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Q63886 (UD11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 1-1

Short name=UDPGT 1-1
Short name=UGT1*1
Short name=UGT1-01
Short name=UGT1.1
EC=2.4.1.17
Alternative name(s):
UDP-glucuronosyltransferase 1A1
UGTBR1
Gene names
Name:Ugt1a1
Synonyms:Ugt1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length535 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subunit structure

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

Subcellular location

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Tissue specificity

Highly expressed in liver and at lower levels in colon, kidney, stomach and intestine. Ref.2

Induction

By dioxin.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   Coding sequence diversityAlternative splicing
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processacute-phase response

Inferred from electronic annotation. Source: Ensembl

biphenyl catabolic process

Inferred from electronic annotation. Source: Ensembl

cellular response to ethanol

Inferred from electronic annotation. Source: Ensembl

cellular response to glucocorticoid stimulus

Inferred from electronic annotation. Source: Ensembl

flavone metabolic process

Inferred from electronic annotation. Source: Ensembl

flavonoid glucuronidation

Inferred from electronic annotation. Source: Ensembl

liver development

Inferred from electronic annotation. Source: Ensembl

organ regeneration

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to nutrient

Inferred from electronic annotation. Source: Ensembl

response to starvation

Inferred from electronic annotation. Source: Ensembl

xenobiotic glucuronidation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytochrome complex

Inferred from electronic annotation. Source: Ensembl

endoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of plasma membrane

Inferred from direct assay PubMed 12951053. Source: MGI

   Molecular_functionenzyme inhibitor activity

Inferred from electronic annotation. Source: Ensembl

glucuronosyltransferase activity

Inferred from sequence alignment PubMed 12051676. Source: MGI

retinoic acid binding

Inferred from electronic annotation. Source: Ensembl

steroid binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.
Isoform 1 (identifier: Q63886-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 535506UDP-glucuronosyltransferase 1-1
PRO_0000036010

Regions

Transmembrane493 – 50917Helical; Potential

Amino acid modifications

Glycosylation891N-linked (GlcNAc...) Potential
Glycosylation2971N-linked (GlcNAc...) Potential
Glycosylation4351N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict251S → Y in AAB26033. Ref.1
Sequence conflict3631L → I in AAB26033. Ref.1
Sequence conflict3781H → R in AAP48593. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 8C938AFD2D6DEB1D

FASTA53560,047
        10         20         30         40         50         60 
MTVVCWSSRL LLLLPYLLLC VFGPSASHAG RLLVFPMDGS HWLSMLGVIQ QLQQKGHEVV 

        70         80         90        100        110        120 
VIAPEASIHI KEGSFYTLRK FPVPFQKENV TATLVELGRT AFNQDSFLLR VVKIYMKVKR 

       130        140        150        160        170        180 
DSSMLLAGCS HLLHNAEFMA SLEESHFDAL LTDPFLPCGS IVAQYLTVPT VYFLNKLPCS 

       190        200        210        220        230        240 
LDSEATQCPV PLSYVPKSLS FNSDRMNFLQ RVKNVLLAVS ENFMCRVVYS PYGSLATEIL 

       250        260        270        280        290        300 
QKEVTVQDLL SPASIWLMRS DFVKDYPRPI MPNMVFIGGI NCLQKKPLSQ EFEAYVNASG 

       310        320        330        340        350        360 
EHGIVVFSLG SMVSEIPEKK AMEIAEALGR IPQTVLWRYT GTRPSNLAKN TILVKWLPQN 

       370        380        390        400        410        420 
DLLGHPKTRA FITHSGSHGI YEGICNGVPM VMMPLFGDQM DNAKRMETRG AGVTLNVLEM 

       430        440        450        460        470        480 
TADDLENALK TVINNKSYKE NIMRLSSLHK DRPIEPLDLA VFWVEYVMRH KGAPHLRPAA 

       490        500        510        520        530 
HDLTWYQYHS LDVIGFLLAI VLTVVFIVFK CCAYGCRKCF GGKGRVKKSH KSKTH 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p)."
Kong A.N., Ma M., Tao D., Yang L.
Pharm. Res. 10:461-465(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation."
Zhang T., Haws P., Wu Q.
Genome Res. 14:79-89(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Colon.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
[4]"A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins."
Meunier L., Usherwood Y.-K., Chung K.T., Hendershot L.M.
Mol. Biol. Cell 13:4456-4469(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: COMPONENT OF A CHAPERONE COMPLEX.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S64760 mRNA. Translation: AAB26033.2.
AY227194 mRNA. Translation: AAP48593.1.
BC093516 mRNA. Translation: AAH93516.1.
RefSeqNP_964007.2. NM_201645.2.
UniGeneMm.300095.

3D structure databases

ProteinModelPortalQ63886.
SMRQ63886. Positions 34-451.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ63886. 4 interactions.
MINTMINT-1859173.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSiteQ63886.

Proteomic databases

PaxDbQ63886.
PRIDEQ63886.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000073049; ENSMUSP00000072803; ENSMUSG00000089960. [Q63886-1]
GeneID394436.
KEGGmmu:394436.
UCSCuc007byk.1. mouse. [Q63886-1]

Organism-specific databases

CTD54658.
MGIMGI:98898. Ugt1a1.

Phylogenomic databases

eggNOGCOG1819.
GeneTreeENSGT00640000091365.
HOGENOMHOG000220832.
HOVERGENHBG004033.
InParanoidQ561M6.
KOK00699.
OMAHREMTIL.
OrthoDBEOG7GBFWS.
TreeFamTF315472.

Gene expression databases

BgeeQ63886.
GenevestigatorQ63886.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio405997.
PROQ63886.
SOURCESearch...

Entry information

Entry nameUD11_MOUSE
AccessionPrimary (citable) accession number: Q63886
Secondary accession number(s): Q561M6, Q6XL50
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot