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Protein
Submitted name:

Alpha globin

Gene

Hba-a3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi88Iron (heme proximal ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • heme binding Source: RGD
  • iron ion binding Source: InterPro
  • organic acid binding Source: RGD
  • oxygen binding Source: InterPro
  • oxygen transporter activity Source: UniProtKB-KW

GO - Biological processi

  • protein heterooligomerization Source: RGD

Keywordsi

Biological processOxygen transportPROSITE-ProRule annotationSAAS annotation, Transport
LigandHemePROSITE-ProRule annotationSAAS annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha globinImported
Submitted name:
Globin c1Imported
Submitted name:
Hemoglobin alpha, adult chain 3Imported
Submitted name:
RCG33691Imported
Gene namesi
Name:Hba-a3Imported
Synonyms:Glnc1Imported, GloAImported, Hba-a1Imported, LOC287167Imported
ORF Names:rCG_33691Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1359209. Hba-a3.

Subcellular locationi

GO - Cellular componenti

  • hemoglobin complex Source: RGD

Expressioni

Gene expression databases

BgeeiENSRNOG00000045989.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041451.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 142GLOBINInterPro annotationAdd BLAST140

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
KOiK13822.
OMAiTLERMFL.
OrthoDBiEOG091G0S0X.
TreeFamiTF332328.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63910-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSEEDKNN IKKAWVKIGN HAAEIGAETI GRLFIVFPSS KTYFPHFNTS
60 70 80 90 100
EGSDQVKAHG KKVADALTNA ASHLDDLPGA LSTLSDLHAH KLRVDPVNFK
110 120 130 140
FLSHCLLVTL ASHHPGDFTP AMHASLDKFF ASVSTVLTSK YR
Length:142
Mass (Da):15,525
Last modified:January 1, 1998 - v2
Checksum:i92B3CA50D9CD8619
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC096051 Genomic DNA. No translation available.
U62315 Genomic DNA. Translation: AAB40623.1.
CH473948 Genomic DNA. Translation: EDM04007.1.
LT548168 Genomic DNA. Translation: SAI82215.1.
PIRiI68530.
RefSeqiNP_001013875.1. NM_001013853.1.
UniGeneiRn.163132.

Genome annotation databases

EnsembliENSRNOT00000052292; ENSRNOP00000041451; ENSRNOG00000045989.
GeneIDi287167.
KEGGirno:287167.
UCSCiRGD:1359209. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC096051 Genomic DNA. No translation available.
U62315 Genomic DNA. Translation: AAB40623.1.
CH473948 Genomic DNA. Translation: EDM04007.1.
LT548168 Genomic DNA. Translation: SAI82215.1.
PIRiI68530.
RefSeqiNP_001013875.1. NM_001013853.1.
UniGeneiRn.163132.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041451.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000052292; ENSRNOP00000041451; ENSRNOG00000045989.
GeneIDi287167.
KEGGirno:287167.
UCSCiRGD:1359209. rat.

Organism-specific databases

CTDi15122.
RGDi1359209. Hba-a3.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
KOiK13822.
OMAiTLERMFL.
OrthoDBiEOG091G0S0X.
TreeFamiTF332328.

Gene expression databases

BgeeiENSRNOG00000045989.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ63910_RAT
AccessioniPrimary (citable) accession number: Q63910
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: January 1, 1998
Last modified: March 15, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.