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Q63871

- RPAB4_MOUSE

UniProt

Q63871 - RPAB4_MOUSE

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Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC4

Gene

Polr2k

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity).By similarity
Factor that activates expression from a metal response element of the mouse metallothionein-I gene.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi19 – 191ZincBy similarity
Metal bindingi22 – 221ZincBy similarity
Metal bindingi36 – 361ZincBy similarity
Metal bindingi39 – 391ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri19 – 3921C4-typeSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. DNA-directed RNA polymerase activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. transcription from RNA polymerase III promoter Source: GOC
  2. transcription from RNA polymerase II promoter Source: UniProtKB
  3. transcription from RNA polymerase I promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_203462. Formation of the Early Elongation Complex.
REACT_205207. RNA Polymerase III Chain Elongation.
REACT_213655. Transcription-coupled NER (TC-NER).
REACT_221403. RNA Polymerase III Transcription Termination.
REACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
REACT_224562. Dual incision reaction in TC-NER.
REACT_226490. RNA Polymerase II Transcription Elongation.
REACT_230204. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_232235. RNA Polymerase I Promoter Escape.
REACT_232708. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_233950. Processing of Capped Intron-Containing Pre-mRNA.
REACT_235610. mRNA Splicing - Minor Pathway.
REACT_235780. RNA Polymerase I Transcription Initiation.
REACT_240508. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
REACT_244380. RNA Polymerase II Transcription Initiation.
REACT_250309. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
REACT_251592. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
REACT_255009. RNA Polymerase II Pre-transcription Events.
REACT_255334. RNA Polymerase II Promoter Escape.
REACT_257165. RNA Polymerase I Transcription Termination.
REACT_257596. RNA Pol II CTD phosphorylation and interaction with CE.
REACT_258231. mRNA Capping.
REACT_259097. RNA Polymerase I Chain Elongation.
REACT_260226. mRNA Splicing - Major Pathway.
REACT_261233. RNA Polymerase III Abortive And Retractive Initiation.
REACT_270446. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC4
Short name:
RNA polymerases I, II, and III subunit ABC4
Alternative name(s):
DNA-directed RNA polymerase II subunit K
Metallothionein-I gene transcription activator
RPB10alpha
Gene namesi
Name:Polr2k
Synonyms:Mt1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:102725. Polr2k.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. DNA-directed RNA polymerase I complex Source: RefGenome
  2. DNA-directed RNA polymerase II, core complex Source: UniProtKB
  3. DNA-directed RNA polymerase III complex Source: RefGenome
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5858DNA-directed RNA polymerases I, II, and III subunit RPABC4PRO_0000159751Add
BLAST

Proteomic databases

PRIDEiQ63871.

Expressioni

Gene expression databases

BgeeiQ63871.
CleanExiMM_POLR2K.
ExpressionAtlasiQ63871. baseline.
GenevestigatoriQ63871.

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ63871.
SMRiQ63871. Positions 15-58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri19 – 3921C4-typeSequence AnalysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG1996.
GeneTreeiENSGT00390000008918.
HOVERGENiHBG054239.
InParanoidiQ63871.
OrthoDBiEOG73540T.
PhylomeDBiQ63871.

Family and domain databases

Gene3Di2.20.28.30. 1 hit.
InterProiIPR006591. RNAP_P/RPABC4.
IPR029040. RPABC4/Spt4.
[Graphical view]
PfamiPF03604. DNA_RNApol_7kD. 1 hit.
[Graphical view]
SMARTiSM00659. RPOLCX. 1 hit.
[Graphical view]
SUPFAMiSSF63393. SSF63393. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63871-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDAQKDVQPP KQQPMIYICG ECHTENEIKS RDPIRCRECG YRIMYKKRTK

RLVVFDAR
Length:58
Mass (Da):6,974
Last modified:November 1, 1997 - v2
Checksum:iD69BB6B37416F036
GO

Sequence cautioni

The sequence AAB27565.2 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S63758 mRNA. Translation: AAB27565.2. Different initiation.
BC028543 mRNA. Translation: AAH28543.1.
CCDSiCCDS56980.1.
RefSeqiNP_075616.2. NM_023127.3.
UniGeneiMm.27375.

Genome annotation databases

EnsembliENSMUST00000180159; ENSMUSP00000136975; ENSMUSG00000045996.
GeneIDi17749.
KEGGimmu:17749.
UCSCiuc007vml.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S63758 mRNA. Translation: AAB27565.2 . Different initiation.
BC028543 mRNA. Translation: AAH28543.1 .
CCDSi CCDS56980.1.
RefSeqi NP_075616.2. NM_023127.3.
UniGenei Mm.27375.

3D structure databases

ProteinModelPortali Q63871.
SMRi Q63871. Positions 15-58.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q63871.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000180159 ; ENSMUSP00000136975 ; ENSMUSG00000045996 .
GeneIDi 17749.
KEGGi mmu:17749.
UCSCi uc007vml.1. mouse.

Organism-specific databases

CTDi 5440.
MGIi MGI:102725. Polr2k.

Phylogenomic databases

eggNOGi COG1996.
GeneTreei ENSGT00390000008918.
HOVERGENi HBG054239.
InParanoidi Q63871.
OrthoDBi EOG73540T.
PhylomeDBi Q63871.

Enzyme and pathway databases

Reactomei REACT_203462. Formation of the Early Elongation Complex.
REACT_205207. RNA Polymerase III Chain Elongation.
REACT_213655. Transcription-coupled NER (TC-NER).
REACT_221403. RNA Polymerase III Transcription Termination.
REACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
REACT_224562. Dual incision reaction in TC-NER.
REACT_226490. RNA Polymerase II Transcription Elongation.
REACT_230204. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_232235. RNA Polymerase I Promoter Escape.
REACT_232708. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_233950. Processing of Capped Intron-Containing Pre-mRNA.
REACT_235610. mRNA Splicing - Minor Pathway.
REACT_235780. RNA Polymerase I Transcription Initiation.
REACT_240508. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
REACT_244380. RNA Polymerase II Transcription Initiation.
REACT_250309. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
REACT_251592. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
REACT_255009. RNA Polymerase II Pre-transcription Events.
REACT_255334. RNA Polymerase II Promoter Escape.
REACT_257165. RNA Polymerase I Transcription Termination.
REACT_257596. RNA Pol II CTD phosphorylation and interaction with CE.
REACT_258231. mRNA Capping.
REACT_259097. RNA Polymerase I Chain Elongation.
REACT_260226. mRNA Splicing - Major Pathway.
REACT_261233. RNA Polymerase III Abortive And Retractive Initiation.
REACT_270446. Transcriptional regulation by small RNAs.

Miscellaneous databases

NextBioi 292405.
PROi Q63871.
SOURCEi Search...

Gene expression databases

Bgeei Q63871.
CleanExi MM_POLR2K.
ExpressionAtlasi Q63871. baseline.
Genevestigatori Q63871.

Family and domain databases

Gene3Di 2.20.28.30. 1 hit.
InterProi IPR006591. RNAP_P/RPABC4.
IPR029040. RPABC4/Spt4.
[Graphical view ]
Pfami PF03604. DNA_RNApol_7kD. 1 hit.
[Graphical view ]
SMARTi SM00659. RPOLCX. 1 hit.
[Graphical view ]
SUPFAMi SSF63393. SSF63393. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of a mouse factor that activates transcription from a metal response element of the mouse metallothionein-I gene in yeast."
    Xu C.
    DNA Cell Biol. 12:517-525(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiRPAB4_MOUSE
AccessioniPrimary (citable) accession number: Q63871
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3