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Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC4

Gene

Polr2k

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity).By similarity
Factor that activates expression from a metal response element of the mouse metallothionein-I gene.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19ZincBy similarity1
Metal bindingi22ZincBy similarity1
Metal bindingi36ZincBy similarity1
Metal bindingi39ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 39C4-typeSequence analysisAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-112382. Formation of RNA Pol II elongation complex.
R-MMU-113418. Formation of the Early Elongation Complex.
R-MMU-1834949. Cytosolic sensors of pathogen-associated DNA.
R-MMU-5250924. B-WICH complex positively regulates rRNA expression.
R-MMU-5578749. Transcriptional regulation by small RNAs.
R-MMU-5601884. PIWI-interacting RNA (piRNA) biogenesis.
R-MMU-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.
R-MMU-674695. RNA Polymerase II Pre-transcription Events.
R-MMU-6781823. Formation of TC-NER Pre-Incision Complex.
R-MMU-6782135. Dual incision in TC-NER.
R-MMU-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-MMU-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-MMU-6803529. FGFR2 alternative splicing.
R-MMU-6807505. RNA polymerase II transcribes snRNA genes.
R-MMU-72086. mRNA Capping.
R-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72165. mRNA Splicing - Minor Pathway.
R-MMU-72203. Processing of Capped Intron-Containing Pre-mRNA.
R-MMU-73762. RNA Polymerase I Transcription Initiation.
R-MMU-73772. RNA Polymerase I Promoter Escape.
R-MMU-73776. RNA Polymerase II Promoter Escape.
R-MMU-73777. RNA Polymerase I Chain Elongation.
R-MMU-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-MMU-73863. RNA Polymerase I Transcription Termination.
R-MMU-75953. RNA Polymerase II Transcription Initiation.
R-MMU-75955. RNA Polymerase II Transcription Elongation.
R-MMU-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-MMU-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
R-MMU-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC4
Short name:
RNA polymerases I, II, and III subunit ABC4
Alternative name(s):
DNA-directed RNA polymerase II subunit K
Metallothionein-I gene transcription activator
RPB10alpha
Gene namesi
Name:Polr2k
Synonyms:Mt1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:102725. Polr2k.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001597511 – 58DNA-directed RNA polymerases I, II, and III subunit RPABC4Add BLAST58

Proteomic databases

MaxQBiQ63871.
PaxDbiQ63871.
PRIDEiQ63871.

PTM databases

PhosphoSitePlusiQ63871.

Expressioni

Gene expression databases

BgeeiENSMUSG00000045996.
CleanExiMM_POLR2K.
ExpressionAtlasiQ63871. baseline and differential.
GenevisibleiQ63871. MM.

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051968.

Structurei

3D structure databases

ProteinModelPortaliQ63871.
SMRiQ63871.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 39C4-typeSequence analysisAdd BLAST21

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3507. Eukaryota.
COG1996. LUCA.
GeneTreeiENSGT00390000008918.
HOVERGENiHBG054239.
InParanoidiQ63871.
PhylomeDBiQ63871.

Family and domain databases

InterProiView protein in InterPro
IPR006591. RNAP_P/RPABC4.
IPR029040. RPABC4/Spt4.
PfamiView protein in Pfam
PF03604. DNA_RNApol_7kD. 1 hit.
SMARTiView protein in SMART
SM00659. RPOLCX. 1 hit.
SUPFAMiSSF63393. SSF63393. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAQKDVQPP KQQPMIYICG ECHTENEIKS RDPIRCRECG YRIMYKKRTK

RLVVFDAR
Length:58
Mass (Da):6,974
Last modified:November 1, 1997 - v2
Checksum:iD69BB6B37416F036
GO

Sequence cautioni

The sequence AAB27565 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S63758 mRNA. Translation: AAB27565.2. Different initiation.
BC028543 mRNA. Translation: AAH28543.1.
CCDSiCCDS56980.1.
RefSeqiNP_075616.2. NM_023127.3.
UniGeneiMm.27375.

Genome annotation databases

EnsembliENSMUST00000180159; ENSMUSP00000136975; ENSMUSG00000045996.
GeneIDi17749.
KEGGimmu:17749.
UCSCiuc007vml.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiRPAB4_MOUSE
AccessioniPrimary (citable) accession number: Q63871
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 27, 2017
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families