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Q63870

- CO7A1_MOUSE

UniProt

Q63870 - CO7A1_MOUSE

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Protein

Collagen alpha-1(VII) chain

Gene
Col7a1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen.By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei2889 – 28902Reactive bond By similarity

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_196595. Anchoring fibril formation.
REACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199055. Collagen degradation.
REACT_202342. Laminin interactions.
REACT_206066. Extracellular matrix organization.
REACT_216309. Integrin cell surface interactions.

Protein family/group databases

MEROPSiI02.967.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(VII) chain
Alternative name(s):
Long-chain collagen
Short name:
LC collagen
Gene namesi
Name:Col7a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:88462. Col7a1.

Subcellular locationi

GO - Cellular componenti

  1. basement membrane Source: MGI
  2. collagen trimer Source: UniProtKB-KW
  3. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice do not express type VII collagen in their skin; they are born with extensive cutaneous blistering and die during the first two weeks of life, possibly because of complications arising from blistering; this mouse mutant resembles the autosomal recessive inherited form of the dystrophic epidermolysis bullosa (DEB) in humans. Heterozygotes by comparison display a normal phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 29442920Collagen alpha-1(VII) chainPRO_0000282951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi338 – 3381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi787 – 7871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1110 – 11101N-linked (GlcNAc...) Reviewed prediction
Modified residuei2158 – 215814-hydroxyproline By similarity
Modified residuei2167 – 216714-hydroxyproline By similarity
Modified residuei2176 – 217614-hydroxyproline By similarity
Modified residuei2179 – 217914-hydroxyproline By similarity
Modified residuei2616 – 261615-hydroxylysine By similarity
Modified residuei2622 – 262215-hydroxylysine By similarity
Disulfide bondi2625 – 2625Interchain By similarity
Modified residuei2655 – 265514-hydroxyproline By similarity
Modified residuei2658 – 265814-hydroxyproline By similarity
Modified residuei2664 – 266414-hydroxyproline By similarity
Disulfide bondi2793 – 2793Interchain By similarity
Disulfide bondi2795 – 2795Interchain By similarity
Disulfide bondi2879 ↔ 2931 By similarity
Disulfide bondi2888 ↔ 2914 By similarity
Disulfide bondi2906 ↔ 2927 By similarity

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiQ63870.
PRIDEiQ63870.

PTM databases

PhosphoSiteiQ63870.

Expressioni

Inductioni

Transcription of COL7A1 is stimulated by TGFB1 in keratinocytes and this is possibly dependent on a putative interaction between SMADS and AP1.1 Publication

Gene expression databases

BgeeiQ63870.
CleanExiMM_COL7A1.
GenevestigatoriQ63870.

Interactioni

Subunit structurei

Homotrimer. Interacts with MIA3/TANGO1; facilitating its loading into transport carriers and subsequent secretion By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-8313134,EBI-8313134

Protein-protein interaction databases

IntActiQ63870. 1 interaction.
MINTiMINT-4109970.

Structurei

3D structure databases

ProteinModelPortaliQ63870.
SMRiQ63870. Positions 31-1205, 2876-2932.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 212174VWFA 1Add
BLAST
Domaini235 – 33096Fibronectin type-III 1Add
BLAST
Domaini331 – 41787Fibronectin type-III 2Add
BLAST
Domaini418 – 50891Fibronectin type-III 3Add
BLAST
Domaini511 – 59888Fibronectin type-III 4Add
BLAST
Domaini601 – 68888Fibronectin type-III 5Add
BLAST
Domaini689 – 77688Fibronectin type-III 6Add
BLAST
Domaini779 – 86789Fibronectin type-III 7Add
BLAST
Domaini870 – 95788Fibronectin type-III 8Add
BLAST
Domaini959 – 105395Fibronectin type-III 9Add
BLAST
Domaini1055 – 1230176VWFA 2Add
BLAST
Domaini2879 – 293153BPTI/Kunitz inhibitorAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni18 – 12541237Nonhelical region (NC1)Add
BLAST
Regioni1255 – 27751521Triple-helical regionAdd
BLAST
Regioni1255 – 1475221Interrupted collagenous regionAdd
BLAST
Regioni2776 – 2944169Nonhelical region (NC2)Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1171 – 11733Cell attachment site Reviewed prediction
Motifi2002 – 20043Cell attachment site Reviewed prediction
Motifi2063 – 20653Cell attachment site Reviewed prediction
Motifi2601 – 26033Cell attachment site Reviewed prediction
Motifi2631 – 26333Cell attachment site Reviewed prediction

Sequence similaritiesi

Contains 2 VWFA domains.

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00720000108691.
HOGENOMiHOG000111866.
HOVERGENiHBG051053.
InParanoidiQ63870.
KOiK16628.
OMAiWHSGHGP.
OrthoDBiEOG7CG6Z4.
PhylomeDBiQ63870.
TreeFamiTF351645.

Family and domain databases

Gene3Di2.60.40.10. 9 hits.
3.40.50.410. 2 hits.
4.10.410.10. 1 hit.
InterProiIPR008160. Collagen.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01391. Collagen. 22 hits.
PF00041. fn3. 9 hits.
PF00014. Kunitz_BPTI. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00060. FN3. 9 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
SSF53300. SSF53300. 2 hits.
SSF57362. SSF57362. 1 hit.
PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
PS50853. FN3. 9 hits.
PS50234. VWFA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63870-1 [UniParc]FASTAAdd to Basket

« Hide

MRLRLLVAAL CAAEILMGAP EVWAQPRDRV TCTRLYAADI VFLLDGSSSI     50
GRSNFREVRG FLEGLVLPFS GAASAQGVRF ATVQYSDDPQ TEFGLDTLGS 100
GSDTIRAIRE LSYKGGNTRT GAALHHVSDR VFLPRLTRPG VPKVCILITD 150
GKSQDLVDTA AQKLKGQGVK LFAVGIKNAD PEELKRVASQ PTSDFFFFVN 200
DFSILRTLLP LISRRVCTTA GGVPVTLPSD DTPSGPRDLV LSEPSSQSLR 250
VQWTAASGPV TGYKVQYTPL TGLGQPLPSE RQEVNIPAGE TSTRLQGLRP 300
LTDYQVTVVA LYANSIGEAV SGTARTTAKE GLELSLQNIT SHSLLVAWRR 350
VPGANGYRVT WRDLSGGPTQ QQDLSPGQGS VFLDHLEPGT DYEVTVSALF 400
GHSVGPAASL TARTASSVEQ TLHPIILSPT SILLSWNLVP EARGYRLEWR 450
RESGLETPQK VELPPDVTRH QLDGLQPGTE YRLTLYTLLE GREVATPATV 500
VPTGLEQLVS PVMNLQAIEL PGQRVRVSWN PVPGATEYRF TVRTTQGVER 550
TLLLPGSQTT FDLDDVRAGL SYTVRVSARV GAQEGDASIL TIHRDPEAPL 600
VVPGLRVVAS DATRIRVAWG LVPGASGFRI SWRTGSGPES SRTLTPDSTV 650
TDILGLQPST SYQVAVSALR GREEGPPVVI VARTDPLGPV RRVHLTQAGS 700
SSVSITWTGV PGATGYRVSW HSGHGPEKSL LVSGDATVAE IDGLEPDTEY 750
IVRVRTHVAG VDGAPASVVV RTAPEPVGSV SKLQILNASS DVLRVTWVGV 800
PGATSYKLAW GRSEGGPMKH RILPGNKESA EIRDLEGGVS YSVRVTALVG 850
DREGAPVSIV ITTPPATPAL LETLQVVQSG EHSLRLRWEP VPGAPGFRLH 900
WQPEGGQEQS LTLGPESNSY NLVGLEPATK YQVWLTVLGQ TGEGPPRKVT 950
AYTEPSHIPS TELRVVDTSI DSVTLTWTPV SGASSYILSW RPLRGTGQEV 1000
PRAPQTLPGT SSSHRVTGLE PGISYVFSLT PIQSGVRGSE ISVTQTPACS 1050
HGPVDVVFLL HATRDNAHNA EAVRRVLERL VSALGPLGPQ AAQVGLLTYS 1100
HRPSPLFPLN SSHDLGIILR KIRDIPYVDP SGNNLGTAVT TAHRYLLASN 1150
APGRRQQVPG VMVLLVDEPL RGDILSPIRE AQTSGLKVMA LSLVGADPEQ 1200
LRRLAPGTDP IQNFFAVDNG PGLDRAVSDL AVALCQAAVT IEPQTGPCAV 1250
HCPKGQKGEP GVTGLQGQAG PPGPPGLPGR TGAPGPQGPP GSTQAKGERG 1300
FPGPEGPPGS PGLPGVPGSP GIKGSTGRPG PRGEQGERGP QGPKGEPGEP 1350
GQITGGGGPG FPGKKGDPGP SGPPGSRGPV GDPGPRGPPG LPGISVKGDK 1400
