UDP-glucuronosyltransferase 1-1 precursor

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Q63886 (UD11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 97. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
UDP-glucuronosyltransferase 1-1
Short name=UDPGT 1-1
Short name=UGT1*1
Short name=UGT1-01
Short name=UGT1.1
EC=2.4.1.17

Alternative name(s):
UDP-glucuronosyltransferase 1A1
UGTBR1

Gene names

Name:	Ugt1a1
Synonyms:	Ugt1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	535 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subunit structure	Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.
Subcellular location	Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Tissue specificity	Highly expressed in liver and at lower levels in colon, kidney, stomach and intestine. Ref.2
Induction	By dioxin.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	acute-phase response Inferred from electronic annotation. Source: Compara biphenyl catabolic process Inferred from electronic annotation. Source: Compara cellular response to ethanol Inferred from electronic annotation. Source: Compara cellular response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara flavone metabolic process Inferred from electronic annotation. Source: Compara flavonoid glucuronidation Inferred from electronic annotation. Source: Compara liver development Inferred from electronic annotation. Source: Compara organ regeneration Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to lipopolysaccharide Inferred from electronic annotation. Source: Compara response to nutrient Inferred from electronic annotation. Source: Compara response to starvation Inferred from electronic annotation. Source: Compara xenobiotic glucuronidation Inferred from electronic annotation. Source: Compara
Cellular_component	cytochrome complex Inferred from electronic annotation. Source: Compara endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Inferred from direct assay PubMed 12951053. Source: MGI
Molecular_function	enzyme inhibitor activity Inferred from electronic annotation. Source: Compara glucuronosyltransferase activity Inferred from sequence alignment PubMed 12051676. Source: MGI retinoic acid binding Inferred from electronic annotation. Source: Compara steroid binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select] Note: A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q63886-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 29

Potential

Chain

30 – 535

506

UDP-glucuronosyltransferase 1-1

PRO_0000036010

Regions

Transmembrane

493 – 509

Helical; Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

297

N-linked (GlcNAc...) Potential

Glycosylation

435

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

S → Y in AAB26033. Ref.1

Sequence conflict

363

L → I in AAB26033. Ref.1

Sequence conflict

378

H → R in AAP48593. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Isoform 1 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 8C938AFD2D6DEB1D
Show »

FASTA

535

60,047

        10         20         30         40         50         60 
MTVVCWSSRL LLLLPYLLLC VFGPSASHAG RLLVFPMDGS HWLSMLGVIQ QLQQKGHEVV 

        70         80         90        100        110        120 
VIAPEASIHI KEGSFYTLRK FPVPFQKENV TATLVELGRT AFNQDSFLLR VVKIYMKVKR 

       130        140        150        160        170        180 
DSSMLLAGCS HLLHNAEFMA SLEESHFDAL LTDPFLPCGS IVAQYLTVPT VYFLNKLPCS 

       190        200        210        220        230        240 
LDSEATQCPV PLSYVPKSLS FNSDRMNFLQ RVKNVLLAVS ENFMCRVVYS PYGSLATEIL 

       250        260        270        280        290        300 
QKEVTVQDLL SPASIWLMRS DFVKDYPRPI MPNMVFIGGI NCLQKKPLSQ EFEAYVNASG 

       310        320        330        340        350        360 
EHGIVVFSLG SMVSEIPEKK AMEIAEALGR IPQTVLWRYT GTRPSNLAKN TILVKWLPQN 

       370        380        390        400        410        420 
DLLGHPKTRA FITHSGSHGI YEGICNGVPM VMMPLFGDQM DNAKRMETRG AGVTLNVLEM 

       430        440        450        460        470        480 
TADDLENALK TVINNKSYKE NIMRLSSLHK DRPIEPLDLA VFWVEYVMRH KGAPHLRPAA 

       490        500        510        520        530 
HDLTWYQYHS LDVIGFLLAI VLTVVFIVFK CCAYGCRKCF GGKGRVKKSH KSKTH

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p)." Kong A.N., Ma M., Tao D., Yang L. Pharm. Res. 10:461-465(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation." Zhang T., Haws P., Wu Q. Genome Res. 14:79-89(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Colon.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Liver.
[4]	"A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins." Meunier L., Usherwood Y.-K., Chung K.T., Hendershot L.M. Mol. Biol. Cell 13:4456-4469(2002) [PubMed] [Europe PMC] [Abstract] Cited for: COMPONENT OF A CHAPERONE COMPLEX.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S64760 mRNA. Translation: AAB26033.2. AY227194 mRNA. Translation: AAP48593.1. BC093516 mRNA. Translation: AAH93516.1.
IPI	IPI00134691.
RefSeq	NP_964007.2. NM_201645.2.
UniGene	Mm.300095.
3D structure databases
ProteinModelPortal	Q63886.
SMR	Q63886. Positions 286-446.
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
PTM databases
PhosphoSite	Q63886.
Proteomic databases
PaxDb	Q63886.
PRIDE	Q63886.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000073049; ENSMUSP00000072803; ENSMUSG00000089960.
GeneID	394436.
KEGG	mmu:394436.
Organism-specific databases
CTD	54658.
MGI	MGI:98898. Ugt1a1.
Phylogenomic databases
eggNOG	COG1819.
GeneTree	ENSGT00640000091365.
HOGENOM	HOG000220832.
HOVERGEN	HBG004033.
InParanoid	Q561M6.
KO	K00699.
OMA	ESHFRRM.
Gene expression databases
ArrayExpress	Q63886.
Bgee	Q63886.
Genevestigator	Q63886.
GermOnline	ENSMUSG00000054545. Mus musculus.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. PTHR11926. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	405997.
SOURCE	Search...

Entry information

Entry name

UD11_MOUSE

Accession

Primary (citable) accession number: Q63886
Secondary accession number(s): Q561M6, Q6XL50

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents