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Protein

Ras-related protein Rab-3B

Gene

Rab3b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 379GTPBy similarity
Nucleotide bindingi48 – 547GTPBy similarity
Nucleotide bindingi77 – 815GTPBy similarity
Nucleotide bindingi135 – 1384GTPBy similarity
Nucleotide bindingi165 – 1673GTPBy similarity

GO - Molecular functioni

  • GDP binding Source: Ensembl
  • GTPase activity Source: GO_Central
  • GTP binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3B
Gene namesi
Name:Rab3b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620922. Rab3b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Ras-related protein Rab-3BPRO_0000121083Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei190 – 1901PhosphoserineBy similarity
Lipidationi217 – 2171S-geranylgeranyl cysteineBy similarity
Modified residuei219 – 2191Cysteine methyl esterBy similarity
Lipidationi219 – 2191S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ63941.
PRIDEiQ63941.

Expressioni

Gene expression databases

ExpressionAtlasiQ63941. baseline and differential.
GenevisibleiQ63941. RN.

Interactioni

Subunit structurei

Interacts with RPH3A and RPH3AL (By similarity). Interacts with RIMS1 and RIMS2.By similarity2 Publications

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010645.

Structurei

3D structure databases

ProteinModelPortaliQ63941.
SMRiQ63941. Positions 18-187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi51 – 599Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118937.
HOVERGENiHBG009351.
InParanoidiQ63941.
KOiK06108.
OMAiWFDFFEA.
OrthoDBiEOG7JQBPC.
PhylomeDBiQ63941.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVTDGNTG IRDASDQNFD YMFKLLIIGN SSVGKTSFLF RYADDTFTPA
60 70 80 90 100
FVSTVGIDFK VKTVYRHEKR VKLQIWDTAG QERYRTITTA YYRGAMGFIL
110 120 130 140 150
MYDITNEESF NAVQDWATQI KTYSWDNAQV ILVGNKCDME EERVIPTEKG
160 170 180 190 200
RLLAEQLGFD FFEASAKENI SVRQAFERLV DAICDKMSDS MDTDPSVLGA
210
SKTTRLSDTP PLLQQNCSC
Length:219
Mass (Da):24,785
Last modified:November 1, 1998 - v2
Checksum:iE68ACC0C2D552F67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14019 mRNA. Translation: CAA74341.1.
S68807 mRNA. Translation: AAB29894.1.
PIRiI53485.
RefSeqiNP_112353.1. NM_031091.2.
UniGeneiRn.3788.
Rn.9822.

Genome annotation databases

EnsembliENSRNOT00000010645; ENSRNOP00000010645; ENSRNOG00000008001.
GeneIDi81755.
KEGGirno:81755.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14019 mRNA. Translation: CAA74341.1.
S68807 mRNA. Translation: AAB29894.1.
PIRiI53485.
RefSeqiNP_112353.1. NM_031091.2.
UniGeneiRn.3788.
Rn.9822.

3D structure databases

ProteinModelPortaliQ63941.
SMRiQ63941. Positions 18-187.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010645.

Proteomic databases

PaxDbiQ63941.
PRIDEiQ63941.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010645; ENSRNOP00000010645; ENSRNOG00000008001.
GeneIDi81755.
KEGGirno:81755.

Organism-specific databases

CTDi5865.
RGDi620922. Rab3b.

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118937.
HOVERGENiHBG009351.
InParanoidiQ63941.
KOiK06108.
OMAiWFDFFEA.
OrthoDBiEOG7JQBPC.
PhylomeDBiQ63941.

Miscellaneous databases

NextBioi615522.
PROiQ63941.

Gene expression databases

ExpressionAtlasiQ63941. baseline and differential.
GenevisibleiQ63941. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Differential expression of Rab3 isoforms during differentiation of pancreatic acinar cell line AR42J."
    Klengel R., Piiper A., Pittelkow S., Zeuzem S.
    Biochem. Biophys. Res. Commun. 236:719-722(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Epididymis.
  2. "RT-PCR cloning of Rab3 isoforms expressed in peritoneal mast cells."
    Oberhauser A.F., Balan V., Fernandez-Badilla C.L., Fernandez J.M.
    FEBS Lett. 339:171-174(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-82.
    Tissue: Mast cell.
  3. "Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion."
    Wang Y., Okamoto M., Schmitz F., Hofmann K., Suedhof T.C.
    Nature 388:593-598(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RIMS1.
  4. "The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins."
    Wang Y., Sugita S., Suedhof T.C.
    J. Biol. Chem. 275:20033-20044(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RIMS2.

Entry informationi

Entry nameiRAB3B_RAT
AccessioniPrimary (citable) accession number: Q63941
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: June 24, 2015
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.