Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

COMM domain-containing protein 3

Gene

Commd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na+ transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Transcription, Transcription regulation, Transport, Ubl conjugation pathway

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 3
Alternative name(s):
Bmi-1 upstream gene protein
Short name:
Bup protein
Gene namesi
Name:Commd3
Synonyms:Bup
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:88218. Commd3.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 195195COMM domain-containing protein 3PRO_0000077390Add
BLAST

Proteomic databases

EPDiQ63829.
MaxQBiQ63829.
PaxDbiQ63829.
PeptideAtlasiQ63829.
PRIDEiQ63829.

PTM databases

iPTMnetiQ63829.

Expressioni

Gene expression databases

BgeeiQ63829.
CleanExiMM_COMMD3.
GenevisibleiQ63829. MM.

Interactioni

Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL3, CUL4A, CUL4B, CUL5.By similarity

Protein-protein interaction databases

BioGridi198407. 1 interaction.
IntActiQ63829. 1 interaction.
MINTiMINT-1846546.
STRINGi10090.ENSMUSP00000049882.

Structurei

3D structure databases

ProteinModelPortaliQ63829.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini124 – 19370COMMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 COMM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IKHX. Eukaryota.
ENOG4111PD7. LUCA.
GeneTreeiENSGT00390000015971.
HOGENOMiHOG000231902.
HOVERGENiHBG051068.
InParanoidiQ63829.
OMAiDASWRLE.
OrthoDBiEOG779P06.
PhylomeDBiQ63829.
TreeFamiTF329267.

Family and domain databases

InterProiIPR017920. COMM.
[Graphical view]
PfamiPF07258. HCaRG. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63829-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSESVQRG IQTLADPGSF DSNAFALLLR AAFQSLLDAR ADEAALDHPY
60 70 80 90 100
LKQIDPVVLK HCHAAAATCI LEAGKHQVDK STLSTYLEDC KFDRERIELF
110 120 130 140 150
CTEYQNNKNS LETLLGSIGR SLPHITDVSW RLEYQIKTNQ LHKMYRPGYL
160 170 180 190
VTLNVENNDS QSYPEINFSC NMEQLQDLVG KLKDASKSLE RATQL
Length:195
Mass (Da):22,037
Last modified:November 1, 1996 - v1
Checksum:i7F7A3ACB43699D6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S54914 Unassigned DNA. Translation: AAB25378.1.
AK041634 mRNA. Translation: BAC31015.1.
AK145955 mRNA. Translation: BAE26783.1.
AK145999 mRNA. Translation: BAE26820.1.
AL928680 Genomic DNA. Translation: CAM23192.1.
BC048815 mRNA. Translation: AAH48815.1.
CCDSiCCDS15710.1.
RefSeqiNP_680087.1. NM_147778.3.
UniGeneiMm.249586.

Genome annotation databases

EnsembliENSMUST00000061158; ENSMUSP00000049882; ENSMUSG00000051154.
ENSMUST00000171845; ENSMUSP00000127385; ENSMUSG00000051154.
GeneIDi12238.
KEGGimmu:12238.
UCSCiuc008ilx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S54914 Unassigned DNA. Translation: AAB25378.1.
AK041634 mRNA. Translation: BAC31015.1.
AK145955 mRNA. Translation: BAE26783.1.
AK145999 mRNA. Translation: BAE26820.1.
AL928680 Genomic DNA. Translation: CAM23192.1.
BC048815 mRNA. Translation: AAH48815.1.
CCDSiCCDS15710.1.
RefSeqiNP_680087.1. NM_147778.3.
UniGeneiMm.249586.

3D structure databases

ProteinModelPortaliQ63829.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198407. 1 interaction.
IntActiQ63829. 1 interaction.
MINTiMINT-1846546.
STRINGi10090.ENSMUSP00000049882.

PTM databases

iPTMnetiQ63829.

Proteomic databases

EPDiQ63829.
MaxQBiQ63829.
PaxDbiQ63829.
PeptideAtlasiQ63829.
PRIDEiQ63829.

Protocols and materials databases

DNASUi12238.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061158; ENSMUSP00000049882; ENSMUSG00000051154.
ENSMUST00000171845; ENSMUSP00000127385; ENSMUSG00000051154.
GeneIDi12238.
KEGGimmu:12238.
UCSCiuc008ilx.1. mouse.

Organism-specific databases

CTDi23412.
MGIiMGI:88218. Commd3.

Phylogenomic databases

eggNOGiENOG410IKHX. Eukaryota.
ENOG4111PD7. LUCA.
GeneTreeiENSGT00390000015971.
HOGENOMiHOG000231902.
HOVERGENiHBG051068.
InParanoidiQ63829.
OMAiDASWRLE.
OrthoDBiEOG779P06.
PhylomeDBiQ63829.
TreeFamiTF329267.

Miscellaneous databases

PROiQ63829.
SOURCEiSearch...

Gene expression databases

BgeeiQ63829.
CleanExiMM_COMMD3.
GenevisibleiQ63829. MM.

Family and domain databases

InterProiIPR017920. COMM.
[Graphical view]
PfamiPF07258. HCaRG. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of bup, an upstream gene in the bmi-1 proviral insertion locus."
    Haupt Y., Barri G., Adams J.M.
    Mol. Biol. Rep. 17:17-20(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta and Thymus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiCOMD3_MOUSE
AccessioniPrimary (citable) accession number: Q63829
Secondary accession number(s): A2ASR4, Q3UKI1, Q8C9P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.