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UniProtKB - Q63801 (TAF6_RAT)

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Protein

Transcription initiation factor TFIID subunit 6

Gene

Taf6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 6
Alternative name(s):
Transcription initiation factor TFIID 70 kDa subunit
Short name:
TAF(II)70
Short name:
TAFII70
Transcription initiation factor TFIID 80 kDa subunit
Short name:
TAF(II)80
Short name:
TAFII-80
Short name:
TAFII80
p80
Gene namesi
Name:Taf6
Synonyms:Taf2e
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1311608. Taf6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188751 – 678Transcription initiation factor TFIID subunit 6Add BLAST678

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei120PhosphothreonineBy similarity1
Modified residuei248PhosphothreonineCombined sources1
Modified residuei253PhosphotyrosineCombined sources1
Modified residuei264PhosphoserineCombined sources1
Modified residuei524Omega-N-methylarginineBy similarity1
Modified residuei626PhosphoserineBy similarity1
Modified residuei634PhosphoserineBy similarity1
Modified residuei636PhosphoserineBy similarity1
Modified residuei653PhosphoserineCombined sources1
Modified residuei660PhosphothreonineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ63801.
PRIDEiQ63801.

PTM databases

iPTMnetiQ63801.
PhosphoSitePlusiQ63801.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001355.
GenevisibleiQ63801. RN.

Interactioni

Subunit structurei

TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Interacts directly with TBP, TAF1/TAFII250, TAF9/TAFII31 AND TAF12/TAFII20. The TAF6/TAFII70-TAF9/TAFII31 heterodimer forms an octamer complex with the TAF4B/TFII105-TAF12/TFIID20 heterodimer. Also interacts with the GTFs, TFIIEalpha/GTF2E1 and TFIIFalpha/GTF2F1. Component of the TFTC-HAT complex. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Protein-protein interaction databases

BioGridi252593. 1 interactor.
STRINGi10116.ENSRNOP00000001829.

Structurei

3D structure databases

ProteinModelPortaliQ63801.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TAF6 family.Curated

Phylogenomic databases

eggNOGiKOG2549. Eukaryota.
COG5095. LUCA.
HOGENOMiHOG000253001.
HOVERGENiHBG012489.
InParanoidiQ63801.
OrthoDBiEOG091G05S9.
PhylomeDBiQ63801.
TreeFamiTF313632.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR009072. Histone-fold.
IPR011442. TAF6_C.
IPR004823. TAF_TATA-bd.
PfamiView protein in Pfam
PF02969. TAF. 1 hit.
PF07571. TAF6_C. 1 hit.
SMARTiView protein in SMART
SM00803. TAF. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
SSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEKKLKLS NTVLPSESMK VVAESMGIAQ IQEETCQLLT DEVSYRIKEI 
        60         70         80         90        100
AQDALKFMHM GKRQKLTTSD IDYALKLKNV EPLYGFHAQE FIPFRFASGG 
       110        120        130        140        150
GRELYFYEEK EVDLSDIINT PLPRVPLDVC LKAHWLSIEG CQPAIPENPP 
       160        170        180        190        200
PAPKEQQKAE ATEPLKSAKP GQEEDGPLKG KGQGAAAADG KGKEKKAPPL 
       210        220        230        240        250
LEGAPFRLKP RSIHELSVEQ QLYYKEITEA CVGSCEAKRA EALQSIATDP 
       260        270        280        290        300
GLYQMLPRFS TFISEGVRVN VVQNNLALLI YLMRMVKALM DNPTLYLEKY 
       310        320        330        340        350
VHELIPAVMT CIVSRQLCLR PDVDNHWALR DFAARLVAQI CKHFSTTTNN 
       360        370        380        390        400
IQSRITKTFT KSWVDEKTPW TTRYGSIAGL AELGHDVIKT LILPRLQQEG 
       410        420        430        440        450
ERIRSVLDGP VLSNIDRIGA DHVQSLLLKH CAPVLAKLRP PPDNQDAYRG 
       460        470        480        490        500
EFGSLGPLLC SHVVKARAQA ALQAQQVNRT TLTITQPRPT LTLSQAPQPG 
       510        520        530        540        550
PRTPGLLKVP GSIALPVQTL VSARAAAPPQ PSPPPTKFIV MSSSSSASST 
       560        570        580        590        600
QQVLSLSTSA PGSGSTTTSP VTTTVPSVQP IVKLVSTATT APPSTAPAGP 
       610        620        630        640        650
GSVQKYIVVS LPPTGEGKGG PPSHPSPVPP SSSSPSPLGG SALCGGKQET 
       660        670 
GDSPPPAPGT PKANGSQPTG PSSPQPAL
Length:678
Mass (Da):72,713
Last modified:November 1, 1996 - v1
Checksum:i92D7225E3B7CC171
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49446 mRNA. Translation: BAA08435.1.
RefSeqiXP_008767283.1. XM_008769061.2.
XP_008767284.1. XM_008769062.2.
XP_017453783.1. XM_017598294.1.
UniGeneiRn.102447.

Genome annotation databases

GeneIDi288533.
UCSCiRGD:1311608. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49446 mRNA. Translation: BAA08435.1.
RefSeqiXP_008767283.1. XM_008769061.2.
XP_008767284.1. XM_008769062.2.
XP_017453783.1. XM_017598294.1.
UniGeneiRn.102447.

3D structure databases

ProteinModelPortaliQ63801.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi252593. 1 interactor.
STRINGi10116.ENSRNOP00000001829.

PTM databases

iPTMnetiQ63801.
PhosphoSitePlusiQ63801.

Proteomic databases

PaxDbiQ63801.
PRIDEiQ63801.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi288533.
UCSCiRGD:1311608. rat.

Organism-specific databases

CTDi6878.
RGDi1311608. Taf6.

Phylogenomic databases

eggNOGiKOG2549. Eukaryota.
COG5095. LUCA.
HOGENOMiHOG000253001.
HOVERGENiHBG012489.
InParanoidiQ63801.
OrthoDBiEOG091G05S9.
PhylomeDBiQ63801.
TreeFamiTF313632.

Miscellaneous databases

PROiPR:Q63801.

Gene expression databases

BgeeiENSRNOG00000001355.
GenevisibleiQ63801. RN.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR009072. Histone-fold.
IPR011442. TAF6_C.
IPR004823. TAF_TATA-bd.
PfamiView protein in Pfam
PF02969. TAF. 1 hit.
PF07571. TAF6_C. 1 hit.
SMARTiView protein in SMART
SM00803. TAF. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
SSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTAF6_RAT
AccessioniPrimary (citable) accession number: Q63801
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 10, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.