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Protein

UDP-glucuronosyltransferase 1-1

Gene

Ugt1a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-156588. Glucuronidation.
R-MMU-189483. Heme degradation.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-1 (EC:2.4.1.17)
Short name:
UDPGT 1-1
Short name:
UGT1*1
Short name:
UGT1-01
Short name:
UGT1.1
Alternative name(s):
UDP-glucuronosyltransferase 1A1
UGTBR1
Gene namesi
Name:Ugt1a1
Synonyms:Ugt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98898. Ugt1a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei493 – 509HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

  • cytochrome complex Source: Ensembl
  • endoplasmic reticulum Source: MGI
  • endoplasmic reticulum chaperone complex Source: ParkinsonsUK-UCL
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000003601030 – 535UDP-glucuronosyltransferase 1-1Add BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi89N-linked (GlcNAc...)Sequence analysis1
Glycosylationi297N-linked (GlcNAc...)Sequence analysis1
Glycosylationi435N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ63886.
PaxDbiQ63886.
PeptideAtlasiQ63886.
PRIDEiQ63886.

PTM databases

iPTMnetiQ63886.
PhosphoSitePlusiQ63886.
SwissPalmiQ63886.

Expressioni

Tissue specificityi

Highly expressed in liver and at lower levels in colon, kidney, stomach and intestine.1 Publication

Inductioni

By dioxin.

Gene expression databases

BgeeiENSMUSG00000089960.
GenevisibleiQ63886. MM.

Interactioni

Subunit structurei

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ63886. 4 interactors.
MINTiMINT-1859173.
STRINGi10090.ENSMUSP00000072803.

Structurei

3D structure databases

ProteinModelPortaliQ63886.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiQ63886.
KOiK00699.
OMAiLEESHFD.
OrthoDBiEOG091G06JC.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.
Isoform 1 (identifier: Q63886-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTVVCWSSRL LLLLPYLLLC VFGPSASHAG RLLVFPMDGS HWLSMLGVIQ
60 70 80 90 100
QLQQKGHEVV VIAPEASIHI KEGSFYTLRK FPVPFQKENV TATLVELGRT
110 120 130 140 150
AFNQDSFLLR VVKIYMKVKR DSSMLLAGCS HLLHNAEFMA SLEESHFDAL
160 170 180 190 200
LTDPFLPCGS IVAQYLTVPT VYFLNKLPCS LDSEATQCPV PLSYVPKSLS
210 220 230 240 250
FNSDRMNFLQ RVKNVLLAVS ENFMCRVVYS PYGSLATEIL QKEVTVQDLL
260 270 280 290 300
SPASIWLMRS DFVKDYPRPI MPNMVFIGGI NCLQKKPLSQ EFEAYVNASG
310 320 330 340 350
EHGIVVFSLG SMVSEIPEKK AMEIAEALGR IPQTVLWRYT GTRPSNLAKN
360 370 380 390 400
TILVKWLPQN DLLGHPKTRA FITHSGSHGI YEGICNGVPM VMMPLFGDQM
410 420 430 440 450
DNAKRMETRG AGVTLNVLEM TADDLENALK TVINNKSYKE NIMRLSSLHK
460 470 480 490 500
DRPIEPLDLA VFWVEYVMRH KGAPHLRPAA HDLTWYQYHS LDVIGFLLAI
510 520 530
VLTVVFIVFK CCAYGCRKCF GGKGRVKKSH KSKTH
Length:535
Mass (Da):60,047
Last modified:July 27, 2011 - v2
Checksum:i8C938AFD2D6DEB1D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25S → Y in AAB26033 (PubMed:8464825).Curated1
Sequence conflicti363L → I in AAB26033 (PubMed:8464825).Curated1
Sequence conflicti378H → R in AAP48593 (PubMed:14672974).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S64760 mRNA. Translation: AAB26033.2.
AY227194 mRNA. Translation: AAP48593.1.
BC093516 mRNA. Translation: AAH93516.1.
CCDSiCCDS15143.1. [Q63886-1]
RefSeqiNP_964007.2. NM_201645.2. [Q63886-1]
UniGeneiMm.300095.

Genome annotation databases

EnsembliENSMUST00000073049; ENSMUSP00000072803; ENSMUSG00000089960. [Q63886-1]
GeneIDi394436.
KEGGimmu:394436.
UCSCiuc007byk.1. mouse. [Q63886-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S64760 mRNA. Translation: AAB26033.2.
AY227194 mRNA. Translation: AAP48593.1.
BC093516 mRNA. Translation: AAH93516.1.
CCDSiCCDS15143.1. [Q63886-1]
RefSeqiNP_964007.2. NM_201645.2. [Q63886-1]
UniGeneiMm.300095.

3D structure databases

ProteinModelPortaliQ63886.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ63886. 4 interactors.
MINTiMINT-1859173.
STRINGi10090.ENSMUSP00000072803.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

iPTMnetiQ63886.
PhosphoSitePlusiQ63886.
SwissPalmiQ63886.

Proteomic databases

MaxQBiQ63886.
PaxDbiQ63886.
PeptideAtlasiQ63886.
PRIDEiQ63886.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073049; ENSMUSP00000072803; ENSMUSG00000089960. [Q63886-1]
GeneIDi394436.
KEGGimmu:394436.
UCSCiuc007byk.1. mouse. [Q63886-1]

Organism-specific databases

CTDi54658.
MGIiMGI:98898. Ugt1a1.

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiQ63886.
KOiK00699.
OMAiLEESHFD.
OrthoDBiEOG091G06JC.
TreeFamiTF315472.

Enzyme and pathway databases

ReactomeiR-MMU-156588. Glucuronidation.
R-MMU-189483. Heme degradation.

Miscellaneous databases

PROiQ63886.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000089960.
GenevisibleiQ63886. MM.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUD11_MOUSE
AccessioniPrimary (citable) accession number: Q63886
Secondary accession number(s): Q561M6, Q6XL50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.