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Protein

COMM domain-containing protein 3

Gene

Commd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na+ transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits.By similarity

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Transcription, Transcription regulation, Transport, Ubl conjugation pathway
LigandSodium

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 3
Alternative name(s):
Bmi-1 upstream gene protein
Short name:
Bup protein
Gene namesi
Name:Commd3
Synonyms:Bup
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:88218 Commd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000773901 – 195COMM domain-containing protein 3Add BLAST195

Proteomic databases

EPDiQ63829
MaxQBiQ63829
PaxDbiQ63829
PeptideAtlasiQ63829
PRIDEiQ63829

PTM databases

iPTMnetiQ63829
PhosphoSitePlusiQ63829

Expressioni

Gene expression databases

BgeeiENSMUSG00000051154
CleanExiMM_COMMD3
GenevisibleiQ63829 MM

Interactioni

Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL3, CUL4A, CUL4B, CUL5.By similarity

Protein-protein interaction databases

BioGridi198407, 1 interactor
IntActiQ63829, 1 interactor
MINTiQ63829
STRINGi10090.ENSMUSP00000049882

Structurei

3D structure databases

ProteinModelPortaliQ63829
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 193COMMPROSITE-ProRule annotationAdd BLAST70

Phylogenomic databases

eggNOGiENOG410IKHX Eukaryota
ENOG4111PD7 LUCA
GeneTreeiENSGT00390000015971
HOGENOMiHOG000231902
HOVERGENiHBG051068
InParanoidiQ63829
KOiK22559
OMAiNQLHKMY
OrthoDBiEOG091G0O9G
PhylomeDBiQ63829
TreeFamiTF329267

Family and domain databases

InterProiView protein in InterPro
IPR017920 COMM
IPR037355 COMMD3
PANTHERiPTHR31159 PTHR31159, 1 hit
PfamiView protein in Pfam
PF07258 COMM_domain, 1 hit
PROSITEiView protein in PROSITE
PS51269 COMM, 1 hit

Sequencei

Sequence statusi: Complete.

Q63829-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSESVQRG IQTLADPGSF DSNAFALLLR AAFQSLLDAR ADEAALDHPY
60 70 80 90 100
LKQIDPVVLK HCHAAAATCI LEAGKHQVDK STLSTYLEDC KFDRERIELF
110 120 130 140 150
CTEYQNNKNS LETLLGSIGR SLPHITDVSW RLEYQIKTNQ LHKMYRPGYL
160 170 180 190
VTLNVENNDS QSYPEINFSC NMEQLQDLVG KLKDASKSLE RATQL
Length:195
Mass (Da):22,037
Last modified:November 1, 1996 - v1
Checksum:i7F7A3ACB43699D6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S54914 Unassigned DNA Translation: AAB25378.1
AK041634 mRNA Translation: BAC31015.1
AK145955 mRNA Translation: BAE26783.1
AK145999 mRNA Translation: BAE26820.1
AL928680 Genomic DNA No translation available.
BC048815 mRNA Translation: AAH48815.1
CCDSiCCDS15710.1
RefSeqiNP_680087.1, NM_147778.3
UniGeneiMm.249586

Genome annotation databases

EnsembliENSMUST00000061158; ENSMUSP00000049882; ENSMUSG00000051154
ENSMUST00000171845; ENSMUSP00000127385; ENSMUSG00000051154
GeneIDi12238
KEGGimmu:12238
UCSCiuc008ilx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCOMD3_MOUSE
AccessioniPrimary (citable) accession number: Q63829
Secondary accession number(s): A2ASR4, Q3UKI1, Q8C9P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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