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Q63934

- PO4F2_MOUSE

UniProt

Q63934 - PO4F2_MOUSE

Protein

POU domain, class 4, transcription factor 2

Gene

Pou4f2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Transcription factor. May play a role in determining or maintaining the identities of a small subset of visual system neurons.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi347 – 40660HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: UniProtKB
    4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB
    5. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. axon extension Source: MGI
    2. axon guidance Source: MGI
    3. axonogenesis Source: MGI
    4. intracellular estrogen receptor signaling pathway Source: UniProtKB
    5. MAPK cascade Source: UniProtKB
    6. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    7. neuromuscular process controlling balance Source: MGI
    8. neuron differentiation Source: MGI
    9. positive regulation of cell differentiation Source: MGI
    10. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    11. retina development in camera-type eye Source: MGI
    12. retinal ganglion cell axon guidance Source: MGI
    13. sensory perception of sound Source: MGI

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 4, transcription factor 2
    Alternative name(s):
    Brain-specific homeobox/POU domain protein 3B
    Short name:
    Brain-3B
    Short name:
    Brn-3B
    Brn-3.2
    Gene namesi
    Name:Pou4f2
    Synonyms:Brn3b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:102524. Pou4f2.

    Subcellular locationi

    Nucleus speckle PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nuclear speck Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 411411POU domain, class 4, transcription factor 2PRO_0000100741Add
    BLAST

    Proteomic databases

    PaxDbiQ63934.
    PRIDEiQ63934.

    PTM databases

    PhosphoSiteiQ63934.

    Expressioni

    Tissue specificityi

    Brain, peripheral sensory nervous system and retina. In the adult nervous system BRN-3.2 predominates in the optical, intermediate, and deep gray areas of the superior colliculus, the dorsal column of the mesencephalic and pontine central gray, and the lateral interpeduncular nucleus.1 Publication

    Developmental stagei

    In the CNS it is selectively expressed in postmitotic, terminally differentiated neurons.

    Gene expression databases

    BgeeiQ63934.
    CleanExiMM_POU4F2.
    GenevestigatoriQ63934.

    Interactioni

    Protein-protein interaction databases

    BioGridi202311. 4 interactions.
    STRINGi10090.ENSMUSP00000034115.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63934.
    SMRiQ63934. Positions 256-405.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini252 – 32978POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi112 – 12110POU-IV box

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1 – 44Poly-Met
    Compositional biasi43 – 519Poly-Ser
    Compositional biasi54 – 6714Poly-GlyAdd
    BLAST
    Compositional biasi69 – 757Poly-Ser
    Compositional biasi76 – 8510Poly-Gly
    Compositional biasi128 – 1314Poly-His
    Compositional biasi157 – 1604Poly-Ser
    Compositional biasi173 – 18412Poly-HisAdd
    BLAST

    Domaini

    The polyhistidine repeat acts as a targeting signal to nuclear speckles.By similarity

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG289030.
    GeneTreeiENSGT00750000117482.
    HOGENOMiHOG000116305.
    HOVERGENiHBG031829.
    InParanoidiQ63934.
    KOiK09366.
    OMAiPSNIFGG.
    OrthoDBiEOG7RV9G7.
    PhylomeDBiQ63934.
    TreeFamiTF316413.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q63934-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMMMSLNSKQ AFSMPHAGSL HVEPKYSALH SASPGSSAPA APSASSPSSS    50
    SNAGGGGGGG GGGGGGGRSS SSSSSGSGGS GGGGGSEAMR RACLPTPPSN 100
    IFGGLDESLL ARAEALAAVD IVSQSKSHHH HPPHHSPFKP DATYHTMNTI 150
    PCTSAASSSS VPISHPSALA GTHHHHHHHH HHHHQPHQAL EGELLEHLSP 200
    GLALGAMAGP DGTVVSTPAH APHMATMNPM HQAALSMAHA HGLPSHMGCM 250
    SDVDADPRDL EAFAERFKQR RIKLGVTQAD VGSALANLKI PGVGSLSQST 300
    ICRFESLTLS HNNMIALKPI LQAWLEEAEK SHREKLTKPE LFNGAEKKRK 350
    RTSIAAPEKR SLEAYFAIQP RPSSEKIAAI AEKLDLKKNV VRVWFCNQRQ 400
    KQKRMKYSAG I 411
    Length:411
    Mass (Da):43,173
    Last modified:November 1, 1996 - v1
    Checksum:i97EA816F7DEC07C9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti90 – 989RRACLPTPP → MCAFYLQLQ(PubMed:8162704)Curated
    Sequence conflicti404 – 4052RM → KV in AAB30578. (PubMed:8162704)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S68377 mRNA. Translation: AAC60672.1.
    AK087546 mRNA. Translation: BAC39921.1.
    S69351 Genomic DNA. Translation: AAB30578.1.
    CCDSiCCDS22429.1.
    RefSeqiNP_620394.2. NM_138944.2.
    UniGeneiMm.234261.

    Genome annotation databases

    EnsembliENSMUST00000034115; ENSMUSP00000034115; ENSMUSG00000031688.
    GeneIDi18997.
    KEGGimmu:18997.
    UCSCiuc009mhy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S68377 mRNA. Translation: AAC60672.1 .
    AK087546 mRNA. Translation: BAC39921.1 .
    S69351 Genomic DNA. Translation: AAB30578.1 .
    CCDSi CCDS22429.1.
    RefSeqi NP_620394.2. NM_138944.2.
    UniGenei Mm.234261.

    3D structure databases

    ProteinModelPortali Q63934.
    SMRi Q63934. Positions 256-405.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202311. 4 interactions.
    STRINGi 10090.ENSMUSP00000034115.

    PTM databases

    PhosphoSitei Q63934.

    Proteomic databases

    PaxDbi Q63934.
    PRIDEi Q63934.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034115 ; ENSMUSP00000034115 ; ENSMUSG00000031688 .
    GeneIDi 18997.
    KEGGi mmu:18997.
    UCSCi uc009mhy.1. mouse.

    Organism-specific databases

    CTDi 5458.
    MGIi MGI:102524. Pou4f2.

    Phylogenomic databases

    eggNOGi NOG289030.
    GeneTreei ENSGT00750000117482.
    HOGENOMi HOG000116305.
    HOVERGENi HBG031829.
    InParanoidi Q63934.
    KOi K09366.
    OMAi PSNIFGG.
    OrthoDBi EOG7RV9G7.
    PhylomeDBi Q63934.
    TreeFami TF316413.

    Miscellaneous databases

    NextBioi 295402.
    PROi Q63934.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q63934.
    CleanExi MM_POU4F2.
    Genevestigatori Q63934.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Brn-3.2: a Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid."
      Turner E.E., Jenne K.J., Rosenfeld M.G.
      Neuron 12:205-218(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Eye.
    3. "Chromosomal localization and sequences of the murine Brn-3 family of developmental control genes."
      Theil T., Zechner U., Klett C., Adolph S., Moeroey T.
      Cytogenet. Cell Genet. 66:267-271(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 90-411.
      Strain: CD.

    Entry informationi

    Entry nameiPO4F2_MOUSE
    AccessioniPrimary (citable) accession number: Q63934
    Secondary accession number(s): Q63954
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3