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Q63850

- NUP62_MOUSE

UniProt

Q63850 - NUP62_MOUSE

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Protein
Nuclear pore glycoprotein p62
Gene
Nup62
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex By similarity.

GO - Molecular functioni

  1. PTB domain binding Source: UniProtKB
  2. SH2 domain binding Source: UniProtKB
  3. protein binding Source: MGI
  4. receptor signaling complex scaffold activity Source: UniProtKB
  5. structural constituent of nuclear pore Source: InterPro
  6. thyroid hormone receptor binding Source: UniProtKB
  7. ubiquitin binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. cell aging Source: MGI
  2. cell death Source: UniProtKB
  3. cell migration Source: UniProtKB
  4. cell surface receptor signaling pathway Source: UniProtKB
  5. mRNA transport Source: UniProtKB-KW
  6. negative regulation of MAP kinase activity Source: UniProtKB
  7. negative regulation of Ras protein signal transduction Source: UniProtKB
  8. negative regulation of apoptotic process Source: UniProtKB
  9. negative regulation of cell proliferation Source: UniProtKB
  10. negative regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
  11. negative regulation of programmed cell death Source: UniProtKB
  12. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  13. positive regulation of transcription, DNA-templated Source: UniProtKB
  14. protein transport Source: UniProtKB-KW
  15. transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_196650. Nuclear Pore Complex (NPC) Disassembly.
REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore glycoprotein p62
Alternative name(s):
62 kDa nucleoporin
Nucleoporin Nup62
Gene namesi
Name:Nup62
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1351500. Nup62.

Subcellular locationi

Nucleusnuclear pore complex. Cytoplasmcytoskeletonspindle pole By similarity
Note: Central region of the nuclear pore, within the transporter. During mitotic cell division, it associates with the poles of the mitotic spindle By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nuclear membrane Source: MGI
  3. nuclear pore Source: UniProtKB
  4. ribonucleoprotein complex Source: MGI
  5. spindle pole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nuclear pore complex, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi479 – 4791C → S: Loss of reduction of influx rate of NLS cargo upon oxidative stress; when associated with S-509. 1 Publication
Mutagenesisi510 – 5101C → S: Loss of reduction of influx rate of NLS cargo upon oxidative stress; when associated with S-478. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 526525Nuclear pore glycoprotein p62
PRO_0000204881Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Glycosylationi377 – 3771O-linked (GlcNAc) By similarity
Modified residuei412 – 4121Phosphoserine1 Publication
Glycosylationi472 – 4721O-linked (GlcNAc) By similarity
Disulfide bondi479 – 479Interchain (with NUP155) Inferred
Disulfide bondi510 – 510Interchain (with NUP155) Inferred

Post-translational modificationi

O-glycosylated.
The the inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC.

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ63850.
PaxDbiQ63850.
PRIDEiQ63850.

PTM databases

PhosphoSiteiQ63850.

Expressioni

Gene expression databases

ArrayExpressiQ63850.
BgeeiQ63850.
CleanExiMM_NUP62.
GenevestigatoriQ63850.

Interactioni

Subunit structurei

Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUPL1. Interacts with Hikeshi By similarity.

Protein-protein interaction databases

BioGridi201879. 6 interactions.
IntActiQ63850. 1 interaction.
MINTiMINT-4104316.

Structurei

3D structure databases

ProteinModelPortaliQ63850.
SMRiQ63850. Positions 365-420.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili332 – 462131 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 295279Thr-rich
Add
BLAST
Compositional biasi202 – 335134Ala-rich
Add
BLAST
Compositional biasi271 – 28414Poly-Thr
Add
BLAST
Compositional biasi292 – 2954Poly-Thr

Domaini

Contains F-X-F-G repeats.

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00730000111010.
HOGENOMiHOG000007693.
HOVERGENiHBG052699.
InParanoidiQ63850.
KOiK14306.
OMAiPAMTYAQ.
OrthoDBiEOG7PZRZB.
PhylomeDBiQ63850.
TreeFamiTF324795.

