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Protein

Serum deprivation-response protein

Gene

Sdpr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in targeting PRKCA to caveolae.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serum deprivation-response protein
Alternative name(s):
Cavin-2
Phosphatidylserine-binding protein
Gene namesi
Name:SdprImported
Synonyms:Sdr1 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:99513. Sdpr.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002389192 – 418Serum deprivation-response proteinAdd BLAST417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineBy similarity1
Modified residuei27PhosphoserineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei37PhosphoserineCombined sources1
Modified residuei51PhosphoserineBy similarity1
Modified residuei196PhosphothreonineBy similarity1
Modified residuei203PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei218PhosphoserineCombined sources1
Modified residuei283PhosphoserineCombined sources1
Modified residuei284PhosphoserineCombined sources1
Modified residuei287PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei293PhosphoserineCombined sources1
Modified residuei296PhosphoserineCombined sources1
Modified residuei327PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1
Modified residuei363PhosphoserineCombined sources1
Modified residuei368PhosphothreonineCombined sources1
Modified residuei388PhosphotyrosineCombined sources1
Modified residuei390PhosphoserineCombined sources1
Modified residuei396PhosphoserineBy similarity1

Post-translational modificationi

The N-terminus is blocked.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ63918.
PaxDbiQ63918.
PeptideAtlasiQ63918.
PRIDEiQ63918.

PTM databases

iPTMnetiQ63918.
PhosphoSitePlusiQ63918.
SwissPalmiQ63918.

Expressioni

Tissue specificityi

Highly expressed in kidney, lung and heart, and expressed at lower levels in liver, spleen, thymus, stomach, intestine and uterus.1 Publication

Developmental stagei

Expression gradually increases during embryonic stages and reaches a maximum in neonates.1 Publication

Inductioni

Up-regulated in response to cardiac hypertrophy and in serum-starved but not in density-dependent growth-arrested NIH3T3 cells. Down-regulated within 6 hours after the addition of serum or epidermal growth factor to serum-starved cells.2 Publications

Gene expression databases

BgeeiENSMUSG00000045954.
CleanExiMM_SDPR.
GenevisibleiQ63918. MM.

Interactioni

Subunit structurei

Binds to PRKCA in the presence of phosphatidylserine. Interacts with MURC; this augments the transactivation of NPPA by MURC (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ63918. 3 interactors.
MINTiMINT-4114971.
STRINGi10090.ENSMUSP00000055694.

Structurei

3D structure databases

ProteinModelPortaliQ63918.
SMRiQ63918.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili61 – 87Sequence analysisAdd BLAST27
Coiled coili126 – 268Sequence analysisAdd BLAST143

Sequence similaritiesi

Belongs to the PTRF/SDPR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEZA. Eukaryota.
ENOG410XP8W. LUCA.
GeneTreeiENSGT00530000063058.
HOGENOMiHOG000293135.
HOVERGENiHBG056807.
InParanoidiQ63918.
OMAiERMDRQC.
OrthoDBiEOG091G09Y1.
PhylomeDBiQ63918.
TreeFamiTF331031.

