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Protein
Submitted name:

Alpha globin

Gene

Hba-a3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi88Iron (heme proximal ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • heme binding Source: RGD
  • iron ion binding Source: InterPro
  • organic acid binding Source: RGD
  • oxygen binding Source: InterPro
  • oxygen carrier activity Source: UniProtKB-KW

GO - Biological processi

  • protein heterooligomerization Source: RGD

Keywordsi

Biological processOxygen transportPROSITE-ProRule annotationSAAS annotation, Transport
LigandHemePROSITE-ProRule annotationSAAS annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-1237044. Erythrocytes take up carbon dioxide and release oxygen.
R-RNO-1247673. Erythrocytes take up oxygen and release carbon dioxide.
R-RNO-2168880. Scavenging of heme from plasma.

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha globinImported
Submitted name:
Globin c1Imported
Submitted name:
Hemoglobin alpha, adult chain 3Imported
Submitted name:
RCG33691Imported
Gene namesi
Name:Hba-a3Imported
Synonyms:Glnc1Imported, GloAImported, Hba-a1Imported, LOC287167Imported
ORF Names:rCG_33691Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1359209. Hba-a3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000045989.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041451.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 142GLOBINInterPro annotationAdd BLAST140

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
KOiK13822.
OMAiEAFGRML.
OrthoDBiEOG091G0S0X.
TreeFamiTF332328.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like_sf.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63910-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSEEDKNN IKKAWVKIGN HAAEIGAETI GRLFIVFPSS KTYFPHFNTS
60 70 80 90 100
EGSDQVKAHG KKVADALTNA ASHLDDLPGA LSTLSDLHAH KLRVDPVNFK
110 120 130 140
FLSHCLLVTL ASHHPGDFTP AMHASLDKFF ASVSTVLTSK YR
Length:142
Mass (Da):15,525
Last modified:January 1, 1998 - v2
Checksum:i92B3CA50D9CD8619
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC096051 Genomic DNA. No translation available.
U62315 Genomic DNA. Translation: AAB40623.1.
CH473948 Genomic DNA. Translation: EDM04007.1.
LT548168 Genomic DNA. Translation: SAI82215.1.
PIRiI68530.
RefSeqiNP_001013875.1. NM_001013853.1.
UniGeneiRn.163132.

Genome annotation databases

EnsembliENSRNOT00000052292; ENSRNOP00000041451; ENSRNOG00000045989.
GeneIDi287167.
KEGGirno:287167.
UCSCiRGD:1359209. rat.

Similar proteinsi

Entry informationi

Entry nameiQ63910_RAT
AccessioniPrimary (citable) accession number: Q63910
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: January 1, 1998
Last modified: November 22, 2017
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported