Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Selenium-binding protein 2

Gene

Selenbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Selenium- and acetaminophen-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Selenium

Names & Taxonomyi

Protein namesi
Recommended name:
Selenium-binding protein 2
Alternative name(s):
56 kDa acetaminophen-binding protein
Short name:
AP56
Gene namesi
Name:Selenbp2
Synonyms:Lpsb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104859. Selenbp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Selenium-binding protein 2PRO_0000174635Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei467 – 4671Phosphoserine1 Publication

Post-translational modificationi

The N-terminus is blocked.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ63836.
MaxQBiQ63836.
PaxDbiQ63836.
PeptideAtlasiQ63836.
PRIDEiQ63836.

2D gel databases

REPRODUCTION-2DPAGEQ63836.

PTM databases

iPTMnetiQ63836.
PhosphoSiteiQ63836.
SwissPalmiQ63836.

Expressioni

Tissue specificityi

Mainly expressed in liver.

Gene expression databases

BgeeiQ63836.
CleanExiMM_SELENBP2.

Interactioni

Protein-protein interaction databases

BioGridi203157. 1 interaction.
IntActiQ63836. 6 interactions.
MINTiMINT-1854990.
STRINGi10090.ENSMUSP00000088358.

Structurei

3D structure databases

ProteinModelPortaliQ63836.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the selenium-binding protein family.Curated

Phylogenomic databases

eggNOGiKOG0918. Eukaryota.
ENOG410XP4F. LUCA.
HOGENOMiHOG000263885.
HOVERGENiHBG017779.
InParanoidiQ63836.
KOiK17285.
OrthoDBiEOG76DTS8.
PhylomeDBiQ63836.
TreeFamiTF315241.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR008826. Se-bd.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR23300. PTHR23300. 1 hit.
PfamiPF05694. SBP56. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63836-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKCTKCGP GYPTPLEAMK GPREEIVYLP CIYRNTGTEA PDYLATVDVD
60 70 80 90 100
PKSPQYSQVI HRLPMPYLKD ELHHSGWNTC SSCFGDSTKS RNKLILPGLI
110 120 130 140 150
SSRIYVVDVG SEPRAPKLHK VIEASEIQAK CNVSNTHTSH CLASGEVMVN
160 170 180 190 200
TLGDLQGNGK GSFVLLDGET FEVKGTWEKP GGASPMGYDF WYQPRHNVMV
210 220 230 240 250
STEWAAPNVF KDGFNPAHVE AGLYGSRIFV WDWQRHEIIQ TLQMTDGLIP
260 270 280 290 300
LEIRFLHDPS ATQGFVGCAL SSNIQRFYKN EEGTWSVEKV IQVPSKKVKG
310 320 330 340 350
WMLPEMPGLI TDILLSLDDR FLYFSNWLHG DIRQYDISNP QKPRLTGQIF
360 370 380 390 400
LGGSIVRGGS VQVLEDQELT CQPEPLVVKG KRIPGGPQMI QLSLDGKRLY
410 420 430 440 450
ATTSLYSDWD KQFYPDLIRE GSVMLQVDVD TVNGGLKLNP NFLVDFGKEP
460 470
LGPALAHELR YPGGDCSSDI WI
Length:472
Mass (Da):52,610
Last modified:May 29, 2007 - v2
Checksum:i923BEBCDC4657511
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001I → M in AAB25841 (PubMed:8453708).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S56599 mRNA. Translation: AAB25841.2.
BC024106 mRNA. Translation: AAH24106.1.
CCDSiCCDS38539.1.
RefSeqiNP_062287.1. NM_019414.2.
UniGeneiMm.225405.

Genome annotation databases

GeneIDi20342.
KEGGimmu:20342.
UCSCiuc008qgx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S56599 mRNA. Translation: AAB25841.2.
BC024106 mRNA. Translation: AAH24106.1.
CCDSiCCDS38539.1.
RefSeqiNP_062287.1. NM_019414.2.
UniGeneiMm.225405.

3D structure databases

ProteinModelPortaliQ63836.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203157. 1 interaction.
IntActiQ63836. 6 interactions.
MINTiMINT-1854990.
STRINGi10090.ENSMUSP00000088358.

PTM databases

iPTMnetiQ63836.
PhosphoSiteiQ63836.
SwissPalmiQ63836.

2D gel databases

REPRODUCTION-2DPAGEQ63836.

Proteomic databases

EPDiQ63836.
MaxQBiQ63836.
PaxDbiQ63836.
PeptideAtlasiQ63836.
PRIDEiQ63836.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20342.
KEGGimmu:20342.
UCSCiuc008qgx.1. mouse.

Organism-specific databases

CTDi20342.
MGIiMGI:104859. Selenbp2.

Phylogenomic databases

eggNOGiKOG0918. Eukaryota.
ENOG410XP4F. LUCA.
HOGENOMiHOG000263885.
HOVERGENiHBG017779.
InParanoidiQ63836.
KOiK17285.
OrthoDBiEOG76DTS8.
PhylomeDBiQ63836.
TreeFamiTF315241.

Miscellaneous databases

PROiQ63836.
SOURCEiSearch...

Gene expression databases

BgeeiQ63836.
CleanExiMM_SELENBP2.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR008826. Se-bd.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR23300. PTHR23300. 1 hit.
PfamiPF05694. SBP56. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Different patterns of regulation of the genes encoding the closely related 56 kDa selenium- and acetaminophen-binding proteins in normal tissues and during carcinogenesis."
    Lanfear J., Fleming J., Walker M., Harrison P.
    Carcinogenesis 14:335-340(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  3. "A metabolite of acetaminophen covalently binds to the 56 kDa selenium binding protein."
    Pumford N.R., Martin B.M., Hinson J.A.
    Biochem. Biophys. Res. Commun. 182:1348-1355(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 175-189; 196-220; 228-242; 290-296; 334-343 AND 399-408.
  4. "Selenium-binding protein 2, the major hepatic target for acetaminophen, shows sex differences in protein abundance."
    Mattow J., Demuth I., Haeselbarth G., Jungblut P.R., Klose J.
    Electrophoresis 27:1683-1691(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 101-113; 227-230 AND 269-276, IDENTIFICATION BY MASS SPECTROMETRY.
  5. "Phosphoproteome analysis of mouse liver using immobilized metal affinity purification and linear ion trap mass spectrometry."
    Jin W.-H., Dai J., Zhou H., Xia Q.-C., Zou H.-F., Zeng R.
    Rapid Commun. Mass Spectrom. 18:2169-2176(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-467.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSBP2_MOUSE
AccessioniPrimary (citable) accession number: Q63836
Secondary accession number(s): Q8R1T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 29, 2007
Last modified: July 6, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.