Family and domain databases

InterProiIPR026752. Cavin_fam.
IPR033298. SDPR.
[Graphical view]
PANTHERiPTHR15240. PTHR15240. 1 hit.
PTHR15240:SF1. PTHR15240:SF1. 1 hit.
PfamiPF15237. PTRF_SDPR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63918-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEDAAQAEK FQHPNTDMLQ EKPSSPSPMP SSTPSPSLNL GSTEEAIRDN
60 70 80 90 100
SQVNAVTVHT LLDKLVNMLD AVRENQHNME QRQINLEGSV KGIQNDLTKL
110 120 130 140 150
SKYQASTSNT VSKLLEKSRK VSAHTRAVRE RLERQCVQVK RLENNHAQLL
160 170 180 190 200
RRNHFKVLIF QEESEIPASV FVKEPVPSAA EGKEELADEN KSLEETLHNV
210 220 230 240 250
DLSSDDELPR DEEALEDSAE EKMEESRAEK IKRSSLKKVD SLKKAFSRQN
260 270 280 290 300
IEKKMNKLGT KIVSVERREK IKKSLTPNHQ KASSGKSSPF KVSPLSFGRK
310 320 330 340 350
KVREGESSVE NETKLEDQMQ EDREEGSFTE GLSEASLPSG LMEGSAEDAE
360 370 380 390 400
KSARRGNNSA VGSNADLTIE EDEEEEPVAL QQAQQVRYES GYMLNSEEME
410
EPSEKQVQPA VLHVDQTA
Length:418
Mass (Da):46,764
Last modified:January 23, 2007 - v3
Checksum:iEFD7B4E383785F41
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14P → L in BAE21104 (PubMed:16141072).Curated1
Sequence conflicti76Q → L in BAC29033 (PubMed:16141072).Curated1
Sequence conflicti173K → R in BAC29033 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67386 mRNA. Translation: AAB28953.1.
AK035324 mRNA. Translation: BAC29033.1.
AK084096 mRNA. Translation: BAC39116.1.
AK132324 mRNA. Translation: BAE21104.1.
BC020008 mRNA. Translation: AAH20008.1.
BC027005 mRNA. Translation: AAH27005.1.
CCDSiCCDS14940.1.
RefSeqiNP_620080.1. NM_138741.1.
UniGeneiMm.398690.

Genome annotation databases

EnsembliENSMUST00000051572; ENSMUSP00000055694; ENSMUSG00000045954.
GeneIDi20324.
KEGGimmu:20324.
UCSCiuc007axk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67386 mRNA. Translation: AAB28953.1.
AK035324 mRNA. Translation: BAC29033.1.
AK084096 mRNA. Translation: BAC39116.1.
AK132324 mRNA. Translation: BAE21104.1.
BC020008 mRNA. Translation: AAH20008.1.
BC027005 mRNA. Translation: AAH27005.1.
CCDSiCCDS14940.1.
RefSeqiNP_620080.1. NM_138741.1.
UniGeneiMm.398690.

3D structure databases

ProteinModelPortaliQ63918.
SMRiQ63918.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ63918. 3 interactors.
MINTiMINT-4114971.
STRINGi10090.ENSMUSP00000055694.

PTM databases

iPTMnetiQ63918.
PhosphoSitePlusiQ63918.
SwissPalmiQ63918.

Proteomic databases

MaxQBiQ63918.
PaxDbiQ63918.
PeptideAtlasiQ63918.
PRIDEiQ63918.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051572; ENSMUSP00000055694; ENSMUSG00000045954.
GeneIDi20324.
KEGGimmu:20324.
UCSCiuc007axk.1. mouse.

Organism-specific databases

CTDi8436.
MGIiMGI:99513. Sdpr.

Phylogenomic databases

eggNOGiENOG410IEZA. Eukaryota.
ENOG410XP8W. LUCA.
GeneTreeiENSGT00530000063058.
HOGENOMiHOG000293135.
HOVERGENiHBG056807.
InParanoidiQ63918.
OMAiERMDRQC.
OrthoDBiEOG091G09Y1.
PhylomeDBiQ63918.
TreeFamiTF331031.

Miscellaneous databases

ChiTaRSiSdpr. mouse.
PROiQ63918.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045954.
CleanExiMM_SDPR.
GenevisibleiQ63918. MM.

Family and domain databases

InterProiIPR026752. Cavin_fam.
IPR033298. SDPR.
[Graphical view]
PANTHERiPTHR15240. PTHR15240. 1 hit.
PTHR15240:SF1. PTHR15240:SF1. 1 hit.
PfamiPF15237. PTRF_SDPR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDPR_MOUSE
AccessioniPrimary (citable) accession number: Q63918
Secondary accession number(s): Q3V1P6, Q78EC3, Q8CBT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds phosphatidylserine (PS) in a calcium-independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.