Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q63871

- RPAB4_MOUSE

UniProt

Q63871 - RPAB4_MOUSE

Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC4

Gene

Polr2k

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively By similarity.By similarity
    Factor that activates expression from a metal response element of the mouse metallothionein-I gene.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi19 – 191ZincBy similarity
    Metal bindingi22 – 221ZincBy similarity
    Metal bindingi36 – 361ZincBy similarity
    Metal bindingi39 – 391ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri19 – 3921C4-typeSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. DNA-directed RNA polymerase activity Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. transcription from RNA polymerase III promoter Source: GOC
    2. transcription from RNA polymerase II promoter Source: UniProtKB
    3. transcription from RNA polymerase I promoter Source: GOC

    Keywords - Biological processi

    Transcription

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_203462. Formation of the Early Elongation Complex.
    REACT_205207. RNA Polymerase III Chain Elongation.
    REACT_213655. Transcription-coupled NER (TC-NER).
    REACT_221178. MicroRNA (miRNA) biogenesis.
    REACT_221403. RNA Polymerase III Transcription Termination.
    REACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
    REACT_224562. Dual incision reaction in TC-NER.
    REACT_226490. RNA Polymerase II Transcription Elongation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerases I, II, and III subunit RPABC4
    Short name:
    RNA polymerases I, II, and III subunit ABC4
    Alternative name(s):
    DNA-directed RNA polymerase II subunit K
    Metallothionein-I gene transcription activator
    RPB10alpha
    Gene namesi
    Name:Polr2k
    Synonyms:Mt1a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:102725. Polr2k.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. DNA-directed RNA polymerase I complex Source: RefGenome
    2. DNA-directed RNA polymerase II, core complex Source: UniProtKB
    3. DNA-directed RNA polymerase III complex Source: RefGenome
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    DNA-directed RNA polymerase, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5858DNA-directed RNA polymerases I, II, and III subunit RPABC4PRO_0000159751Add
    BLAST

    Proteomic databases

    PRIDEiQ63871.

    Expressioni

    Gene expression databases

    BgeeiQ63871.
    CleanExiMM_POLR2K.
    GenevestigatoriQ63871.

    Interactioni

    Subunit structurei

    Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ63871.
    SMRiQ63871. Positions 15-58.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri19 – 3921C4-typeSequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1996.
    GeneTreeiENSGT00390000008918.
    HOVERGENiHBG054239.
    InParanoidiQ63871.
    OrthoDBiEOG73540T.
    PhylomeDBiQ63871.

    Family and domain databases

    Gene3Di2.20.28.30. 1 hit.
    InterProiIPR006591. RNAP_P/RPABC4.
    IPR029040. RPABC4/Spt4.
    [Graphical view]
    PfamiPF03604. DNA_RNApol_7kD. 1 hit.
    [Graphical view]
    SMARTiSM00659. RPOLCX. 1 hit.
    [Graphical view]
    SUPFAMiSSF63393. SSF63393. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q63871-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDAQKDVQPP KQQPMIYICG ECHTENEIKS RDPIRCRECG YRIMYKKRTK   50
    RLVVFDAR 58
    Length:58
    Mass (Da):6,974
    Last modified:November 1, 1997 - v2
    Checksum:iD69BB6B37416F036
    GO

    Sequence cautioni

    The sequence AAB27565.2 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S63758 mRNA. Translation: AAB27565.2. Different initiation.
    BC028543 mRNA. Translation: AAH28543.1.
    CCDSiCCDS56980.1.
    RefSeqiNP_075616.2. NM_023127.3.
    UniGeneiMm.27375.

    Genome annotation databases

    EnsembliENSMUST00000180159; ENSMUSP00000136975; ENSMUSG00000045996.
    GeneIDi17749.
    KEGGimmu:17749.
    UCSCiuc007vml.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S63758 mRNA. Translation: AAB27565.2 . Different initiation.
    BC028543 mRNA. Translation: AAH28543.1 .
    CCDSi CCDS56980.1.
    RefSeqi NP_075616.2. NM_023127.3.
    UniGenei Mm.27375.

    3D structure databases

    ProteinModelPortali Q63871.
    SMRi Q63871. Positions 15-58.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q63871.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000180159 ; ENSMUSP00000136975 ; ENSMUSG00000045996 .
    GeneIDi 17749.
    KEGGi mmu:17749.
    UCSCi uc007vml.1. mouse.

    Organism-specific databases

    CTDi 5440.
    MGIi MGI:102725. Polr2k.

    Phylogenomic databases

    eggNOGi COG1996.
    GeneTreei ENSGT00390000008918.
    HOVERGENi HBG054239.
    InParanoidi Q63871.
    OrthoDBi EOG73540T.
    PhylomeDBi Q63871.

    Enzyme and pathway databases

    Reactomei REACT_203462. Formation of the Early Elongation Complex.
    REACT_205207. RNA Polymerase III Chain Elongation.
    REACT_213655. Transcription-coupled NER (TC-NER).
    REACT_221178. MicroRNA (miRNA) biogenesis.
    REACT_221403. RNA Polymerase III Transcription Termination.
    REACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
    REACT_224562. Dual incision reaction in TC-NER.
    REACT_226490. RNA Polymerase II Transcription Elongation.

    Miscellaneous databases

    NextBioi 292405.
    PROi Q63871.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q63871.
    CleanExi MM_POLR2K.
    Genevestigatori Q63871.

    Family and domain databases

    Gene3Di 2.20.28.30. 1 hit.
    InterProi IPR006591. RNAP_P/RPABC4.
    IPR029040. RPABC4/Spt4.
    [Graphical view ]
    Pfami PF03604. DNA_RNApol_7kD. 1 hit.
    [Graphical view ]
    SMARTi SM00659. RPOLCX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63393. SSF63393. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of a mouse factor that activates transcription from a metal response element of the mouse metallothionein-I gene in yeast."
      Xu C.
      DNA Cell Biol. 12:517-525(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiRPAB4_MOUSE
    AccessioniPrimary (citable) accession number: Q63871
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3