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Protein

GTP-binding protein Rab-3D

Gene

Rab3d

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in regulated exocytosis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37GTPBy similarity9
Nucleotide bindingi48 – 54GTPBy similarity7
Nucleotide bindingi77 – 81GTPBy similarity5
Nucleotide bindingi135 – 138GTPBy similarity4
Nucleotide bindingi165 – 167GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein Rab-3D
Gene namesi
Name:Rab3d
Synonyms:Rab16
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi620924. Rab3d.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001210902 – 219GTP-binding protein Rab-3DAdd BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei190PhosphoserineBy similarity1
Lipidationi217S-geranylgeranyl cysteineBy similarity1
Modified residuei219Cysteine methyl ester; partial1 Publication1
Lipidationi219S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

In fetal glands the majority of the proteins are methylated, whereas in neonatal and adult glands, only 50% are methylated.1 Publication

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ63942.
PRIDEiQ63942.

PTM databases

iPTMnetiQ63942.
PhosphoSitePlusiQ63942.

Expressioni

Tissue specificityi

Highest levels found in lung.1 Publication

Gene expression databases

BgeeiENSRNOG00000011582.
GenevisibleiQ63942. RN.

Interactioni

Subunit structurei

Interacts with RIMS1, RIMS2, RPH3A and RPH3AL (By similarity). Interacts with RAB3IP.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ63942. 1 interactor.
MINTiMINT-1506189.
STRINGi10116.ENSRNOP00000015609.

Structurei

3D structure databases

ProteinModelPortaliQ63942.
SMRiQ63942.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 59Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0093. Eukaryota.
ENOG410ZZXQ. LUCA.
GeneTreeiENSGT00890000139330.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ63942.
KOiK07884.
OMAiEPSSCSC.
OrthoDBiEOG091G0J64.
PhylomeDBiQ63942.
TreeFamiTF313199.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASASEPPAS PRDAADQNFD YMFKLLLIGN SSVGKTSFLF RYADDSFTPA
60 70 80 90 100
FVSTVGIDFK VKTVYRHDKR IKLQIWDTAG QERYRTITTA YYRGAMGFLL
110 120 130 140 150
MYDIANQESF TAVQDWATQI KTYSWDNAQV ILVGNKCDLE DERVVSAEDG
160 170 180 190 200
QRLAGDLGFE FFEASAKENI NVKQVFERLV DIICDKMNES LEPSSSPGSN
210
GKGPALGDTP PPQPSSCGC
Length:219
Mass (Da):24,290
Last modified:November 1, 1998 - v2
Checksum:iED82C97D66BF194A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205A → S in AAA41996 (PubMed:1313420).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90206 mRNA. Translation: AAB81202.1.
BC081741 mRNA. Translation: AAH81741.1.
S68808 mRNA. Translation: AAB29895.1.
M83681 mRNA. Translation: AAA41996.1.
PIRiI67631.
RefSeqiNP_542147.1. NM_080580.2.
XP_006242656.1. XM_006242594.3.
XP_017450911.1. XM_017595422.1.
UniGeneiRn.9822.

Genome annotation databases

EnsembliENSRNOT00000015609; ENSRNOP00000015609; ENSRNOG00000011582.
GeneIDi140665.
KEGGirno:140665.
UCSCiRGD:620924. rat.

Similar proteinsi

Entry informationi

Entry nameiRAB3D_RAT
AccessioniPrimary (citable) accession number: Q63942
Secondary accession number(s): P35291
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: August 30, 2017
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families