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Q63886

- UD11_MOUSE

UniProt

Q63886 - UD11_MOUSE

Protein

UDP-glucuronosyltransferase 1-1

Gene

Ugt1a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. enzyme inhibitor activity Source: Ensembl
    2. glucuronosyltransferase activity Source: MGI
    3. retinoic acid binding Source: Ensembl
    4. steroid binding Source: Ensembl

    GO - Biological processi

    1. acute-phase response Source: Ensembl
    2. biphenyl catabolic process Source: Ensembl
    3. cellular response to ethanol Source: Ensembl
    4. cellular response to glucocorticoid stimulus Source: Ensembl
    5. flavone metabolic process Source: Ensembl
    6. flavonoid glucuronidation Source: Ensembl
    7. liver development Source: Ensembl
    8. organ regeneration Source: Ensembl
    9. response to drug Source: Ensembl
    10. response to lipopolysaccharide Source: Ensembl
    11. response to nutrient Source: Ensembl
    12. response to starvation Source: Ensembl
    13. xenobiotic glucuronidation Source: Ensembl

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 1-1 (EC:2.4.1.17)
    Short name:
    UDPGT 1-1
    Short name:
    UGT1*1
    Short name:
    UGT1-01
    Short name:
    UGT1.1
    Alternative name(s):
    UDP-glucuronosyltransferase 1A1
    UGTBR1
    Gene namesi
    Name:Ugt1a1
    Synonyms:Ugt1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:98898. Ugt1a1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytochrome complex Source: Ensembl
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 535506UDP-glucuronosyltransferase 1-1PRO_0000036010Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi435 – 4351N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ63886.
    PaxDbiQ63886.
    PRIDEiQ63886.

    PTM databases

    PhosphoSiteiQ63886.

    Expressioni

    Tissue specificityi

    Highly expressed in liver and at lower levels in colon, kidney, stomach and intestine.1 Publication

    Inductioni

    By dioxin.

    Gene expression databases

    BgeeiQ63886.
    GenevestigatoriQ63886.

    Interactioni

    Subunit structurei

    Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

    Protein-protein interaction databases

    IntActiQ63886. 4 interactions.
    MINTiMINT-1859173.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63886.
    SMRiQ63886. Positions 34-451.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei493 – 50917HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    GeneTreeiENSGT00640000091365.
    HOGENOMiHOG000220832.
    HOVERGENiHBG004033.
    InParanoidiQ561M6.
    KOiK00699.
    OMAiIVAPEIN.
    OrthoDBiEOG7GBFWS.
    TreeFamiTF315472.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.

    Isoform 1 (identifier: Q63886-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTVVCWSSRL LLLLPYLLLC VFGPSASHAG RLLVFPMDGS HWLSMLGVIQ    50
    QLQQKGHEVV VIAPEASIHI KEGSFYTLRK FPVPFQKENV TATLVELGRT 100
    AFNQDSFLLR VVKIYMKVKR DSSMLLAGCS HLLHNAEFMA SLEESHFDAL 150
    LTDPFLPCGS IVAQYLTVPT VYFLNKLPCS LDSEATQCPV PLSYVPKSLS 200
    FNSDRMNFLQ RVKNVLLAVS ENFMCRVVYS PYGSLATEIL QKEVTVQDLL 250
    SPASIWLMRS DFVKDYPRPI MPNMVFIGGI NCLQKKPLSQ EFEAYVNASG 300
    EHGIVVFSLG SMVSEIPEKK AMEIAEALGR IPQTVLWRYT GTRPSNLAKN 350
    TILVKWLPQN DLLGHPKTRA FITHSGSHGI YEGICNGVPM VMMPLFGDQM 400
    DNAKRMETRG AGVTLNVLEM TADDLENALK TVINNKSYKE NIMRLSSLHK 450
    DRPIEPLDLA VFWVEYVMRH KGAPHLRPAA HDLTWYQYHS LDVIGFLLAI 500
    VLTVVFIVFK CCAYGCRKCF GGKGRVKKSH KSKTH 535
    Length:535
    Mass (Da):60,047
    Last modified:July 27, 2011 - v2
    Checksum:i8C938AFD2D6DEB1D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251S → Y in AAB26033. (PubMed:8464825)Curated
    Sequence conflicti363 – 3631L → I in AAB26033. (PubMed:8464825)Curated
    Sequence conflicti378 – 3781H → R in AAP48593. (PubMed:14672974)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S64760 mRNA. Translation: AAB26033.2.
    AY227194 mRNA. Translation: AAP48593.1.
    BC093516 mRNA. Translation: AAH93516.1.
    CCDSiCCDS15143.1. [Q63886-1]
    RefSeqiNP_964007.2. NM_201645.2. [Q63886-1]
    UniGeneiMm.300095.

    Genome annotation databases

    EnsembliENSMUST00000073049; ENSMUSP00000072803; ENSMUSG00000089960. [Q63886-1]
    GeneIDi394436.
    KEGGimmu:394436.
    UCSCiuc007byk.1. mouse. [Q63886-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S64760 mRNA. Translation: AAB26033.2 .
    AY227194 mRNA. Translation: AAP48593.1 .
    BC093516 mRNA. Translation: AAH93516.1 .
    CCDSi CCDS15143.1. [Q63886-1 ]
    RefSeqi NP_964007.2. NM_201645.2. [Q63886-1 ]
    UniGenei Mm.300095.

    3D structure databases

    ProteinModelPortali Q63886.
    SMRi Q63886. Positions 34-451.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q63886. 4 interactions.
    MINTi MINT-1859173.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    PTM databases

    PhosphoSitei Q63886.

    Proteomic databases

    MaxQBi Q63886.
    PaxDbi Q63886.
    PRIDEi Q63886.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000073049 ; ENSMUSP00000072803 ; ENSMUSG00000089960 . [Q63886-1 ]
    GeneIDi 394436.
    KEGGi mmu:394436.
    UCSCi uc007byk.1. mouse. [Q63886-1 ]

    Organism-specific databases

    CTDi 54658.
    MGIi MGI:98898. Ugt1a1.

    Phylogenomic databases

    eggNOGi COG1819.
    GeneTreei ENSGT00640000091365.
    HOGENOMi HOG000220832.
    HOVERGENi HBG004033.
    InParanoidi Q561M6.
    KOi K00699.
    OMAi IVAPEIN.
    OrthoDBi EOG7GBFWS.
    TreeFami TF315472.

    Miscellaneous databases

    NextBioi 405997.
    PROi Q63886.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q63886.
    Genevestigatori Q63886.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p)."
      Kong A.N., Ma M., Tao D., Yang L.
      Pharm. Res. 10:461-465(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation."
      Zhang T., Haws P., Wu Q.
      Genome Res. 14:79-89(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Colon.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    4. "A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins."
      Meunier L., Usherwood Y.-K., Chung K.T., Hendershot L.M.
      Mol. Biol. Cell 13:4456-4469(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: COMPONENT OF A CHAPERONE COMPLEX.

    Entry informationi

    Entry nameiUD11_MOUSE
    AccessioniPrimary (citable) accession number: Q63886
    Secondary accession number(s): Q561M6, Q6XL50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3