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Protein

Oligodendrocyte-myelin glycoprotein

Gene

Omg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.

GO - Molecular functioni

  • identical protein binding Source: MGI
  • protein homodimerization activity Source: MGI

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • central nervous system myelination Source: MGI
  • neuron projection regeneration Source: MGI
  • regulation of collateral sprouting of intact axon in response to injury Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Oligodendrocyte-myelin glycoprotein
Gene namesi
Name:Omg
Synonyms:Omgp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:106586. Omg.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 417393Oligodendrocyte-myelin glycoproteinPRO_0000021890Add
BLAST
Propeptidei418 – 44023Removed in mature formSequence analysisPRO_0000021891Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence analysis
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence analysis
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence analysis
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence analysis
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis
Glycosylationi234 – 2341N-linked (GlcNAc...)Sequence analysis
Glycosylationi364 – 3641N-linked (GlcNAc...)Sequence analysis
Glycosylationi389 – 3891N-linked (GlcNAc...)Sequence analysis
Lipidationi417 – 4171GPI-anchor amidated serineSequence analysis
Glycosylationi425 – 4251N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

O-glycosylated in its Ser/Thr-rich repeat domain.Curated

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ63912.
PaxDbiQ63912.
PRIDEiQ63912.

PTM databases

PhosphoSiteiQ63912.

Expressioni

Tissue specificityi

Oligodendrocytes and myelin of the central nervous system.

Gene expression databases

BgeeiQ63912.
CleanExiMM_OMG.

Interactioni

Subunit structurei

Binds to RTN4R.

GO - Molecular functioni

  • identical protein binding Source: MGI
  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

IntActiQ63912. 2 interactions.
MINTiMINT-4105847.
STRINGi10090.ENSMUSP00000132918.

Structurei

3D structure databases

ProteinModelPortaliQ63912.
SMRiQ63912. Positions 25-276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 5531LRRNTAdd
BLAST
Repeati56 – 7823LRR 1Add
BLAST
Repeati79 – 10022LRR 2Add
BLAST
Repeati101 – 12121LRR 3Add
BLAST
Repeati124 – 14522LRR 4Add
BLAST
Repeati147 – 16822LRR 5Add
BLAST
Repeati169 – 18921LRR 6Add
BLAST
Repeati192 – 21322LRR 7Add
BLAST
Repeati216 – 23924LRR 8Add
BLAST
Repeati229 – 27042Ser/Thr-richAdd
BLAST
Repeati271 – 29222Ser/Thr-richAdd
BLAST
Repeati293 – 33543Ser/Thr-richAdd
BLAST
Repeati336 – 37742Ser/Thr-richAdd
BLAST
Repeati378 – 41639Ser/Thr-richAdd
BLAST

Sequence similaritiesi

Contains 8 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000115267.
HOVERGENiHBG007868.
InParanoidiQ63912.
KOiK16666.
PhylomeDBiQ63912.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63912-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYQILKMSS CLFILLFLTP GILCICPLQC TCTERHRHVD CSGRNLTTLP
60 70 80 90 100
PGLQENIIHL NLSYNHFTDL HNQLTPYTNL RTLDISNNRL ESLPAQLPRS
110 120 130 140 150
LWNMSAANNN IKLLDKSDTA YQWNLKYLDV SKNMLEKVVL IKNTLRSLEV
160 170 180 190 200
LNLSSNKLWT VPTNMPSKLH IVDLSNNSLT QILPGTLINL TNLTHLYLHN
210 220 230 240 250
NKFTFIPEQS FDQLLQLQEI TLHNNRWSCD HKQNITYLLK WVMETKAHVI
260 270 280 290 300
GTPCSKQVSS LKEQSMYPTP PGFTSSLFTM SEMQTVDTIN SLSMVTQPKV
310 320 330 340 350
TKTPKQYRGK ETTFGVTLSK DTTFSSTDRA VVAYPEDTPT EMTNSHEAAA
360 370 380 390 400
ATLTIHLQDG MSSNASLTSA TKSPPSPVTL SIARGMPNNF SEMPRQSTTL
410 420 430 440
NLRREETTAN GNTRPPSAAS AWKVNASLLL MLNAVVMLAG
Length:440
Mass (Da):49,284
Last modified:November 1, 1997 - v1
Checksum:i2F23047A41FC458A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67043 Genomic DNA. Translation: AAB28991.2.
BC024757 mRNA. Translation: AAH24757.1.
PIRiA47530.
RefSeqiNP_062282.2. NM_019409.2.
UniGeneiMm.93335.

Genome annotation databases

GeneIDi18377.
KEGGimmu:18377.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67043 Genomic DNA. Translation: AAB28991.2.
BC024757 mRNA. Translation: AAH24757.1.
PIRiA47530.
RefSeqiNP_062282.2. NM_019409.2.
UniGeneiMm.93335.

3D structure databases

ProteinModelPortaliQ63912.
SMRiQ63912. Positions 25-276.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ63912. 2 interactions.
MINTiMINT-4105847.
STRINGi10090.ENSMUSP00000132918.

PTM databases

PhosphoSiteiQ63912.

Proteomic databases

MaxQBiQ63912.
PaxDbiQ63912.
PRIDEiQ63912.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi18377.
KEGGimmu:18377.

Organism-specific databases

CTDi4974.
MGIiMGI:106586. Omg.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000115267.
HOVERGENiHBG007868.
InParanoidiQ63912.
KOiK16666.
PhylomeDBiQ63912.

Miscellaneous databases

NextBioi293954.
PROiQ63912.
SOURCEiSearch...

Gene expression databases

BgeeiQ63912.
CleanExiMM_OMG.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The oligodendrocyte-myelin glycoprotein of mouse: primary structure and gene structure."
    Mikol D.D., Rongnoparut P., Allwardt B.A., Marton L.S., Stefansson K.
    Genomics 17:604-610(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Retina.
  3. "Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth."
    Wang K.C., Koprivica V., Kim J.A., Sivasankaran R., Guo Y., Neve R.L., He Z.
    Nature 417:941-944(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RTN4R.

Entry informationi

Entry nameiOMGP_MOUSE
AccessioniPrimary (citable) accession number: Q63912
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 11, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Do not confuse oligodendrocyte-myelin glycoprotein (OMG) with myelin-oligodendrocyte glycoprotein (MOG).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.