Family and domain databases

InterProiIPR026010. NSP1/NUP62.
IPR007758. Nucleoporin_NSP1_C.
[Graphical view]
PANTHERiPTHR12084. PTHR12084. 1 hit.
PfamiPF05064. Nsp1_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63850-1 [UniParc]FASTAAdd to Basket

« Hide

MSGFNFGGTG APAGGFTFGT AKTATTTPAT GFSFSASGTG TGGFNFGTPS    50
QPAATTPSTS LFSLTTQTPT TQTPGFNFGT TPASGGTGFS LGISTPKLSL 100
SNAAATPATA NTGSFGLGSS TLTNAISSGS TSNQGTAPTG FVFGSSTTSA 150
PSTGSTGFSF TSGSASQPGA SGFSLGSVGS SAQPTALSGS PFTPATLVTT 200
TAGATQPAAA APTAATTSAG STLFASIAAA PASSSATGLS LPAPVTTAAT 250
PSAGTLGFSL KAPGAAPGAS TTSTTTTTTT TTTTAAAAAA STTTTGFALS 300
LKPLVSAGPS SVAATALPAS STAAGTATGP AMTYAQLESL INKWSLELED 350
QERHFLQQAT QVNAWDRTLI ENGEKITSLH REVEKVKLDQ KRLDQELDFI 400
LSQQKELEDL LSPLEESVKE QSGTIYLQHA DEEREKTYKL AENIDAQLKR 450
MAQDLKDIIE HLNMAGGPAD TSDPLQQICK ILNAHMDSLQ WVDQSSALLQ 500
RRVEEASRVC EGRRKEQERS LRIAFD 526
Length:526
Mass (Da):53,255
Last modified:May 27, 2002 - v2
Checksum:i54AE74B211018FE4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131G → V in AAB19953. 1 Publication
Sequence conflicti319 – 3191A → V in AAB19953. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S59342 mRNA. Translation: AAB19953.1.
BC005784 mRNA. Translation: AAH05784.1.
CCDSiCCDS21216.1.
PIRiA56573.
RefSeqiNP_444304.1. NM_053074.1.
UniGeneiMm.2565.
Mm.440497.

Genome annotation databases

EnsembliENSMUST00000057195; ENSMUSP00000056785; ENSMUSG00000043858.
ENSMUST00000107891; ENSMUSP00000103523; ENSMUSG00000043858.
GeneIDi18226.
KEGGimmu:18226.
UCSCiuc009gqw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S59342 mRNA. Translation: AAB19953.1 .
BC005784 mRNA. Translation: AAH05784.1 .
CCDSi CCDS21216.1.
PIRi A56573.
RefSeqi NP_444304.1. NM_053074.1.
UniGenei Mm.2565.
Mm.440497.

3D structure databases

ProteinModelPortali Q63850.
SMRi Q63850. Positions 365-420.
ModBasei Search...

Protein-protein interaction databases

BioGridi 201879. 6 interactions.
IntActi Q63850. 1 interaction.
MINTi MINT-4104316.

PTM databases

PhosphoSitei Q63850.

Proteomic databases

MaxQBi Q63850.
PaxDbi Q63850.
PRIDEi Q63850.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000057195 ; ENSMUSP00000056785 ; ENSMUSG00000043858 .
ENSMUST00000107891 ; ENSMUSP00000103523 ; ENSMUSG00000043858 .
GeneIDi 18226.
KEGGi mmu:18226.
UCSCi uc009gqw.2. mouse.

Organism-specific databases

CTDi 23636.
MGIi MGI:1351500. Nup62.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00730000111010.
HOGENOMi HOG000007693.
HOVERGENi HBG052699.
InParanoidi Q63850.
KOi K14306.
OMAi PAMTYAQ.
OrthoDBi EOG7PZRZB.
PhylomeDBi Q63850.
TreeFami TF324795.

Enzyme and pathway databases

Reactomei REACT_196650. Nuclear Pore Complex (NPC) Disassembly.
REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.

Miscellaneous databases

NextBioi 293652.
PROi Q63850.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q63850.
Bgeei Q63850.
CleanExi MM_NUP62.
Genevestigatori Q63850.

Family and domain databases

InterProi IPR026010. NSP1/NUP62.
IPR007758. Nucleoporin_NSP1_C.
[Graphical view ]
PANTHERi PTHR12084. PTHR12084. 1 hit.
Pfami PF05064. Nsp1_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nuclear pore complex glycoprotein p62 of Xenopus laevis and mouse: cDNA cloning and identification of its glycosylated region."
    Cordes V., Waizenegger I., Krohne G.
    Eur. J. Cell Biol. 55:31-47(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Intermolecular disulfide bonds between nucleoporins regulate karyopherin-dependent nuclear transport."
    Yoshimura S.H., Otsuka S., Kumeta M., Taga M., Takeyasu K.
    J. Cell Sci. 126:3141-3150(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS, MUTAGENESIS OF CYS-479 AND CYS-510.

Entry informationi

Entry nameiNUP62_MOUSE
AccessioniPrimary (citable) accession number: Q63850
Secondary accession number(s): Q99JN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: September 3, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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