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Q63941 (RAB3B_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-3B
Gene names
Name:Rab3b
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Protein transport. Probably involved in vesicular traffic By similarity.

Subunit structure

Interacts with RPH3A and RPH3AL By similarity. Interacts with RIMS1 and RIMS2. Ref.3 Ref.4

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 219219Ras-related protein Rab-3B
PRO_0000121083

Regions

Nucleotide binding29 – 379GTP By similarity
Nucleotide binding48 – 547GTP By similarity
Nucleotide binding77 – 815GTP By similarity
Nucleotide binding135 – 1384GTP By similarity
Nucleotide binding165 – 1673GTP By similarity
Motif51 – 599Effector region By similarity

Amino acid modifications

Modified residue1901Phosphoserine By similarity
Modified residue2191Cysteine methyl ester By similarity
Lipidation2171S-geranylgeranyl cysteine By similarity
Lipidation2191S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q63941 [UniParc].

Last modified November 1, 1998. Version 2.
Checksum: E68ACC0C2D552F67

FASTA21924,785
        10         20         30         40         50         60 
MASVTDGNTG IRDASDQNFD YMFKLLIIGN SSVGKTSFLF RYADDTFTPA FVSTVGIDFK 

        70         80         90        100        110        120 
VKTVYRHEKR VKLQIWDTAG QERYRTITTA YYRGAMGFIL MYDITNEESF NAVQDWATQI 

       130        140        150        160        170        180 
KTYSWDNAQV ILVGNKCDME EERVIPTEKG RLLAEQLGFD FFEASAKENI SVRQAFERLV 

       190        200        210 
DAICDKMSDS MDTDPSVLGA SKTTRLSDTP PLLQQNCSC 

« Hide

References

[1]"Differential expression of Rab3 isoforms during differentiation of pancreatic acinar cell line AR42J."
Klengel R., Piiper A., Pittelkow S., Zeuzem S.
Biochem. Biophys. Res. Commun. 236:719-722(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Epididymis.
[2]"RT-PCR cloning of Rab3 isoforms expressed in peritoneal mast cells."
Oberhauser A.F., Balan V., Fernandez-Badilla C.L., Fernandez J.M.
FEBS Lett. 339:171-174(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-82.
Tissue: Mast cell.
[3]"Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion."
Wang Y., Okamoto M., Schmitz F., Hofmann K., Suedhof T.C.
Nature 388:593-598(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RIMS1.
[4]"The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins."
Wang Y., Sugita S., Suedhof T.C.
J. Biol. Chem. 275:20033-20044(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RIMS2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y14019 mRNA. Translation: CAA74341.1.
S68807 mRNA. Translation: AAB29894.1.
PIRI53485.
RefSeqNP_112353.1. NM_031091.2.
UniGeneRn.3788.
Rn.9822.

3D structure databases

ProteinModelPortalQ63941.
SMRQ63941. Positions 18-187.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ63941.
PRIDEQ63941.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000010645; ENSRNOP00000010645; ENSRNOG00000008001.
GeneID81755.
KEGGrno:81755.

Organism-specific databases

CTD5865.
RGD620922. Rab3b.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00740000115041.
HOVERGENHBG009351.
InParanoidQ63941.
KOK06108.
OMAWFDFFEA.
OrthoDBEOG7JQBPC.
PhylomeDBQ63941.

Gene expression databases

GenevestigatorQ63941.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio615522.

Entry information

Entry nameRAB3B_RAT
AccessionPrimary (citable) accession number: Q63941
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families