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Q63941

- RAB3B_RAT

UniProt

Q63941 - RAB3B_RAT

Protein

Ras-related protein Rab-3B

Gene

Rab3b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Protein transport. Probably involved in vesicular traffic By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi29 – 379GTPBy similarity
    Nucleotide bindingi48 – 547GTPBy similarity
    Nucleotide bindingi77 – 815GTPBy similarity
    Nucleotide bindingi135 – 1384GTPBy similarity
    Nucleotide bindingi165 – 1673GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: RGD

    GO - Biological processi

    1. peptidyl-cysteine methylation Source: Ensembl
    2. protein transport Source: UniProtKB-KW
    3. regulation of exocytosis Source: RGD
    4. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-3B
    Gene namesi
    Name:Rab3b
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi620922. Rab3b.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. cytosol Source: RGD
    2. plasma membrane Source: UniProtKB-SubCell
    3. secretory granule Source: Ensembl
    4. synaptic vesicle Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 219219Ras-related protein Rab-3BPRO_0000121083Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei190 – 1901PhosphoserineBy similarity
    Lipidationi217 – 2171S-geranylgeranyl cysteineBy similarity
    Modified residuei219 – 2191Cysteine methyl esterBy similarity
    Lipidationi219 – 2191S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Proteomic databases

    PaxDbiQ63941.
    PRIDEiQ63941.

    Expressioni

    Gene expression databases

    GenevestigatoriQ63941.

    Interactioni

    Subunit structurei

    Interacts with RPH3A and RPH3AL By similarity. Interacts with RIMS1 and RIMS2.By similarity2 Publications

    Structurei

    3D structure databases

    ProteinModelPortaliQ63941.
    SMRiQ63941. Positions 18-187.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi51 – 599Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00740000115041.
    HOVERGENiHBG009351.
    InParanoidiQ63941.
    KOiK06108.
    OMAiWFDFFEA.
    OrthoDBiEOG7JQBPC.
    PhylomeDBiQ63941.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q63941-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASVTDGNTG IRDASDQNFD YMFKLLIIGN SSVGKTSFLF RYADDTFTPA    50
    FVSTVGIDFK VKTVYRHEKR VKLQIWDTAG QERYRTITTA YYRGAMGFIL 100
    MYDITNEESF NAVQDWATQI KTYSWDNAQV ILVGNKCDME EERVIPTEKG 150
    RLLAEQLGFD FFEASAKENI SVRQAFERLV DAICDKMSDS MDTDPSVLGA 200
    SKTTRLSDTP PLLQQNCSC 219
    Length:219
    Mass (Da):24,785
    Last modified:November 1, 1998 - v2
    Checksum:iE68ACC0C2D552F67
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14019 mRNA. Translation: CAA74341.1.
    S68807 mRNA. Translation: AAB29894.1.
    PIRiI53485.
    RefSeqiNP_112353.1. NM_031091.2.
    UniGeneiRn.3788.
    Rn.9822.

    Genome annotation databases

    EnsembliENSRNOT00000010645; ENSRNOP00000010645; ENSRNOG00000008001.
    GeneIDi81755.
    KEGGirno:81755.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14019 mRNA. Translation: CAA74341.1 .
    S68807 mRNA. Translation: AAB29894.1 .
    PIRi I53485.
    RefSeqi NP_112353.1. NM_031091.2.
    UniGenei Rn.3788.
    Rn.9822.

    3D structure databases

    ProteinModelPortali Q63941.
    SMRi Q63941. Positions 18-187.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q63941.
    PRIDEi Q63941.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000010645 ; ENSRNOP00000010645 ; ENSRNOG00000008001 .
    GeneIDi 81755.
    KEGGi rno:81755.

    Organism-specific databases

    CTDi 5865.
    RGDi 620922. Rab3b.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00740000115041.
    HOVERGENi HBG009351.
    InParanoidi Q63941.
    KOi K06108.
    OMAi WFDFFEA.
    OrthoDBi EOG7JQBPC.
    PhylomeDBi Q63941.

    Miscellaneous databases

    NextBioi 615522.

    Gene expression databases

    Genevestigatori Q63941.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential expression of Rab3 isoforms during differentiation of pancreatic acinar cell line AR42J."
      Klengel R., Piiper A., Pittelkow S., Zeuzem S.
      Biochem. Biophys. Res. Commun. 236:719-722(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Epididymis.
    2. "RT-PCR cloning of Rab3 isoforms expressed in peritoneal mast cells."
      Oberhauser A.F., Balan V., Fernandez-Badilla C.L., Fernandez J.M.
      FEBS Lett. 339:171-174(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-82.
      Tissue: Mast cell.
    3. "Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion."
      Wang Y., Okamoto M., Schmitz F., Hofmann K., Suedhof T.C.
      Nature 388:593-598(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RIMS1.
    4. "The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins."
      Wang Y., Sugita S., Suedhof T.C.
      J. Biol. Chem. 275:20033-20044(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RIMS2.

    Entry informationi

    Entry nameiRAB3B_RAT
    AccessioniPrimary (citable) accession number: Q63941
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3