-protein interaction databases

    IntActiQ63942. 1 interaction.
    MINTiMINT-1506189.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63942.
    SMRiQ63942. Positions 20-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi51 – 599Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00740000115041.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiQ63942.
    KOiK07884.
    OMAiEPSSCSC.
    OrthoDBiEOG7JQBPC.
    PhylomeDBiQ63942.
    TreeFamiTF313199.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q63942-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASASEPPAS PRDAADQNFD YMFKLLLIGN SSVGKTSFLF RYADDSFTPA    50
    FVSTVGIDFK VKTVYRHDKR IKLQIWDTAG QERYRTITTA YYRGAMGFLL 100
    MYDIANQESF TAVQDWATQI KTYSWDNAQV ILVGNKCDLE DERVVSAEDG 150
    QRLAGDLGFE FFEASAKENI NVKQVFERLV DIICDKMNES LEPSSSPGSN 200
    GKGPALGDTP PPQPSSCGC 219
    Length:219
    Mass (Da):24,290
    Last modified:November 1, 1998 - v2
    Checksum:iED82C97D66BF194A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti205 – 2051A → S in AAA41996. (PubMed:1313420)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90206 mRNA. Translation: AAB81202.1.
    BC081741 mRNA. Translation: AAH81741.1.
    S68808 mRNA. Translation: AAB29895.1.
    M83681 mRNA. Translation: AAA41996.1.
    PIRiI67631.
    RefSeqiNP_542147.1. NM_080580.2.
    XP_006242656.1. XM_006242594.1.
    XP_006242657.1. XM_006242595.1.
    UniGeneiRn.9822.

    Genome annotation databases

    EnsembliENSRNOT00000015609; ENSRNOP00000015609; ENSRNOG00000011582.
    GeneIDi140665.
    KEGGirno:140665.
    UCSCiRGD:620924. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90206 mRNA. Translation: AAB81202.1 .
    BC081741 mRNA. Translation: AAH81741.1 .
    S68808 mRNA. Translation: AAB29895.1 .
    M83681 mRNA. Translation: AAA41996.1 .
    PIRi I67631.
    RefSeqi NP_542147.1. NM_080580.2.
    XP_006242656.1. XM_006242594.1.
    XP_006242657.1. XM_006242595.1.
    UniGenei Rn.9822.

    3D structure databases

    ProteinModelPortali Q63942.
    SMRi Q63942. Positions 20-189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q63942. 1 interaction.
    MINTi MINT-1506189.

    PTM databases

    PhosphoSitei Q63942.

    Proteomic databases

    PaxDbi Q63942.
    PRIDEi Q63942.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000015609 ; ENSRNOP00000015609 ; ENSRNOG00000011582 .
    GeneIDi 140665.
    KEGGi rno:140665.
    UCSCi RGD:620924. rat.

    Organism-specific databases

    CTDi 9545.
    RGDi 620924. Rab3d.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00740000115041.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi Q63942.
    KOi K07884.
    OMAi EPSSCSC.
    OrthoDBi EOG7JQBPC.
    PhylomeDBi Q63942.
    TreeFami TF313199.

    Miscellaneous databases

    NextBioi 620635.
    PROi Q63942.

    Gene expression databases

    Genevestigatori Q63942.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Involvement of the ras-like GTPase rab3d in RBL-2H3 mast cell exocytosis following stimulation via high affinity IgE receptors (Fc epsilonRI)."
      Roa M., Paumet F., le Mao J., David B., Blank U.
      J. Immunol. 159:2815-2823(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. "RT-PCR cloning of Rab3 isoforms expressed in peritoneal mast cells."
      Oberhauser A.F., Balan V., Fernandez-Badilla C.L., Fernandez J.M.
      FEBS Lett. 339:171-174(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-82.
      Tissue: Mast cell.
    4. "Rab15, a novel low molecular weight GTP-binding protein specifically expressed in rat brain."
      Elferink L.A., Anzai K., Scheller R.H.
      J. Biol. Chem. 267:5768-5775(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-219, TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Brain.
    5. "Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A."
      Brondyk W.H., McKiernan C.J., Fortner K.A., Stabila P., Holz R.W., Macara I.G.
      Mol. Cell. Biol. 15:1137-1143(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RAB3IP.
    6. "Carboxyl methylation of rab3D is developmentally regulated in the rat pancreas: correlation with exocrine function."
      Valentijn J.A., Jamieson J.D.
      Eur. J. Cell Biol. 76:204-211(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: METHYLATION AT CYS-219.
      Tissue: Pancreas.

    Entry informationi

    Entry nameiRAB3D_RAT
    AccessioniPrimary (citable) accession number: Q63942
    Secondary accession number(s): P35291
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3