GDRGERGPPG PGIGASEQGD PGLPGLPGSP GPQGPAGRPG EKGEKGDCED 1450
GGPGLPGQPG PPGEPGLRGA PGMTGPKGDR GLTGTPGEPG VKGERGHPGP 1500
VGPQGLPGAA GHPGVEGPEG PPGPTGRRGE KGEPGRPGDP AVGPGGAGAK 1550
GEKGEAGLPG PRGASGSKGE QGAPGLALPG DPGPKGDPGD RGPIGLTGRA 1600
GPTGDSGPPG EKGEPGRPGS PGPVGPRGRD GEAGEKGDEG IPGEPGLPGK 1650
AGERGLRGAP GPRGPVGEKG DQGDPGEDGR NGSPGSSGPK GDRGEPGPPG 1700
PPGRLVDAGI ESRDKGEPGQ EGPRGPKGDP GPPGVSGERG IDGLRGPPGP 1750
QGDPGVRGPA GDKGDRGPPG LDGRSGLDGK PGAPGPPGLH GASGKAGDPG 1800
RDGLPGLRGE HGPPGPPGPP GVPGKAGDDG KPGLNGKNGD PGDPGEDGRK 1850
GEKGDSGAPG REGPDGPKGE RGAPGNPGLQ GPPGLPGQVG PPGQGFPGVP 1900
GITGPKGDRG ETGSKGEQGL PGERGLRGEP GSLPNAERLL ETAGIKVSAL 1950
REIVDTWDES SGSFLPVPER RPGPKGDPGD RGPPGKEGLI GFPGERGLKG 2000
ERGDPGPQGP PGLALGERGP PGPPGLAGEP GKPGIPGLPG RAGGSGEAGR 2050
PGERGERGEK GERGDQGRDG LPGLPGPPGP PGPKVAIEEP GPGLAREQGP 2100
PGLKGAKGEP GSDGDPGPKG DRGVPGIKGD VGEPGKRGHD GNPGLPGERG 2150
VAGPEGKPGL QGPRGTPGPV GSHGDPGPPG APGLAGPAGP QGPSGLKGEP 2200
GETGPPGRGL PGPVGAVGLP GPPGPSGLVG PQGSPGLPGQ VGETGKPGPP 2250
GRDGSSGKDG DRGSPGVPGS PGLPGPVGPK GEPGPVGAPG QVVVGPPGAK 2300
GEKGAPGDLA GALLGEPGAK GDRGLPGPRG EKGEAGRAGG PGDPGEDGQK 2350
GAPGLKGLKG EPGIGVQGPP GPSGPPGMKG DLGPPGAPGA PGVVGFPGQT 2400
GPRGETGQPG PVGERGLAGP PGREGAPGPL GPPGPPGSAG APGASGLKGD 2450
KGDPGAGLPG PRGERGEPGV RGEDGHPGQE GPRGLVGPPG SRGEQGEKGA 2500
AGAAGLKGDK GDSAVIEGPP GPRGAKGDMG ERGPRGIDGD KGPRGESGNP 2550
GDKGSKGEPG DKGSAGSIGV RGLTGPKGEP GAAGIPGEPG APGKDGIPGF 2600
RGDKGDIGFM GPRGLKGEKG IKGTCGRDGE RGDKGEAGFP GRPGLAGKKG 2650
DMGEPGLPGQ SGAPGKEGLI GPKGDRGFDG QSGPKGDQGE KGERGPPGVG 2700
GFPGPRGNDG SSGPPGPPGG VGPKGPEGLQ GQKGERGPPG ESVVGAPGAP 2750
GTPGERGEQG RPGPAGPRGE KGEAALTEDD IRDFVRQEMS QHCACQGQFI 2800
ASGSRPLPGY AADTAGSQLH HVPVLRVSHV EEEGQVPPED DDDFSEYSVY 2850
SVEDYQEPEV PWDGEAEIKG WDQRGSDLCS LPLDEGSCTA YTLRWYHRAV 2900
PGGTACHPFV YGGCGGNANR FGTREACERR CPPQGVHSQK TGAA 2944
Length:2,944
Mass (Da):295,232
Last modified:April 3, 2007 - v3
Checksum:i13D01CA7ED36C958
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti659 – 6591S → G in AAB66593. 1 Publication
Sequence conflicti1927 – 19271R → A in AAB66593. 1 Publication
Sequence conflicti1927 – 19271R → A in AAB27492. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32107 mRNA. Translation: AAB66593.1.
AC174646 Genomic DNA. No translation available.
S63654 mRNA. Translation: AAB27492.1.
CCDSiCCDS40770.1.
PIRiA45748.
RefSeqiNP_031764.2. NM_007738.3.
XP_006511998.1. XM_006511935.1.
UniGeneiMm.6200.

Genome annotation databases

EnsembliENSMUST00000026740; ENSMUSP00000026740; ENSMUSG00000025650.
ENSMUST00000112070; ENSMUSP00000107701; ENSMUSG00000025650.
GeneIDi12836.
KEGGimmu:12836.
UCSCiuc009rrh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32107 mRNA. Translation: AAB66593.1 .
AC174646 Genomic DNA. No translation available.
S63654 mRNA. Translation: AAB27492.1 .
CCDSi CCDS40770.1.
PIRi A45748.
RefSeqi NP_031764.2. NM_007738.3.
XP_006511998.1. XM_006511935.1.
UniGenei Mm.6200.

3D structure databases

ProteinModelPortali Q63870.
SMRi Q63870. Positions 31-1205, 2876-2932.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q63870. 1 interaction.
MINTi MINT-4109970.

Protein family/group databases

MEROPSi I02.967.

PTM databases

PhosphoSitei Q63870.

Proteomic databases

PaxDbi Q63870.
PRIDEi Q63870.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026740 ; ENSMUSP00000026740 ; ENSMUSG00000025650 .
ENSMUST00000112070 ; ENSMUSP00000107701 ; ENSMUSG00000025650 .
GeneIDi 12836.
KEGGi mmu:12836.
UCSCi uc009rrh.1. mouse.

Organism-specific databases

CTDi 1294.
MGIi MGI:88462. Col7a1.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00720000108691.
HOGENOMi HOG000111866.
HOVERGENi HBG051053.
InParanoidi Q63870.
KOi K16628.
OMAi WHSGHGP.
OrthoDBi EOG7CG6Z4.
PhylomeDBi Q63870.
TreeFami TF351645.

Enzyme and pathway databases

Reactomei REACT_196595. Anchoring fibril formation.
REACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199055. Collagen degradation.
REACT_202342. Laminin interactions.
REACT_206066. Extracellular matrix organization.
REACT_216309. Integrin cell surface interactions.

Miscellaneous databases

NextBioi 282356.
PROi Q63870.
SOURCEi Search...

Gene expression databases

Bgeei Q63870.
CleanExi MM_COL7A1.
Genevestigatori Q63870.

Family and domain databases

Gene3Di 2.60.40.10. 9 hits.
3.40.50.410. 2 hits.
4.10.410.10. 1 hit.
InterProi IPR008160. Collagen.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF01391. Collagen. 22 hits.
PF00041. fn3. 9 hits.
PF00014. Kunitz_BPTI. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view ]
PRINTSi PR00759. BASICPTASE.
SMARTi SM00060. FN3. 9 hits.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 5 hits.
SSF53300. SSF53300. 2 hits.
SSF57362. SSF57362. 1 hit.
PROSITEi PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
PS50853. FN3. 9 hits.
PS50234. VWFA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of mouse type VII collagen reveals evolutionary conservation of functional protein domains and genomic organization."
    Kivirikko S., Li K., Christiano A.M., Uitto J.
    J. Invest. Dermatol. 106:1300-1306(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "cDNA cloning and chromosomal mapping of the mouse type VII collagen gene (Col7a1): evidence for rapid evolutionary divergence of the gene."
    Li K., Christiano A.M., Copeland N.G., Gilbert D.J., Chu M.-L., Jenkins N.A., Uitto J.
    Genomics 16:733-739(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1139-2058.
  4. "Targeted inactivation of the type VII collagen gene (Col7a1) in mice results in severe blistering phenotype: a model for recessive dystrophic epidermolysis bullosa."
    Heinonen S., Mannikko M., Klement J.F., Whitaker-Menezes D., Murphy G.F., Uitto J.
    J. Cell Sci. 112:3641-3648(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  5. "Transcriptional control of the mouse Col7a1 gene in keratinocytes: basal and transforming growth factor-beta regulated expression."
    Naso M., Uitto J., Klement J.F.
    J. Invest. Dermatol. 121:1469-1478(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiCO7A1_MOUSE
AccessioniPrimary (citable) accession number: Q63870
Secondary accession number(s): Q78EC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 3, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi