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Q63871 (RPAB4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC4

Short name=RNA polymerases I, II, and III subunit ABC4
Alternative name(s):
DNA-directed RNA polymerase II subunit K
Metallothionein-I gene transcription activator
RPB10alpha
Gene names
Name:Polr2k
Synonyms:Mt1a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length58 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively By similarity.

Factor that activates expression from a metal response element of the mouse metallothionein-I gene.

Subunit structure

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family.

Sequence caution

The sequence AAB27565.2 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5858DNA-directed RNA polymerases I, II, and III subunit RPABC4
PRO_0000159751

Regions

Zinc finger19 – 3921C4-type Potential

Sites

Metal binding191Zinc By similarity
Metal binding221Zinc By similarity
Metal binding361Zinc By similarity
Metal binding391Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q63871 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: D69BB6B37416F036

FASTA586,974
        10         20         30         40         50 
MDAQKDVQPP KQQPMIYICG ECHTENEIKS RDPIRCRECG YRIMYKKRTK RLVVFDAR 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning of a mouse factor that activates transcription from a metal response element of the mouse metallothionein-I gene in yeast."
Xu C.
DNA Cell Biol. 12:517-525(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S63758 mRNA. Translation: AAB27565.2. Different initiation.
BC028543 mRNA. Translation: AAH28543.1.
CCDSCCDS56980.1.
RefSeqNP_075616.2. NM_023127.3.
UniGeneMm.27375.

3D structure databases

ProteinModelPortalQ63871.
SMRQ63871. Positions 15-58.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ63871.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000180159; ENSMUSP00000136975; ENSMUSG00000045996.
GeneID17749.
KEGGmmu:17749.
UCSCuc007vml.1. mouse.

Organism-specific databases

CTD5440.
MGIMGI:102725. Polr2k.

Phylogenomic databases

eggNOGCOG1996.
GeneTreeENSGT00390000008918.
HOVERGENHBG054239.
InParanoidQ63871.
OrthoDBEOG73540T.
PhylomeDBQ63871.

Gene expression databases

BgeeQ63871.
CleanExMM_POLR2K.
GenevestigatorQ63871.

Family and domain databases

Gene3D2.20.28.30. 1 hit.
InterProIPR006591. RNAP_P/RPABC4.
IPR029040. RPABC4/Spt4.
[Graphical view]
PfamPF03604. DNA_RNApol_7kD. 1 hit.
[Graphical view]
SMARTSM00659. RPOLCX. 1 hit.
[Graphical view]
SUPFAMSSF63393. SSF63393. 1 hit.
ProtoNetSearch...

Other

NextBio292405.
PROQ63871.
SOURCESearch...

Entry information

Entry nameRPAB4_MOUSE
AccessionPrimary (citable) accession number: Q63871
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot