Q63941 (RAB3B_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-3B

Gene names

Name:

Rab3b

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Protein transport. Probably involved in vesicular traffic By similarity.
Subunit structure	Interacts with RPH3A and RPH3AL By similarity. Interacts with RIMS1 and RIMS2. Ref.3 Ref.4
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell membrane Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Methylation Phosphoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-cysteine methylation Inferred from electronic annotation. Source: Compara protein transport Inferred from electronic annotation. Source: UniProtKB-KW regulation of exocytosis Traceable author statement Ref.1. Source: RGD small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cytosol Inferred from direct assay PubMed 8366094. Source: RGD plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell secretory granule Inferred from electronic annotation. Source: Compara synaptic vesicle Inferred from electronic annotation. Source: Compara
Molecular_function	GTP binding Non-traceable author statement Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 219	219	Ras-related protein Rab-3B		PRO_0000121083
Regions
	Nucleotide binding	29 – 37	9	GTP By similarity
	Nucleotide binding	48 – 54	7	GTP By similarity
	Nucleotide binding	77 – 81	5	GTP By similarity
	Nucleotide binding	135 – 138	4	GTP By similarity
	Nucleotide binding	165 – 167	3	GTP By similarity
	Motif	51 – 59	9	Effector region By similarity
Amino acid modifications
	Modified residue	188	1	Phosphoserine By similarity
	Modified residue	190	1	Phosphoserine By similarity
	Modified residue	219	1	Cysteine methyl ester By similarity
	Lipidation	217	1	S-geranylgeranyl cysteine By similarity
	Lipidation	219	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q63941 [UniParc]. Last modified November 1, 1998. Version 2. Checksum: E68ACC0C2D552F67	FASTA	219	24,785
	10 20 30 40 50 60 MASVTDGNTG IRDASDQNFD YMFKLLIIGN SSVGKTSFLF RYADDTFTPA FVSTVGIDFK 70 80 90 100 110 120 VKTVYRHEKR VKLQIWDTAG QERYRTITTA YYRGAMGFIL MYDITNEESF NAVQDWATQI 130 140 150 160 170 180 KTYSWDNAQV ILVGNKCDME EERVIPTEKG RLLAEQLGFD FFEASAKENI SVRQAFERLV 190 200 210 DAICDKMSDS MDTDPSVLGA SKTTRLSDTP PLLQQNCSC

References

[1]	"Differential expression of Rab3 isoforms during differentiation of pancreatic acinar cell line AR42J." Klengel R., Piiper A., Pittelkow S., Zeuzem S. Biochem. Biophys. Res. Commun. 236:719-722(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Epididymis.
[2]	"RT-PCR cloning of Rab3 isoforms expressed in peritoneal mast cells." Oberhauser A.F., Balan V., Fernandez-Badilla C.L., Fernandez J.M. FEBS Lett. 339:171-174(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-82. Tissue: Mast cell.
[3]	"Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion." Wang Y., Okamoto M., Schmitz F., Hofmann K., Suedhof T.C. Nature 388:593-598(1997) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RIMS1.
[4]	"The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins." Wang Y., Sugita S., Suedhof T.C. J. Biol. Chem. 275:20033-20044(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RIMS2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y14019 mRNA. Translation: CAA74341.1. S68807 mRNA. Translation: AAB29894.1.
IPI	IPI00470247.
PIR	I53485.
RefSeq	NP_112353.1. NM_031091.2.
UniGene	Rn.3788. Rn.9822.
3D structure databases
ProteinModelPortal	Q63941.
SMR	Q63941. Positions 18-187.
ModBase	Search...
Proteomic databases
PaxDb	Q63941.
PRIDE	Q63941.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000010645; ENSRNOP00000010645; ENSRNOG00000008001.
GeneID	81755.
KEGG	rno:81755.
Organism-specific databases
CTD	5865.
RGD	620922. Rab3b.
Phylogenomic databases
eggNOG	COG1100.
GeneTree	ENSGT00690000101942.
HOVERGEN	HBG009351.
InParanoid	Q63941.
KO	K06108.
OrthoDB	EOG4TB4C6.
Gene expression databases
ArrayExpress	Q63941.
Genevestigator	Q63941.
GermOnline	ENSRNOG00000008001. Rattus norvegicus.
Family and domain databases
InterPro	IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	615522.

Entry information

Entry name

RAB3B_RAT

Accession

Primary (citable) accession number: Q63941

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1998
Last modified:	May 29, 2013
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program