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Protein

Calcineurin subunit B type 2

Gene

Ppp3r2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi31 – 421Add BLAST12
Calcium bindingi63 – 742Add BLAST12
Calcium bindingi100 – 1113Add BLAST12
Calcium bindingi141 – 1524Add BLAST12

GO - Molecular functioni

  • calcium-dependent protein serine/threonine phosphatase activity Source: MGI
  • calcium ion binding Source: InterPro

GO - Biological processi

  • defense response Source: MGI
  • glycogen metabolic process Source: MGI
  • sperm displacement Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcineurin subunit B type 2
Alternative name(s):
Protein phosphatase 2B regulatory subunit 2
Protein phosphatase 3 regulatory subunit B beta isoform
Gene namesi
Name:Ppp3r2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:107171. Ppp3r2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000735002 – 179Calcineurin subunit B type 2Add BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiQ63811.
PaxDbiQ63811.
PRIDEiQ63811.

PTM databases

iPTMnetiQ63811.
PhosphoSitePlusiQ63811.

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSMUSG00000028310.
ExpressionAtlasiQ63811. baseline and differential.
GenevisibleiQ63811. MM.

Interactioni

Subunit structurei

Composed of a catalytic subunit (A) and a regulatory subunit (B).

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029991.

Structurei

3D structure databases

ProteinModelPortaliQ63811.
SMRiQ63811.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 53EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini87 – 122EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini128 – 163EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0034. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00860000133729.
HOGENOMiHOG000233019.
HOVERGENiHBG105307.
InParanoidiQ63811.
KOiK06268.
OMAiNNLKDWQ.
OrthoDBiEOG091G0R0W.
PhylomeDBiQ63811.
TreeFamiTF105558.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNEASYQTE LCNHFDQEEI RRLGKSFRKL DLDKSGSLSI EEFMRLPELQ
60 70 80 90 100
QNPLVGRVID IFDTDGNGEV DFHEFIVGTS QFSVKGDEEQ KLRFAFRIYD
110 120 130 140 150
MDNDGFISNG ELFQVLKMMV GNNLKDWQLQ QLVDKSILVL DKDGDGRISF
160 170
EEFSDVVKTM EIHKKLVVFV EHGQEDLKA
Length:179
Mass (Da):20,659
Last modified:January 23, 2007 - v3
Checksum:i941E8DFDC5708B57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S43865 mRNA. Translation: AAB23172.1.
AK029998 mRNA. Translation: BAC26725.1.
CCDSiCCDS18179.1.
PIRiJC1221.
RefSeqiNP_001004025.1. NM_001004025.4.
UniGeneiMm.46125.

Genome annotation databases

EnsembliENSMUST00000029991; ENSMUSP00000029991; ENSMUSG00000028310.
GeneIDi19059.
KEGGimmu:19059.
UCSCiuc008swd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S43865 mRNA. Translation: AAB23172.1.
AK029998 mRNA. Translation: BAC26725.1.
CCDSiCCDS18179.1.
PIRiJC1221.
RefSeqiNP_001004025.1. NM_001004025.4.
UniGeneiMm.46125.

3D structure databases

ProteinModelPortaliQ63811.
SMRiQ63811.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029991.

PTM databases

iPTMnetiQ63811.
PhosphoSitePlusiQ63811.

Proteomic databases

MaxQBiQ63811.
PaxDbiQ63811.
PRIDEiQ63811.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029991; ENSMUSP00000029991; ENSMUSG00000028310.
GeneIDi19059.
KEGGimmu:19059.
UCSCiuc008swd.1. mouse.

Organism-specific databases

CTDi5535.
MGIiMGI:107171. Ppp3r2.

Phylogenomic databases

eggNOGiKOG0034. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00860000133729.
HOGENOMiHOG000233019.
HOVERGENiHBG105307.
InParanoidiQ63811.
KOiK06268.
OMAiNNLKDWQ.
OrthoDBiEOG091G0R0W.
PhylomeDBiQ63811.
TreeFamiTF105558.

Miscellaneous databases

PROiQ63811.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028310.
ExpressionAtlasiQ63811. baseline and differential.
GenevisibleiQ63811. MM.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCANB2_MOUSE
AccessioniPrimary (citable) accession number: Q63811
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein has four functional calcium-binding sites.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.