Reviewed, UniProtKB/Swiss-Prot Q63886 (UD11_MOUSE)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 1-1
      Short name=UDPGT
      Short name=UGT1*1
    EC=2.4.1.17
Alternative name(s):
    UGT1-01
      Short name=UGT1.1
    UGT1A1
    UGTBR1

Gene names

Name:	Ugt1a1
Synonyms:	Ugt1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	535 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subunit structure	Part a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.
Subcellular location	Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Induction	By dioxin.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Inferred from direct assay. Source: MGI microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q63886-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 535	506	UDP-glucuronosyltransferase 1-1		PRO_0000036010
Regions
	Transmembrane	493 – 509	17	Potential
Amino acid modifications
	Glycosylation	89	1	N-linked (GlcNAc...) Potential
	Glycosylation	297	1	N-linked (GlcNAc...) Potential
	Glycosylation	435	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: B5AE3C209979BBB8	FASTA	535	60,123
	10 20 30 40 50 60 MTVVCWSSRL LLLLPYLLLC VFGPYASHAG RLLVFPMDGS HWLSMLGVIQ QLQQKGHEVV 70 80 90 100 110 120 VIAPEASIHI KEGSFYTLRK FPVPFQKENV TATLVELGRT AFNQDSFLLR VVKIYMKVKR 130 140 150 160 170 180 DSSMLLAGCS HLLHNAEFMA SLEESHFDAL LTDPFLPCGS IVAQYLTVPT VYFLNKLPCS 190 200 210 220 230 240 LDSEATQCPV PLSYVPKSLS FNSDRMNFLQ RVKNVLLAVS ENFMCRVVYS PYGSLATEIL 250 260 270 280 290 300 QKEVTVQDLL SPASIWLMRS DFVKDYPRPI MPNMVFIGGI NCLQKKPLSQ EFEAYVNASG 310 320 330 340 350 360 EHGIVVFSLG SMVSEIPEKK AMEIAEALGR IPQTVLWRYT GTRPSNLAKN TILVKWLPQN 370 380 390 400 410 420 DLIGHPKTRA FITHSGSHGI YEGICNGVPM VMMPLFGDQM DNAKRMETRG AGVTLNVLEM 430 440 450 460 470 480 TADDLENALK TVINNKSYKE NIMRLSSLHK DRPIEPLDLA VFWVEYVMRH KGAPHLRPAA 490 500 510 520 530 HDLTWYQYHS LDVIGFLLAI VLTVVFIVFK CCAYGCRKCF GGKGRVKKSH KSKTH

References

[1]	"Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p)." Kong A.N., Ma M., Tao D., Yang L. Pharm. Res. 10:461-465(1993) [PubMed: 8464825] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins." Meunier L., Usherwood Y.-K., Chung K.T., Hendershot L.M. Mol. Biol. Cell 13:4456-4469(2002) [PubMed: 12475965] [Abstract] Cited for: COMPONENT OF A CHAPERONE COMPLEX.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	S64760 mRNA. Translation: AAB26033.2.
IPI	IPI00134691.
UniGene	Mm.300095
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Genome annotation databases
Ensembl	ENSMUSG00000054545. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:98898. Ugt1a1.
Phylogenomic databases
HOGENOM	Q63886.
HOVERGEN	Q63886.
Enzyme and pathway databases
BRENDA	2.4.1.17. 244.
Gene expression databases
ArrayExpress	Q63886.
Bgee	Q63886.
GermOnline	ENSMUSG00000054545. Mus musculus.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

UD11_MOUSE

Accession

Primary (citable) accession number: Q63886

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)