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Protein

Ras-related protein Rab-3B

Gene

Rab3b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37GTPBy similarity9
Nucleotide bindingi48 – 54GTPBy similarity7
Nucleotide bindingi77 – 81GTPBy similarity5
Nucleotide bindingi135 – 138GTPBy similarity4
Nucleotide bindingi165 – 167GTPBy similarity3

GO - Molecular functioni

  • GDP binding Source: RGD
  • GTPase activity Source: RGD
  • GTP binding Source: RGD
  • GTP-dependent protein binding Source: RGD
  • myosin V binding Source: RGD

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3B
Gene namesi
Name:Rab3b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620922. Rab3b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001210832 – 219Ras-related protein Rab-3BAdd BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei188PhosphoserineCombined sources1
Modified residuei190PhosphoserineCombined sources1
Lipidationi217S-geranylgeranyl cysteineBy similarity1
Modified residuei219Cysteine methyl esterBy similarity1
Lipidationi219S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ63941.
PRIDEiQ63941.

PTM databases

iPTMnetiQ63941.
PhosphoSitePlusiQ63941.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008001.
GenevisibleiQ63941. RN.

Interactioni

Subunit structurei

Interacts with RPH3A and RPH3AL (By similarity). Interacts with RIMS1 and RIMS2.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010645.

Structurei

3D structure databases

ProteinModelPortaliQ63941.
SMRiQ63941.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 59Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0093. Eukaryota.
ENOG410ZZXQ. LUCA.
GeneTreeiENSGT00890000139330.
HOVERGENiHBG009351.
InParanoidiQ63941.
KOiK06108.
OMAiPSQQNCS.
OrthoDBiEOG091G0J64.
PhylomeDBiQ63941.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVTDGNTG IRDASDQNFD YMFKLLIIGN SSVGKTSFLF RYADDTFTPA
60 70 80 90 100
FVSTVGIDFK VKTVYRHEKR VKLQIWDTAG QERYRTITTA YYRGAMGFIL
110 120 130 140 150
MYDITNEESF NAVQDWATQI KTYSWDNAQV ILVGNKCDME EERVIPTEKG
160 170 180 190 200
RLLAEQLGFD FFEASAKENI SVRQAFERLV DAICDKMSDS MDTDPSVLGA
210
SKTTRLSDTP PLLQQNCSC
Length:219
Mass (Da):24,785
Last modified:November 1, 1998 - v2
Checksum:iE68ACC0C2D552F67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14019 mRNA. Translation: CAA74341.1.
S68807 mRNA. Translation: AAB29894.1.
PIRiI53485.
RefSeqiNP_112353.1. NM_031091.2.
UniGeneiRn.3788.
Rn.9822.

Genome annotation databases

EnsembliENSRNOT00000010645; ENSRNOP00000010645; ENSRNOG00000008001.
GeneIDi81755.
KEGGirno:81755.

Similar proteinsi

Entry informationi

Entry nameiRAB3B_RAT
AccessioniPrimary (citable) accession number: Q63941
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 22, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families