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Q63934

- PO4F2_MOUSE

UniProt

Q63934 - PO4F2_MOUSE

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Protein

POU domain, class 4, transcription factor 2

Gene
Pou4f2, Brn3b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcription factor. May play a role in determining or maintaining the identities of a small subset of visual system neurons.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi347 – 40660HomeoboxAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: UniProtKB
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB
  5. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. axon extension Source: MGI
  2. axon guidance Source: MGI
  3. axonogenesis Source: MGI
  4. intracellular estrogen receptor signaling pathway Source: UniProtKB
  5. MAPK cascade Source: UniProtKB
  6. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  7. neuromuscular process controlling balance Source: MGI
  8. neuron differentiation Source: MGI
  9. positive regulation of cell differentiation Source: MGI
  10. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  11. retina development in camera-type eye Source: MGI
  12. retinal ganglion cell axon guidance Source: MGI
  13. sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 4, transcription factor 2
Alternative name(s):
Brain-specific homeobox/POU domain protein 3B
Short name:
Brain-3B
Short name:
Brn-3B
Brn-3.2
Gene namesi
Name:Pou4f2
Synonyms:Brn3b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:102524. Pou4f2.

Subcellular locationi

Nucleus speckle By similarity

GO - Cellular componenti

  1. nuclear speck Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411POU domain, class 4, transcription factor 2PRO_0000100741Add
BLAST

Proteomic databases

PaxDbiQ63934.
PRIDEiQ63934.

PTM databases

PhosphoSiteiQ63934.

Expressioni

Tissue specificityi

Brain, peripheral sensory nervous system and retina. In the adult nervous system BRN-3.2 predominates in the optical, intermediate, and deep gray areas of the superior colliculus, the dorsal column of the mesencephalic and pontine central gray, and the lateral interpeduncular nucleus.1 Publication

Developmental stagei

In the CNS it is selectively expressed in postmitotic, terminally differentiated neurons.

Gene expression databases

BgeeiQ63934.
CleanExiMM_POU4F2.
GenevestigatoriQ63934.

Interactioni

Protein-protein interaction databases

BioGridi202311. 4 interactions.
STRINGi10090.ENSMUSP00000034115.

Structurei

3D structure databases

ProteinModelPortaliQ63934.
SMRiQ63934. Positions 256-405.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini252 – 32978POU-specificAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi112 – 12110POU-IV box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 44Poly-Met
Compositional biasi43 – 519Poly-Ser
Compositional biasi54 – 6714Poly-GlyAdd
BLAST
Compositional biasi69 – 757Poly-Ser
Compositional biasi76 – 8510Poly-Gly
Compositional biasi128 – 1314Poly-His
Compositional biasi157 – 1604Poly-Ser
Compositional biasi173 – 18412Poly-HisAdd
BLAST

Domaini

The polyhistidine repeat acts as a targeting signal to nuclear speckles By similarity.

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG289030.
GeneTreeiENSGT00750000117482.
HOGENOMiHOG000116305.
HOVERGENiHBG031829.
InParanoidiQ63934.
KOiK09366.
OMAiPSNIFGG.
OrthoDBiEOG7RV9G7.
PhylomeDBiQ63934.
TreeFamiTF316413.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63934-1 [UniParc]FASTAAdd to Basket

« Hide

MMMMSLNSKQ AFSMPHAGSL HVEPKYSALH SASPGSSAPA APSASSPSSS    50
SNAGGGGGGG GGGGGGGRSS SSSSSGSGGS GGGGGSEAMR RACLPTPPSN 100
IFGGLDESLL ARAEALAAVD IVSQSKSHHH HPPHHSPFKP DATYHTMNTI 150
PCTSAASSSS VPISHPSALA GTHHHHHHHH HHHHQPHQAL EGELLEHLSP 200
GLALGAMAGP DGTVVSTPAH APHMATMNPM HQAALSMAHA HGLPSHMGCM 250
SDVDADPRDL EAFAERFKQR RIKLGVTQAD VGSALANLKI PGVGSLSQST 300
ICRFESLTLS HNNMIALKPI LQAWLEEAEK SHREKLTKPE LFNGAEKKRK 350
RTSIAAPEKR SLEAYFAIQP RPSSEKIAAI AEKLDLKKNV VRVWFCNQRQ 400
KQKRMKYSAG I 411
Length:411
Mass (Da):43,173
Last modified:November 1, 1996 - v1
Checksum:i97EA816F7DEC07C9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 989RRACLPTPP → MCAFYLQLQ1 Publication
Sequence conflicti404 – 4052RM → KV in AAB30578. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S68377 mRNA. Translation: AAC60672.1.
AK087546 mRNA. Translation: BAC39921.1.
S69351 Genomic DNA. Translation: AAB30578.1.
CCDSiCCDS22429.1.
RefSeqiNP_620394.2. NM_138944.2.
UniGeneiMm.234261.

Genome annotation databases

EnsembliENSMUST00000034115; ENSMUSP00000034115; ENSMUSG00000031688.
GeneIDi18997.
KEGGimmu:18997.
UCSCiuc009mhy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S68377 mRNA. Translation: AAC60672.1 .
AK087546 mRNA. Translation: BAC39921.1 .
S69351 Genomic DNA. Translation: AAB30578.1 .
CCDSi CCDS22429.1.
RefSeqi NP_620394.2. NM_138944.2.
UniGenei Mm.234261.

3D structure databases

ProteinModelPortali Q63934.
SMRi Q63934. Positions 256-405.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202311. 4 interactions.
STRINGi 10090.ENSMUSP00000034115.

PTM databases

PhosphoSitei Q63934.

Proteomic databases

PaxDbi Q63934.
PRIDEi Q63934.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034115 ; ENSMUSP00000034115 ; ENSMUSG00000031688 .
GeneIDi 18997.
KEGGi mmu:18997.
UCSCi uc009mhy.1. mouse.

Organism-specific databases

CTDi 5458.
MGIi MGI:102524. Pou4f2.

Phylogenomic databases

eggNOGi NOG289030.
GeneTreei ENSGT00750000117482.
HOGENOMi HOG000116305.
HOVERGENi HBG031829.
InParanoidi Q63934.
KOi K09366.
OMAi PSNIFGG.
OrthoDBi EOG7RV9G7.
PhylomeDBi Q63934.
TreeFami TF316413.

Miscellaneous databases

NextBioi 295402.
PROi Q63934.
SOURCEi Search...

Gene expression databases

Bgeei Q63934.
CleanExi MM_POU4F2.
Genevestigatori Q63934.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Brn-3.2: a Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid."
    Turner E.E., Jenne K.J., Rosenfeld M.G.
    Neuron 12:205-218(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.
  3. "Chromosomal localization and sequences of the murine Brn-3 family of developmental control genes."
    Theil T., Zechner U., Klett C., Adolph S., Moeroey T.
    Cytogenet. Cell Genet. 66:267-271(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 90-411.
    Strain: CD.

Entry informationi

Entry nameiPO4F2_MOUSE
AccessioniPrimary (citable) accession number: Q63934
Secondary accession number(s): Q63954
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi