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Protein

UDP-glucuronosyltransferase 1-1

Gene

Ugt1a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. enzyme binding Source: MGI
  2. enzyme inhibitor activity Source: MGI
  3. glucuronosyltransferase activity Source: MGI
  4. protein heterodimerization activity Source: MGI
  5. protein homodimerization activity Source: MGI
  6. retinoic acid binding Source: MGI
  7. steroid binding Source: MGI

GO - Biological processi

  1. acute-phase response Source: Ensembl
  2. biphenyl catabolic process Source: Ensembl
  3. cellular glucuronidation Source: MGI
  4. cellular response to ethanol Source: Ensembl
  5. cellular response to glucocorticoid stimulus Source: Ensembl
  6. cellular response to hormone stimulus Source: GO_Central
  7. flavone metabolic process Source: MGI
  8. flavonoid biosynthetic process Source: GO_Central
  9. flavonoid glucuronidation Source: MGI
  10. liver development Source: Ensembl
  11. negative regulation of catalytic activity Source: MGI
  12. negative regulation of cellular glucuronidation Source: MGI
  13. organ regeneration Source: Ensembl
  14. response to drug Source: Ensembl
  15. response to lipopolysaccharide Source: Ensembl
  16. response to nutrient Source: Ensembl
  17. response to starvation Source: Ensembl
  18. xenobiotic glucuronidation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_233393. Heme degradation.
REACT_257519. Glucuronidation.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-1 (EC:2.4.1.17)
Short name:
UDPGT 1-1
Short name:
UGT1*1
Short name:
UGT1-01
Short name:
UGT1.1
Alternative name(s):
UDP-glucuronosyltransferase 1A1
UGTBR1
Gene namesi
Name:Ugt1a1
Synonyms:Ugt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:98898. Ugt1a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei493 – 50917HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytochrome complex Source: Ensembl
  2. endoplasmic reticulum Source: MGI
  3. endoplasmic reticulum chaperone complex Source: ParkinsonsUK-UCL
  4. endoplasmic reticulum membrane Source: GO_Central
  5. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 535506UDP-glucuronosyltransferase 1-1PRO_0000036010Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi435 – 4351N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ63886.
PaxDbiQ63886.
PRIDEiQ63886.

PTM databases

PhosphoSiteiQ63886.

Expressioni

Tissue specificityi

Highly expressed in liver and at lower levels in colon, kidney, stomach and intestine.1 Publication

Inductioni

By dioxin.

Gene expression databases

BgeeiQ63886.
ExpressionAtlasiQ63886. baseline.
GenevestigatoriQ63886.

Interactioni

Subunit structurei

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

Protein-protein interaction databases

IntActiQ63886. 4 interactions.
MINTiMINT-1859173.

Structurei

3D structure databases

ProteinModelPortaliQ63886.
SMRiQ63886. Positions 34-451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiQ63886.
KOiK00699.
OMAiLEESHFD.
OrthoDBiEOG7GBFWS.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q63886-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTVVCWSSRL LLLLPYLLLC VFGPSASHAG RLLVFPMDGS HWLSMLGVIQ
60 70 80 90 100
QLQQKGHEVV VIAPEASIHI KEGSFYTLRK FPVPFQKENV TATLVELGRT
110 120 130 140 150
AFNQDSFLLR VVKIYMKVKR DSSMLLAGCS HLLHNAEFMA SLEESHFDAL
160 170 180 190 200
LTDPFLPCGS IVAQYLTVPT VYFLNKLPCS LDSEATQCPV PLSYVPKSLS
210 220 230 240 250
FNSDRMNFLQ RVKNVLLAVS ENFMCRVVYS PYGSLATEIL QKEVTVQDLL
260 270 280 290 300
SPASIWLMRS DFVKDYPRPI MPNMVFIGGI NCLQKKPLSQ EFEAYVNASG
310 320 330 340 350
EHGIVVFSLG SMVSEIPEKK AMEIAEALGR IPQTVLWRYT GTRPSNLAKN
360 370 380 390 400
TILVKWLPQN DLLGHPKTRA FITHSGSHGI YEGICNGVPM VMMPLFGDQM
410 420 430 440 450
DNAKRMETRG AGVTLNVLEM TADDLENALK TVINNKSYKE NIMRLSSLHK
460 470 480 490 500
DRPIEPLDLA VFWVEYVMRH KGAPHLRPAA HDLTWYQYHS LDVIGFLLAI
510 520 530
VLTVVFIVFK CCAYGCRKCF GGKGRVKKSH KSKTH
Length:535
Mass (Da):60,047
Last modified:July 27, 2011 - v2
Checksum:i8C938AFD2D6DEB1D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251S → Y in AAB26033 (PubMed:8464825).Curated
Sequence conflicti363 – 3631L → I in AAB26033 (PubMed:8464825).Curated
Sequence conflicti378 – 3781H → R in AAP48593 (PubMed:14672974).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S64760 mRNA. Translation: AAB26033.2.
AY227194 mRNA. Translation: AAP48593.1.
BC093516 mRNA. Translation: AAH93516.1.
CCDSiCCDS15143.1. [Q63886-1]
RefSeqiNP_964007.2. NM_201645.2. [Q63886-1]
UniGeneiMm.300095.

Genome annotation databases

EnsembliENSMUST00000073049; ENSMUSP00000072803; ENSMUSG00000089960. [Q63886-1]
GeneIDi394436.
KEGGimmu:394436.
UCSCiuc007byk.1. mouse. [Q63886-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S64760 mRNA. Translation: AAB26033.2.
AY227194 mRNA. Translation: AAP48593.1.
BC093516 mRNA. Translation: AAH93516.1.
CCDSiCCDS15143.1. [Q63886-1]
RefSeqiNP_964007.2. NM_201645.2. [Q63886-1]
UniGeneiMm.300095.

3D structure databases

ProteinModelPortaliQ63886.
SMRiQ63886. Positions 34-451.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ63886. 4 interactions.
MINTiMINT-1859173.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSiteiQ63886.

Proteomic databases

MaxQBiQ63886.
PaxDbiQ63886.
PRIDEiQ63886.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073049; ENSMUSP00000072803; ENSMUSG00000089960. [Q63886-1]
GeneIDi394436.
KEGGimmu:394436.
UCSCiuc007byk.1. mouse. [Q63886-1]

Organism-specific databases

CTDi54658.
MGIiMGI:98898. Ugt1a1.

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiQ63886.
KOiK00699.
OMAiLEESHFD.
OrthoDBiEOG7GBFWS.
TreeFamiTF315472.

Enzyme and pathway databases

ReactomeiREACT_233393. Heme degradation.
REACT_257519. Glucuronidation.

Miscellaneous databases

NextBioi405997.
PROiQ63886.
SOURCEiSearch...

Gene expression databases

BgeeiQ63886.
ExpressionAtlasiQ63886. baseline.
GenevestigatoriQ63886.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p)."
    Kong A.N., Ma M., Tao D., Yang L.
    Pharm. Res. 10:461-465(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation."
    Zhang T., Haws P., Wu Q.
    Genome Res. 14:79-89(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Colon.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  4. "A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins."
    Meunier L., Usherwood Y.-K., Chung K.T., Hendershot L.M.
    Mol. Biol. Cell 13:4456-4469(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPONENT OF A CHAPERONE COMPLEX.

Entry informationi

Entry nameiUD11_MOUSE
AccessioniPrimary (citable) accession number: Q63886
Secondary accession number(s): Q561M6, Q6XL50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: February 4, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.