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Q63912 (OMGP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Oligodendrocyte-myelin glycoprotein
Gene names
Name:Omg
Synonyms:Omgp
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.

Subunit structure

Binds to RTN4R. Ref.3

Subcellular location

Cell membrane; Lipid-anchor › GPI-anchor.

Tissue specificity

Oligodendrocytes and myelin of the central nervous system By similarity.

Post-translational modification

O-glycosylated in its Ser/Thr-rich repeat domain Potential.

Sequence similarities

Contains 8 LRR (leucine-rich) repeats.

Contains 1 LRRNT domain.

Caution

Do not confuse oligodendrocyte-myelin glycoprotein (OMG) with myelin-oligodendrocyte glycoprotein (MOG).

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 By similarity
Chain25 – 417393Oligodendrocyte-myelin glycoprotein
PRO_0000021890
Propeptide418 – 44023Removed in mature form Potential
PRO_0000021891

Regions

Domain25 – 5531LRRNT
Repeat56 – 7823LRR 1
Repeat79 – 10022LRR 2
Repeat101 – 12121LRR 3
Repeat124 – 14522LRR 4
Repeat147 – 16822LRR 5
Repeat169 – 18921LRR 6
Repeat192 – 21322LRR 7
Repeat216 – 23924LRR 8
Repeat229 – 27042Ser/Thr-rich
Repeat271 – 29222Ser/Thr-rich
Repeat293 – 33543Ser/Thr-rich
Repeat336 – 37742Ser/Thr-rich
Repeat378 – 41639Ser/Thr-rich

Amino acid modifications

Lipidation4171GPI-anchor amidated serine Potential
Glycosylation451N-linked (GlcNAc...) Potential
Glycosylation611N-linked (GlcNAc...) Potential
Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation1521N-linked (GlcNAc...) Potential
Glycosylation1761N-linked (GlcNAc...) Potential
Glycosylation1891N-linked (GlcNAc...) Potential
Glycosylation1921N-linked (GlcNAc...) Potential
Glycosylation2341N-linked (GlcNAc...) Potential
Glycosylation3641N-linked (GlcNAc...) Potential
Glycosylation3891N-linked (GlcNAc...) Potential
Glycosylation4251N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q63912 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 2F23047A41FC458A

FASTA44049,284
        10         20         30         40         50         60 
MEYQILKMSS CLFILLFLTP GILCICPLQC TCTERHRHVD CSGRNLTTLP PGLQENIIHL 

        70         80         90        100        110        120 
NLSYNHFTDL HNQLTPYTNL RTLDISNNRL ESLPAQLPRS LWNMSAANNN IKLLDKSDTA 

       130        140        150        160        170        180 
YQWNLKYLDV SKNMLEKVVL IKNTLRSLEV LNLSSNKLWT VPTNMPSKLH IVDLSNNSLT 

       190        200        210        220        230        240 
QILPGTLINL TNLTHLYLHN NKFTFIPEQS FDQLLQLQEI TLHNNRWSCD HKQNITYLLK 

       250        260        270        280        290        300 
WVMETKAHVI GTPCSKQVSS LKEQSMYPTP PGFTSSLFTM SEMQTVDTIN SLSMVTQPKV 

       310        320        330        340        350        360 
TKTPKQYRGK ETTFGVTLSK DTTFSSTDRA VVAYPEDTPT EMTNSHEAAA ATLTIHLQDG 

       370        380        390        400        410        420 
MSSNASLTSA TKSPPSPVTL SIARGMPNNF SEMPRQSTTL NLRREETTAN GNTRPPSAAS 

       430        440 
AWKVNASLLL MLNAVVMLAG

« Hide

References

« Hide 'large scale' references
[1]"The oligodendrocyte-myelin glycoprotein of mouse: primary structure and gene structure."
Mikol D.D., Rongnoparut P., Allwardt B.A., Marton L.S., Stefansson K.
Genomics 17:604-610(1993) [PubMed: 8244377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Retina.
[3]"Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth."
Wang K.C., Koprivica V., Kim J.A., Sivasankaran R., Guo Y., Neve R.L., He Z.
Nature 417:941-944(2002) [PubMed: 12068310] [Abstract]
Cited for: INTERACTION WITH RTN4R.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		S67043 Genomic DNA. Translation: AAB28991.2.
BC024757 mRNA. Translation: AAH24757.1.
IPIIPI00990035.
PIRA47530.
RefSeqNP_062282.2. NM_019409.2.
UniGeneMm.93335.

3D structure databases

ProteinModelPortalQ63912.
SMRQ63912. Positions 28-295, 369-433.
ModBaseSearch...

Protein-protein interaction databases

IntActQ63912. 1 interaction.
STRINGQ63912.

Proteomic databases

PRIDEQ63912.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000056559; ENSMUSP00000054140; ENSMUSG00000049612.
GeneID18377.
KEGGmmu:18377.

Organism-specific databases

CTD4974.
MGIMGI:106586. Omg.

Phylogenomic databases

HOGENOMHBG125163.
HOVERGENHBG007868.
InParanoidQ63912.
OMAQNITYLL.
PhylomeDBQ63912.

Gene expression databases

ArrayExpressQ63912.
BgeeQ63912.
CleanExMM_OMG.
GenevestigatorQ63912.
GermOnlineENSMUSG00000049612. Mus musculus.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamPF01462. LRRNT. 1 hit.
[Graphical view]
SMARTSM00369. LRR_TYP. 2 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio293954.
SOURCESearch...

Entry information

Entry nameOMGP_MOUSE
AccessionPrimary (citable) accession number: Q63912
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 16, 2011
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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